Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
E1A-associated protein
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "E1A-associated protein" in MCE Product Catalog:
Cat. No.: HY-161958
Target:
Research Areas:
dCE-2 is a CBP/EP300 PROTAC degrader with a DC50 of 40 nM against CBP. dCE-2 forms a ternary complex with the bromodomains of CBP/EP300 and the CRBN E3 ligase, driving proteasomal degradation of CBP/EP300 via positive cooperativity. dCE-2 is applicable to research related to multiple myeloma, prostate cancer, and neuroblastoma .
Cat. No.: HY-161960
Research Areas:
EP300/CBP ligand 2 (compound S19) is a ligand targeting the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). EP300/CBP ligand 2 can be used as a target protein ligand in the PROTAC structure, and can be coupled to the E3 ubiquitin ligase ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, EP300/CBP ligand 2 can be coupled with the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc (HY-161961) to produce the PROTAC molecule dCE-2 (HY-161958) .
Cat. No.: HY-161250
Target:
Research Areas:
Pomalidomide-NH-PEG6-amide-C2-CPI-1612 is a CBP/EP300 PROTAC degrader with a DC50 value of 1.3 μM. Pomalidomide-NH-PEG6-amide-C2-CPI-1612 mediates the formation of a ternary complex between CRBN and the core of CBP, with an EC50 of 1.2 μM. Pomalidomide-NH-PEG6-amide-C2-CPI-1612 inhibits cancer cell growth and exhibits cell line-specific degradation activity. Pomalidomide-NH-PEG6-amide-C2-CPI-1612 can be used in research related to multiple myeloma and leukemia .
Cat. No.: HY-P702892
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: EP300; Histone Crotonyltransferase P300; EP300 Lysine Acetyltransferase; Histone Butyryltransferase P300; P300; protein Lactyltransferas P300; Histone Acetyltransferase P300; E1A-associated protein P300; E1A Binding protein P300; P300 HAT; KAT3B; E1A-Bind
Species:
Human
Source:
E. coli
Cat. No.: HY-P702963
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EP300; Histone Crotonyltransferase P300; EP300 Lysine Acetyltransferase; Histone Butyryltransferase P300; P300; protein Lactyltransferas P300; Histone Acetyltransferase P300; E1A-associated protein P300; E1A Binding protein P300; P300 HAT; KAT3B; E1A-Bind
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P7S0575
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EP300; Histone Crotonyltransferase P300; EP300 Lysine Acetyltransferase; Histone Butyryltransferase P300; P300; protein Lactyltransferas P300; Histone Acetyltransferase P300; E1A-associated protein P300; E1A Binding protein P300; P300 HAT; KAT3B; E1A-Binding protein, 300kD; protein 2-Hydroxyisobutyryltransferase P300; Histone Acetyltransferase; protein Isonicotinyltransferase P300; MKHK2; protein Propionyltransferase P300; RSTS2
Species:
Human
Source:
E. coli
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
