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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
177 Results for "
ENT
" in MedChemExpress (MCE) Product Catalog:
Products (177)
177 Results for "ENT" in MCE Product Catalog:
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Altretamine is an alkylating antineoplastic agent.
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Nitrobenzylthioinosine is an ENT1 transporter inhibitor that binds to ENT1 transporter with high affinity. Nitrobenzylthioinosine is a photoaffinity probe for adenosine uptake sites in brain. Nitrobenzylthioinosine can cross the blood-brain barrier .
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2 Cited Publications
Cat. No.: HY-N2112
CAS No.: 79498-31-0
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Infection Triterpenes Animals Terpenoids Marine natural products Other marine organisms Disease Research Fields Cancer
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Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate c-Jun and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice .
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1 Cited Publications
Cat. No.: HY-18776
CAS No.: 41552-95-8
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A2AR-agonist-1 is a potent A2AR agonist and ENT1 inhibitor with Ki of 4.39 and 3.47 for A2AR and ENT1.
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1 Cited Publications
Cat. No.: HY-N2113
CAS No.: 80508-81-2
Category:
Labiatae Terpenoids Sesquiterpenes Plants Glycyrrhiza lepidota Pursh Disease Research Fields Cancer
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1
1 Cited Publications
Synonyms: R-75231; R88021
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Draflazine (R-75231) is a ENT1 inhibitor. Draflazine (R-75231) completely reverses the hypersensitivity in the complete Freund’s adjuvant (CFA) model of mechanical hyperalgesia and the carrageenan inflammation model of thermal and mechanical hyperalgesia .
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1 Cited Publications
Cat. No.: HY-N6833
CAS No.: 1220616-44-3
Category:
Plants Compositae Sweeteners Food Research Trifolium hybridum L. other families Terpenoids Other Diseases Diterpenoids Disease Research Fields
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N6-(4-Hydroxybenzyl) adenosine (Para-topolin riboside) is an equilibrative nucleoside transporter 1 (ENT1) inhibitor and a selective agonist of adenosine A2a receptor (A2aR), and also exhibits activity against P2Y12 receptor. N6-(4-Hydroxybenzyl) adenosine reduces ethanol intake and preference, attenuates operant conditioning-induced ethanol place preference, decreases the value of ethanol-related rewards, and inhibits collagen-induced platelet aggregation. N6-(4-Hydroxybenzyl) adenosine can be used in studies related to alcohol use disorder .
Cat. No.: HY-N7491A
CAS No.: 2056011-05-1
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ent-(+)-verticilide is a potent and selective inhibitor of cardiac ryanodine receptor (RyR2) calcium release channels with antiarrhythmic activity. ent-(+)-verticilide inhibits RyR2-mediated diastolic Ca2+ leak and exhibits higher potency and a distinct mechanism of action compared with theDantrolene and Tetracaine. ent-(+)-verticilide is a useful tool to investigate the therapeutic potential of targeting RyR2 hyperactivity in heart and brain pathologies .
Cat. No.: HY-133695S1
Cat. No.: HY-N16614
CAS No.: 1292294-31-5
Category:
Flavonoids Akebia quinata (Houttuyn) Decaisne Flavones Lardizabalaceae Terpenoids Sesquiterpenes Plants
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Cat. No.: HY-P990917
CAS No.: 2572467-73-1
Synonyms: ENT-001
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Cat. No.: HY-90009C
CAS No.: 629652-72-8
Synonyms: ENT-IC-351
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ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent PDE5 inhibitor with an IC50 of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 µM .
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ENT-C225 is an effective activator of TrkB neurotrophin receptor. ENT-C225 has high effect on activating TrkB receptor (TrkBR), and has good physicochemical properties and neuroprotective properties .
Cat. No.: HY-164425
CAS No.: 2597832-98-7
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ENT-03 is a centrally acting mammalian aminosterol. ENT-03 upregulates cFos activation, inhibits PTP1b and induces phosphorylation of STAT3. ENT-03 normalizes blood glucose, induces weight loss. ENT-03 can be used in the research of type 2 diabetes and obesity .
Cat. No.: HY-118465
CAS No.: 65085-69-0
Synonyms: ENT-PGE2
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ent-Prostaglandin E2 (ent-PGE2) is an enantiomer of PGE2 (HY-101952). unlike PGE2, ent-PGE2 is a poor substrate for 15-hydroxyprostaglandin dehydrogenase .
Cat. No.: HY-135388
CAS No.: 1376614-99-1
Synonyms: ENT-SCH 58235
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ent-Ezetimibe (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetimibe is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator .
Cat. No.: HY-172515
CAS No.: 1035895-88-5
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ent-Oseltamivir, the enantiomer of Oseltamivir (HY-13317), is a neuraminidase (NA) of influenza virus inhibitor. ent-Oseltamivir is promising for research of influenza virus infections .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
