42 Results for "

FOXO-1

" in MedChemExpress (MCE) Product Catalog:
Products (42)

42 Results for "FOXO-1" in MCE Product Catalog:

  • Isoforms Recommended:
  • Targets Recommended:
88
AS1842856
AS1842856
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88 Publications Verification
Cat. No.: HY-100596
CAS No.: 836620-48-5
Purity:  99.88%
Target:  

Autophagy

Research Areas:  

Metabolic Disease

AS1842856, a specific Foxo1 inhibitor (IC50=30 nM), potently suppresses autophagy [1]. AS1842856 reduces Foxo1 activity and, to a lesser extent, inhibits Foxo1 protein expression by simply binding to Foxo1 .
3
Xanthosine
Xanthosine
0 Images
3 Cited Publications
Cat. No.: HY-W011527
CAS No.: 146-80-5
Category:  

Natural Products Microorganisms Marine natural products Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Akt AMPK FOXO

Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine activates the AMPK/FoxO1/AKT/GSK3β signaling cascade. Xanthosine promotes cell proliferation and regulates blood glucose metabolism. Xanthosine increases milk production in cows and goats. Xanthosine is used in mammary stem cell and type 2 diabetes research [1] .
3
AS1708727
AS1708727
0 Images
3 Cited Publications
Cat. No.: HY-123046
CAS No.: 1253226-93-5
Purity:  99.44%
Target:  

Autophagy

Research Areas:  

Metabolic Disease Cancer

AS1708727 is an orally active Foxo1 inhibitor, with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively [1].
3
Marein
Marein
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3 Cited Publications
Cat. No.: HY-N7676
CAS No.: 535-96-6
Category:  

Cardiovascular Disease other families Flavonoids Chalcones Neurological Disease Phenols Polyphenols Plants Disease Research Fields

Target:  

AMPK HDAC

Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC50 of 100 μM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects [1] .
2
JY-2
JY-2
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2 Cited Publications
Cat. No.: HY-153347
CAS No.: 339103-05-8
Purity:  99.75%
Target:  

FOXO

Research Areas:  

Metabolic Disease

JY-2 is a moderately selective and orally active Forkhead transcription factor forkhead box O1 (FoxO1) inhibitor that inhibits FoxO1 transcriptional activity with an IC50 of 22 μM. JY-2 shows moderate inhibition against FoxO3a and FoxO4. JY-2 shows anti-diabetic activity [1].
1
PFI-90
PFI-90
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1 Cited Publications
Cat. No.: HY-139348
CAS No.: 53995-62-3
Purity:  99.86%
Target:  

Histone Demethylase Apoptosis

Research Areas:  

Cancer

PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1).
1
FOXO1-IN-3
FOXO1-IN-3
0 Images
1 Cited Publications
Cat. No.: HY-153617
CAS No.: 2451093-95-9
Purity:  99.05%
Target:  

FOXO

Research Areas:  

Metabolic Disease

FOXO1-IN-3 is a highly-selective and orally active FOXO1 inhibitor. FOXO1-IN-3 reduces hepatic glucose production in mice. FOXO1-IN-3 improves insulin sensitivity and glucose control in db/db mice without causing weight gain [1].
1
Piperacetazine
Piperacetazine
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1 Cited Publications
Cat. No.: HY-B1152
CAS No.: 3819-00-9
Target:  

Dopamine Receptor CD276/B7-H3 FOXO

Research Areas:  

Neurological Disease Cancer

Piperacetazine is an orally active dopamine receptor antagonist and phenothiazine antipsychotic. Piperacetazine can directly bind to the PAX3::FOXO1 fusion protein and inhibit its transcriptional activity. Piperacetazine also exhibits antitumor activity with an IC50 of 7.627 μM against PANC-1 cells. Piperacetazine can be used for the research of diseases such as schizophrenia and pancreatic cancer and other tumors [1] .
1
SB-699551
SB-699551
0 Images
1 Cited Publications
Cat. No.: HY-103100
CAS No.: 864741-95-7
Purity:  99.53%
Target:  

5-HT Receptor Epigenetic Reader Domain Akt Ribosomal S6 Kinase (RSK) FOXO

Research Areas:  

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

SB-699551 is a selective and brain penetrant 5-HT5A receptor antagonist with a pKi of 8.2 nM. SB-699551 shows high selectivity over most other 5-HT receptor subtypes, dopamine receptors, and α1B adrenoceptor. SB-699551 disrupts Gαi/o-coupled and PI3K/AKT/mTOR signaling pathways, alters CREB, ATF1, AKT, PRAS40, S6K, and FOXO1 phosphorylation in breast tumor cells. SB-699551 can be used for the research of anxiety, breast cancer, and Alzheimer's disease [1] .
1
NSC45586 sodium
NSC45586 sodium
0 Images
1 Cited Publications
Cat. No.: HY-19820A
CAS No.: 6300-44-3
Target:  

Akt Ser/Thr Protease Apoptosis MMP

Research Areas:  

Cardiovascular Disease Neurological Disease Inflammation/Immunology

NSC45586 sodium is an inhibitor of PHLPP. NSC45586 sodium targets the PP2C phosphatase domains of PHLPP1 and PHLPP2, blocks the phosphatase activity of PHLPP, increases the expression level of FOXO1 in the nucleus, and reduces the protein expression of PHLPP1. NSC45586 sodium activates the AKT survival signaling pathway, enhances IGF-1-induced AKT activation, and inhibits the phosphorylation of AKT/ERK under basal conditions. NSC45586 sodium reduces staurosporine-induced neuronal death, preserves notochord cell morphology and KRT19 expression, inhibits cell apoptosis (apoptosis), improves the viability and proliferation of nucleus pulposus cells, upregulates the expression of ACAN/SOX9, and downregulates the expression of MMP13. NSC45586 sodium binds tightly to bovine serum albumin (bovine serum albumin), and exerts a more significant effect on nucleus pulposus in male individuals. NSC45586 sodium can be used in studies related to global cerebral ischemia and intervertebral disc degeneration [1] .
1
DIM-C-pPhCO2Me
DIM-C-pPhCO2Me
0 Images
1 Cited Publications
Cat. No.: HY-112056
CAS No.: 151358-48-4
Purity:  99.47%
Target:  

Nuclear Hormone Receptor 4A/NR4A Apoptosis DAPK Isocitrate Dehydrogenase (IDH) PERK

Research Areas:  

Cancer

DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhCO2Me induces Apoptosis. DIM-C-pPhCO2Me decreases PAX3-FOXO1A, N-Myc, Rassf4, MyoD1, Grem1, and DAPK1 proteins. DIM-C-pPhCO2Me decreases expression of TXNDC5 and IDH1, induces markers of ER stress (CHOP, ATF4 and p-PERK). DIM-C-pPhCO2Me inhibits renal cell carcinoma, breast cancer. DIM-C-pPhCO2Me can also be used in rhabdomyosarcoma research [1] .
Methyl protodioscin
Methyl protodioscin
0 Images
Cat. No.: HY-N0863
CAS No.: 54522-52-0
Synonyms: NSC-698790; Smilax saponin B
Category:  

other families Plants Disease Research Fields Cancer Steroids

Target:  

Bcl-2 Family Apoptosis Akt c-Myc ERK p38 MAPK JNK FOXO

Methyl protodioscin (NSC-698790; Smilax saponin B) is a multi-target, selective, steroidal diglycoside inhibitor with antitumor activity that induces cell cycle arrest. The mechanism of action of Methyl protodioscin is complex, involving the induction of G2/M cell cycle arrest, regulation of the Bcl-2/Bax apoptotic pathway, inhibition of the Akt1/c-Myc axis and MAPK/ERK signaling, while simultaneously downregulating ADAM15 and inducing FOXO1 to reduce cholesterol synthesis. It also inhibits the JNK/c-Jun pathway, reducing the production of inflammatory factors (IL-6, TNF-α). Methyl protodioscin exhibits significant antitumor (inhibiting proliferation, migration, invasion, and inducing apoptosis), anti-inflammatory, and anti-restenosis activities. Methyl protodioscin can be used in research on lung cancer, prostate cancer, pancreatic cancer, and other tumors, as well as inflammatory diseases such as airway inflammation and enteritis [1] .
5,7-Dihydroxy-4-methylcoumarin
5,7-Dihydroxy-4-methylcoumarin
0 Images
Cat. No.: HY-N4102
CAS No.: 2107-76-8
Category:  

Infection other families Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields

Target:  

Apoptosis JNK FOXO Reactive Oxygen Species (ROS) Caspase

5,7-Dihydroxy-4-methylcoumarin is an antioxidant. 5,7-Dihydroxy-4-methylcoumarin protects mouse cochlear hair cells from Cisplatin-induced damage, enhances cell viability and inhibits apoptosis. 5,7-Dihydroxy-4-methylcoumarin downregulates phosphorylated JNK levels, increases the ratio of phosphorylated FoxO1 to total FoxO1, scavenges free radicals, reduces ROS accumulation, maintains mitochondrial membrane potential and alleviates mitochondrial dysfunction. 5,7-Dihydroxy-4-methylcoumarin downregulates the expression of caspase-3 and improves cell viability. 5,7-Dihydroxy-4-methylcoumarin can be used in studies related to ototoxicity [1] .
N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride
N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride
0 Images
Cat. No.: HY-137038
CAS No.: 4238-41-9
Synonyms: TLCK hydrochloride
Target:  

Caspase Ser/Thr Protease FOXO

Research Areas:  

Cardiovascular Disease Cancer

N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride (TLCK hydrochloride) is a Serine protease inhibitor with an IC50 of 12.0 μM against Caspase-3, 54.5 μM against Caspase-6, and 19.3 μM against Caspase-7. It inhibits thrombin-induced nuclear translocation of FOXO1. N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride can be used in research related to leukemia and cardiovascular diseases [1].
Matairesinol
Matairesinol
0 Images
Cat. No.: HY-N3312
CAS No.: 580-72-3
Category:  

Infection other families Anti-aging Lignans Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields

Target:  

p38 MAPK JNK NF-κB

Matairesinol is an orally active bioactive compound with anti-inflammatory, antioxidant and anticancer activities. Matairesinol inhibits the phosphorylation of MAPK, JNK and NF-κB, downregulates RANKL-induced NFATc1 expression and activity, and suppresses the activation of the PI3K/AKT/FOXO1 pathway. Matairesinol can be used in research related to sepsis-mediated brain injury, osteoporosis, heart failure, atopic dermatitis and cancer [1] .
Psammaplysene A
Psammaplysene A
0 Images
Cat. No.: HY-111299
CAS No.: 850013-02-4
Purity:  99.72%
Target:  

Apoptosis

Research Areas:  

Cancer

Psammaplysene A, a brominated tyrosine derivative, can promote the nuclear localization of FOXO1, leading to cell cycle arrest and apoptosis, and can be used in cancer research [1].
FOXO1 Human Pre-designed siRNA Set A
FOXO1 Human Pre-designed siRNA Set A
Cat. No.: HY-RS05069
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

FOXO1 Human Pre-designed siRNA Set A contains three designed siRNAs for FOXO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Carpachromene
Carpachromene
0 Images
Cat. No.: HY-N3542
CAS No.: 57498-96-1
Category:  

Flavonoids Flavones Plants Calophyllaceae Calophyllum symingtonianum M.R.Hend. & Wyatt-Sm.

Target:  

Glycosidase

Carpachromene is a potent α-glucosidase enzyme inhibitor. Carpachromene ameliorates insulin resistance in HepG2 cells via modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 pathway [1].
Xanthosine dihydrate
Xanthosine dihydrate
0 Images
Cat. No.: HY-W013803
CAS No.: 5968-90-1
Category:  

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Akt AMPK FOXO

Xanthosine dihydrate is a nucleoside derived from xanthine and ribose. Xanthosine dihydrate activates the AMPK/FoxO1/AKT/GSK3β signaling cascade. Xanthosine dihydrate promotes cell proliferation and regulates blood glucose metabolism. Xanthosine dihydrate increases milk production in cows and goats. Xanthosine dihydrate is used in mammary stem cell and type 2 diabetes research [1] .
Foxo1 Rat Pre-designed siRNA Set A
Foxo1 Rat Pre-designed siRNA Set A
Cat. No.: HY-RS22991
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

Foxo1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Foxo1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Assay Types