580-72-3
580-72-3
Chemical Structure
Matairesinol
- CAS No.: 580-72-3
- Formula:C20H22O6
- Molecular Weight:358.39
IUPAC Name: (3R,4R)-3,4-bis(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one
InChIKey: MATGKVZWFZHCLI-LSDHHAIUSA-N
SMILES: O=C1OC[C@H](CC2=CC=C(O)C(OC)=C2)[C@H]1CC3=CC=C(O)C(OC)=C3
Biological Activity: Matairesinol is an orally active bioactive compound with anti-inflammatory, antioxidant and anticancer activities. Matairesinol inhibits the phosphorylation of MAPK, JNK and NF-κB, downregulates RANKL-induced NFATc1 expression and activity, and suppresses the activation of the PI3K/AKT/FOXO1 pathway. Matairesinol can be used in research related to sepsis-mediated brain injury, osteoporosis, heart failure, atopic dermatitis and cancer[1][2][3][4][5].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Matairesinol | 98.78% | Matairesinol is an orally active bioactive compound with anti-inflammatory, antioxidant and anticancer activities. Matairesinol inhibits the phosphorylation of MAPK, JNK and NF-κB, downregulates RANKL-induced NFATc1 expression and activity, and suppresses the activation of the PI3K/AKT/FOXO1 pathway. Matairesinol can be used in research related to sepsis-mediated brain injury, osteoporosis, heart failure, atopic dermatitis and cancer. | ||||||||||||||||||||
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Matairesinol (Standard) | 98.73% | Matairesinol (Standard) is the analytical standard of Matairesinol. This product is intended for research and analytical applications. Matairesinol confers anti-allergic effects in an allergic dermatitis mouse model. DfE-induced changes in IL-4 and IFN-γ mRNA expression in the ears of NC/Nga mice were reversed by matairesinol application. | ||||||||||||||||||||
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Arctigenin (Standard) | 99.50% | Arctigenin (Standard) is the analytical standard of Arctigenin. This product is intended for research and analytical applications. Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions. | ||||||||||||||||||||
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(-)-Haplomyrfolin | (-)-Haplomyrfolin is a natural lignan with anticancer effects. | |||||||||||||||||||||
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3′-O-Demethylarctigenin | 3′-O-Demethylarctigenin is a phenolic compound that can be isolated from the seeds of Arctium lappa. 3′-O-Demethylarctigenin shows cytotoxicity for PANC-1 cells with an IC50 value of 4.38 µM. | |||||||||||||||||||||
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4'-O-Methylthujaplicatin | 4'-O-Methylthujaplicatin is a thujaplicatin derivative. 4'-O-Methylthujaplicatin is related to the Yatein (HY-N1060) biosynthetic pathway. | |||||||||||||||||||||
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Thujaplicatin | Thujaplicatin is a natural lignan. | |||||||||||||||||||||
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Dimethylmatairesinol | Dimethylmatairesinol (compound 8) is a lignan compound isolated from the seed of Hernandia nymphaeifolia. Dimethylmatairesinol shows cytotoxicity against the KKU-M156 and HepG2 cell line with IC50s of 5.4 μM (Emax 59%) and 5.2 μM (Emax 78%), respectively. | |||||||||||||||||||||
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Anhydrosecoisolariciresinol | 99.94% | Anhydrosecoisolariciresinol is from the flower of Wedelia biflora, has anti-tumor activities. Anhydrosecoisolariciresinol decreases the growth of human breast cancer MCF-7 and MDA-MB-231 cell lines. | ||||||||||||||||||||
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(+)-Matairesinol | (+)-Matairesinol is a lignan. (+)-Matairesinol has no cytotoxic activity for human pancreatic PANC-1 cancer cells. | |||||||||||||||||||||
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Pluviatolide | 95.0% | Pluviatolide ((-)-Pluviatolide) is a lignan that can be found in the bark of Zanthoxylum pluviatile Hartley. Pluviatolide can be used as (-)-Podophyllotoxin precursor. | ||||||||||||||||||||
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3,4-Divanilyltetrahydrofuran | 3,4-Divanilyltetrahydrofuran is a sex hormone-binding globulin (SHBG) ligand with a pKd value of 6.51. | |||||||||||||||||||||
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References
- [1]. Wu Q, et al. Matairesinol exerts anti-inflammatory and antioxidant effects in sepsis-mediated brain injury by repressing the MAPK and NF-κB pathways through up-regulating AMPK. Aging (Albany NY). 2021;13(20):23780-23795. [Content Brief]
- [2]. Choi SW, et al. Anti-osteoclastogenic activity of matairesinol via suppression of p38/ERK-NFATc1 signaling axis. BMC Complement Altern Med. 2014;14:35. Published 2014 Jan 21. [Content Brief]
- [3]. Zhang T, et al. Matairesinol blunts adverse cardiac remodeling and heart failure induced by pressure overload by regulating Prdx1 and PI3K/AKT/FOXO1 signaling. Phytomedicine. 2024;135:156054. [Content Brief]
- [4]. Sung YY, et al. Forsythia suspensa fruit extracts and the constituent matairesinol confer anti-allergic effects in an allergic dermatitis mouse model. J Ethnopharmacol. 2016;187:49-56. [Content Brief]
- [5]. Lee B, et al. Matairesinol inhibits angiogenesis via suppression of mitochondrial reactive oxygen species. Biochem Biophys Res Commun. 2012;421(1):76-80. [Content Brief]
