3819-00-9
Chemical Structure
Piperacetazine
- CAS No.: 3819-00-9
- Formula:C24H30N2O2S
- Molecular Weight:410.57
IUPAC Name: 1-(10-(3-(4-(2-hydroxyethyl)piperidin-1-yl)propyl)-10H-phenothiazin-2-yl)ethan-1-one
InChIKey: BTFMCMVEUCGQDX-UHFFFAOYSA-N
SMILES: CC(C(C=C1N2CCCN3CCC(CCO)CC3)=CC=C1SC4=C2C=CC=C4)=O
Biological Activity: Piperacetazine is an orally active dopamine receptor antagonist and phenothiazine antipsychotic. Piperacetazine can directly bind to the PAX3::FOXO1 fusion protein and inhibit its transcriptional activity. Piperacetazine also exhibits antitumor activity with an IC50 of 7.627 μM against PANC-1 cells. Piperacetazine can be used for the research of diseases such as schizophrenia and pancreatic cancer and other tumors[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Piperacetazine | 98.03% | Piperacetazine is an orally active dopamine receptor antagonist and phenothiazine antipsychotic. Piperacetazine can directly bind to the PAX3::FOXO1 fusion protein and inhibit its transcriptional activity. Piperacetazine also exhibits antitumor activity with an IC50 of 7.627 μM against PANC-1 cells. Piperacetazine can be used for the research of diseases such as schizophrenia and pancreatic cancer and other tumors. | ||||||||||||||||||||
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- [1]. Nakazawa K, et al. Piperacetazine Directly Binds to the PAX3::FOXO1 Fusion Protein and Inhibits Its Transcriptional Activity. Cancer Res Commun. 2023 Oct 6;3(10):2030-2043. [Content Brief]
- [2]. WEAVER LC, et al. Toxicopathologic and pharmacologic properties of piperacetazine, a potent tranquilizing agent. Toxicol Appl Pharmacol. 1963 Jan;5:49-60. [Content Brief]
- [3]. Deng J, et al. Identification of an autophagy-related gene signature for predicting prognosis and immune activity in pancreatic adenocarcinoma. Sci Rep. 2022 Apr 29;12(1):7006. [Content Brief]
Keywords
