1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Pericyazine

Pericyazine (Synonyms: Propericiazine; RP 8909)

Cat. No.: HY-14263 Purity: 99.83%
Handling Instructions

Pericyazine (Propericiazine) is a first-generation antipsychotic agent that is used as an adjunct to the short-term management of severe anxiety states and psychosis. Pericyazine is a selective D2-dopamine receptor antagonist. Pericyazine has adrenolytic, anticholinergic, and extrapyramidal effects.

For research use only. We do not sell to patients.

Pericyazine Chemical Structure

Pericyazine Chemical Structure

CAS No. : 2622-26-6

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 80 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
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10 mg USD 150 In-stock
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25 mg USD 300 In-stock
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50 mg USD 500 In-stock
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100 mg USD 850 In-stock
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Description

Pericyazine (Propericiazine) is a first-generation antipsychotic agent that is used as an adjunct to the short-term management of severe anxiety states and psychosis[1]. Pericyazine is a selective D2-dopamine receptor antagonist[2][3]. Pericyazine has adrenolytic, anticholinergic, and extrapyramidal effects[4].

IC50 & Target

D2-dopamine receptor[2]

In Vivo

Studies in rodents show that Pericyazine is able to produce potentiation of ether and hexobarbital narcosis and morphine analgesia. It also has hypothermic activity and produces depression of spontaneous motor activity in mice. On a milligram potency basis, Pericyazine is more potent than chlorpromizine in the potentiation of barbiturate narcosis test and the blocking of conditioned avoidance in rats. Pericyazine demonstrates analgesic properties similar to methotrimeprazine in mice and rats and produces adrenergic blocking effects in mice and dogs[4].

Molecular Weight

365.49

Formula

C₂₁H₂₃N₃OS

CAS No.

2622-26-6

SMILES

N#CC(C=C1N2CCCN3CCC(O)CC3)=CC=C1SC4=C2C=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (684.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7361 mL 13.6803 mL 27.3605 mL
5 mM 0.5472 mL 2.7361 mL 5.4721 mL
10 mM 0.2736 mL 1.3680 mL 2.7361 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.69 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.69 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PericyazinePropericiazineRP 8909RP8909RP-8909Dopamine ReceptorantipsychoticanxietypsychosisadrenolyticanticholinergicextrapyramidalInhibitorinhibitorinhibit

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Product Name:
Pericyazine
Cat. No.:
HY-14263
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