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Results for "

Gene Delivery

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (2) Amyloid-β (1) Bacterial (3) Biochemical Assay Reagents (51) DNA Alkylator/Crosslinker (3) DNA/RNA Synthesis (3) Drug Derivative (1) Endogenous Metabolite (1) Environmental Pollutants (1) Exosomes (1) Fluorescent Dye (6) HBV (1) HIV (2) IFNAR (1) Interleukin Related (1) Isotope-Labeled Compounds (2) Lipase (1) Liposome (45) mRNA (2) nAChR (3) Peptide-Drug Conjugates (PDCs) (1) Phosphoramidites (3) Potassium Channel (1) Progesterone Receptor (1) Proteasome (3) RABV (1) SARS-CoV (1) Small Interfering RNA (siRNA) (1) TMV (1) Transferrin Receptor (1) Transthyretin (TTR) (1)
By Research Areas:	Cancer (25) Infection (7) Inflammation/Immunology (10) Metabolic Disease (4) Neurological Disease (7)
Click Chemistry:	DBCO (1)
Oligonucleotides:	Pegylated Lipids (6) Adenine (1) Liposome (4) Cytosine (1) mRNA (2) Phospholipids (3) Cationic Lipids (26) Reporter Genes (1) Polymers (5) Phosphoramidites (3) Guanine (1) Cholesterol (3)

119

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: LAG-3 CGRP Receptor MALT1 Dan family RIG-I-like receptor (RLR) NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138170

ALC-0315 Maximum Cited Publications 39 Publications Verification	Liposome SARS-CoV	Infection
ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .

HY-W127378

DOTAP methylsulfate 10+ Cited Publications 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate	Liposome	Others
DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design .

HY-W250110

Polyethylenimine (branched) (30% in water) 5+ Cited Publications	Environmental Pollutants Biochemical Assay Reagents	Infection Others
Polyethylenimine (branched) (30% in water) is a organic macromolecule with high cationic-charge-density potential. Polyethylenimine (branched) (30% in water) can ensnare DNA as well as attach to cell membrane. Polyethylenimine (branched) (30% in water) also retains a substantial buffering capacity at virtually any pH. Polyethylenimine (branched) (30% in water) is widely used as transfection reagent .

HY-131119

Dimethyldioctadecylammonium bromide Dioctadecyldimethylammonium bromide; DODAB	Liposome	Others
Dimethyldioctadecylammonium bromide is a synthetic cationic lipid commonly used in gene delivery and vaccine development. Also known as DODAB or DDAB, it consists of a positively charged ammonium head group and two long hydrophobic tails. These properties make it useful for forming liposomes and other lipid-based nanoparticles that can efficiently deliver genetic material into cells. In addition to its applications in biotechnology, DDAB is also used in surfactants, emulsifiers and fabric softeners. However, due to its potential toxicity and irritation, extreme care should be taken when handling DDAB.

HY-112758

DLin-KC2-DMA 5+ Cited Publications	Liposome	Others
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .

HY-112760

18:0 mPEG2000 PE sodium 1 Publications Verification DSPE-mPEG2000 sodium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] sodium	Liposome	Others
18:0 mPEG2000 PE (DSPE-mPEG2000) sodium is a conjugate of phospholipid and polyethylene glycol, and it can serve as an important PEG lipid component in lipid nanoparticles (LNPs). 18:0 mPEG2000 PE sodium can be used in the research of gene transfection, drug carriers and drug delivery .

HY-126437E

Poly-L-lysine hydrobromide (MW 15000-30000)	Biochemical Assay Reagents	Others
Poly-L-lysine hydrobromide (with a molecular weight of 15,000 - 30,000) is an amino acid polymer with positive charge, and it serves as a non-specific attachment factor for cells. Poly-L-lysine hydrobromide (with a molecular weight of 15,000 - 30,000) can be used for gene delivery and the construction of nano-delivery systems .

HY-155882

mPEG750-amine mPEG750-NH2	Biochemical Assay Reagents	Cancer
mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folate receptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells .

HY-W007599

(S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid	Drug Derivative	Cancer
(S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid is a polypeptide derivative, can be used to synthesis multifunctional amphiphilic peptide dendrimer for non-viral gene delivery in cancer research. (S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid can be used in the preparation of organic substances that enhance the luminescence intensity of alkaline phosphatase substrates .

HY-126437H

Poly-L-lysine hydrobromide (MW 4000-15000) 1 Publications Verification	Biochemical Assay Reagents	Others
Poly-L-lysine hydrobromide (MW 4000-15000) is a positively charged amino acid polymer that acts as a non-specific attachment factor for cells. Poly-L-lysine hydrobromide (MW 4000-15000) enhances the electrostatic interaction between the negative ions of the cell membrane and the surface of the culture medium, thereby promoting the adhesion of cells to solid substrates. Poly-L-lysine hydrobromide (MW 4000-15000) can be used for gene delivery .

HY-E70313

Lipase,Candida antarctica (Immobilized on hydrophilic carrier) Candida antarctica lipase B	Biochemical Assay Reagents	Others
Lipase,Candida antarctica (Immobilized on hydrophilic carrier) (Candida antarctica lipase B) is a lipase derived from Candida antarctica and immobilized on a hydrophilic carrier. Lipase,Candida antarctica (Immobilized on hydrophilic carrier) is a green catalyst that can be used to catalyze polymer synthesis .

HY-P4121

L17E	Potassium Channel	Inflammation/Immunology Cancer
L17E is an attenuated cationic amphiphilic lytic (ACAL) peptide that can be used to deliver a variety of macromolecules, including proteins, antibodies, and DNA nanostructures. L17E inserts and cleaves the membrane structure through electrostatic interaction, enabling intracellular escape. The efficiency of L17E-mediated delivery is strongly correlated with the expression level of KCNN4 (the gene encoding the calcium-activated potassium channel KCa3.1). L17E also promotes the cellular uptake of macromolecules by inducing micropinocytosis. L17E can be further optimized and improved through dimerization strategies and in combination with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles .

HY-174497

eGFP mRNA	mRNA	Others
eGFP mRNA expresses green fluorescent protein derived from the jellyfish Aequorea victoria. eGFP is a commonly used direct-detection reporter gene in mammalian cell culture, which produces bright green fluorescence. This product is synthesized without modified nucleosides, with a Cap1 version cap analog at the 5' end and a 100nt PolyA tail at the 3' end. It can be used as a positive reference for IVT (in vitro transcription) or LNP delivery systems.

HY-153229

Firefly luciferase mRNA-LNP 1 Publications Verification	mRNA Biochemical Assay Reagents	Others
Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing firefly luciferase mRNA. Firefly luciferase mRNA-LNP exhibits a stable nanostructure, in which LNP plays a key role in effectively protecting and transporting mRNA to cells. Luciferase is a bioluminescent reporter gene for gene regulation and functional studies. Firefly Luciferase mRNA-LNP expresses firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Firefly luciferase mRNA-LNP is studied in research for RNA delivery, cell viability, and translation efficiency .

HY-143702

Fluorescent DOTAP NBD-DOTAP	Fluorescent Dye Liposome	Inflammation/Immunology Cancer
Fluorescent DOTAP (NBD-DOTAP) is a cationic lipid which can be used for nucleic acid and protein delivery. Fluorescent DOTAP is labeled with a fluorophore NBD (maximum excitation/emission wavelength ∼463/536 nm). Fluorescent DOTAP can be used for gene delivery systems, drug delivery, as well as cell imaging and nanocarrier tracking. Fluorescent DOTAP is an ideal candidate for both biological and pharmaceutical formulation (e.g. co-delivery of vaccines) research .

HY-126437I

Poly-L-lysine hydrobromide (MW 1000-5000)	Biochemical Assay Reagents DNA Alkylator/Crosslinker Amino Acid Derivatives	Cancer
Poly-L-lysine hydrobromide (MW 1000-5000) is a homopolymer of L-lysine and a polycationic non-viral gene delivery vector. Poly-L-lysine hydrobromide (MW 1000-5000) forms complexes with plasmid DNA. Poly-L-lysine hydrobromide (MW 1000-5000) is applicable to relevant research on lung cancer .

HY-112624U

Dextran T20 (MW 20,000) Dextran 20; Dextran D20; Dextran T20(MW 16000-24000)	Biochemical Assay Reagents	Others
Dextran T20 (Dextran 20; Dextran D20) (MW 20,000) is a dehydrated glucose polymer with an average molecular weight of 20,000. Dextran T20 (MW 20,000) has excellent biodegradability and good biocompatibility, and can be used as a gene delivery vector, an immune adjuvant carrier, and a hemoglobin stabilizer .

HY-147087

YSK 05	Liposome	Cancer
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .

HY-P4086

Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R)	RABV nAChR	Neurological Disease Cancer
Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) is a cell-penetrating peptide that is synthesized by adding nona-arginine motif to the carboxy terminus of RVG (rabies virus glycoprotein). Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) binds to nAChR on neuronal cells to mediate receptor-mediated endocytosis and targeted siRNA delivery. Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) protects complexed siRNA from degradation, enhances transcellular siRNA delivery in neuronal cells, and promotes efficient, pecific gene silencing. Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) can be used for the researches of neurological disease and cancer .

HY-153232

eGFP circRNA-LNP	Fluorescent Dye Liposome	Others
eGFP circRNA-LNP is a lipid nanoparticle (LNP) containing eGFP circRNA, suitable for assays of RNA delivery, translation efficiency, cell viability, etc. eGFP circRNA carries Enhanced Green Fluorescent Protein (Enhanced Green Fluorescent Protein) eGFP, which will express green fluorescent protein after entering the cell. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry .

HY-149037A

GL67 pentahydrochloride N4-Spermine cholesteryl carbamate pentahydrochloride	Liposome	Others
GL67 (N4-Spermine cholesteryl carbamate) (pentahydrochloride) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .

HY-134783

1,19-Bis(2-butyloctyl) 10-[[3-(dimethylamino)propyl](1-oxononyl)amino]nonadecanedioate	Liposome	Others
1,19-Bis(2-butyloctyl) 10-[[3-(dimethylamino)propyl](1-oxononyl)amino]nonadecanedioate is an excipient for vaccines. 1,19-Bis(2-butyloctyl) 10-[[3-(dimethylamino)propyl](1-oxononyl)amino]nonadecanedioate can be used for the research of the development of COVID-19 vaccines and drug delivery for gene therapy .

HY-144022

16:0 DAP	Liposome	Others
16:0 DAP is a cationic lipids that can be used for drug delivery, gene transfection and vaccine delivery .

HY-172705

DSPE-PEG2000-RVG29	Liposome nAChR	Neurological Disease
DSPE-PEG2000-RVG29 is a PEG conjugate composed of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 specifically binds to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB), crosses the BBB, and mediates receptor-dependent transcytosis. DSPE-PEG2000-RVG29 can be used for brain-targeted drug delivery, surface modification of nanocarriers, as well as gene and nucleic acid delivery. DSPE-PEG2000-RVG29 is applicable to research related to hypoxic-ischemic brain injury, Parkinson's disease, and other conditions .

HY-W591476B

m-PEG750-thiol mPEG750-SH	Biochemical Assay Reagents	Others
m-PEG750-thiol modifies DNA thiolation for the synthesis of gold nanorods (AuNRs). Thiolated DNA can be loaded onto AuNR by the mPEG-SH/Tween 20 assisted method (Tween 20 and mPEG-SH repeatedly displace CTAB on the AuNR surface). DNA AuNRs have been widely used in nanostructure assembly, gene therapy, biosensing, and drug delivery.

HY-N3540

Caraphenol A	Others	Inflammation/Immunology
Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC₅₀s of 5.9 μM and 12.1 μM, respectively .

HY-P10991A

Stearyl-(homoarginine)8 TFA Stearylated octaarginine TFA	Biochemical Assay Reagents	Others
Stearyl-(homoarginine)8 (Stearylated octaarginine) TFA is an effective gene delivery vector that can deliver plasmid DNA into cells. Stearyl-(homoarginine)8 TFA can make plasmid DNA more effectively internalized into cells and improve the nuclear delivery rate .

HY-153231A

eGFP mRNA-LNP (500 ng/μL)	Fluorescent Dye Liposome	Others
eGFP mRNA-LNP (500 ng/μL) is a lipid nanoparticle (LNP) containing eGFP mRNA. eGFP mRNA-LNP carries Enhanced Green Fluorescent Protein (eGFP), which will express green fluorescent protein after entering the cell. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry (excitation wavelength = 488 nm; emission wavelength = 535/40 bandpass). eGFP mRNA-LNP can be used for RNA delivery, translation efficiency and cell viability .

HY-172526

4A3-SCC-10	Liposome	Cancer
4A3-SCC-10 is a biodegradable ionizable lipid containing disulfide bonds. 4A3-SCC-10 can be used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. 4A3-SCC-10 can be used for broad applications such as gene editing, vaccine, and cancer detection .

HY-137499

NT1-O12B	Liposome Endogenous Metabolite	Neurological Disease
NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB)-impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination .

HY-P4118

EB1 peptide Penetrating analog	Amino Acid Derivatives Peptide-Drug Conjugates (PDCs)	Others
EB1 peptide (Penetrating analog) is an endosomolytic agent and siRNA delivery agent. EB1 peptide forms an amphipathic alpha helix upon protonation in early-late endosomes, drives endosomal membrane permeabilization, and enables endocytosed siRNA escape into the cytosol. EB1 peptide facilitates biologically active siRNA cellular uptake and targeted gene silencing. EB1 peptide forms complexes with siRNA. EB1 peptide can be used for drug delivery research .

HY-164035

DOPE-PEG2000-DBCO	Biochemical Assay Reagents	Others
DOPE-PEG2000-DBCO is a PEG lipid with a DOPE and a DBCO as functional groups. DOPE can be used as a helper lipid in gene transfection. PEG is used in drug delivery system. DBCO can be used for click chemistry .

HY-160852

YSK 12C4	Liposome	Inflammation/Immunology
YSK 12C4 is an ionizable cationic lipid primarily used to enhance siRNA cellular delivery via multifunctional envelope-type nanodevices (MEND). YSK 12C4 promotes siRNA uptake and endosomal escape, effectively silencing genes in human immune cell lines .

HY-159067

DEAE-dextran, MW 500000 hydrochloride DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides); Diethylaminoethyl-dextran, MW 500000 hydrochloride	Biochemical Assay Reagents	Cancer
DEAE-dextran, MW 500000 hydrochloride (DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides)) is a high-molecular-weight positively charged polymer that significantly enhances the uptake of viral RNA by tissue culture cells. When employed in the delivery system for "tumor immunity" RNA-splenocyte transfer, DEAE-dextran can markedly extend the lifespan of tumor-bearing animals, comparable to that of actively immunized animals. Furthermore, DEAE-dextran serves as a complexing agent for nucleic acids, forming composite particles with DNA/RNA for extensive applications in gene delivery. Additionally, DEAE-dextran can be utilized as a coating for liposomes .

HY-D1005I

Poloxamer L61	Biochemical Assay Reagents	Others
Poloxamer L61 is a non-ionic triblock copolymer surfactant. Poloxamer L61 effectively achieves intracellular molecular delivery to cancer cells during photoacoustic molecular delivery, and maintains cell viability by promoting cell membrane resealing, thus avoiding irreversible damage caused by laser-induced membrane permeabilization. Poloxamer L61 is a key component of SP1017, a compound related to gene therapy, which regulates the interaction between DNA and extracellular matrix as well as cellular uptake, and significantly enhances the distribution and bioavailability of plasmid DNA in skeletal muscle. Poloxamer L61 can be used in studies on local or systemic therapeutic protein production .

HY-W591476C

m-PEG550-thiol mPEG550-SH	Biochemical Assay Reagents	Others
m-PEG550-thiol modifies DNA thiolation for the synthesis of gold nanorods (AuNRs). Thiolated DNA can be loaded onto AuNR by the mPEG-SH/Tween 20 assisted method (Tween 20 and mPEG-SH repeatedly displace CTAB on the AuNR surface). DNA AuNRs have been widely used in nanostructure assembly, gene therapy, biosensing, and drug delivery.

HY-P4087

Cys(Npys)-(Arg)9	HIV	Infection Cancer
Cys(Npys)-(Arg)9 is a synthetic cationic cell-penetrating peptide with a reversible thiol-reactive nitropyridyl (Npys) group. Cys(Npys)-(Arg)9 efficiently mediates the internalization and delivery of various "cargo" such as proteins and antibodies by forming reversible disulfide bonds with surface-exposed cysteine residues. Cys(Npys)-(Arg)9 endows TALEN proteins with cell-penetrating activity, enabling gene knockout in mammalian cells and protein transduction in wheat microspores. Cys(Npys)-(Arg)9 can be conjugated with antibodies to form cationized IgG for enhancing endosomal escape of oligonucleotides, or form siRNA delivery complexes. When the molar ratio of Cys(Npys)-(Arg)9 to loaded molecules is higher than 1:1, it exerts certain cytotoxic effects on cells. Cys(Npys)-(Arg)9 can be used in studies related to oral squamous cell carcinoma and HIV infection .

HY-P10514

Transportan 10	Small Interfering RNA (siRNA)	Others
Transportan 10 is a derivative of Transportan (HY-P1732) and is an amphiphilic cell penetrating peptide (CPP). Transportan 10 helps molecules penetrate cell membrane barriers by directly interacting with the lipid bilayer. Transportan 10 can be used in gene therapy or siRNA delivery vector research .

HY-159709

VL-422	Liposome	Metabolic Disease
VL-422 is an ionizable cationic lipid. VL-422 delivers CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA to enable in vitro and in vivo gene editing. LNPs containing VL-422 loaded with Cas9 mRNA and sgRNA targeting the ANGPTL3 gene induce the deletion of premature stop codons within the ANGPTL3 gene in the liver of cynomolgus monkeys. Loss-of-function of ANGPTL3 leads to decreased levels of LDL, HDL and cholesterol in plasma. The VL-422 delivery system can be used for the research of gene editing strategies targeting lipid metabolism diseases .

HY-144001

DSPE-PEG-Carboxylic acid ammonium	Liposome	Others
DSPE-PEG-Carboxylic acid ammonium is a phospholipid PEG conjugate. DSPE-PEG-Carboxylic Acid can be widely used in the delivery of targeted agents and genes .

HY-P10991

Stearyl-homoarginine8 Stearylated octaarginine	Biochemical Assay Reagents	Others
Stearyl-(homoarginine)8 (Stearylated octaarginine) is an effective gene delivery vector that can deliver plasmid DNA into cells. Stearyl-(homoarginine)8 can make plasmid DNA more effectively internalized into cells and improve the nuclear delivery rate .

HY-149037

GL67 N4-Spermine cholesteryl carbamate	Liposome	Others
GL67 (N4-Spermine cholesteryl carbamate) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .

HY-109659

1-(3-Aminopropyl)-4-methylpiperazine	Biochemical Assay Reagents DNA Alkylator/Crosslinker	Others
1-(3-Aminopropyl)-4-methylpiperazine is a capping agent. The 1-(3-Aminopropyl)-4-methylpiperazine-capped Poly (β-amino ester) (PBAE) poly (1,4-butanediol diacrylate-co-4-amino-1-butanol) undergoes electrostatic interactions with anionic molecules such as DNA and exhibits low cytotoxicity. The 1-(3-Aminopropyl)-4-methylpiperazine-capped Poly (1,4-butanediol diacrylate-co-4-amino-1-butanol) PBAE effectively delivers nucleic acids in various systems .

HY-P10560

M918	Biochemical Assay Reagents	Others
M918 is a cell-penetrating peptide. M918 is internalized by cells through endocytosis and can effectively penetrate a variety of cells in a non-toxic manner. M918 can be used in gene therapy and drug delivery system research .

HY-P4087B

Cys(Npys)-(Arg)9 acetate	HIV	Others
Cys(Npys)-(Arg)9 acetate is a synthetic cationic cell-penetrating peptide with a reversible thiol-reactive nitropyridyl (Npys) group. Cys(Npys)-(Arg)9 acetate efficiently mediates the internalization and delivery of various "cargo" such as proteins and antibodies by forming reversible disulfide bonds with surface-exposed cysteine residues. Cys(Npys)-(Arg)9 acetate endows TALEN proteins with cell-penetrating activity, enabling gene knockout in mammalian cells and protein transduction in wheat microspores. Cys(Npys)-(Arg)9 acetate can be conjugated with antibodies to form cationized IgG for enhancing endosomal escape of oligonucleotides, or form siRNA delivery complexes. When the molar ratio of Cys(Npys)-(Arg)9 acetate to loaded molecules is higher than 1:1, it exerts certain cytotoxic effects on cells. Cys(Npys)-(Arg)9 acetate can be used in studies related to oral squamous cell carcinoma and HIV infection .

HY-142995

DODAP hydrochloride	Liposome	Others
DODAP (hydrochloride) is an ionizable lipid. DODAP (hydrochloride) has the potential for the research of gene delivery .

HY-149664

3β-[N-(N′,N′-Dimethylaminoethyl)carbamoyl]cholesterol DC-Chol	Liposome	Cancer
3β-[N-(N′,N′-Dimethylaminoethyl)carbamoyl]cholesterol, a lipid, has been investigated in cancer gene therapy and vaccine delivery system .

HY-160576

DNCA	Liposome	Cancer
DNCA is a neutral lipid that can be used in the generation of lipid nanoparticles (LNPs). DNCA can be used in nucleic acid delivery .

HY-P11083

Xentry	HBV	Cancer
Xentry is a cell-penetrating peptide (CCP) consisting of only 7 amino acids of hepatitis B virus: LCLRPVG. Xentry-linked anti-B-raf antibodies and siRNAs demonstrates the capability to kill B-raf-dependent melanoma cells. Xentry alone or conjugated to β-galactosidase leads to its delivery to most tissues in mice, except circulating blood cells. Xentry can be used for the delivery of large molecules (antibodies, siRNA, enzymes) .

HY-17650

DMDHP (±)-Dimyristoyl-2,3-dimethylhydroxypropylamine	Liposome	Others
DMDHP ((±)-Dimyristoyl-2,3-dimethylhydroxypropylamine) is a cationic lipid with a polar head group containing a dihydroxy group. DMDHP exhibits superior transfection efficiency and lower toxicity at high DNA doses in mouse intrapulmonary transfection model. DMDHP is commonly used for gene delivery .

Cat. No.	Product Name

HY-L214

Liposome Library

191 compounds

Liposomes are spherical or multilayered spherical vesicles formed by the self-assembly of diacyl chain phospholipids (lipid bilayers) in aqueous solutions, which can be made from natural or synthetic phospholipids and exhibit good biocompatibility and low toxicity. They can serve as delivery carriers for various bioactive substances (such as drugs, proteins, nucleic acids, etc.) and are widely used in biomedical and chemical research. The main advantages of liposomes include 1) Protective effect: Their bilayer structure can protect encapsulated molecules from enzymatic degradation, oxidation, and other influences, extending stability and activity; 2) Active targeting: Surface modifications enable active targeting, enhancing the concentration of drugs or molecules in specific tissues or cells; 3) Customizability: The composition and structure of liposomes can be adjusted according to needs, such as altering phospholipid types or adding targeting ligands. These properties make liposomes highly valuable in developing novel drug delivery systems, serving as nucleic acid carriers for gene transfection, studying cellular uptake mechanisms and drug release kinetics, as well as developing functional food additives to improve the bioavailability of nutritional components.

MCE contains 191 liposome compounds, which is a good tool for lipidomic-related studies.

HY-L251

Ionizable Lipid Compound Library

95 compounds

Ionizable lipids are a class of specialized, functional lipid molecules with pH-sensitive charge characteristics. They are primarily divided into two major categories: ionizable cationic lipids and ionizable anionic lipids, though the term typically specifies ionizable cationic lipids within the biomedical field. Structurally, these lipids consist of an ionizable hydrophilic headgroup, a biodegradable linker, and hydrophobic tails. Their primary application is serving as the key delivery vehicle in lipid nanoparticles (LNPs) to encapsulate negatively charged nucleic acid macromolecules, such as mRNA vaccines, siRNA therapeutics, and CRISPR gene-editing components. In a physiological, neutral environment, they remain electrically neutral to minimize systemic toxicity and prolong circulation time. Upon entering the acidic microenvironment of cellular endosomes, however, they undergo protonation to become positively charged, thereby inducing membrane fusion and enabling the highly efficient intracellular release of the nucleic acid cargo. Consequently, they serve as the technological cornerstone for bringing nucleic acid therapies into clinical application.

To accelerate the translational process of cutting-edge nucleic acid drugs, MCE has meticulously constructed an ionizable lipid compound library containing 95 high-performance molecules, aiming to provide researchers and pharmaceutical professionals with a high-throughput, multi-dimensional lipid screening platform.

Cat. No.	Product Name	Type

HY-D2846

m-PEG-PEI800-Cy5	Fluorescent Dye
m-PEG-PEI800-Cy5 is a fluorescent dye composed of CY5 (HY-D0821), methoxypolyethylene glycol (mPEG), and polyethyleneimine (PEI). m-PEG-PEI8800-Cy5 is used for gene delivery, nanodrug delivery, cell imaging and biosensing and bioanalysis (Ex/Em = 633/670 nm).

HY-D2846A

m-PEG2000-PEI2000-Cy5	Fluorescent Dye
m-PEG2000-PEI2000-Cy5 is a fluorescent dye composed of CY5 (HY-D0821), methoxypolyethylene glycol (mPEG), and polyethyleneimine (PEI). m-PEG2000-PEI2000-Cy5 is used for gene delivery, nanodrug delivery, cell imaging and biosensing and bioanalysis (Ex/Em=633/670 nm).

HY-D2846B

m-PEG5000-PEI5000-Cy5	Fluorescent Dye
m-PEG5000-PEI5000-Cy5 is a fluorescent dye composed of CY5 (HY-D0821), methoxypolyethylene glycol (mPEG), and polyethyleneimine (PEI). m-PEG5000-PEI5000-Cy5 is used for gene delivery, nanodrug delivery, cell imaging and biosensing and bioanalysis (Ex/Em=633/670 nm).

Cat. No.	Product Name	Type

HY-138170

ALC-0315 Maximum Cited Publications 39 Publications Verification	Biochemical Assay Reagents
ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .

HY-W127378

DOTAP methylsulfate

10+ Cited Publications

1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate

Biochemical Assay Reagents

DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design .

HY-131119

Dimethyldioctadecylammonium bromide

Dioctadecyldimethylammonium bromide; DODAB

Biochemical Assay Reagents

Dimethyldioctadecylammonium bromide is a synthetic cationic lipid commonly used in gene delivery and vaccine development. Also known as DODAB or DDAB, it consists of a positively charged ammonium head group and two long hydrophobic tails. These properties make it useful for forming liposomes and other lipid-based nanoparticles that can efficiently deliver genetic material into cells. In addition to its applications in biotechnology, DDAB is also used in surfactants, emulsifiers and fabric softeners. However, due to its potential toxicity and irritation, extreme care should be taken when handling DDAB.

HY-112758

DLin-KC2-DMA 5+ Cited Publications	Biochemical Assay Reagents
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .

HY-W583868

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE

1,2-POPE; 16:0-18:1 PE

Biochemical Assay Reagents

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines .

HY-112760

18:0 mPEG2000 PE sodium 1 Publications Verification DSPE-mPEG2000 sodium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] sodium	Biochemical Assay Reagents
18:0 mPEG2000 PE (DSPE-mPEG2000) sodium is a conjugate of phospholipid and polyethylene glycol, and it can serve as an important PEG lipid component in lipid nanoparticles (LNPs). 18:0 mPEG2000 PE sodium can be used in the research of gene transfection, drug carriers and drug delivery .

HY-137131

DC-Chol hydrochloride

DC-Cholesterol hydrochloride

Biochemical Assay Reagents

DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .

HY-126437E

Poly-L-lysine hydrobromide (MW 15000-30000)	Biochemical Assay Reagents
Poly-L-lysine hydrobromide (with a molecular weight of 15,000 - 30,000) is an amino acid polymer with positive charge, and it serves as a non-specific attachment factor for cells. Poly-L-lysine hydrobromide (with a molecular weight of 15,000 - 30,000) can be used for gene delivery and the construction of nano-delivery systems .

HY-155882

mPEG750-amine

mPEG750-NH2

Biochemical Assay Reagents

mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folate receptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells .

HY-126437H

Poly-L-lysine hydrobromide (MW 4000-15000)

1 Publications Verification

Biochemical Assay Reagents

Poly-L-lysine hydrobromide (MW 4000-15000) is a positively charged amino acid polymer that acts as a non-specific attachment factor for cells. Poly-L-lysine hydrobromide (MW 4000-15000) enhances the electrostatic interaction between the negative ions of the cell membrane and the surface of the culture medium, thereby promoting the adhesion of cells to solid substrates. Poly-L-lysine hydrobromide (MW 4000-15000) can be used for gene delivery .

HY-172723

DSPE-PEG2000-T7

Biochemical Assay Reagents

DSPE-PEG2000-T7 is a PEGylated compound composed of DSPE and peptideT7. T7 (HAIYPRH) specifically binds to TfR. DSPE-PEG2000-T7 can be used to prepare T7-modified liposomes, where liposomes modified with both T7 and DA7R peptides can effectively co-deliver Doxorubicin (HY-15142A) and Vincristine (HY-N0488A) to gliomas. DSPE-PEG2000-T7 can also be used to prepare nanomodulators that mediate the co-delivery of tyrosine hydroxylase mRNA and interferon gene stimulator antagonists for synergistic intervention in Parkinson's disease .

HY-153229

Firefly luciferase mRNA-LNP

1 Publications Verification

Biochemical Assay Reagents

Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing firefly luciferase mRNA. Firefly luciferase mRNA-LNP exhibits a stable nanostructure, in which LNP plays a key role in effectively protecting and transporting mRNA to cells. Luciferase is a bioluminescent reporter gene for gene regulation and functional studies. Firefly Luciferase mRNA-LNP expresses firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Firefly luciferase mRNA-LNP is studied in research for RNA delivery, cell viability, and translation efficiency .

HY-145795

OF-02

Biochemical Assay Reagents

OF-02 is an ionizable lipid for mRNA delivery and a key component of lipid nanoparticles (LNPs). OF-02 is protonated in the acidic endosomal environment to promote endosomal escape of mRNA and efficiently induce protein expression in target cells. OF-02 relies on the pH-responsive membrane fusion properties to form a complex with mRNA and destroy the endosomal membrane structure to achieve mRNA release in the cytoplasm. OF-02 is mainly used in the development of mRNA vaccines, gene editing, and protein replacement therapy[1][2][3].

HY-143702

Fluorescent DOTAP

NBD-DOTAP

Biochemical Assay Reagents

Fluorescent DOTAP (NBD-DOTAP) is a cationic lipid which can be used for nucleic acid and protein delivery. Fluorescent DOTAP is labeled with a fluorophore NBD (maximum excitation/emission wavelength ∼463/536 nm). Fluorescent DOTAP can be used for gene delivery systems, drug delivery, as well as cell imaging and nanocarrier tracking. Fluorescent DOTAP is an ideal candidate for both biological and pharmaceutical formulation (e.g. co-delivery of vaccines) research .

HY-126437I

Poly-L-lysine hydrobromide (MW 1000-5000)	Biochemical Assay Reagents
Poly-L-lysine hydrobromide (MW 1000-5000) is a homopolymer of L-lysine and a polycationic non-viral gene delivery vector. Poly-L-lysine hydrobromide (MW 1000-5000) forms complexes with plasmid DNA. Poly-L-lysine hydrobromide (MW 1000-5000) is applicable to relevant research on lung cancer .

HY-112624U

Dextran T20 (MW 20,000) Dextran 20; Dextran D20; Dextran T20(MW 16000-24000)	Biochemical Assay Reagents
Dextran T20 (Dextran 20; Dextran D20) (MW 20,000) is a dehydrated glucose polymer with an average molecular weight of 20,000. Dextran T20 (MW 20,000) has excellent biodegradability and good biocompatibility, and can be used as a gene delivery vector, an immune adjuvant carrier, and a hemoglobin stabilizer .

HY-150229

306-N16B

Biochemical Assay Reagents

306-N16B is a selective lung-targeted lipid nanoparticle that reversibly targets lung endothelial cells and specific immune cells through selective adsorption of a protein corona mediated by differences in tail structure (such as fibrinogen β/γ chain). 306-N16B binds to specific plasma proteins in the blood to form a protein corona, which guides the particles to be enriched in the lungs, releases mRNA and promotes target cell gene expression, exerts efficient lung cell transfection activity, and can precisely regulate gene delivery of different cell types in the lungs (such as endothelial cells and macrophages). 306-N16B can be used in gene therapy technologies for hereditary lung diseases including pulmonary lymphangioleiomyomatosis (LAM), restoring tumor suppressor function by delivering Tsc2 mRNA, and can also be used for lung-specific mRNA vaccines and gene editing therapies .

HY-147087

YSK 05	Biochemical Assay Reagents
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .

HY-153232

eGFP circRNA-LNP

Biochemical Assay Reagents

eGFP circRNA-LNP is a lipid nanoparticle (LNP) containing eGFP circRNA, suitable for assays of RNA delivery, translation efficiency, cell viability, etc. eGFP circRNA carries Enhanced Green Fluorescent Protein (Enhanced Green Fluorescent Protein) eGFP, which will express green fluorescent protein after entering the cell. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry .

HY-149037A

GL67 pentahydrochloride N4-Spermine cholesteryl carbamate pentahydrochloride	Biochemical Assay Reagents
GL67 (N4-Spermine cholesteryl carbamate) (pentahydrochloride) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .

HY-144022

16:0 DAP	Biochemical Assay Reagents
16:0 DAP is a cationic lipids that can be used for drug delivery, gene transfection and vaccine delivery .

HY-172705

DSPE-PEG2000-RVG29

Biochemical Assay Reagents

DSPE-PEG2000-RVG29 is a PEG conjugate composed of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 specifically binds to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB), crosses the BBB, and mediates receptor-dependent transcytosis. DSPE-PEG2000-RVG29 can be used for brain-targeted drug delivery, surface modification of nanocarriers, as well as gene and nucleic acid delivery. DSPE-PEG2000-RVG29 is applicable to research related to hypoxic-ischemic brain injury, Parkinson's disease, and other conditions .

HY-W591476B

m-PEG750-thiol mPEG750-SH	Biochemical Assay Reagents
m-PEG750-thiol modifies DNA thiolation for the synthesis of gold nanorods (AuNRs). Thiolated DNA can be loaded onto AuNR by the mPEG-SH/Tween 20 assisted method (Tween 20 and mPEG-SH repeatedly displace CTAB on the AuNR surface). DNA AuNRs have been widely used in nanostructure assembly, gene therapy, biosensing, and drug delivery.

HY-153231A

eGFP mRNA-LNP (500 ng/μL)

Biochemical Assay Reagents

eGFP mRNA-LNP (500 ng/μL) is a lipid nanoparticle (LNP) containing eGFP mRNA. eGFP mRNA-LNP carries Enhanced Green Fluorescent Protein (eGFP), which will express green fluorescent protein after entering the cell. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry (excitation wavelength = 488 nm; emission wavelength = 535/40 bandpass). eGFP mRNA-LNP can be used for RNA delivery, translation efficiency and cell viability .

HY-137499

NT1-O12B

Biochemical Assay Reagents

NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB)-impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination .

HY-164035

DOPE-PEG2000-DBCO	Biochemical Assay Reagents
DOPE-PEG2000-DBCO is a PEG lipid with a DOPE and a DBCO as functional groups. DOPE can be used as a helper lipid in gene transfection. PEG is used in drug delivery system. DBCO can be used for click chemistry .

HY-159067

DEAE-dextran, MW 500000 hydrochloride

DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides); Diethylaminoethyl-dextran, MW 500000 hydrochloride

Biochemical Assay Reagents

DEAE-dextran, MW 500000 hydrochloride (DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides)) is a high-molecular-weight positively charged polymer that significantly enhances the uptake of viral RNA by tissue culture cells. When employed in the delivery system for "tumor immunity" RNA-splenocyte transfer, DEAE-dextran can markedly extend the lifespan of tumor-bearing animals, comparable to that of actively immunized animals. Furthermore, DEAE-dextran serves as a complexing agent for nucleic acids, forming composite particles with DNA/RNA for extensive applications in gene delivery. Additionally, DEAE-dextran can be utilized as a coating for liposomes .

HY-D1005I

Poloxamer L61

Biochemical Assay Reagents

Poloxamer L61 is a non-ionic triblock copolymer surfactant. Poloxamer L61 effectively achieves intracellular molecular delivery to cancer cells during photoacoustic molecular delivery, and maintains cell viability by promoting cell membrane resealing, thus avoiding irreversible damage caused by laser-induced membrane permeabilization. Poloxamer L61 is a key component of SP1017, a compound related to gene therapy, which regulates the interaction between DNA and extracellular matrix as well as cellular uptake, and significantly enhances the distribution and bioavailability of plasmid DNA in skeletal muscle. Poloxamer L61 can be used in studies on local or systemic therapeutic protein production .

HY-W591476C

m-PEG550-thiol mPEG550-SH	Biochemical Assay Reagents
m-PEG550-thiol modifies DNA thiolation for the synthesis of gold nanorods (AuNRs). Thiolated DNA can be loaded onto AuNR by the mPEG-SH/Tween 20 assisted method (Tween 20 and mPEG-SH repeatedly displace CTAB on the AuNR surface). DNA AuNRs have been widely used in nanostructure assembly, gene therapy, biosensing, and drug delivery.

HY-144001

DSPE-PEG-Carboxylic acid ammonium	Biochemical Assay Reagents
DSPE-PEG-Carboxylic acid ammonium is a phospholipid PEG conjugate. DSPE-PEG-Carboxylic Acid can be widely used in the delivery of targeted agents and genes .

HY-149037

GL67 N4-Spermine cholesteryl carbamate	Biochemical Assay Reagents
GL67 (N4-Spermine cholesteryl carbamate) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .

HY-142995

DODAP hydrochloride	Biochemical Assay Reagents
DODAP (hydrochloride) is an ionizable lipid. DODAP (hydrochloride) has the potential for the research of gene delivery .

HY-149664

3β-[N-(N′,N′-Dimethylaminoethyl)carbamoyl]cholesterol DC-Chol	Biochemical Assay Reagents
3β-[N-(N′,N′-Dimethylaminoethyl)carbamoyl]cholesterol, a lipid, has been investigated in cancer gene therapy and vaccine delivery system .

HY-W591476A

m-PEG3400-thiol mPEG3400-SH	Biochemical Assay Reagents
m-PEG3400-thiol modifies DNA thiolation for the synthesis of gold nanorods (AuNRs). Thiolated DNA can be loaded onto AuNR by the mPEG-SH/Tween 20 assisted method (Tween 20 and mPEG-SH repeatedly displace CTAB on the AuNR surface). DNA AuNRs have been widely used in nanostructure assembly, gene therapy, biosensing, and drug delivery.

HY-W591476D

m-PEG350-thiol mPEG350-SH	Biochemical Assay Reagents
m-PEG350-thiol modifies DNA thiolation for the synthesis of gold nanorods (AuNRs). Thiolated DNA can be loaded onto AuNR by the mPEG-SH/Tween 20 assisted method (Tween 20 and mPEG-SH repeatedly displace CTAB on the AuNR surface). DNA AuNRs have been widely used in nanostructure assembly, gene therapy, biosensing, and drug delivery.

HY-166997

AL-A12	Biochemical Assay Reagents
AL-A12 is a short-chain amino lipid with high gene delivery efficiency and low toxicity, and can be used in drug delivery research .

HY-174964

8-Arm-PEG400-DSPE	Biochemical Assay Reagents
8-Arm-PEG400-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174957A

6-Arm-PEG600-DSPE	Biochemical Assay Reagents
6-Arm-PEG600-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG600-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-W1123922D

4-Arm-PEG3400-DSPE	Biochemical Assay Reagents
4-Arm-PEG3400-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG3400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174957C

6-Arm-PEG2000-DSPE	Biochemical Assay Reagents
6-Arm-PEG2000-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG2000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-158709

Cho-es-Lys	Biochemical Assay Reagents
Cho-es-Lys is a cationic lipid synthesized by coupling natural cholesterol and amino acids, which has high gene transfection efficiency. Cho-es-Lys can be used in drug delivery research .

HY-172705A

DSPE-PEG3400-RVG29

Biochemical Assay Reagents

DSPE-PEG3400-RVG29 is a PEG conjugate composed of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 specifically binds to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB), crosses the BBB, and mediates receptor-dependent transcytosis. DSPE-PEG3400-RVG29 can be used for brain-targeted drug delivery, surface modification of nanocarriers, as well as gene and nucleic acid delivery. DSPE-PEG3400-RVG29 is applicable to research related to hypoxic-ischemic brain injury, Parkinson's disease, and other conditions

HY-153230

Firefly luciferase circRNA-LNP

Biochemical Assay Reagents

Firefly luciferase circRNA-LNP is a lipid nanoparticle (LNP) containing Firefly luciferase circRNA, suitable for assays of RNA delivery, translation efficiency, cell viability, etc. Luciferase is commonly used as a bioluminescent reporter gene for gene regulation and function studies. Firefly Luciferase circRNA will express firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Common luciferase are firefly luciferase and sea kidney luciferase .

HY-W250187

DDMAB

Biochemical Assay Reagents

DDMAB, or didodecyldimethylammonium bromide, is a cationic surfactant commonly used in a variety of industrial and research applications. It belongs to the family of quaternary ammonium compounds and has a positively charged head and a hydrophobic tail, which allows it to be used as a detergent, emulsifier and antimicrobial. Known for its ability to disrupt cell membranes, DDMAB is commonly used in microbiology to selectively isolate and identify bacteria. It is also used in nanotechnology to synthesize metal nanoparticles and other materials. In addition, DDMAB has the ability to interact with and penetrate cell membranes, which has potential applications in drug delivery, gene therapy, and other medical fields.

HY-W1123922H

4-Arm-PEG10000-DSPE	Biochemical Assay Reagents
4-Arm-PEG10000-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG10000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174964H

8-Arm-PEG10000-DSPE	Biochemical Assay Reagents
8-Arm-PEG10000-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG10000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174964E

8-Arm-PEG5000-DSPE	Biochemical Assay Reagents
8-Arm-PEG5000-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG5000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174964C

8-Arm-PEG2000-DSPE	Biochemical Assay Reagents
8-Arm-PEG2000-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG2000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-W1123922A

4-Arm-PEG600-DSPE	Biochemical Assay Reagents
4-Arm-PEG600-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG600-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174957

6-Arm-PEG400-DSPE	Biochemical Assay Reagents
6-Arm-PEG400-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

Cat. No.	Product Name	Target	Research Area

HY-P5423

GALA	Exosomes Liposome	Cancer
GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. GALA significantly promotes the cytosolic release of cargos carried by exosomes, plasmids and liposomes, effectively enhances gene transfection efficiency, and drives gene knockdown of functional macromolecules (such as siRNA) in alveolar epithelial cells (with no significant cytotoxicity at effective concentrations). GALA serves as a critical tool for studies on lung cancer metastasis (e.g., melanoma lung metastasis) and lung-targeted drug delivery systems .

HY-W007599

(S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid	Drug Derivative	Cancer
(S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid is a polypeptide derivative, can be used to synthesis multifunctional amphiphilic peptide dendrimer for non-viral gene delivery in cancer research. (S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid can be used in the preparation of organic substances that enhance the luminescence intensity of alkaline phosphatase substrates .

HY-P4121

L17E	Potassium Channel	Inflammation/Immunology Cancer
L17E is an attenuated cationic amphiphilic lytic (ACAL) peptide that can be used to deliver a variety of macromolecules, including proteins, antibodies, and DNA nanostructures. L17E inserts and cleaves the membrane structure through electrostatic interaction, enabling intracellular escape. The efficiency of L17E-mediated delivery is strongly correlated with the expression level of KCNN4 (the gene encoding the calcium-activated potassium channel KCa3.1). L17E also promotes the cellular uptake of macromolecules by inducing micropinocytosis. L17E can be further optimized and improved through dimerization strategies and in combination with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles .

HY-P4086

Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R)	RABV nAChR	Neurological Disease Cancer
Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) is a cell-penetrating peptide that is synthesized by adding nona-arginine motif to the carboxy terminus of RVG (rabies virus glycoprotein). Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) binds to nAChR on neuronal cells to mediate receptor-mediated endocytosis and targeted siRNA delivery. Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) protects complexed siRNA from degradation, enhances transcellular siRNA delivery in neuronal cells, and promotes efficient, pecific gene silencing. Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) can be used for the researches of neurological disease and cancer .

HY-P10991A

Stearyl-(homoarginine)8 TFA Stearylated octaarginine TFA	Biochemical Assay Reagents	Others
Stearyl-(homoarginine)8 (Stearylated octaarginine) TFA is an effective gene delivery vector that can deliver plasmid DNA into cells. Stearyl-(homoarginine)8 TFA can make plasmid DNA more effectively internalized into cells and improve the nuclear delivery rate .

HY-P4118

EB1 peptide Penetrating analog	Amino Acid Derivatives Peptide-Drug Conjugates (PDCs)	Others
EB1 peptide (Penetrating analog) is an endosomolytic agent and siRNA delivery agent. EB1 peptide forms an amphipathic alpha helix upon protonation in early-late endosomes, drives endosomal membrane permeabilization, and enables endocytosed siRNA escape into the cytosol. EB1 peptide facilitates biologically active siRNA cellular uptake and targeted gene silencing. EB1 peptide forms complexes with siRNA. EB1 peptide can be used for drug delivery research .

HY-P4087

Cys(Npys)-(Arg)9	HIV	Infection Cancer
Cys(Npys)-(Arg)9 is a synthetic cationic cell-penetrating peptide with a reversible thiol-reactive nitropyridyl (Npys) group. Cys(Npys)-(Arg)9 efficiently mediates the internalization and delivery of various "cargo" such as proteins and antibodies by forming reversible disulfide bonds with surface-exposed cysteine residues. Cys(Npys)-(Arg)9 endows TALEN proteins with cell-penetrating activity, enabling gene knockout in mammalian cells and protein transduction in wheat microspores. Cys(Npys)-(Arg)9 can be conjugated with antibodies to form cationized IgG for enhancing endosomal escape of oligonucleotides, or form siRNA delivery complexes. When the molar ratio of Cys(Npys)-(Arg)9 to loaded molecules is higher than 1:1, it exerts certain cytotoxic effects on cells. Cys(Npys)-(Arg)9 can be used in studies related to oral squamous cell carcinoma and HIV infection .

HY-P2483B

Octaarginine acetate	Bacterial Proteasome	Infection Inflammation/Immunology Cancer
Octaarginine acetate is a cell-penetrating peptide and proteasome inhibitor. Octaarginine acetate exhibits mixed-type inhibition against 20S proteasome chymotrypsin-like, caspase-like, and trypsin-like activities, and inhibits 26S proteasome activity with decreased efficiency. Octaarginine acetate induces ubiquitin-conjugated protein accumulation, mediates HSPG-dependent cellular internalization via macropinocytosis, enhances liposomal cargo uptake and gene delivery. Octaarginine acetate can be used for the research of cervix carcinoma, collagen antibody-induced arthritis, and bacterial infections .

HY-P2483

Octaarginine	Proteasome Bacterial	Infection Inflammation/Immunology Cancer
Octaarginine is a cell-penetrating peptide and proteasome inhibitor. Octaarginine exhibits mixed-type inhibition against 20S proteasome chymotrypsin-like, caspase-like, and trypsin-like activities, and inhibits 26S proteasome activity with decreased efficiency. Octaarginine induces ubiquitin-conjugated protein accumulation, mediates HSPG-dependent cellular internalization via macropinocytosis, enhances liposomal cargo uptake and gene delivery. Octaarginine can be used for the research of cervix carcinoma, collagen antibody-induced arthritis, and bacterial infections .

HY-P10514

Transportan 10	Small Interfering RNA (siRNA)	Others
Transportan 10 is a derivative of Transportan (HY-P1732) and is an amphiphilic cell penetrating peptide (CPP). Transportan 10 helps molecules penetrate cell membrane barriers by directly interacting with the lipid bilayer. Transportan 10 can be used in gene therapy or siRNA delivery vector research .

HY-P10991

Stearyl-homoarginine8 Stearylated octaarginine	Biochemical Assay Reagents	Others
Stearyl-(homoarginine)8 (Stearylated octaarginine) is an effective gene delivery vector that can deliver plasmid DNA into cells. Stearyl-(homoarginine)8 can make plasmid DNA more effectively internalized into cells and improve the nuclear delivery rate .

HY-P10560

M918	Biochemical Assay Reagents	Others
M918 is a cell-penetrating peptide. M918 is internalized by cells through endocytosis and can effectively penetrate a variety of cells in a non-toxic manner. M918 can be used in gene therapy and drug delivery system research .

HY-P4087B

Cys(Npys)-(Arg)9 acetate	HIV	Others
Cys(Npys)-(Arg)9 acetate is a synthetic cationic cell-penetrating peptide with a reversible thiol-reactive nitropyridyl (Npys) group. Cys(Npys)-(Arg)9 acetate efficiently mediates the internalization and delivery of various "cargo" such as proteins and antibodies by forming reversible disulfide bonds with surface-exposed cysteine residues. Cys(Npys)-(Arg)9 acetate endows TALEN proteins with cell-penetrating activity, enabling gene knockout in mammalian cells and protein transduction in wheat microspores. Cys(Npys)-(Arg)9 acetate can be conjugated with antibodies to form cationized IgG for enhancing endosomal escape of oligonucleotides, or form siRNA delivery complexes. When the molar ratio of Cys(Npys)-(Arg)9 acetate to loaded molecules is higher than 1:1, it exerts certain cytotoxic effects on cells. Cys(Npys)-(Arg)9 acetate can be used in studies related to oral squamous cell carcinoma and HIV infection .

HY-P11083

Xentry	HBV	Cancer
Xentry is a cell-penetrating peptide (CCP) consisting of only 7 amino acids of hepatitis B virus: LCLRPVG. Xentry-linked anti-B-raf antibodies and siRNAs demonstrates the capability to kill B-raf-dependent melanoma cells. Xentry alone or conjugated to β-galactosidase leads to its delivery to most tissues in mice, except circulating blood cells. Xentry can be used for the delivery of large molecules (antibodies, siRNA, enzymes) .

HY-P4250

Arg-Arg-Arg-Arg	Peptides	Others
Tetraarginine (RRRR), consisting of four arginines, is used in cell-penetrating peptide-based gene delivery vehicles .

HY-126721

Tetralysine	Biochemical Assay Reagents	Others
Tetralysine is a cationic moietie that may be used in the construction of gene delivery vectors and DNA nanoparticles .

HY-P4250A

Arg-Arg-Arg-Arg acetate	Biochemical Assay Reagents	Others
Arg-Arg-Arg-Arg (acetate), consisting of four arginines, is used in cell-penetrating peptide-based gene delivery vehicles .

HY-P10562

BMV Gag-(7−25)	TMV	Others
BMV Gag-(7 25) is an arginine-rich peptide with cell-penetrating ability. BMV Gag-(7 25) can be used in drug delivery and gene therapy research .

HY-P2483A

Octaarginine TFA	Proteasome Bacterial	Infection Neurological Disease Cancer
Octaarginine TFA is a cell-penetrating peptide and proteasome inhibitor. Octaarginine TFA exhibits mixed-type inhibition against 20S proteasome chymotrypsin-like, caspase-like, and trypsin-like activities, and inhibits 26S proteasome activity with decreased efficiency. Octaarginine TFA induces ubiquitin-conjugated protein accumulation, mediates HSPG-dependent cellular internalization via macropinocytosis, enhances liposomal cargo uptake and gene delivery. Octaarginine TFA can be used for the research of cervix carcinoma, collagen antibody-induced arthritis, and bacterial infections .

HY-P10520

RWmix	Peptides	Others
RWmix is ??a synthetic cell-penetrating peptide. The secondary amphiphilic nature of RWmix promotes cellular uptake, mainly due to the alternating arrangement of arginine and tryptophan. The presence of tryptophan enhances the anchoring of the peptide to the cell membrane, thereby improving its ability to penetrate the cell membrane. RWmix can be used for gene therapy and siRNA delivery research .

HY-P11612

ATS-9R	Biochemical Assay Reagents	Metabolic Disease
ATS-9R is a peptide consisting of an adipocyte-targeting sequence and D-form 9-arginine. ATS-9R selectively transfects mature adipocytes by binding to prohibitin. ATS-9R allows an adipocyte-targeted gene delivery in vitro and in vivo. ATS-9R can be used for the development of an adipocyte-targeted gene carrier. ATS-9R can be used for the study of obesity as well as obesity-induced metabolic syndromes .

HY-P11698

Guanidino-G-Clamp-PNA	DNA Alkylator/Crosslinker Transthyretin (TTR)	Cancer
Guanidino-G-Clamp-PNA is a highly efficient sequence-specific RNA binder and gene silencer. Guanidino-G-Clamp-PNA precisely targets such targets as miR-155 or transthyretin (TTR) mRNA through base pairing: the former regulates tumor-related signaling pathways by reducing microRNA activity, while the latter inhibits the translation of harmful proteins via steric hindrance. Guanidino-G-Clamp-PNA effectively stabilizes DNA/RNA duplexes, induces cancer cell apoptosis, and suppresses tumor growth. In addition, Guanidino-G-Clamp-PNA can be conjugated with targeting ligands to improve tissue-specific delivery and reduce in vivo adverse reactions, and it can also enhance the splicing regulation efficacy of other oligonucleotide platforms (such as PMO) when integrated into them. Guanidino-G-Clamp-PNA is applicable to the research of various diseases including diffuse large B-cell lymphoma and hereditary transthyretin-related amyloidosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3540

Caraphenol A	Leguminosae Phenols Polyphenols Plants Caragana sinica (Buchoz) Rehd.	Others
Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC₅₀s of 5.9 μM and 12.1 μM, respectively .

HY-137499

NT1-O12B	Alkaloids Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Indole Alkaloids Source Classification	Liposome Endogenous Metabolite
NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB)-impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination .

Cat. No.	Product Name	Chemical Structure

HY-W724291

Dimethyldioctadecylammonium-d3 bromide

Dimethyldioctadecylammonium-d₃ bromide (Dioctadecyldimethylammonium-d₃ bromide) is the deuterium labeled Dimethyldioctadecylammonium bromide (HY-131119). Dimethyldioctadecylammonium bromide is a synthetic cationic lipid commonly used in gene delivery and vaccine development. Also known as DODAB or DDAB, it consists of a positively charged ammonium head group and two long hydrophobic tails. These properties make it useful for forming liposomes and other lipid-based nanoparticles that can efficiently deliver genetic material into cells. In addition to its applications in biotechnology, DDAB is also used in surfactants, emulsifiers and fabric softeners. However, due to its potential toxicity and irritation, extreme care should be taken when handling DDAB.

HY-W583868S

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE-d62

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE-d₆₂ (1,2-POPE-d₆₂) is the deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines .

Cat. No.	Product Name		Classification

HY-164035

DOPE-PEG2000-DBCO		DBCO
DOPE-PEG2000-DBCO is a PEG lipid with a DOPE and a DBCO as functional groups. DOPE can be used as a helper lipid in gene transfection. PEG is used in drug delivery system. DBCO can be used for click chemistry .

Cat. No.	Product Name		Classification

HY-138170

ALC-0315 Maximum Cited Publications 39 Publications Verification		Cationic Lipids
ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .

HY-W127378

DOTAP methylsulfate 10+ Cited Publications 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate		Cationic Lipids
DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design .

HY-131119

Dimethyldioctadecylammonium bromide Dioctadecyldimethylammonium bromide; DODAB		Cationic Lipids
Dimethyldioctadecylammonium bromide is a synthetic cationic lipid commonly used in gene delivery and vaccine development. Also known as DODAB or DDAB, it consists of a positively charged ammonium head group and two long hydrophobic tails. These properties make it useful for forming liposomes and other lipid-based nanoparticles that can efficiently deliver genetic material into cells. In addition to its applications in biotechnology, DDAB is also used in surfactants, emulsifiers and fabric softeners. However, due to its potential toxicity and irritation, extreme care should be taken when handling DDAB.

HY-112758

DLin-KC2-DMA 5+ Cited Publications		Cationic Lipids
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .

HY-W583868

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE 1,2-POPE; 16:0-18:1 PE		Phospholipids
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines .

HY-112760

18:0 mPEG2000 PE sodium 1 Publications Verification DSPE-mPEG2000 sodium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] sodium		Pegylated Lipids
18:0 mPEG2000 PE (DSPE-mPEG2000) sodium is a conjugate of phospholipid and polyethylene glycol, and it can serve as an important PEG lipid component in lipid nanoparticles (LNPs). 18:0 mPEG2000 PE sodium can be used in the research of gene transfection, drug carriers and drug delivery .

HY-137131

DC-Chol hydrochloride DC-Cholesterol hydrochloride		Cholesterol
DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .

HY-155882

mPEG750-amine mPEG750-NH2		Polymers
mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folate receptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells .

HY-172723

DSPE-PEG2000-T7		Pegylated Lipids
DSPE-PEG2000-T7 is a PEGylated compound composed of DSPE and peptideT7. T7 (HAIYPRH) specifically binds to TfR. DSPE-PEG2000-T7 can be used to prepare T7-modified liposomes, where liposomes modified with both T7 and DA7R peptides can effectively co-deliver Doxorubicin (HY-15142A) and Vincristine (HY-N0488A) to gliomas. DSPE-PEG2000-T7 can also be used to prepare nanomodulators that mediate the co-delivery of tyrosine hydroxylase mRNA and interferon gene stimulator antagonists for synergistic intervention in Parkinson's disease .

HY-174497

eGFP mRNA		mRNA Reporter Genes
eGFP mRNA expresses green fluorescent protein derived from the jellyfish Aequorea victoria. eGFP is a commonly used direct-detection reporter gene in mammalian cell culture, which produces bright green fluorescence. This product is synthesized without modified nucleosides, with a Cap1 version cap analog at the 5' end and a 100nt PolyA tail at the 3' end. It can be used as a positive reference for IVT (in vitro transcription) or LNP delivery systems.

HY-153229

Firefly luciferase mRNA-LNP 1 Publications Verification		mRNA Liposome
Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing firefly luciferase mRNA. Firefly luciferase mRNA-LNP exhibits a stable nanostructure, in which LNP plays a key role in effectively protecting and transporting mRNA to cells. Luciferase is a bioluminescent reporter gene for gene regulation and functional studies. Firefly Luciferase mRNA-LNP expresses firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Firefly luciferase mRNA-LNP is studied in research for RNA delivery, cell viability, and translation efficiency .

HY-145795

OF-02		Cationic Lipids
OF-02 is an ionizable lipid for mRNA delivery and a key component of lipid nanoparticles (LNPs). OF-02 is protonated in the acidic endosomal environment to promote endosomal escape of mRNA and efficiently induce protein expression in target cells. OF-02 relies on the pH-responsive membrane fusion properties to form a complex with mRNA and destroy the endosomal membrane structure to achieve mRNA release in the cytoplasm. OF-02 is mainly used in the development of mRNA vaccines, gene editing, and protein replacement therapy[1][2][3].

HY-143702

Fluorescent DOTAP NBD-DOTAP		Cationic Lipids
Fluorescent DOTAP (NBD-DOTAP) is a cationic lipid which can be used for nucleic acid and protein delivery. Fluorescent DOTAP is labeled with a fluorophore NBD (maximum excitation/emission wavelength ∼463/536 nm). Fluorescent DOTAP can be used for gene delivery systems, drug delivery, as well as cell imaging and nanocarrier tracking. Fluorescent DOTAP is an ideal candidate for both biological and pharmaceutical formulation (e.g. co-delivery of vaccines) research .

HY-112766

DPyPE		Phospholipids
DPyPE is a neutral phosphatidylethanolamine lipid composed of a polyisoprene alkyl chain with two pyridine-containing phosphine ligands. DPyPE is mainly used in liposome formulations and to enhance the efficiency of gene delivery in vitro and in vivo. For example, DPyPE can be mixed with cationic lipids such as VC1052 (HY-156616) (in a 1:1 ratio) to form the vaccine adjuvant Vaxfectin (HY-142998). DPyPE assists VC1052 in binding to negatively charged pDNA to form a uniform liposome complex by regulating the fluidity and stability of the liposome membrane .

HY-150229

306-N16B		Cationic Lipids
306-N16B is a selective lung-targeted lipid nanoparticle that reversibly targets lung endothelial cells and specific immune cells through selective adsorption of a protein corona mediated by differences in tail structure (such as fibrinogen β/γ chain). 306-N16B binds to specific plasma proteins in the blood to form a protein corona, which guides the particles to be enriched in the lungs, releases mRNA and promotes target cell gene expression, exerts efficient lung cell transfection activity, and can precisely regulate gene delivery of different cell types in the lungs (such as endothelial cells and macrophages). 306-N16B can be used in gene therapy technologies for hereditary lung diseases including pulmonary lymphangioleiomyomatosis (LAM), restoring tumor suppressor function by delivering Tsc2 mRNA, and can also be used for lung-specific mRNA vaccines and gene editing therapies .

HY-147087

YSK 05		Cationic Lipids
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .

HY-153232

eGFP circRNA-LNP		Liposome
eGFP circRNA-LNP is a lipid nanoparticle (LNP) containing eGFP circRNA, suitable for assays of RNA delivery, translation efficiency, cell viability, etc. eGFP circRNA carries Enhanced Green Fluorescent Protein (Enhanced Green Fluorescent Protein) eGFP, which will express green fluorescent protein after entering the cell. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry .

HY-154974

LNP Lipid-8		Cationic Lipids
LNP Lipid-8 (11-A-M) is an ionizable single-tail multi-head lipid that can be used as a lipid nanoparticle (LNP) to deliver siRNA to T cells without targeting ligands. LNP Lipid-8 is more selective for T cells than other cell types such as hepatocytes. LNP Lipid-8 selectively delivers siRNA/sgRNA to T cells (especially CD8+ T cells) through endogenous lipid transport pathways, and can enter cells and release RNA through endocytosis to achieve gene silencing. LNP Lipid-8 loaded with GFP siRNA (siGFP) significantly led to GFP gene silencing in mouse models. LNP Lipid-8 showed good efficacy and safety in both cells and animals, without obvious liver targeting and toxicity. LNP Lipid-8 can be used for RNA delivery research in the fields of tumor immunotherapy and T cell-mediated autoimmune diseases .

HY-149037A

GL67 pentahydrochloride N4-Spermine cholesteryl carbamate pentahydrochloride		Cationic Lipids
GL67 (N4-Spermine cholesteryl carbamate) (pentahydrochloride) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .

HY-134783

1,19-Bis(2-butyloctyl) 10-[[3-(dimethylamino)propyl](1-oxononyl)amino]nonadecanedioate		Pegylated Lipids
1,19-Bis(2-butyloctyl) 10-[[3-(dimethylamino)propyl](1-oxononyl)amino]nonadecanedioate is an excipient for vaccines. 1,19-Bis(2-butyloctyl) 10-[[3-(dimethylamino)propyl](1-oxononyl)amino]nonadecanedioate can be used for the research of the development of COVID-19 vaccines and drug delivery for gene therapy .

HY-144022

16:0 DAP		Cationic Lipids
16:0 DAP is a cationic lipids that can be used for drug delivery, gene transfection and vaccine delivery .

HY-172705

DSPE-PEG2000-RVG29		Pegylated Lipids
DSPE-PEG2000-RVG29 is a PEG conjugate composed of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 specifically binds to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB), crosses the BBB, and mediates receptor-dependent transcytosis. DSPE-PEG2000-RVG29 can be used for brain-targeted drug delivery, surface modification of nanocarriers, as well as gene and nucleic acid delivery. DSPE-PEG2000-RVG29 is applicable to research related to hypoxic-ischemic brain injury, Parkinson's disease, and other conditions .

HY-W591476B

m-PEG750-thiol mPEG750-SH		Polymers
m-PEG750-thiol modifies DNA thiolation for the synthesis of gold nanorods (AuNRs). Thiolated DNA can be loaded onto AuNR by the mPEG-SH/Tween 20 assisted method (Tween 20 and mPEG-SH repeatedly displace CTAB on the AuNR surface). DNA AuNRs have been widely used in nanostructure assembly, gene therapy, biosensing, and drug delivery.

HY-164583

DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite		Phosphoramidites Adenine
DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite is an RNA phosphoramidite monomer. DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite allows site-specific introduction of a 2'-O-C22 lipophilic modification at adenosine positions to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipophilicity and tissue uptake efficiency of dsRNA. DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite can be used for the construction and mechanism research of nucleic acid silencing molecules .

HY-153231A

eGFP mRNA-LNP (500 ng/μL)		Liposome
eGFP mRNA-LNP (500 ng/μL) is a lipid nanoparticle (LNP) containing eGFP mRNA. eGFP mRNA-LNP carries Enhanced Green Fluorescent Protein (eGFP), which will express green fluorescent protein after entering the cell. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry (excitation wavelength = 488 nm; emission wavelength = 535/40 bandpass). eGFP mRNA-LNP can be used for RNA delivery, translation efficiency and cell viability .

HY-137499

NT1-O12B		Cationic Lipids
NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB)-impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination .

HY-164035

DOPE-PEG2000-DBCO		Pegylated Lipids
DOPE-PEG2000-DBCO is a PEG lipid with a DOPE and a DBCO as functional groups. DOPE can be used as a helper lipid in gene transfection. PEG is used in drug delivery system. DBCO can be used for click chemistry .

HY-160852

YSK 12C4		Cationic Lipids
YSK 12C4 is an ionizable cationic lipid primarily used to enhance siRNA cellular delivery via multifunctional envelope-type nanodevices (MEND). YSK 12C4 promotes siRNA uptake and endosomal escape, effectively silencing genes in human immune cell lines .

HY-W591476C

m-PEG550-thiol mPEG550-SH		Polymers
m-PEG550-thiol modifies DNA thiolation for the synthesis of gold nanorods (AuNRs). Thiolated DNA can be loaded onto AuNR by the mPEG-SH/Tween 20 assisted method (Tween 20 and mPEG-SH repeatedly displace CTAB on the AuNR surface). DNA AuNRs have been widely used in nanostructure assembly, gene therapy, biosensing, and drug delivery.

HY-164582

DMTr-2'-O-C22-rC(Ac)-3'-CE-Phosphoramidite		Phosphoramidites Cytosine
DMTr-2'-O-C22-rC (Ac)-3'-CE-Phosphoramidite is an RNA phosphoramidite monomer. DMTr-2'-O-C22-rC (Ac)-3'-CE-Phosphoramidite enables site-specific introduction of 2'-O-C22 lipophilic modification at cytidine positions during oligonucleotide synthesis, which is used to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2'-O-C22-rC (Ac)-3'-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipophilicity and tissue uptake efficiency of dsRNA. Construction and mechanism study of DMTr-2'-O-C22-rC (Ac)-3'-CE-Phosphoramidite nucleic acid silencing molecules .

HY-159709

VL-422		Cationic Lipids
VL-422 is an ionizable cationic lipid. VL-422 delivers CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA to enable in vitro and in vivo gene editing. LNPs containing VL-422 loaded with Cas9 mRNA and sgRNA targeting the ANGPTL3 gene induce the deletion of premature stop codons within the ANGPTL3 gene in the liver of cynomolgus monkeys. Loss-of-function of ANGPTL3 leads to decreased levels of LDL, HDL and cholesterol in plasma. The VL-422 delivery system can be used for the research of gene editing strategies targeting lipid metabolism diseases .

HY-164581

DMTr-2'-O-C22-rG(ibu)-3'-CE-Phosphoramidite		Phosphoramidites Guanine
DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite is an RNA phosphoramidite monomer for oligonucleotide synthesis. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite enables site-specific introduction of 2'-O-C22 lipophilic modification at guanosine positions to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipid solubility and tissue uptake efficiency of dsRNA. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite can be used for the construction and mechanism research of nucleic acid silencing molecules .

HY-144001

DSPE-PEG-Carboxylic acid ammonium		Pegylated Lipids
DSPE-PEG-Carboxylic acid ammonium is a phospholipid PEG conjugate. DSPE-PEG-Carboxylic Acid can be widely used in the delivery of targeted agents and genes .

HY-149037

GL67 N4-Spermine cholesteryl carbamate		Cationic Lipids
GL67 (N4-Spermine cholesteryl carbamate) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .

HY-142995

DODAP hydrochloride		Cationic Lipids
DODAP (hydrochloride) is an ionizable lipid. DODAP (hydrochloride) has the potential for the research of gene delivery .

HY-149664

3β-[N-(N′,N′-Dimethylaminoethyl)carbamoyl]cholesterol DC-Chol		Cholesterol
3β-[N-(N′,N′-Dimethylaminoethyl)carbamoyl]cholesterol, a lipid, has been investigated in cancer gene therapy and vaccine delivery system .

HY-160576

DNCA		Phospholipids
DNCA is a neutral lipid that can be used in the generation of lipid nanoparticles (LNPs). DNCA can be used in nucleic acid delivery .

HY-17650

DMDHP (±)-Dimyristoyl-2,3-dimethylhydroxypropylamine		Cationic Lipids
DMDHP ((±)-Dimyristoyl-2,3-dimethylhydroxypropylamine) is a cationic lipid with a polar head group containing a dihydroxy group. DMDHP exhibits superior transfection efficiency and lower toxicity at high DNA doses in mouse intrapulmonary transfection model. DMDHP is commonly used for gene delivery .

HY-176754

TCL065		Cationic Lipids
TCL065 is an ionizable lipid with a pK_a of 6.3. TCL065 can be used to generate lipid nanoparticles (LNPs) for the delivery of mRNA as well as single-guide RNA (sgRNA) both in vitro and in vivo. TCL065-containing LNPs can studied in research for Duchenne muscular dystrophy and gene-editing technologies .

HY-W591476A

m-PEG3400-thiol mPEG3400-SH		Polymers
m-PEG3400-thiol modifies DNA thiolation for the synthesis of gold nanorods (AuNRs). Thiolated DNA can be loaded onto AuNR by the mPEG-SH/Tween 20 assisted method (Tween 20 and mPEG-SH repeatedly displace CTAB on the AuNR surface). DNA AuNRs have been widely used in nanostructure assembly, gene therapy, biosensing, and drug delivery.

HY-W591476D

m-PEG350-thiol mPEG350-SH		Polymers
m-PEG350-thiol modifies DNA thiolation for the synthesis of gold nanorods (AuNRs). Thiolated DNA can be loaded onto AuNR by the mPEG-SH/Tween 20 assisted method (Tween 20 and mPEG-SH repeatedly displace CTAB on the AuNR surface). DNA AuNRs have been widely used in nanostructure assembly, gene therapy, biosensing, and drug delivery.

HY-165427

Lipid 11		Cationic Lipids
Lipid 11 (Compound Lipid 1) is a cationic lipid for nucleic acid delivery. Lipid 11 forms lipid nanoparticles (LNPs) through electrostatic binding with nucleic acids (such as ceDNA). Lipid 11 forms complexes with negatively charged nucleic acids via cationic amine groups, which can be endocytosed by cells to release nucleic acids for activity. Lipid 11 is promising for research of gene therapy drug delivery systems .

HY-166997

AL-A12		Cationic Lipids
AL-A12 is a short-chain amino lipid with high gene delivery efficiency and low toxicity, and can be used in drug delivery research .

HY-145523

OH-Chol		Cationic Lipids
OH-Chol is a cationic cholesterol derivative. OH-Chol can be used for siRNA delivery and gene silencing .

HY-158709

Cho-es-Lys		Cholesterol
Cho-es-Lys is a cationic lipid synthesized by coupling natural cholesterol and amino acids, which has high gene transfection efficiency. Cho-es-Lys can be used in drug delivery research .

HY-159675

1-A-N		Cationic Lipids
1-A-N is a lipid nanoparticle (LNP) used for in vivo delivery of siRNA. 1-A-N can regulate immune response by delivering siCD45 (siRNA targeting CD45) to T cells and silencing the CD45 gene .

HY-171953

THP1 Lipid		Cationic Lipids
THP1 Lipid is an ionizable lipidoid. THP1 Lipid can be used to synthesize lipid nanoparticles (LNPs) for delivering mRNA to muscles with minimal toxicity and editing genes in specific liver tissues in tdTomato transgenic mice model. THP1 Lipid can be used for vaccine delivery and CRISPR/Cas9-mediated gene editing research .

HY-160581

OH-C-Chol		Cationic Lipids
OH-C-Chol is a cationic liposome that serves as a siRNA delivery vehicle. OH-C-Chol (LP-C) and OH-NC-Chol (LP-NC)/siRNA complexes (lipoplexes) showed better performance than NP-C and NP-NC/siRNA complexes (nanocomplexes), respectively. ) greater gene silencing effect .

HY-153230

Firefly luciferase circRNA-LNP		Liposome
Firefly luciferase circRNA-LNP is a lipid nanoparticle (LNP) containing Firefly luciferase circRNA, suitable for assays of RNA delivery, translation efficiency, cell viability, etc. Luciferase is commonly used as a bioluminescent reporter gene for gene regulation and function studies. Firefly Luciferase circRNA will express firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Common luciferase are firefly luciferase and sea kidney luciferase .

HY-171904

BCP-NC2-C12		Cationic Lipids
BCP-NC2-C12 is an ionizable cationic lipid. BCP-NC2-C12 can be used to generate lipid nanoparticles (LNPs) for in vivo delivery of mRNA. BCP-NC2-C12 LNPs mediated an approximately 90% reduction in PCSK9 serum protein levels via CRISPR/Cas9 gene knockout .

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