148 Results for "

Gene Delivery

" in MedChemExpress (MCE) Product Catalog:
Products (148)

148 Results for "Gene Delivery" in MCE Product Catalog:

44
44 Publications Verification
Cat. No.: HY-138170
CAS No.: 2036272-55-4
Purity:  99.81%
ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .
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19
19 Cited Publications
Cat. No.: HY-W127378
CAS No.: 144189-73-1
Synonyms: 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate
DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design .
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9
9 Cited Publications
Cat. No.: HY-W250110
CAS No.: 9002-98-6
Research Areas:  

Others

Polyethylenimine (branched) (30% in water) is a organic macromolecule with high cationic-charge-density potential. Polyethylenimine (branched) (30% in water) can ensnare DNA as well as attach to cell membrane. Polyethylenimine (branched) (30% in water) also retains a substantial buffering capacity at virtually any pH .
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9
9 Cited Publications
Cat. No.: HY-112758
CAS No.: 1190197-97-7
Purity:  99.88%
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .
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1
1 Cited Publications
Cat. No.: HY-112760
CAS No.: 247925-28-6
Purity:  ≥98.0%
Synonyms: DSPE-mPEG2000 sodium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] sodium
18:0 mPEG2000 PE (DSPE-mPEG2000) sodium is a conjugate of phospholipid and polyethylene glycol, and it can serve as an important PEG lipid component in lipid nanoparticles (LNPs). 18:0 mPEG2000 PE sodium can be used in the research of gene transfection, drug carriers and drug delivery .
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1
1 Cited Publications
Cat. No.: HY-126437H
CAS No.: 25988-63-0
Poly-L-lysine hydrobromide (MW 4000-15000) is a positively charged amino acid polymer that acts as a non-specific attachment factor for cells. Poly-L-lysine hydrobromide (MW 4000-15000) enhances the electrostatic interaction between the negative ions of the cell membrane and the surface of the culture medium, thereby promoting the adhesion of cells to solid substrates. Poly-L-lysine hydrobromide (MW 4000-15000) can be used for gene delivery .
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1
1 Cited Publications
Cat. No.: HY-153229
Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing firefly luciferase mRNA. Firefly luciferase mRNA-LNP exhibits a stable nanostructure, in which LNP plays a key role in effectively protecting and transporting mRNA to cells. Luciferase is a bioluminescent reporter gene for gene regulation and functional studies. Firefly Luciferase mRNA-LNP expresses firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Firefly luciferase mRNA-LNP is studied in research for RNA delivery, cell viability, and translation efficiency .
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1
1 Cited Publications
Cat. No.: HY-W583868
CAS No.: 26662-94-2
Synonyms: 1,2-POPE; 16:0-18:1 PE
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines .
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Cat. No.: HY-126437E
CAS No.: 25988-63-0
Poly-L-lysine hydrobromide (with a molecular weight of 15,000 - 30,000) is an amino acid polymer with positive charge, and it serves as a non-specific attachment factor for cells. Poly-L-lysine hydrobromide (with a molecular weight of 15,000 - 30,000) can be used for gene delivery and the construction of nano-delivery systems .
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Cat. No.: HY-155882
CAS No.: 80506-64-5
Synonyms: mPEG750-NH2
mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folate receptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells .
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Cat. No.: HY-E70313
Synonyms: Candida antarctica lipase B
Research Areas:  

Others

Lipase,Candida antarctica (Immobilized on hydrophilic carrier) (Candida antarctica lipase B) is a lipase derived from Candida antarctica and immobilized on a hydrophilic carrier. Lipase,Candida antarctica (Immobilized on hydrophilic carrier) is a green catalyst that can be used to catalyze polymer synthesis .
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Cat. No.: HY-P4121
CAS No.: 1898254-09-5
Target:  

Potassium Channel

Research Areas:  

Inflammation/Immunology Cancer

L17E is an attenuated cationic amphiphilic lytic (ACAL) peptide that can be used to deliver a variety of macromolecules, including proteins, antibodies, and DNA nanostructures. L17E inserts and cleaves the membrane structure through electrostatic interaction, enabling intracellular escape. The efficiency of L17E-mediated delivery is strongly correlated with the expression level of KCNN4 (the gene encoding the calcium-activated potassium channel KCa3.1). L17E also promotes the cellular uptake of macromolecules by inducing micropinocytosis. L17E can be further optimized and improved through dimerization strategies and in combination with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles .
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Cat. No.: HY-143702
CAS No.: 1010076-97-7
Purity:  95.20%
Synonyms: NBD-DOTAP
Fluorescent DOTAP (NBD-DOTAP) is a cationic lipid which can be used for nucleic acid and protein delivery. Fluorescent DOTAP is labeled with a fluorophore NBD (maximum excitation/emission wavelength ∼463/536 nm). Fluorescent DOTAP can be used for gene delivery systems, drug delivery, as well as cell imaging and nanocarrier tracking. Fluorescent DOTAP is an ideal candidate for both biological and pharmaceutical formulation (e.g. co-delivery of vaccines) research .
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Cat. No.: HY-168940B
CAS No.: 139729-28-5
NH2-PEG5000-COOH is a compound composed of an NH2 group, PEG units (MW = 2000) and a carboxyl group (-COOH) . NH2-PEG-COOH is widely used for surface modification and functionalization of polymer carriers or nanoparticles .
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Cat. No.: HY-126437I
CAS No.: 25988-63-0
Poly-L-lysine hydrobromide (MW 1000-5000) is a homopolymer of L-lysine and a polycationic non-viral gene delivery vector. Poly-L-lysine hydrobromide (MW 1000-5000) forms complexes with plasmid DNA. Poly-L-lysine hydrobromide (MW 1000-5000) is applicable to relevant research on lung cancer .
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Cat. No.: HY-112624U
CAS No.: 9004-54-0
Synonyms: Dextran 20; Dextran D20; Dextran T20(MW 16000-24000)
Dextran T20 (Dextran 20; Dextran D20) (MW 20,000) is a dehydrated glucose polymer with an average molecular weight of 20,000. Dextran T20 (MW 20,000) has excellent biodegradability and good biocompatibility, and can be used as a gene delivery vector, an immune adjuvant carrier, and a hemoglobin stabilizer .
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Cat. No.: HY-147087
CAS No.: 1318793-78-0
Purity:  ≥98.0%
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .
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Cat. No.: HY-P4086
CAS No.: 1678417-57-6
Target:  

RABV nAChR

Research Areas:  

Neurological Disease Cancer

Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) is a cell-penetrating peptide that is synthesized by adding nona-arginine motif to the carboxy terminus of RVG (rabies virus glycoprotein). Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) binds to
nAChR
on neuronal cells to mediate receptor-mediated endocytosis and targeted siRNA delivery. Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) protects complexed siRNA from degradation, enhances transcellular siRNA delivery in neuronal cells, and promotes efficient, pecific gene silencing. Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) can be used for the researches of neurological disease and cancer .
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Cat. No.: HY-134783
CAS No.: 2036272-50-9
Purity:  ≥98.0%
Target:  

Liposome

Research Areas:  

Others

1,19-Bis(2-butyloctyl) 10-[[3-(dimethylamino)propyl](1-oxononyl)amino]nonadecanedioate is an excipient for vaccines. 1,19-Bis(2-butyloctyl) 10-[[3-(dimethylamino)propyl](1-oxononyl)amino]nonadecanedioate can be used for the research of the development of COVID-19 vaccines and drug delivery for gene therapy .
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Cat. No.: HY-144022
CAS No.: 96326-74-8
Purity:  ≥98.0%
16:0 DAP is a cationic lipids that can be used for drug delivery, gene transfection and vaccine delivery .
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