5 Results for "

Gq-biased agonist

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "Gq-biased agonist" in MCE Product Catalog:

Cat. No.: HY-P3137
CAS No.: 812644-79-4
Target:  

Angiotensin Receptor

Research Areas:  

Cardiovascular Disease

TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists .
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Cat. No.: HY-P2381
CAS No.: 2410957-04-7
Target:  

Angiotensin Receptor

Research Areas:  

Others

Sar-Arg-Val-Tyr-Val-His-NH2 is a Gq-biased agonists, exhibits 10-fold larger molecular efficacies at the AT1R-Gq fusion protein compared with the AT1R-βarr2 fusion protein .
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Cat. No.: HY-P11540
CAS No.: 2923120-30-1
CCKBR agonist-1 (Compound 3r1) is a Gq-protein-preferring cholecystokinin B receptor (CCKBR) agonist with an EC50 of 35 pM. CCKBR agonist-1 significantly increases the survival rate of neurons, with an EC50 of 37 pM. CCKBR agonist-1 can improve the cognitive decline in mice by upregulating α-secretase (ADAM10) and calcium signaling molecule PLCB4, reduce the number of amyloid β () plaques, and promote long-term potentiation (LTP). CCKBR agonist-1 can be used for the study of Alzheimer's disease .
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Cat. No.: HY-179008
CAS No.: 2841457-05-2
Target:  

5-HT Receptor

Research Areas:  

Neurological Disease

5-HT2CR agonist 2 (Compound 16k) is a selective, blood-brain barrier-penetrating and Gq-biased 5-HT2CR agonist, with an EC50 of 36 nM. 5-HT2CR agonist 2 attenuates MK801 (HY-15084B)-induced hyperlocomotion and reverses Phencyclidine-induced hyperlocomotor activity .
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Cat. No.: HY-P2382
CAS No.: 40678-47-5
Target:  

Inhibitory Antibodies

Research Areas:  

Others

TRV120056 is a Gq-biased agonists, exhibits 10-fold larger molecular efficacies at the AT1R-Gq fusion protein compared with the AT1R-βarr2 fusion protein .
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