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Pathways Recommended:	Membrane Transporter/Ion Channel

Results for "

HCN2 ion channel

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HCN Channel (5) Potassium Channel (2)
By Research Areas:	Inflammation/Immunology (1) Neurological Disease (6)

Targets Recommended: HCN Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-186061

HCN2-IN-4	HCN Channel	Neurological Disease
HCN2-IN-4 is an orally active *HCN2* ion channel inhibitor, with an IC₅₀ of 3 nM. HCN2-IN-4 inhibits the activity of *HCN2* ion channels. HCN2-IN-4 can be used in the research of pain, tinnitus and central nervous system diseases .

HY-186059

HCN2 modulator-4	Potassium Channel	Neurological Disease
HCN2 modulator-4 is a *HCN2* ion channel inhibitor. HCN2 modulator-4 inhibits *HCN2* ion channel activity. HCN2 modulator-4 can be used for the research of pain, inflammatory pain, neuropathic pain, tinnitus, central nervous system disorders, psychiatric disorders, mood disorders .

HY-186059A

HCN2 modulator-5	Potassium Channel	Neurological Disease
HCN2 modulator-5 (S-configuration 39) is a *HCN2* ion channel inhibitor. HCN2 modulator-5 inhibits *HCN2* ion channel activity. HCN2 modulator-5 can be used for the research of pain, inflammatory pain, neuropathic pain, tinnitus, central nervous system disorders, psychiatric disorders, mood disorders .

HY-186060

HCN2 modulator-6	HCN Channel	Neurological Disease
HCN2 modulator-6 is a *HCN2* ion channel inhibitor has an IC₅₀ of 7 nM. HCN2 modulator-6 inhibits *HCN2* ion channel activity. HCN2 modulator-6 can be used for the research of pain, inflammatory pain, neuropathic pain, tinnitus, central nervous system disorders, psychiatric disorders, mood disorders .

HY-186057

HCN2-IN-5	HCN Channel
HCN2-IN-5 is a *HCN2* ion channel inhibitor with an IC₅₀ of 9 nM. HCN2-IN-5 shows weak inhibitory activity for HCN4. HCN2-IN-5 can be used for the research of inflammatory disease and neurological disorders .

HY-186056

HCN2-IN-3	HCN Channel	Neurological Disease
HCN2-IN-3 is an orally active *HCN2* inhibitor. HCN2-IN-3 inhibits the activity of *HCN2* ion channels. HCN2-IN-3 is applicable to research related to pain, tinnitus, central nervous system diseases, mental illnesses and mood disorders .

HY-186058

HCN2-IN-6	HCN Channel	Neurological Disease Inflammation/Immunology
HCN2-IN-6 is a *HCN2* ion channel inhibitor with an IC₅₀ of 7 nM. HCN2-IN-6 shows weak inhibitory activity for HCN4. HCN2-IN-6 can be used for the research of inflammatory disease and neurological disorders .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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HCN2 ion channel

Inhibitors & Agonists