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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
107 Results for "
HMGB
" in MedChemExpress (MCE) Product Catalog:
Products (107)
107 Results for "HMGB" in MCE Product Catalog:
110
110 Publications Verification
Target:
Research Areas:
GSK-872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury .
110
110 Publications Verification
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Research Areas:
GSK-872 hydrochloride is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 hydrochloride decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury .
80
80 Cited Publications
Synonyms: Amethopterin; CL14377; WR19039
Research Areas:
Methotrexate (Amethopterin; CL14377; WR19039) is an orally active antifolate (Antifolate). Methotrexate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .
80
80 Cited Publications
Synonyms: Amethopterin disodium; CL14377 disodium; WR19039 disodium
Methotrexate disodium (Amethopterin disodium; CL14377 disodium; WR19039 disodium) is an orally active antifolate (Antifolate). Methotrexate disodium inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate disodium promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate disodium induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate disodium is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .
80
80 Cited Publications
Synonyms: Amethopterin hydrate; CL14377 hydrate; WR19039 hydrate
66
Category:
Triterpenes Leguminosae Terpenoids Metabolic Disease Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Sweeteners Food Research
Target:
66
66 Cited Publications
Cat. No.: HY-N0184A
CAS No.: 68797-35-3
Synonyms: Glycyrrhizic acid dipotassium; Dipotassium glycyrrhizate
Category:
Triterpenes Leguminosae Terpenoids Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology
Target:
20
20 Cited Publications
Cat. No.: HY-B0581
CAS No.: 24584-09-6
Synonyms: ICRF-187; ADR-529; NSC-169780
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Dexrazoxane, as an intracellular iron chelating agent, reduces the formation of superoxide radicals and has cardioprotective, anti-inflammatory, antioxidant, anti-tumor and neuroprotective activities. Dexrazoxane inhibits ferroptosis of H9c2 cells by inhibiting HMGB1. Dexrazoxane induces DNA damage and apoptosis in human fibrosarcoma cells .
8
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Ethyl pyruvate is a simple derivative of the endogenous metabolite pyruvate. Ethyl pyruvate is an HMGB1 release inhibitor. Ethyl pyruvate can induce apoptosis by autophagy. Ethyl pyruvate has anti-inflammatory, antioxidant and anti-tumor activity. Ethyl pyruvate can be used in the study of neurodegenerative diseases such as Alzheimer's and Parkinson's disease .
6
6 Cited Publications
Cat. No.: HY-P70570
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HMGB1; Sulfoglucuronyl Carbohydrate Binding Protein; Prev. HMG1; Amphoterin; High Mobility Group Protein B1; HMG-1; High Mobility Group Protein 1; Nuclear Dot-Associated Sp100 Protein; SBP-1; Nuclear Autoantigen Sp-100; HMG3; High-Mobility Group Box 1; Hi
5
5 Cited Publications
Cat. No.: HY-P2268
CAS No.: 1092460-91-7
Target:
Research Areas:
5
5 Cited Publications
Cat. No.: HY-P2268A
Target:
Research Areas:
5
5 Cited Publications
Cat. No.: HY-P73104
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HMGB1; Sulfoglucuronyl Carbohydrate Binding Protein; Prev. HMG1; Amphoterin; High Mobility Group Protein B1; HMG-1; High Mobility Group Protein 1; Nuclear Dot-Associated Sp100 Protein; SBP-1; Nuclear Autoantigen Sp-100; HMG3; High-Mobility Group Box 1; Hi
4
4 Cited Publications
Cat. No.: HY-N0772
CAS No.: 24699-16-9
4
4 Cited Publications
Cat. No.: HY-P73104A
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: HMGB1; Sulfoglucuronyl Carbohydrate Binding Protein; Prev. HMG1; Amphoterin; High Mobility Group Protein B1; HMG-1; High Mobility Group Protein 1; Nuclear Dot-Associated Sp100 Protein; SBP-1; Nuclear Autoantigen Sp-100; HMG3; High-Mobility Group Box 1; Hi
4
4
4 Cited Publications
Synonyms: γ-Glu-Cys TFA
2
2 Cited Publications
Research Areas:
Necrocide 1, a necrosis by sodium overload (NECSO) inducer, is a selective transient receptor potential melastatin 4 (TRPM4) agonist with an EC50 of 306.3 nM for human TRPM4. Necrocide 1 triggers TRPM4-dependent necrotic cell death through the induction of sodium influx. Necrocide 1 induces hallmarks of immunogenic cell death incurring calreticulin (CALR) exposure, ATP secretion and high mobility group box 1 (HMGB1) release. Necrocide 1 can be used for the study of breast and prostate cancer .
2
2 Cited Publications
Cat. No.: HY-P72797
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HMGB1; Sulfoglucuronyl Carbohydrate Binding Protein; Prev. HMG1; Amphoterin; High Mobility Group Protein B1; HMG-1; High Mobility Group Protein 1; Nuclear Dot-Associated Sp100 Protein; SBP-1; Nuclear Autoantigen Sp-100; HMG3; High-Mobility Group Box 1; Hi
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
