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LaKe

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By Targets:	Aryl Hydrocarbon Receptor (3) Biochemical Assay Reagents (3) Cytochrome P450 (1) DNA/RNA Synthesis (3) Drug Intermediate (3) Drug Isomer (1) Drug Metabolite (1) Endogenous Metabolite (2) Environmental Pollutants (1) Fluorescent Dye (1) Insecticide (1) Integrin (3)
By Research Areas:	Cancer (3) Infection (1) Metabolic Disease (2) Neurological Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W014566

4-Nitro-3-(trifluoromethyl)phenol 3-(Trifluoromethyl)-4-Nitrophenol; TFM	Environmental Pollutants Cytochrome P450 Insecticide	Infection
4-Nitro-3-(trifluoromethyl)phenol (TFM) is a piscicide that is toxic to lampreys (P. marinus) (LC₅₀ values are 1.97-2.11 for cysts, 2.05-2.21 for fry, 1.6-2.45 for juveniles, and 1.6-1.63 for adults, respectively). 4-Nitro-3-(trifluoromethyl)phenol is also toxic to juvenile lake sturgeons (A. fulvescens) less than 100 mm, but is nontoxic to a variety of other fish species. 4-Nitro-3-(trifluoromethyl)phenol (50 μM) dissociates oxidative phosphorylation by 22% and 28% in isolated livers of lampreys and rainbow trout (O. mykiss), respectively. 4-Nitro-3-(trifluoromethyl)phenol can be used to control lamprey larval populations.

HY-16031

AFP464 free base NSC710464 free base	Aryl Hydrocarbon Receptor Integrin Drug Intermediate DNA/RNA Synthesis	Cancer
AFP464 (NSC710464) free base is a prodrug of Aminoflavone (HY-132974) and an agonist of the aryl hydrocarbon receptor (AhR). AFP464 free base downregulates the expression of α6-integrin (α6-integrin), inhibits breast tumor growth, reduces the population of tumor-initiating cells, disrupts mammosphere structure, induces the formation of mucin lake clusters, triggers DNA damage, and exerts antiproliferative activity. AFP464 free base is rapidly converted to Aminoflavone by nonspecific esterases in plasma and cell culture media. AFP464 free base is applicable to research related to breast cancer .

HY-16031B

AFP464 dihydrochloride NSC710464 dihydrochloride	Aryl Hydrocarbon Receptor Integrin Drug Intermediate DNA/RNA Synthesis	Cancer
AFP464 (NSC710464) dihydrochloride is a prodrug of Aminoflavone (HY-132974) and an agonist of the aryl hydrocarbon receptor (AhR). AFP464 dihydrochloride downregulates the expression of α6-integrin (α6-integrin), inhibits breast tumor growth, reduces the population of tumor-initiating cells, disrupts mammosphere structure, induces the formation of mucin lake clusters, triggers DNA damage, and exerts antiproliferative activity. AFP464 dihydrochloride is rapidly converted to Aminoflavone by nonspecific esterases in plasma and cell culture media. AFP464 dihydrochloride is applicable to research related to breast cancer .

HY-117964

Pigment Red 53 LaKe Red C	Endogenous Metabolite
Pigment Red 53 (Lake Red C) is an organic pigment with good color stability and spectral properties. Pigment Red 53 is widely used in the coatings and plastics industries to provide a vivid red color. Pigment Red 53 is also used in food and cosmetics as a safe colorant to ensure an attractive product appearance.

HY-175418

*LaKe*	Drug Metabolite	Neurological Disease Metabolic Disease
LaKe is an orally active simple ester prodrug. LaKe is promising for research of metabolic syndrome and neurodegenerative diseases .

HY-115416

Pigment Red 49:1 Barium lithol red	Fluorescent Dye	Others
Pigment Red 49:1 (Barium lithol red) is an azo lake pigment. The color of Pigment Red 49:1 ranges from yellow to purplish blue .

HY-175118

Scyllo-Inositol hexakisphosphate sodium Scyllo-IP6 sodium	Drug Isomer	Others
Scyllo-Inositol hexakisphosphate (Scyllo-IP6) sodium is a orthophosphate monoester found in lake sediments .

HY-Y1005

Triammonium phosphate trihydrate	Biochemical Assay Reagents	Others
Triammonium phosphate trihydrate interacts with the magnesium ions to form a precipitate, which can be used for magnesium separation from lithium in salt-lake brines .

HY-N7835

Methyl dotriacontanoate C32:0 FAME; Lacceric acid methyl ester; Methyl Dotriacontanoate	Endogenous Metabolite	Metabolic Disease
Dotriacontanoic acid methyl ester is a naturally occurring fatty acid methyl ester that has been found in the cuticular wax of P. abies needles. It has also been found in sediment samples from the Harney River in Florida and Lake Kivu in the East African rift valley.

HY-116615

Methyl 2-hydroxytetracosanoate Methyl cerebronate	Biochemical Assay Reagents	Others
Methyl (+/-)-2-hydroxytetracosanoate, a hydroxylated fatty acid methyl ester, has been found in mature and immature strawberry homogenates, Pseudosuberites and S. massa sponges, sediment samples from Hani River and Lake Kivu, and aerial parts of Escherichia coli found in. sun mirror.

HY-121774

Naphthol AS-ITR C.I. 37550	Biochemical Assay Reagents	Others
Naphthol AS-ITR (C.I. 37550) is used as a dyeing base agent for cotton and has a high affinity for cotton. Naphthol AS-ITR can also be used for dyeing viscose fibers, silk, nylon, and printing cotton fabrics, as well as for manufacturing lake pigments .

HY-16031A

AFP464 NSC710464	Aryl Hydrocarbon Receptor Integrin Drug Intermediate DNA/RNA Synthesis	Cancer
AFP464 (NSC710464) is a prodrug of Aminoflavone (HY-132974) and an agonist of the aryl hydrocarbon receptor (AhR). AFP464 downregulates the expression of α6-integrin (α6-integrin), inhibits breast tumor growth, reduces the population of tumor-initiating cells, disrupts mammosphere structure, induces the formation of mucin lake clusters, triggers DNA damage, and exerts antiproliferative activity. AFP464 is rapidly converted to Aminoflavone by nonspecific esterases in plasma and cell culture media. AFP464 is applicable to research related to breast cancer .

Cat. No.	Product Name	Type

HY-Y1005

Triammonium phosphate trihydrate	Biochemical Assay Reagents
Triammonium phosphate trihydrate interacts with the magnesium ions to form a precipitate, which can be used for magnesium separation from lithium in salt-lake brines .

HY-116615

Methyl 2-hydroxytetracosanoate Methyl cerebronate	Biochemical Assay Reagents
Methyl (+/-)-2-hydroxytetracosanoate, a hydroxylated fatty acid methyl ester, has been found in mature and immature strawberry homogenates, Pseudosuberites and S. massa sponges, sediment samples from Hani River and Lake Kivu, and aerial parts of Escherichia coli found in. sun mirror.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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