503 Results for "

M+phase

" in MedChemExpress (MCE) Product Catalog:
Products (503)

503 Results for "M+phase" in MCE Product Catalog:

129
Chlorpromazine
Chlorpromazine
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129 Publications Verification
Cat. No.: HY-12708
CAS No.: 50-53-3
Pureté:  99.75%
Target:  

Dopamine Receptor Cytochrome P450 Autophagy 5-HT Receptor

Domaines de recherche:  

Cardiovascular Disease Neurological Disease Cancer

Chlorpromazine is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine also can inhibit clathrin-mediated endocytosis .
129
Chlorpromazine hydrochloride
Chlorpromazine hydrochloride
0 Images
129 Publications Verification
Cat. No.: HY-B0407A
CAS No.: 69-09-0
Target:  

Dopamine Receptor Autophagy Cytochrome P450 5-HT Receptor

Domaines de recherche:  

Cardiovascular Disease Neurological Disease Cancer

Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis .
72
Romidepsin
Romidepsin
0 Images
72 Cited Publications
Cat. No.: HY-15149
CAS No.: 128517-07-7
Pureté:  99.87%
Synonyms: FK 228; FR 901228; NSC 630176
Target:  

HDAC Apoptosis

Domaines de recherche:  

Cancer

Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively . Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis .
34
Citric acid
Citric acid
0 Images
34 Cited Publications
Cat. No.: HY-N1428
CAS No.: 77-92-9
Category:  

Cardiovascular Disease Preservatives Anti-aging Metabolic Disease Endocrine diseases Endogenous metabolite Food Research Infection Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Disease Research Fields Inflammation/Immunology Cancer

Target:  

Environmental Pollutants Endogenous Metabolite Bacterial Apoptosis

Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
27
Hesperetin
Hesperetin
0 Images
27 Cited Publications
Cat. No.: HY-N0168
CAS No.: 520-33-2
Category:  

other families Flavonoids Neurological Disease Sunscreen Flavonones Cosmetic Research Plants Disease Research Fields Cancer

Target:  

p38 MAPK Autophagy Apoptosis Reactive Oxygen Species (ROS) NF-κB Bcl-2 Family

Hesperetin is a natural flavanone that can be found in citrus, and acts as a potent and orally active broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Hesperetin displays a range of bioactivities including antioxidant, anti-inflammatory, and anti-cancer. Hesperetin is found to induce cell-cycle arrest at G2/M phase. Hesperetin can reduce Bcl-2 and enhance BaxM. Hesperetin induces apoptosis through inhibiting NF-κB receptor .
27
SKF-96365 (hydrochloride)
SKF-96365 (hydrochloride)
0 Images
27 Cited Publications
Cat. No.: HY-100001
CAS No.: 130495-35-1
Pureté:  ≥99.01%
Target:  

TRP Channel CRAC Channel Autophagy CaMK Akt Apoptosis Na+/Ca2+ Exchanger Calcium Channel

Domaines de recherche:  

Neurological Disease Inflammation/Immunology Cancer

SKF-96365 hydrochloride is a TRPC channel antagonist and store-operated calcium entry (SOCE) inhibitor. SKF-96365 hydrochloride reduces calcium ion influx by inhibiting the activity and expression of TRPC6, STIM1 and Orai1. SKF-96365 hydrochloride inhibits voltage-gated sodium current (cardiac INa/NaV1.5) and slows myocardial conduction. SKF-96365 hydrochloride inhibits phosphorylation/activation of CaMKIIγ and suppresses the downstream AKT signaling pathway. SKF-96365 hydrochloride induces G2/M phase cell cycle arrest, apoptosis and cytoprotective autophagy in colorectal cancer cells. SKF-96365 hydrochloride alleviates allergic rhinitis symptoms by reducing inflammatory cytokine levels. SKF-96365 hydrochloride reduces intracellular calcium overload, inhibits Homer1 expression, prevents nuclear damage and suppresses apoptosis. SKF-96365 hydrochloride inhibits the growth of colorectal cancer xenografts in nude mice . SKF-96365 hydrochloride is applicable to research related to allergic rhinitis, colorectal cancer, Parkinson's disease, persistent spontaneous nociception and hyperalgesia .
27
SKF-96365
SKF-96365
0 Images
27 Cited Publications
Cat. No.: HY-125942
CAS No.: 162849-90-3
Target:  

CRAC Channel TRP Channel CaMK Akt Apoptosis Autophagy Na+/Ca2+ Exchanger Calcium Channel

Domaines de recherche:  

Neurological Disease Inflammation/Immunology Cancer

SKF-96365 is a TRPC channel antagonist and store-operated calcium entry (SOCE) inhibitor. SKF-96365 reduces calcium ion influx by inhibiting the activity and expression of TRPC6, STIM1 and Orai1. SKF-96365 inhibits voltage-gated sodium current (cardiac INa/NaV1.5) and slows myocardial conduction. SKF-96365 inhibits phosphorylation/activation of CaMKIIγ and suppresses the downstream AKT signaling pathway. SKF-96365 induces G2/M phase cell cycle arrest, apoptosis and cytoprotective autophagy in colorectal cancer cells. SKF-96365 alleviates allergic rhinitis symptoms by reducing inflammatory cytokine levels. SKF-96365 reduces intracellular calcium overload, inhibits Homer1 expression, prevents nuclear damage and suppresses apoptosis. SKF-96365 inhibits the growth of colorectal cancer xenografts in nude mice . SKF-96365 is applicable to research related to allergic rhinitis, colorectal cancer, Parkinson's disease, persistent spontaneous nociception and hyperalgesia .
22
Hoechst 33258
Hoechst 33258
0 Images
22 Cited Publications
Cat. No.: HY-15558
CAS No.: 23491-44-3
Pureté:  99.11%
Synonyms: bisBenzimide H 33258; H 33258
Hoechst 33258 is a blue to blue-green fluorescent live cell dye that can label DNA. Hoechst 33258 can specifically bind to the minor groove of DNA (and tends to bind to A/T-rich DNA), resulting in a significant increase in fluorescence intensity. Hoechst 33258 can cross the cell membrane and cause changes in DNA structure, such as G2/M phase arrest. Hoechst 33258 can bind to live or fixed cells, and the fluorescence intensity increases with increasing solution pH. As a DNA-specific probe, Hoechst 33258 can be used to detect DNA content, analyze cell cycle, etc. The excitation wavelength of Hoechst 33258 is 350-365 nm, and the emission wavelength is 460-490 nm .
11
Citric acid trisodium
Citric acid trisodium
0 Images
11 Cited Publications
Cat. No.: HY-B2201
CAS No.: 68-04-2
Synonyms: Sodium citrate; Trisodium citrate anhydrous
Citric acid trisodium (Sodium citrate) is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
11
Citric acid tripotassium hydrate
Citric acid tripotassium hydrate
0 Images
11 Cited Publications
Cat. No.: HY-W009156
CAS No.: 6100-05-6
Synonyms: Potassium citrate monohydrate
Category:  

Ketones, Aldehydes, Acids Guttiferae Metabolic Disease Plants Garcinia cambogia Disease Research Fields Inflammation/Immunology

Target:  

Environmental Pollutants Endogenous Metabolite Bacterial Apoptosis

Citric acid tripotassium hydrate (Potassium citrate monohydrate) is a natural preservative and food tartness enhancer. Citric acid tripotassium hydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid tripotassium hydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid tripotassium hydrate is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
11
Lithium citrate tetrahydrate
Lithium citrate tetrahydrate
0 Images
11 Cited Publications
Cat. No.: HY-B1295
CAS No.: 6080-58-6
Synonyms: Litarex tetrahydrate
Category:  

Infection Microorganisms Ketones, Aldehydes, Acids Disease Research Fields

Target:  

Apoptosis Endogenous Metabolite Bacterial

Lithium citrate (Litarex) tetrahydrate is a natural preservative and food tartness enhancer. Lithium citrate tetrahydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Lithium citrate tetrahydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Lithium citrate tetrahydrate is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
9
Ixabepilone
Ixabepilone
0 Images
9 Cited Publications
Cat. No.: HY-10222
CAS No.: 219989-84-1
Pureté:  99.84%
Synonyms: BMS-247550; Aza-epothilone B
Target:  

Microtubule/Tubulin Apoptosis Bacterial

Domaines de recherche:  

Cancer

Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis.
9
Cinobufagin
Cinobufagin
0 Images
9 Cited Publications
Cat. No.: HY-N0421
CAS No.: 470-37-1
Synonyms: Cinobufagine
Category:  

Animals Disease Research Fields Cancer Steroids

Target:  

Apoptosis

Cinobufagin is an anticancer agent that can be secreted by the Asiatic toad Bufo gargarizans. Cinobufagin induces the cell cycle arrests in the G1 phase or G2/M phase, leading to apoptosis in cancer cells. Cinobufagin inhibits tumor growth in melanoma and glioblastoma multiforme xenograft mouse models .
9
Digitoxin
Digitoxin
0 Images
9 Cited Publications
Cat. No.: HY-B1357
CAS No.: 71-63-6
Category:  

Cardiovascular Disease Digitalis purpurea Linn. Scrophulariaceae Plants Disease Research Fields Steroids

Target:  

Environmental Pollutants Apoptosis Na+/K+ ATPase Bcl-2 Family Caspase HSV Calcium Channel

Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure .
8
Eribulin mesylate
Eribulin mesylate
0 Images
8 Cited Publications
Cat. No.: HY-13442A
CAS No.: 441045-17-6
Pureté:  99.91%
Synonyms: B1939 mesylate; E7389 mesylate; ER-086526 mesylate
Target:  

Microtubule/Tubulin Apoptosis

Domaines de recherche:  

Cancer

Eribulin mesylate is an inhibitor for microtubule. Eribulin mesylate inhibits the proliferation of cancer cell LM8 and Dunn, inhibits the cell migration of LM8, arrests the cell cycle at G2/M phase, and induces apoptosis in LM8. Eribulin mesylate exhibits antitumor efficacy in mouse model .
8
Citric acid monohydrate
Citric acid monohydrate
0 Images
8 Cited Publications
Cat. No.: HY-N1428A
CAS No.: 5949-29-1
Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
8
Citric acid (standard)
Citric acid (standard)
0 Images
8 Cited Publications
Cat. No.: HY-N1428R
CAS No.: 77-92-9
Category:  

Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Cancer

Target:  

Reference Standards Apoptosis Endogenous Metabolite Bacterial

Citric acid (Standard) is the analytical standard of Citric acid (HY-N1428). This product is intended for research and analytical applications. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
6
Y-320
Y-320
0 Images
6 Cited Publications
Cat. No.: HY-15898
CAS No.: 288250-47-5
Pureté:  99.03%
Target:  

Interleukin Related Apoptosis

Domaines de recherche:  

Inflammation/Immunology Cancer

Y-320 is a potent, orally active phenylpyrazoleanilide immunomodulator. Y-320 inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Y-320 enhances TP53, DMD, and COL17A1 PTC readthrough by G418 and increases cellular protein levels and protein synthesis. Y-320 concomitants use of with a low dose of Paclitaxel (HY-B0015) significantly sensitized multidrug resistance (MDR) tumors by inducing G2/M phase arrest and apoptosis. Y-320 can be used for research of rheumatoid arthritis (RA) and cancer .
5
Lobaplatin
Lobaplatin
0 Images
5 Cited Publications
Cat. No.: HY-105930
CAS No.: 135558-11-1
Pureté:  ≥98.0%
Synonyms: D-19466
Target:  

Apoptosis Caspase Bcl-2 Family

Domaines de recherche:  

Cancer

Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin arrests cell cycle at G1 and G2/M phase. Lobaplatin induces apoptosis by increasing expressions of caspase and Bax, decreasing expression of Bcl-2. Lobaplatin can be used for research of cancer .
5
Polyphyllin I
Polyphyllin I
0 Images
5 Cited Publications
Cat. No.: HY-N0047
CAS No.: 50773-41-6
Category:  

Liliaceae Paris polyphylla Smith Plants Disease Research Fields Saccharides Cancer Steroids

Target:  

JNK mTOR Akt PDK-1 Autophagy Apoptosis

Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis .
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