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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
58 Results for "
MCA
" in MedChemExpress (MCE) Product Catalog:
Products (58)
58 Results for "MCA" in MCE Product Catalog:
28
28 Publications Verification
Research Areas:
Gly-β-MCA, a bile acid, is a potent, sable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor that may be a candidate for the treatment of metabolic disorders .
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2 Cited Publications
Cat. No.: HY-P4931
CAS No.: 720710-69-0
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2 Cited Publications
Cat. No.: HY-P2536
CAS No.: 305336-82-7
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2
2 Cited Publications
Synonyms: T-α-MCA sodium
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1
1 Cited Publications
Cat. No.: HY-P3722
CAS No.: 192723-42-5
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1
1 Cited Publications
Cat. No.: HY-P3722A
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Synonyms: MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2
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Cat. No.: HY-W027544
CAS No.: 62935-72-2
Synonyms: 7-Methoxycoumarin-4-acetic acid
Cat. No.: HY-P4326
CAS No.: 65147-04-8
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Cat. No.: HY-P3749
CAS No.: 323577-36-2
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Cat. No.: HY-162275
CAS No.: 861224-48-8
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JMJD1C-IN-1 is an orally active and selective inhibitor of JMJD1C (IC50 = 0.59 μM, Kd = 1.96 μM). JMJD1C-IN-1 inhibits the binding of JMJD1C to H3K9me2 peptide substrate in the HTRF assay (IC50 = 1.47 μM). JMJD1C-IN-1 disrupts intratumoral regulatory T (Treg) cell fitness by dual mechanisms: promoting H3K9me2 accumulation to downregulate PD1 expression and reducing STAT3 demethylation to enhance STAT3 activation. JMJD1C-IN-1 demonstrates dose-dependent antitumor efficacy in multiple mouse tumor models (MCA205 fibrosarcoma, B16-F10 melanoma, LLC lung cancer, Hepa1-6 hepatocellular carcinoma, CT26 colorectal cancer). JMJD1C-IN-1 can be used for the study of tumor immunotherapy by selectively targeting intratumoral Treg cells .
Cat. No.: HY-P3792
CAS No.: 185698-23-1
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Cat. No.: HY-P4920
CAS No.: 1802078-32-5
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Cat. No.: HY-P1859
CAS No.: 438625-61-7
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Cat. No.: HY-P4645
CAS No.: 140430-55-3
Synonyms: MCA-Pro-Leu
Cat. No.: HY-P2616A
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Cat. No.: HY-P3120
CAS No.: 1926163-82-7
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Cat. No.: HY-P5272
CAS No.: 112844-49-2
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Cat. No.: HY-P2616
CAS No.: 189696-01-3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
