25613-05-2
Chemical Structure
Tauro-α-muricholic acid
Synonym(s): T-α-MCA
- CAS No.: 25613-05-2
- Formula:C26H45NO7S
- Molecular Weight:515.70
IUPAC Name: 2-((R)-4-((3R,5R,6S,7S,8S,9S,10R,13R,14S,17R)-3,6,7-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethane-1-sulfonic acid
InChIKey: XSOLDPYUICCHJX-QQXJNSDFSA-N
SMILES: C[C@@H]([C@H]1CC[C@]2([C@@]3([C@@H]([C@H]([C@@]4(C[C@@H](CC[C@@]4([C@]3(CC[C@]12C)[H])C)O)[H])O)O)[H])[H])CCC(NCCS(=O)(O)=O)=O
Biological Activity: Tauro-α-muricholic acid (T-α-MCA) is a Taurine (HY-B0351)-conjugated primary Bile acid. Tauro-α-muricholic acid is a FXR antagonist with an IC50 of 28 µM. Tauro-α-muricholic acid attenuates other bile acid-activated FXR signaling. Tauro-α-muricholic acid can be used in the research of Alzheimer's disease, glucose metabolism, and lipid metabolism[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tauro-α-muricholic acid | 99.18% | Tauro-α-muricholic acid (T-α-MCA) is a Taurine (HY-B0351)-conjugated primary Bile acid. Tauro-α-muricholic acid is a FXR antagonist with an IC50 of 28 µM. Tauro-α-muricholic acid attenuates other bile acid-activated FXR signaling. Tauro-α-muricholic acid can be used in the research of Alzheimer's disease, glucose metabolism, and lipid metabolism. | ||||||||||||||||||||
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- [1]. Miyata M, et al. Cholesterol-lowering effects of taurine through the reduction of ileal FXR signaling due to the alteration of ileal bile acid composition. Amino Acids. 2021 Oct;53(10):1523-1532. [Content Brief]
- [2]. Wu J, et al. Gender differences in the bile acid profiles of APP/PS1 transgenic AD mice. Brain Res Bull. 2020 Aug;161:116-126. [Content Brief]
Keywords
