Tauro-ω-muricholic acid sodium
Based on 1 publication(s) in Google Scholar
Tauro-ω-muricholic acid sodium (TωMCA sodium) is a bile acid released by the liver and an analog of tauro-α-muricholic acid. Tauro-ω-muricholic acid sodium is investigated as a potential marker in plasma for early-onset neonatal sepsis (EOS) and cholestasis studies
For research use only. We do not sell to patients.
- Purity: 97.81%
- CAS No.: 2456348-84-6
- Formula: C26H44NNaO7S
- Molecular Weight:537.68
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Tauro-ω-muricholic acid sodium
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Biological Activity
Description
In Vivo
10 BAs from the NAFLD group are significantly decreased in the liver, including 4 tauro-conjugated BA species including taurolithocholic acid (TLCA), THDCA, taurodeoxycholic acid (TDCA) and tauro ω-muricholic acid (TωMCA). Furthermore, βDCA, HDCA, 6-ketoLCA, 23-nordeoxycholic acid (NorDCA), LCA and 3β-chenodeoxycholic acid (βCDCA) shows lower levels in the NAFLD group[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2456348-84-6
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Appearance Solid
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Molecular Weight 537.68
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Formula C26H44NNaO7S
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Color White to off-white
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SMILES
C[C@@H]([C@]1(CC[C@]2([C@@]3([C@H]([C@@H]([C@@]4(C[C@@H](CC[C@@]4([C@]3(CC[C@@]21C)[H])C)O)[H])O)O)[H])[H])[H])CCC(NCCS(=O)(O[Na])=O)=O
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Synonyms
TωMCA sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227
Solvent & Solubility
In Vitro:
DMSO : 10 mg/mL (18.60 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Zöhrer E, et al. Neonatal sepsis leads to early rise of rare serum bile acid tauro-omega-muricholic acid (TOMCA).Pediatr Res. 2018 Jul;84(1):66-70. [Content Brief]
[2]. Tang Y, et al. Turnover of bile acids in liver, serum and caecal content by high-fat diet feeding affects hepatic steatosis in rats. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1293-1304 [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8598 mL | 9.2992 mL | 18.5984 mL | 46.4961 mL |
| 5 mM | 0.3720 mL | 1.8598 mL | 3.7197 mL | 9.2992 mL | |
| 10 mM | 0.1860 mL | 0.9299 mL | 1.8598 mL | 4.6496 mL | |
| 15 mM | 0.1240 mL | 0.6199 mL | 1.2399 mL | 3.0997 mL |
Tauro-ω-muricholic acid sodium Related Classifications
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