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Results for "

MDMX

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (6) c-Myc (1) Caspase (1) Drug Derivative (1) E1/E2/E3 Enzyme (2) HDAC (1) Ligands for E3 Ligase (1) MDM-2/p53 (18) NF-κB (1) PARP (2) Reference Standards (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (20) Inflammation/Immunology (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P4210

Sulanemadlin 1 Publications Verification ALRN-6924; MP-4897	MDM-2/p53	Cancer
Sulanemadlin (ALRN-6924) is a potent and cell-permeating p53-based peptidomimetic macrocycles. Sulanemadlin is a inhibitor of the p53-MDM2, p53-MDMX, or both p53 and MDM2 and MDMX protein-protein interactions. Sulanemadlin can be used for cancers research .

HY-108638

NSC 146109 hydrochloride 2 Publications Verification XI-011 hydrochloride	MDM-2/p53 Apoptosis PARP	Cancer
NSC 146109 hydrochloride (XI-011 hydrochloride) is a p53 activator and *MDMX* inhibitor. NSC 146109 hydrochloride inhibits *MDMX* gene transcription, downregulates MDMX mRNA and protein levels, stabilizes p53 and activates the transcriptional activity of p53. NSC 146109 hydrochloride induces cancer cell apoptosis (apoptosis) and inhibits the growth of transformed cells. NSC 146109 hydrochloride inhibits the growth of xenograft tumors. NSC 146109 hydrochloride can be used in research related to breast cancer and cervical cancer .

HY-141584

ATSP-7041	MDM-2/p53	Cancer
ATSP-7041, a selective dual peptide inhibitor of MDM2 and *MDMX*, effectively reactivates the p53 tumor suppressor pathway in a mechanism-dependent manner in p53-positive cancers .

HY-16664

SJ-172550 2 Publications Verification	MDM-2/p53 E1/E2/E3 Enzyme	Cancer
SJ-172550 is a small molecule inhibitor of *MDMX; competes for the wild type p53 peptide binding to MDMX* with an EC₅₀ of 5 μM.

HY-120086

RO-5963 1 Publications Verification	MDM-2/p53 E1/E2/E3 Enzyme	Cancer
RO-5963 is a dual p53-MDM2 and *p53-MDMX* inhibitor with IC₅₀s of ~17 nM and ~24 nM, respectively .

HY-14714

NSC-207895 2 Publications Verification XI-006	MDM-2/p53	Cancer
NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator .

HY-123950

MMRi64	MDM-2/p53 Apoptosis	Cancer
MMRi64 disrupts *Mdm2-MdmX* interactions. MMRi64 downregulates Mdm2 and MdmX in leukemia cells. MMRi64 induces p53 accumulation, and induces the apoptotic arm of the p53 pathway in leukemia/lymphoma cells. MMRi64 can be used for cancer research .

HY-148106

MEL23	Ligands for E3 Ligase	Cancer
MEL23 is a MDM2 E3 ligase inhibitor that blocks the E3 ligase activity of the MDM2-MDMX complex. MEL23 inhibits Mdm2 and p53 ubiquitination in cells, reduce viability of cells with wild-type p53. MEL23 stabilizes MDM2 via a mechanism independent of p53 transcription .

HY-149250

MDMX/MDM2-IN-2	MDM-2/p53 Apoptosis	Cancer
MDMX/MDM2-IN-2 is a potent *p53-MDM2/MDMX* dual inhibitors with K_is of 0.23 μM and 2.45 μM for MDM2 and MDMX, respectively. MDMX/MDM2-IN-2 inhibits the binding of p53 and MDM2 proteins. MDMX/MDM2-IN-2 restores the function of p53 and enables cell cycle arrest and apoptosis. MDMX/MDM2-IN-2 inhibits cell migration and invasion. MDMX/MDM2-IN-2 has antitumor activity .

HY-124791

MMRi6	MDM-2/p53 PARP	Cancer
MMRi6 is a Mdm2-MdmX RING domain inhibitor that can disrupt Mdm2-MdmX RING-RING interaction in vitro. MMRi6 inhibits MdmX-stimulated Mdm2 autoubiquitination and Mdm2-MdmX-mediated p53 polyubiquitination in vitro without affecting NEDD4-1 autoubiquitination. MMRi6 induces p53 stabilization and accumulation and induces PARP cleavage in wt-p53 Emu-myc lymphoma cells. MMRi6 inhibits the growth of wt-p53 and p53-null Emu-myc lymphoma cells with IC₅₀s of approximately 0.5 μM and 3 μM, respectively. MMRi6 can be used for the study of leukemia/lymphoma .

HY-P11256

pDI	MDM-2/p53	Cancer
pDI is a peptide. pDI inhibits MDM2-p53 and *MDMX-p53* interactions with IC₅₀s of 10 and 100 nM respectively. pDI can be used in the research of colorectal cancer .

HY-P11255

SPDI-48-T1	MDM-2/p53	Cancer
SPDI-48-T1 is a lysine-stapled peptide. SPDI-48-T1 exhibits discernible binding affinities for MDM2 and *MDMX, with K_d* values of 396 nM and 456 nM, respectively. SPDI-48-T1 exhibits anticancer activity against breast cancer, colorectal cancer, non-small cell lung cancer, cervical cancer, and malignant melanoma .

HY-107466

WK298	MDM-2/p53	Cancer
WK298 is a potent inhibitor of the MDM2/MDMX-p53 interaction with good anti-tumor activity. WK298 can fully activate the p53 pathway by inhibiting the binding of MDM2 and MDMX to p53. The development of WK298 benefited from a deep understanding of the key elements of the p53-MDM2/MDMX interaction structure .

HY-RS16923

Mdm4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mdm4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mdm4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mdm4 Mouse Pre-designed siRNA Set A Mdm4 Mouse Pre-designed siRNA Set A

HY-P10286

Phage-derived 12/1 peptide	MDM-2/p53	Cancer
Phage-derived 12/1 peptide exhibits antitumor activity by targeting MDM2 and *MDMX, an thus disrupt the MDM2-p53 and MDMX-p53 interaction, with IC₅₀* of 0.15 and 1.25 μM .

HY-164550

YF438	HDAC	Cancer
YF438 is an HDAC inhibitor with effective anticancer activity both in vitro and in vivo. YF438 inhibits the growth and metastasis of triple-negative breast cancer (TNBC) cells by blocking the interaction between HDAC and MDM2, inducing the dissociation of MDM2-MDMX, and promoting the degradation of MDM2 .

HY-RS08267

MDM4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MDM4 Human Pre-designed siRNA Set A contains three designed siRNAs for MDM4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MDM4 Human Pre-designed siRNA Set A MDM4 Human Pre-designed siRNA Set A

HY-163275

MDM2-IN-24	MDM-2/p53 Apoptosis	Cancer
MDM2-IN-24 (compound A3f) exhibits MDM2-inhibiting and *MDMX*-activating properties in triple-negative breast cancer (TNBC) cells, with apoptotic and anti-proliferative activities .

HY-P11490

DPMI-ω	MDM-2/p53	Inflammation/Immunology Cancer
DPMI-ω is a dual-specificity d-peptide antagonist of oncogenic proteins MDM2 and *MDMX. DPMI-ω, upon fabrication on gold nanoparticles, efficiently traverses tumor cells and kills them by reactivating the p53* signaling pathway. DPMI-ω can disrupte the p53-MDM2/MDMX complex. DPMI-ω can inhibit B16 melanoma growth and induce cells G0/G1 phase arrest. DPMI-ω can augment the efficacy of immunotherapy by expanding CD3 ⁺/CD8 ⁺ cytotoxic T cells and suppressing CD4 ⁺/CD25 ⁺ regulatory T cells companied with anti-PD1 antibody. DPMI-ω can be used for research of melanoma .

HY-P11635

ATSP-7342	Drug Derivative MDM-2/p53	Cancer
ATSP-7342 is a negative control analog of ATSP-7041. ATSP-7342 exhibits lower binding affinity to both MDM2 (K_i = 536 nM) and *MDMX* (K_i >1000 nM), compared with ATSP-7041 .

HY-108638R

NSC 146109 hydrochloride (Standard) XI-011 hydrochloride (Standard)	Reference Standards MDM-2/p53 Apoptosis	Cancer
NSC 146109 hydrochloride (Standard) is the analytical standard of NSC 146109 (hydrochloride) (HY-108638). This product is intended for research and analytical applications. NSC 146109 hydrochloride is a small-molecule p53 activator that target MDMX and can be used for breast cancer research. NSC 146109 hydrochloride is a pseudourea derivative, promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes .

HY-115797

LQFM030	MDM-2/p53 Caspase c-Myc Apoptosis NF-κB	Cancer
LQFM030 is a novel small molecule MDM2 inhibitor. LQFM030 exhibits concentration dependent cytotoxicity in K562 cells (IC₅₀ = 0.28 mM). LQFM030 induces cell apoptosis through G0/G1 phase cell cycle arrest and increased Caspase activity. LQFM030 downregulates the mRNA expression of *MDM2, MDMX, p73, MYC, and NF-κB*. LQFM030 is commonly used in research on cancers such as leukemia .

Cat. No.	Product Name	Target	Research Area

HY-P4210

Sulanemadlin 1 Publications Verification ALRN-6924; MP-4897	MDM-2/p53	Cancer
Sulanemadlin (ALRN-6924) is a potent and cell-permeating p53-based peptidomimetic macrocycles. Sulanemadlin is a inhibitor of the p53-MDM2, p53-MDMX, or both p53 and MDM2 and MDMX protein-protein interactions. Sulanemadlin can be used for cancers research .

HY-141584

ATSP-7041	MDM-2/p53	Cancer
ATSP-7041, a selective dual peptide inhibitor of MDM2 and *MDMX*, effectively reactivates the p53 tumor suppressor pathway in a mechanism-dependent manner in p53-positive cancers .

HY-P11256

pDI	MDM-2/p53	Cancer
pDI is a peptide. pDI inhibits MDM2-p53 and *MDMX-p53* interactions with IC₅₀s of 10 and 100 nM respectively. pDI can be used in the research of colorectal cancer .

HY-P11255

SPDI-48-T1	MDM-2/p53	Cancer
SPDI-48-T1 is a lysine-stapled peptide. SPDI-48-T1 exhibits discernible binding affinities for MDM2 and *MDMX, with K_d* values of 396 nM and 456 nM, respectively. SPDI-48-T1 exhibits anticancer activity against breast cancer, colorectal cancer, non-small cell lung cancer, cervical cancer, and malignant melanoma .

HY-P10286

Phage-derived 12/1 peptide	MDM-2/p53	Cancer
Phage-derived 12/1 peptide exhibits antitumor activity by targeting MDM2 and *MDMX, an thus disrupt the MDM2-p53 and MDMX-p53 interaction, with IC₅₀* of 0.15 and 1.25 μM .

HY-P11490

DPMI-ω	MDM-2/p53	Inflammation/Immunology Cancer
DPMI-ω is a dual-specificity d-peptide antagonist of oncogenic proteins MDM2 and *MDMX. DPMI-ω, upon fabrication on gold nanoparticles, efficiently traverses tumor cells and kills them by reactivating the p53* signaling pathway. DPMI-ω can disrupte the p53-MDM2/MDMX complex. DPMI-ω can inhibit B16 melanoma growth and induce cells G0/G1 phase arrest. DPMI-ω can augment the efficacy of immunotherapy by expanding CD3 ⁺/CD8 ⁺ cytotoxic T cells and suppressing CD4 ⁺/CD25 ⁺ regulatory T cells companied with anti-PD1 antibody. DPMI-ω can be used for research of melanoma .

HY-P11635

ATSP-7342	Drug Derivative MDM-2/p53	Cancer
ATSP-7342 is a negative control analog of ATSP-7041. ATSP-7342 exhibits lower binding affinity to both MDM2 (K_i = 536 nM) and *MDMX* (K_i >1000 nM), compared with ATSP-7041 .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P74756

	*MDM4/MDMX* Protein, Human (His)** Protein Mdm4; Protein MDMX; MDM4; MDMX	Human	E. coli
	MDM4/MDMX proteins cooperate with MDM2 to regulate TP53 (p53) and inhibit the transcriptional activation domains of p53 and p73. This hinders their ability to induce cell cycle arrest and apoptosis. MDM4/MDMX Protein, Human (His) is the recombinant human-derived MDM4/MDMX protein, expressed by E. coli , with N-His labeled tag.

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Host:	Mouse (2)
Reactivity:	Human (2)
Application:	IHC-P (2) WB (2) FC (2) ELISA (2)
Isotype:	IgG1 (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1)
Modification:	Unmodified (1)

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HY-P85272

	MDMX Antibody (YA4964) MDM4; MDMX; Protein Mdm4; Double minute 4 protein; Mdm2-like p53-binding protein; Protein MDMX; p53-binding protein Mdm4	WB, IHC-P, FC, ELISA	Human
	MDMX Antibody (YA4964) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MDMX.

HY-P85272A

	MDMX Antibody (YA4964)(PBS only) MDM4; MDMX; Protein Mdm4; Double minute 4 protein; Mdm2-like p53-binding protein; Protein MDMX; p53-binding protein Mdm4	WB, IHC-P, FC, ELISA	Human
	MDMX Antibody (YA4964) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MDMX.

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Mdm4 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Mdm4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mdm4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

MDM4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MDM4 Human Pre-designed siRNA Set A contains three designed siRNAs for MDM4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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