SPDI-48-T1
SPDI-48-T1 is a lysine-stapled peptide. SPDI-48-T1 exhibits discernible binding affinities for MDM2 and MDMX, with Kd values of 396 nM and 456 nM, respectively. SPDI-48-T1 exhibits anticancer activity against breast cancer, colorectal cancer, non-small cell lung cancer, cervical cancer, and malignant melanoma.
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- Formule: C91H129N21O20
- Masse moléculaire:1837.13
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
Kd: 396 nM (MDM2) and 456 nM (MDMX)[1]
Chemical Information
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Masse moléculaire 1837.13
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Formule C91H129N21O20
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Sequence
Ac-Leu-Thr-Phe-Lys-His-Tyr-Trp-Lys-Gln-Leu-Thr-Ser-Ala-Ala-NH2 (Lys stapled via 1,3-bismethylenebenzene)
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Sequence Shortening
Ac-LTFKHYWKQLTSAA-NH2 (Lys stapled via 1,3-bismethylenebenzene)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SPDI-48-T1 Related Classifications
HY-P11255 Related Classifications
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