1067654-70-9
Chemical Structure
WK298
- CAS No.: 1067654-70-9
- Formula:C35H38Cl2N6O
- Molecular Weight:629.62
IUPAC Name: (S)-(6-chloro-3-(1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl)-1H-indol-2-yl)(3-((3-(dimethylamino)propyl)(methyl)amino)pyrrolidin-1-yl)methanone
InChIKey: LWWQYOWAPGRPRH-NDEPHWFRSA-N
SMILES: O=C(N1C[C@H](CC1)N(C)CCCN(C)C)C2=C(C3=C(C4=CC=CC=C4)N=CN3CC5=CC=C(C=C5)Cl)C6=CC=C(Cl)C=C6N2
Biological Activity: WK298 is a potent inhibitor of the MDM2/MDMX-p53 interaction with good anti-tumor activity. WK298 can fully activate the p53 pathway by inhibiting the binding of MDM2 and MDMX to p53. The development of WK298 benefited from a deep understanding of the key elements of the p53-MDM2/MDMX interaction structure[1].
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WK298 | WK298 is a potent inhibitor of the MDM2/MDMX-p53 interaction with good anti-tumor activity. WK298 can fully activate the p53 pathway by inhibiting the binding of MDM2 and MDMX to p53. The development of WK298 benefited from a deep understanding of the key elements of the p53-MDM2/MDMX interaction structure. | |||||||||||||||||||||
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Keywords
