59474-01-0
Chemical Structure
NSC 146109 hydrochloride
Synonym(s): XI-011 hydrochloride
- CAS No.: 59474-01-0
- Formula:C17H17ClN2S
- Molecular Weight:316.85
IUPAC Name: (10-methylanthracen-9-yl)methyl carbamimidothioate hydrochloride
InChIKey: VIBMUYOXJUCEMA-UHFFFAOYSA-N
SMILES: [H]Cl.NC(SCC1=C2C=CC=CC2=C(C)C3=CC=CC=C13)=N
Biological Activity: NSC 146109 hydrochloride (XI-011 hydrochloride) is a p53 activator and MDMX inhibitor. NSC 146109 hydrochloride inhibits MDMX gene transcription, downregulates MDMX mRNA and protein levels, stabilizes p53 and activates the transcriptional activity of p53. NSC 146109 hydrochloride induces cancer cell apoptosis (apoptosis) and inhibits the growth of transformed cells. NSC 146109 hydrochloride inhibits the growth of xenograft tumors. NSC 146109 hydrochloride can be used in research related to breast cancer and cervical cancer[1][2].
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NSC 146109 hydrochloride | 99.89% | NSC 146109 hydrochloride (XI-011 hydrochloride) is a p53 activator and MDMX inhibitor. NSC 146109 hydrochloride inhibits MDMX gene transcription, downregulates MDMX mRNA and protein levels, stabilizes p53 and activates the transcriptional activity of p53. NSC 146109 hydrochloride induces cancer cell apoptosis (apoptosis) and inhibits the growth of transformed cells. NSC 146109 hydrochloride inhibits the growth of xenograft tumors. NSC 146109 hydrochloride can be used in research related to breast cancer and cervical cancer. | ||||||||||||||||||||
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NSC 146109 hydrochloride (Standard) | ≥98% | NSC 146109 hydrochloride (Standard) is the analytical standard of NSC 146109 (hydrochloride) (HY-108638). This product is intended for research and analytical applications. NSC 146109 hydrochloride is a small-molecule p53 activator that target MDMX and can be used for breast cancer research. NSC 146109 hydrochloride is a pseudourea derivative, promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. | ||||||||||||||||||||
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- [1]. Wang H, et al. A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells. Neoplasia. 2011 Jul;13(7):611-9. [Content Brief]
- [2]. Zhang J, et al. A small-molecule inhibitor of MDMX suppresses cervical cancer cells via the inhibition of E6-E6AP-p53 axis. Pharmacol Res. 2022;177:106128. [Content Brief]
