3043723-74-3
Chemical Structure
MDMX/MDM2-IN-2
- CAS No.: 3043723-74-3
- Formula:C28H25Cl3FN3O3
- Molecular Weight:576.87
IUPAC Name: N-(1-(2-chloro-4-fluorophenyl)-2-(4-chlorophenyl)-2-oxoethyl)-N-(4-chlorophenyl)-4-oxo-4-(piperazin-1-yl)butanamide
InChIKey: POLUTPKUGFNVJI-UHFFFAOYSA-N
SMILES: O=C(C(N(C1=CC=C(C=C1)Cl)C(CCC(N2CCNCC2)=O)=O)C3=CC=C(C=C3Cl)F)C4=CC=C(C=C4)Cl
Biological Activity: MDMX/MDM2-IN-2 is a potent p53-MDM2/MDMX dual inhibitors with Kis of 0.23 μM and 2.45 μM for MDM2 and MDMX, respectively. MDMX/MDM2-IN-2 inhibits the binding of p53 and MDM2 proteins. MDMX/MDM2-IN-2 restores the function of p53 and enables cell cycle arrest and apoptosis. MDMX/MDM2-IN-2 inhibits cell migration and invasion. MDMX/MDM2-IN-2 has antitumor activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MDMX/MDM2-IN-2 | 98.55% | MDMX/MDM2-IN-2 is a potent p53-MDM2/MDMX dual inhibitors with Kis of 0.23 μM and 2.45 μM for MDM2 and MDMX, respectively. MDMX/MDM2-IN-2 inhibits the binding of p53 and MDM2 proteins. MDMX/MDM2-IN-2 restores the function of p53 and enables cell cycle arrest and apoptosis. MDMX/MDM2-IN-2 inhibits cell migration and invasion. MDMX/MDM2-IN-2 has antitumor activity. | ||||||||||||||||||||
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Keywords
