MDM2-IN-24

Cat. No.: HY-163275: FAQs
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MDM2-IN-24 (compound A3f) exhibits MDM2-inhibiting and MDMX-activating properties in triple-negative breast cancer (TNBC) cells, with apoptotic and anti-proliferative activities.

For research use only. We do not sell to patients.

MDM2-IN-24 Chemical Structure

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Description

MDM2-IN-24 (compound A3f) exhibits MDM2-inhibiting and MDMX-activating properties in triple-negative breast cancer (TNBC) cells, with apoptotic and anti-proliferative activities^[1].

In Vitro

MDM2-IN-24 is a G-quadruplex ligand, which binds with G-rich sequences of MDM2 and MDMX with K_ds of 4.9 and 5.2 μM, respectively^[1].
MDM2-IN-24 (6 μM) inhibits MDM2 and thereby induces proliferation and apoptosis in TNBC cells^[1].
MDM2-IN-24 (6 μM) exhibits cytotoxicity in HCC1937 cells (survival rate is 27.7%)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:	HCC1937
Concentration:	3 μM
Incubation Time:
Result:	Decreased mRNA levels of MDM2 and increased mRNA levels of MDMX.

Western Blot Analysis^[1]

Cell Line:	HCC1937
Concentration:	0-6 μM
Incubation Time:	24 h
Result:	Decreased MDM2 expression, increased levels of MDMX and cleaved caspase-3 in normal HCC1937. Reactivated cleaved caspase-3 in HCC1937 cells with siMDMX.

Molecular Weight

612.33

Formula

C₃₃H₂₅Br₂P

SMILES

BrC1=C2C=CC=CC2=C(C[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)C6=CC=CC=C16.[Br-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Feng Y, et al., Targeting G-rich sequence to regulate the transcription of murine double minute (MDM) genes in triple-negative breast cancers. Eur J Med Chem. 2024 Jan 25;267:116156. [Content Brief]

MDM2-IN-24 Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDM2-IN-24MDM-2/p53ApoptosisTNBCp53HCC1937Inhibitorinhibitorinhibit

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