186180-20-1
186180-20-1
Chemical Structure
Phage-derived 12/1 peptide
- CAS No.: 186180-20-1
- Formula:C71H99N17O19S2
- Molecular Weight:1558.78
InChIKey: RGOFIFHQAOWKKW-HWFADAJJSA-N
SMILES: O=C(N1[C@@H](CCC1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCSC)N
Biological Activity: Phage-derived 12/1 peptide exhibits antitumor activity by targeting MDM2 and MDMX, an thus disrupt the MDM2-p53 and MDMX-p53 interaction, with IC50 of 0.15 and 1.25 μM[1].
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Phage-derived 12/1 peptide | Phage-derived 12/1 peptide exhibits antitumor activity by targeting MDM2 and MDMX, an thus disrupt the MDM2-p53 and MDMX-p53 interaction, with IC50 of 0.15 and 1.25 μM. | |||||||||||||||||||||
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References
Keywords
