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Results for "

MGL

" in MedChemExpress (MCE) Product Catalog:

188

Inhibitors & Agonists

14

Biochemical Assay Reagents

7

Peptides

32

Natural
Products

6

Recombinant Proteins

7

Isotope-Labeled Compounds

3

Antibodies

5

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12216
    Resmetirom
    20+ Cited Publications

    MGL-3196; VIA-3196

    Thyroid Hormone Receptor Cardiovascular Disease Endocrinology
    Resmetirom (MGL-3196) is a highly selective and orally active thyroid hormone receptor β (THR-β) agonist with an EC50 value of 0.21 μM. Resmetirom can be used for the study of noncirrhotic nonalcoholic steatohepatitis .
    Resmetirom
  • HY-N1937
    Pristimerin
    5+ Cited Publications

    Celastrol methyl ester

    Bacterial Cancer
    Pristimerin is a potent and reversible monoacylglycerol lipase (MGL) inhibitor with an IC50 of 93 nM.
    Pristimerin
  • HY-17568
    Nonivamide
    2 Publications Verification

    Pelargonic acid vanillylamide; Nonanoic acid vanillylamide; Pseudocapsaicin

    Environmental Pollutants TRP Channel Neurological Disease
    Nonivamide is a agonist, which exhibits 4d-EC50 value of 5.1 mg/L in static toxicity tests.
    Nonivamide
  • HY-B2234
    Povidone iodine
    2 Publications Verification

    iodopovidone

    Environmental Pollutants Bacterial Infection
    Povidone iodine (iodopovidone) displays excellent antibacterial activity which can against MRSA and MSSA strains with MICs of 31.25 mg/L and 7.82 mg/L, respectively.
    Povidone iodine
  • HY-N0313

    MAGL Endogenous Metabolite Inflammation/Immunology
    Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain .
    Euphol
  • HY-B0319
    Tioconazole
    4 Publications Verification

    UK-20349

    Fungal Antibiotic Parasite Akt PI3K mTOR Autophagy Infection Cancer
    Tioconazole (UK-20349) is a broad-spectrum antifungal imidazole derivative. Tioconazole inhibits several dermatophytes and yeasts, with MIC50 values of less than 3.12 mg/L and 9 mg/L, respectively. Additionally, Tioconazole exhibits anti-parasitic activity. Tioconazole exerts anticancer activity by inhibiting the PI3K/AKT/mTOR signaling pathway and blocking autophagy. Tioconazole is applicable for research in the fields of anti-infection and anticancer therapy .
    Tioconazole
  • HY-19806

    CXA-101 free base; FR264205 free base

    Antibiotic Bacterial Infection
    Ceftolozane (CXA-101 free base; FR264205 free base) is a cephalosporin antibiotic with potent activity againstPseudomonas aeruginosa and strains Enterobacteriaceae, with MICs of 0.5 and 0.25-0.5 mg/L .
    Ceftolozane
  • HY-Y1667
    2,6-Dibromophenol
    1 Publications Verification

    Calcium Channel Fungal Parasite Metabolic Disease
    2,6-Dibromophenol (2,6-DBP) is a weak inhibitor targeting voltage-gated Ca 2+ channels. 2,6-Dibromophenol has no significant effect on potassium-induced calcium elevation in PC12 cells. 2,6-Dibromophenol shows a 48 h EC50 of 2.78 mg/L for Daphnia magna and a 96 h EC50 of 9.90 mg/L for algae (Scenedesmus quadricauda) .
    2,6-Dibromophenol
  • HY-D0862

    Biochemical Assay Reagents Others
    DIDNTB is a dye. DIDNTB exhibits chemical sensitivity and specificity toward albumin. DIDNTB is much less affected by other proteins. DIDNTB enables the detection of urinary albumin at concentrations ≥10 mg/L .\n
    DIDNTB
  • HY-119033

    MAGL Inflammation/Immunology
    MGL-IN-1 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. MGL-IN-1 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. MGL-IN-1 displays high membrane permeability and brain penetrant .
    MGL-IN-1
  • HY-100792

    Bacterial Cancer
    URB602 is a selective monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL with IC50 of 28±4 μM through a noncompetitive mechanism.
    URB602
  • HY-N2417

    Bacterial Infection
    Stearyl glycyrrhetinate, a major component in licorice extract, has a MIC against S. aureus strains of more than 256 mg/L. Stearyl glycyrrhetinate has antibacterial effects .
    Stearyl glycyrrhetinate
  • HY-167887

    Endogenous Metabolite Infection
    7PPD-Q is a substituted p-phenylenediamine antioxidants derivatives. 7PPD-Q has toxic to the bacterium V. fischeri (EC50 = 14.9 mg/L) .
    7PPD-Q
  • HY-117089

    Environmental Pollutants Fungal Infection
    Tetraconazole is a selective irreversible inhibitor of 14-α-sterol demethylase (CYP51) with antifungal activity. Tetraconazole competitively binds to the enzyme to block fungal ergosterol synthesis, resulting in cell membrane damage. The EC50 of tetraconazole against wheat pathogens is 0.382-0.802 mg/L, and the EC50 against onion root tip meristem cell growth is 6.7 mg/L, and (R)-(+)-Tetraconazole is 1.49-1.98 times more active than (S)-(-)-Tetraconazole. Tetraconazole can also induce oxidative stress and chromosomal aberrations in plant cells .
    Tetraconazole
  • HY-N1673

    Gentisaldehyde

    Bacterial Infection
    2,5-Dihydroxybenzaldehyde (Gentisaldehyde) is a naturally occurring antimicrobial that inhibits the growth of Mycobacterium avium subsp. paratuberculosis. 2,5-Dihydroxybenzaldehyde is active against S. aureus strains with a MIC50 of 500 mg/L .
    2,5-Dihydroxybenzaldehyde
  • HY-118653

    MAGL Metabolic Disease
    SAR629 is a potent monoglyceride lipase (MGL) covalent inhibitor. SAR629 also inhibits 2-Arachidonoylglycerol (2-AG) degradation .
    SAR629
  • HY-118158

    FAAH Neurological Disease
    FAAH/MAGL-IN-4 (Compound 13) is a potent fatty acid amide hydrolase (FAAH) and monoglyceride lipase (MGL) inhibitor with IC50s of 9.1 nM and 7.9 μM, respectively. FAAH/MAGL-IN-4 can be used for the research of pain and CNS disorders .
    FAAH/MAGL-IN-4
  • HY-151600

    Transketolase Others
    Transketolase-IN-2 (compound 4w) is a potent Transketolase inhibitor. Transketolase-IN-2 shows strong inhibition of Digitaria sanguinalis and Amaranthus retroflexus (over 90% at 200 mg/L and about 80% at 100 mg/L). Transketolase-IN-2 can be used in studies of weed control .
    Transketolase-IN-2
  • HY-N11654

    Cardol monoene

    Insecticide Infection Cancer
    Bilobol is a potent insecticide against Aedes aegypti with a LC50 of 7.67 mg/L. Bilobol also has antitumor activity .
    Bilobol
  • HY-U00249

    R66905

    Fungal Infection
    Saperconazole (R66905) is a broad-spectrum antifungal triazole and has potent activity against Aspergillus with an MIC90 of 0.19 mg/L.
    Saperconazole
  • HY-137898

    Bacterial Antibiotic Infection
    Avilamycin A is an oral active antibiotic. Avilamycin A is active against veterinary isolates of C. perfringens (MICs ≤ 0.06-0.5 mg/L) and B. hyodysenteriae (MICs = 12.5-100 μg/ml) .
    Avilamycin A
  • HY-N3706

    Fungal Infection
    Dehydro-α-lapachone can be isolated from the methanol extract of stems of Catalpa ovata G Don. Dehydro-α-lapachone inhibits mycelial growth of Botrytis cinerea with IC50 value 0.41 mg/L .
    Dehydro-α-lapachone
  • HY-19506

    Antibiotic Bacterial Infection
    AR-709 is a diaminopyrimidine antibiotic. AR-709 exhibits potent antibacterial activity against Streptococcus pneumoniae (MIC = 0.03 mg/L). AR-709 can be used for research on bacterial infections .
    AR-709
  • HY-RS18435

    Small Interfering RNA (siRNA) Others

    Clec10a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Clec10a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Clec10a Mouse Pre-designed siRNA Set A
    Clec10a Mouse Pre-designed siRNA Set A
  • HY-N0313R

    MAGL Endogenous Metabolite Reference Standards Inflammation/Immunology
    Euphol (Standard) is the analytical standard of Euphol. This product is intended for research and analytical applications. Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain .
    Euphol (Standard)
  • HY-Y0988

    Environmental Pollutants Biochemical Assay Reagents Others
    Copper(I) chloride is an inorganic chloride of copper. Copper(I) chloride exhibits ecotoxicity towards Grooved Carpet Shell with a LC50 of 3.7 mg/L .
    Copper(I) chloride
  • HY-114689

    Drug Metabolite Inflammation/Immunology
    Diclofenac methyl ester is a metabolite of Diclofenac (HY-15036), which exhibits acute cytotoxicity with a LC50 of 0.5 mg/L in H. azteca .
    Diclofenac methyl ester
  • HY-59320

    Biochemical Assay Reagents Drug Intermediate Metabolic Disease
    4-Thiazolecarboxylic acid (Compound 1e) is an intermediate. 4-Thiazolecarboxylic acid can be used in the synthesis of MGL-IN-2 (HY-177534). MGL-IN-2 inhibits wild-type MGL enzyme activity with an IC50 of 0.0121 μM. 4-Thiazolecarboxylic acid can be used in the research of metabolic diseases .
    4-Thiazolecarboxylic acid
  • HY-Y1826

    Bacterial Antibiotic Infection
    IITR01324 is an antimicrobial agent. IITR01324 has antimicrobial activity against Escherichia coli (MIC = 3.58 mg/L) and other Gram-negative bacteria (Shigella flexneri: MIC = 3.58 mg/L; Cronobacter sakazakii: MIC = 28.63 mg/L). IITR01324 exerts its antimicrobial activity by destroying bacterial DNA after activation of intracellular reductases. IITR01324 can be used to study the development of new antimicrobial drugs, especially against multidrug-resistant (MDR) pathogens .
    IITR01324
  • HY-123652

    Parasite Infection
    Etofamide is an antimicrobial agent with IC50 value of 5.96 mg/L against amoeba .
    Etofamide
  • HY-W010235

    Drug Derivative Infection
    3,5-Dimethoxytoluene, a methylated phenolic derivative, is one of characteristic scent compounds emitted from flowers of most rose varieties. 3,5-Dimethoxytoluene shows significant fumigant toxicity against L. serricorne and L. bostrychophila with LC50 values of 4.99 mg/L air and 0.91 mg/L air, respectively .
    3,5-Dimethoxytoluene
  • HY-122298

    XDE 777

    Antibiotic Fungal Infection
    Fenpicoxamid is a new fungicide. Fenpicoxamid inhibits the growth of the fungus Z. tritici with an EC50 value of 0.051 mg/L .
    Fenpicoxamid
  • HY-Y1667R

    Calcium Channel Fungal Parasite Reference Standards Metabolic Disease
    2,6-Dibromophenol (2,6-DBP) is a weak inhibitor targeting voltage-gated Ca2+ channels. 2,6-Dibromophenol has no significant effect on potassium-induced calcium elevation in PC12 cells. 2,6-Dibromophenol shows a 48 h EC50 of 2.78 mg/L for Daphnia magna and a 96 h EC50 of 9.90 mg/L for algae (Scenedesmus quadricauda) .
    2,6-Dibromophenol (Standard)
  • HY-177534

    MAGL Metabolic Disease
    MGL-IN-2 (Compound 1) is a MGL inhibitor with IC50 values of 0.006 μM and 0.0121 μM for mutant MGL and wild-type MGL, respectively. MGL-IN-2 can be used in the research of metabolic diseases .
    MGL-IN-2
  • HY-144375

    MAGL Others
    Monoacylglycerol lipase inhibitor 1 is a potent monoacylglycerol lipase inhibitor (compound 13) .
    Monoacylglycerol lipase inhibitor 1
  • HY-RS16868

    Small Interfering RNA (siRNA) Others

    Mgll Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mgll gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Mgll Mouse Pre-designed siRNA Set A
    Mgll Mouse Pre-designed siRNA Set A
  • HY-111019

    Antibiotic Bacterial Infection
    SCH 34343 is a penem antibiotic. SCH 34343 is highly active against Streptococcus pneumoniae (MIC50 ≤ 0.015 mg/L), viridans streptococci (MIC50 = 0.06 mg/L), streptococci of groups A (MIC50 = 0.03 mg/L), B (MIC50 = 0.06 mg/L), C and G (MIC50 = 0.03 mg/L), and Str. bovis. SCH 34343 can be used for antibacterial research .
    SCH 34343
  • HY-RS24917

    Small Interfering RNA (siRNA) Others

    Clec10a Rat Pre-designed siRNA Set A contains three designed siRNAs for Clec10a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Clec10a Rat Pre-designed siRNA Set A
    Clec10a Rat Pre-designed siRNA Set A
  • HY-114706

    MDL-26479

    GABA Receptor Neurological Disease
    Suritozole (MGL-26479) is a cognitive enhancer that acts as a partial inverse agonist of benzodiazepine receptor sites on GABAA ion channel complexes. Suritozole can be used in the study of neurodegenerative diseases .
    Suritozole
  • HY-RS08409

    Small Interfering RNA (siRNA) Others

    MGLL Human Pre-designed siRNA Set A contains three designed siRNAs for MGLL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MGLL Human Pre-designed siRNA Set A
    MGLL Human Pre-designed siRNA Set A
  • HY-168042

    Bacterial Fungal Infection
    Antibacterial agent 243 is an antibacterial agent, with EC50 values of 0.64 mg/L for Valsa mali, 26 mg/L for allicin, and 0.33 mg/L for tebuconazole. Antibacterial agent 243 can induce hyphal shrinkage and collapse, trigger the accumulation of reactive oxygen species inside cells, regulate antioxidant enzyme activity, initiate lipid peroxidation, and ultimately cause irreversible oxidative damage to Valsa mali cells .
    Antibacterial agent 243
  • HY-172810

    Succinate Dehydrogenase Fungal Infection
    Succinate dehydrogenase-IN-8 (compound i19) is a potent succinate dehydrogenase (SDH) inhibitor. Succinate dehydrogenase-IN-8, an indene amino acid derivative, demonstrates potent in vitro antifungal activity against Rhizoctonia solani (EC50=0.1843 mg/L), Botrytis cinerea (EC50=0.4829 mg/L), and Sclerotinia sclerotiorum (EC50=0.1349 mg/L) .
    Succinate dehydrogenase-IN-8
  • HY-100792R

    Reference Standards Bacterial Cancer
    URB602 (Standard) is the analytical standard of URB602. This product is intended for research and analytical applications. URB602 is a selective monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL with IC50 of 28±4 μM through a noncompetitive mechanism.
    URB602 (Standard)
  • HY-146109

    Parasite Infection
    RyRs activator 1 (compound 7f) is a potent activator of ryanodine receptors (RyRs). RyRs activator 1 at 0.5 mg/L displays 100% larvicidal activity. The larvicidal activity of RyRs activator 1 is 90% at 0.01 mg/L .
    RyRs activator 1
  • HY-116498

    Others Infection
    Penigequinolone A is an alkaloid isolated from Penicillium. It is lethal to P. penetrans (LD50=100 mg/L) but has no effect on C. elegans at concentrations up to 1000 mg/L.1 Penigequinolone A also accelerates the root growth of rice seedlings in a dose-dependent manner.
    Penigequinolone A
  • HY-157015

    Fungal Infection
    Antifungal agent 81(G22)exhibitsexcellent in vitro antifungal activities against Valsa mali withIC50values of 0.48 mg/L. Antifungal agent 81also exhibits excellent in vivo protective againstV. maliat 40 mg/L .
    Antifungal agent 81
  • HY-115946

    Mitochondrial Metabolism Fungal Infection
    Complex III-IN-2 (Compd 4d-2) is a complex III inhibitor. Complex III-IN-2 shows antifungal activity with an EC50 of 29.98 mg/L and 29.31 mg/L against sclerotinia sclerotiorum and R. solani, respectively .
    Complex III-IN-2
  • HY-159486

    Succinate Dehydrogenase Fungal Infection
    SDH-IN-18 (Compound 3a) is an inhibitor for succinate dehydrogenase (SDH) with an IC50 of 8.70 mg/L. SDH-IN-18 destroys fungal morphology and reproduction, exhibits antifungal activity against Rhizoctonia solani and Sclerotinia sclerotiorum with EC50 of 0.48 and 1.4 mg/L .
    SDH-IN-18
  • HY-169169

    Parasite Infection
    Insecticidal agent 14 (compound 8a) shows potent insecticidal activity against Plutella xylostella and Mythimna separata, with LC50 values of 0.79 and 9.17 mg/L against P. xylostella, respectively, and 3.58 and 83.09 mg/L against M. separata, respectively .
    Insecticidal agent 14
  • HY-B0319R

    UK-20349 (Standard)

    Reference Standards Fungal Antibiotic Infection
    Tioconazole (Standard) is the analytical standard of Tioconazole. This product is intended for research and analytical applications. Tioconazole (UK-20349) is an antifungal imidazole derivative with broad spectrum activity. Tioconazole has inhibitory active aginst several dermatophytes and several yeasts with MIC50s <3.12 mg/L and <9 mg/L, respectively .
    Tioconazole (Standard)

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