65899-73-2
Chemical Structure
Tioconazole
Synonym(s): UK-20349
- CAS No.: 65899-73-2
- Formula:C16H13Cl3N2OS
- Molecular Weight:387.71
IUPAC Name: 1-(2-((2-chlorothiophen-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
InChIKey: QXHHHPZILQDDPS-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C(OCC2=C(Cl)SC=C2)CN3C=CN=C3)C(Cl)=C1
Biological Activity: Tioconazole (UK-20349) is a broad-spectrum antifungal imidazole derivative. Tioconazole inhibits several dermatophytes and yeasts, with MIC50 values of less than 3.12 mg/L and 9 mg/L, respectively. Additionally, Tioconazole exhibits anti-parasitic activity. Tioconazole exerts anticancer activity by inhibiting the PI3K/AKT/mTOR signaling pathway and blocking autophagy. Tioconazole is applicable for research in the fields of anti-infection and anticancer therapy[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tioconazole | 99.86% | Tioconazole (UK-20349) is a broad-spectrum antifungal imidazole derivative. Tioconazole inhibits several dermatophytes and yeasts, with MIC50 values of less than 3.12 mg/L and 9 mg/L, respectively. Additionally, Tioconazole exhibits anti-parasitic activity. Tioconazole exerts anticancer activity by inhibiting the PI3K/AKT/mTOR signaling pathway and blocking autophagy. Tioconazole is applicable for research in the fields of anti-infection and anticancer therapy. | ||||||||||||||||||||
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Tioconazole (Standard) | ≥98% | Tioconazole (Standard) is the analytical standard of Tioconazole. This product is intended for research and analytical applications. Tioconazole (UK-20349) is an antifungal imidazole derivative with broad spectrum activity. Tioconazole has inhibitory active aginst several dermatophytes and several yeasts with MIC50s <3.12 mg/L and <9 mg/L, respectively. | ||||||||||||||||||||
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References
- [1]. S P Clissold, et al. Tioconazole. A review of its antimicrobial activity and therapeutic use in superficial mycoses. Drugs. 1986 Jan;31(1):29-51. [Content Brief]
- [2]. Yamamoto ES, et al. Activity of Fenticonazole, Tioconazole and Nystatin on New World Leishmania Species. Curr Top Med Chem. 2018;18(27):2338-2346. [Content Brief]
- [3]. Sebastian J, et al. Cytotoxic mechanism of tioconazole involves cell cycle arrest at mitosis through inhibition of microtubule assembly. Cytotechnology. 2022 Feb;74(1):141-162. [Content Brief]
- [4]. El-Gowily AH, et al. Tioconazole and Chloroquine Act Synergistically to Combat Doxorubicin-Induced Toxicity via Inactivation of PI3K/AKT/mTOR Signaling Mediated ROS-Dependent Apoptosis and Autophagic Flux Inhibition in MCF-7 Breast Cancer Cells. Pharmaceuticals (Basel). 2021 Mar 11;14(3):254. [Content Brief]
- [5]. Liu PF, et al. Drug Repurposing Screening Identifies Tioconazole as an ATG4 Inhibitor that Suppresses Autophagy and Sensitizes Cancer Cells to Chemotherapy. Theranostics. 2018 Jan 1;8(3):830-845. [Content Brief]
