31 Results for "

MUC5

" in MedChemExpress (MCE) Product Catalog:
Products (31)

31 Results for "MUC5" in MCE Product Catalog:

4
4 Cited Publications
Cat. No.: HY-N2609
CAS No.: 2196-14-7
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM .
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4
4 Cited Publications
Cat. No.: HY-100958
CAS No.: 1952-15-4
Purity:  99.96%
Synonyms: 4-DAMP methiodide
4-DAMP (4-DAMP methiodide) is a potent and selective antagonist of M3 receptors and also has a high affinity for the closely-related M5 receptors. 4-DAMP combined with 5-Fluorouracil (5-Fu) (HY-90006) could significantly reduce the cell viability and enhance apoptosis in MKN45 and BGC823 gastric cancer cells. 4-DAMP inhibits lipopolysaccharide (LPS)- and tobacco-induced pulmonary inflammation and reduces mucin 5AC (MUC5AC), oligomeric mucus/gel-forming secretion .
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4
4 Cited Publications
Cat. No.: HY-N2098
CAS No.: 477-85-0
Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway . Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein .
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1
1 Cited Publications
Cat. No.: HY-NP159
House Dust Mite Extract, from D.farinae is a house dust mite allergen extract derived from Dermatophagoides farinae. House Dust Mite Extract, from D.farinae significantly increases the levels of cytokines (IL-4, IL-5, IL-6) in bronchoalveolar lavage fluid. House Dust Mite Extract, from D.farinae upregulates the overexpression of MUC5AC. House Dust Mite Extract, from D.farinae induces allergic asthma and pulmonary inflammation .
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1
1 Cited Publications
Cat. No.: HY-B0393
CAS No.: 13189-98-5
Research Areas:  

Inflammation/Immunology

Fudosteine is a cysteine derivative and a mucoactive agent. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression .
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Cat. No.: HY-N1510
CAS No.: 22149-35-5
Kaempferol 3-O-gentiobioside is an orally active flavonoid, with a Ka value of 57 µM against human NOTCH1 and an IC50 value of 50 μM against α-glucosidase. Kaempferol 3-O-gentiobioside inhibits the NOTCH signaling pathway. It downregulates the expression of TLR4 and NLRP3, and suppresses the activation and nuclear translocation of NF-κB. Kaempferol 3-O-gentiobioside inhibits the expression of MUC5AC, reduces nitrite and ROS levels, and attenuates excessive mucus secretion. It exhibits antibacterial activity, reducing the formation and growth of MRSA biofilms. Kaempferol 3-O-gentiobioside blocks the TGF-β/ALK5/Smad signaling pathway and inhibits epithelial-mesenchymal transition. It suppresses the proliferation, migration, invasion and metastatic growth of tumor cells. Kaempferol 3-O-gentiobioside alleviates airway inflammation and mucus hypersecretion in mice with allergic asthma . It reduces the volume of ovarian cancer xenografts in mice. Kaempferol 3-O-gentiobioside can be used in research related to allergic asthma, diabetes, MRSA infection, breast cancer, gastric cancer and ovarian cancer .
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Cat. No.: HY-P0280
CAS No.: 244049-41-0
Target:  

Mucin

Research Areas:  

Inflammation/Immunology Cancer

MUC5AC motif peptide is a 16-amino acid fragment of mucin 5.
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Cat. No.: HY-P99362
CAS No.: 1092658-06-4
Synonyms: Anti-MUC5AC Reference Antibody (ensituximab); NEO-102

Target:  

Mucin

Research Areas:  

Cancer

Ensituximab (NEO-102; NPC-1C) is a chimeric monoclonal IgG1 antibody targeting a variant of MUC5AC. Ensituximab shows specificity to colorectal and pancreatic cancer .
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Cat. No.: HY-117616
CAS No.: 128-76-7
Synonyms: (+)-Laurotetanine
Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and NF-κB signaling pathways .
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Cat. No.: HY-RS08844
Research Areas:  

Others

MUC5AC Human Pre-designed siRNA Set A contains three designed siRNAs for MUC5AC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS08845
Research Areas:  

Others

MUC5B Human Pre-designed siRNA Set A contains three designed siRNAs for MUC5B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P84810
Synonyms: MG1; MUC5; MUC9; MUC-5B

Host:  

Mouse

Application:  

IHC-P, FC, ELISA

Reactivity:  

Human

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Cat. No.: HY-P84446
Synonyms: TBM; leB; MUC5; MUCin

Host:  

Mouse

Application:  

IHC-P, FC, ELISA

Reactivity:  

Human

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Cat. No.: HY-N2609R
CAS No.: 2196-14-7
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM .
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Cat. No.: HY-P84810A
Synonyms: MG1; MUC5; MUC9; MUC-5B

Host:  

Mouse

Application:  

IHC-P, FC, ELISA

Reactivity:  

Human

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Cat. No.: HY-P5512
CAS No.: 869012-66-8
Target:  

Peptides

Research Areas:  

Others

MUC5AC-3 is a biological active peptide. (glycopeptide transferase, ppGaNTase-T9 substrate)
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Cat. No.: HY-P84446A
Synonyms: TBM; leB; MUC5; MUCin

Host:  

Mouse

Application:  

IHC-P, FC, ELISA

Reactivity:  

Human

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Cat. No.: HY-P5508
CAS No.: 869012-67-9
Target:  

Peptides

Research Areas:  

Others

MUC5AC-13 is a biological active peptide. (This glycopeptide is an N-acetyl galactosamine (GalNAc)-modified MUC5AC mucin peptide containing the single site of threonine 13 labeled with GalNAc (T*). Polypeptide N-acetylgalactosaminyltransferase (ppGaNTase) catalyzes the transfer of GalNAc from the nucleotide sugar UDP-GalNAc to threonine. The MUC5AC gene is mainly expressed in gastric and tracheo-bronchial mucosae, and some tumors.)
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Cat. No.: HY-P5511
CAS No.: 869012-68-0
Target:  

Peptides

Research Areas:  

Others

MUC5AC-3/13 is a biological active peptide. (glycopeptide transferase, ppGaNTase-T9 substrate)
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Cat. No.: HY-RS17212
Research Areas:  

Others

Muc5ac Mouse Pre-designed siRNA Set A contains three designed siRNAs for Muc5ac gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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