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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
74 Results for "
NPCs
" in MedChemExpress (MCE) Product Catalog:
Products (74)
74 Results for "NPCs" in MCE Product Catalog:
16
Target:
Forschungsgebiete:
Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
5
5 Cited Publications
Art. -Nr.: HY-N2292
CAS. Nr.: 151870-74-5
Category:
Natural Products Orchidaceae Extract Plants Anoectochilus Disease Research Fields Inflammation/Immunology
Target:
3
3 Cited Publications
Art. -Nr.: HY-N6954
CAS. Nr.: 76996-27-5
2
2 Cited Publications
Target:
Forschungsgebiete:
Lalistat 1 is a potent, selective, and competitive inhibitor of lysosomal acid lipase (LAL) and against purified human LAL (phLAL) with an IC50 of 68 nM. Lalistat 1 is a inhibitor of immunoglobulin A1 protease (IgA1P) proteases for H. influenzae, has less effects on other serine hydrolases (trypsin or β-lactamase, etc.). Lalistat 1 can be used for the research of niemann-pick type C (NPC) disease .
1
1
1 Cited Publications
Art. -Nr.: HY-W395779
CAS. Nr.: 1335113-30-8
EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor of Ebola virus (EBOV). EBOV-IN-1 targets Niemann-Pick C1 (NPC1) and inhibits its binding to the EBOV glycoprotein (GP) that activates and mediates viral penetration into host cells, thereby inhibiting EBOV infection. EBOV-IN-1 inhibits pseudotyped EBOV infection with an IC50 of 13 nM .
1
1 Cited Publications
Target:
Art. -Nr.: HY-P99621
CAS. Nr.: 2467411-25-0
Synonyms: NPC-21; EV2038
Art. -Nr.: HY-W010514
CAS. Nr.: 1460-57-7
Target:
N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568 .
Art. -Nr.: HY-P99544
CAS. Nr.: 2417649-97-7
Synonyms: HBM-9167; KL-A167
Target:
Forschungsgebiete:
Art. -Nr.: HY-W014780
CAS. Nr.: 122-40-7
Synonyms: 2-Benzylideneheptanal; α-Pentylcinnamaldehyde
Target:
Forschungsgebiete:
α-Amylcinnamaldehyde is a ligand for the Niemann-Pick type C2 (NPC2) protein of arthropod moths and may play a key role in the identification of moth volatiles. NPC2 is a key enzyme for cholesterol transport in the body .
Art. -Nr.: HY-136059
CAS. Nr.: 302781-98-2
Target:
Forschungsgebiete:
Desfluoro-ezetimibe is a desfluoro impurity of Ezetimibe. Ezetimibe is a potent, metabolically stable cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator .
Art. -Nr.: HY-17376S1
CAS. Nr.: 1093659-89-2
Synonyms: SCH 58235-d4-1
Art. -Nr.: HY-17376R
CAS. Nr.: 163222-33-1
Synonyms: SCH 58235 (Standard)
Target:
Forschungsgebiete:
Ezetimibe (Standard) is the analytical standard of Ezetimibe. This product is intended for research and analytical applications. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
Art. -Nr.: HY-17376S
CAS. Nr.: 1093659-90-5
Synonyms: SCH 58235-d4
Art. -Nr.: HY-129980
CAS. Nr.: 141774-20-1
Target:
Forschungsgebiete:
NPC-15437 dihydrochloride is a selective, penetrable and reversible protein kinase C (PKC) inhibitor, with an IC50 of 19 μM. NPC-15437 dihydrochloride interferes with mechanisms underlying memory consolidation .
Art. -Nr.: HY-P99362
CAS. Nr.: 1092658-06-4
Synonyms: Anti-MUC5AC Reference Antibody (ensituximab); NEO-102
Art. -Nr.: HY-17640
CAS. Nr.: 1269181-69-2
Target:
Forschungsgebiete:
Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
