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Results for "

PAF antagonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Apoptosis (1) Autophagy (6) Calcium Channel (1) Caspase (1) Cholinesterase (ChE) (2) FAP (1) Histamine Receptor (9) Integrin (2) Interleukin Related (2) Isotope-Labeled Compounds (3) Leukotriene Receptor (4) Lipoxygenase (1) PGE synthase (1) Phosphatase (1) Platelet-activating Factor Receptor (PAFR) (58) Prostaglandin Receptor (1) Reference Standards (4) Thrombin (1) TNF Receptor (2) UGT (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (32) Infection (3) Inflammation/Immunology (39) Metabolic Disease (2) Neurological Disease (5)

By Targets:

AMPK (1)

Apoptosis (1)

Autophagy (6)

Calcium Channel (1)

Caspase (1)

Cholinesterase (ChE) (2)

FAP (1)

Histamine Receptor (9)

Integrin (2)

Interleukin Related (2)

Isotope-Labeled Compounds (3)

Leukotriene Receptor (4)

Lipoxygenase (1)

PGE synthase (1)

Phosphatase (1)

Platelet-activating Factor Receptor (PAFR) (58)

Prostaglandin Receptor (1)

Reference Standards (4)

Thrombin (1)

TNF Receptor (2)

UGT (1)

By Research Areas:

Cancer (5)

Cardiovascular Disease (32)

Infection (3)

Inflammation/Immunology (39)

Metabolic Disease (2)

Neurological Disease (5)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13511A

Rupatadine Fumarate 2 Publications Verification UR-12592 Fumarate	Histamine Receptor Autophagy	Inflammation/Immunology
Rupatadine (UR-12592) Fumarate is a potent, orally active and long-lasting dual *PAF/H1* antagonist, with K_is of 0.55 μM and 0.1 μM, respectively. Rupatadine Fumarate can be used for the research of allergic rhinitis and urticaria .

HY-108634

Apafant 3 Publications Verification WEB 2086	Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
Apafant (WEB 2086), a chemical probe, is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a K_i of 9.9 nM. Apafant increases the gene expression of PAF-r, α-globin, β-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit .

HY-13511

Rupatadine 2 Publications Verification UR-12592	Histamine Receptor Autophagy	Inflammation/Immunology
Rupatadine (UR-12592) is a potent, orally active and long-lasting dual *PAF/H1* antagonist, with K_is of 0.55 μM and 0.1 μM, respectively. Rupatadine can be used for the research of allergic rhinitis and urticaria .

HY-109897

CV-6209	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
CV-6209 is a potent antagonist of platelet activating factor (PAF). CV-6209 inhibits the PAF-induced aggregation of rabbit and human platelets, with IC₅₀s of 75 nM and 170 nM, respectively. CV-6209 can inhibit PAF-induced hypotension in rats .

HY-128694

Foropafant SR27417	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a K_i value of 57 pM for [ ³H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets .

HY-19121A

TCV-309 chloride	Platelet-activating Factor Receptor (PAFR)	Cancer
TCV-309 chloride is a potent and specific platelet activating factor (PAF) antagonist. TCV-309 chloride specifically inhibits PAF-induced aggregation of rabbit and human platelets, and [3H]PAF binding to rabbit platelet microsomes with IC₅₀ values of 33 nM, 58 nM and 27 nM, respectively. TCV-309 chloride has beneficial effects in anaphylactic shock .

HY-N7343

Pregomisin	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
Pregomisin is a natural compound isolated from the fruits of Schizandra chinensis Baill. Pregomisin showed *PAF* antagonistic activity and the IC₅₀ values were 48 μM .

HY-13511AR

Rupatadine Fumarate (Standard) UR-12592 Fumarate (Standard)	Reference Standards Histamine Receptor Autophagy	Inflammation/Immunology
Rupatadine (Fumarate) (Standard) is the analytical standard of Rupatadine (Fumarate). This product is intended for research and analytical applications. Rupatadine (UR-12592) Fumarate is a potent, orally active and long-lasting dual *PAF/H1* antagonist, with K_is of 0.55 μM and 0.1 μM, respectively. Rupatadine Fumarate can be used for the research of allergic rhinitis and urticaria .

HY-N4267

Yangambin	Calcium Channel Platelet-activating Factor Receptor (PAFR) UGT Leukotriene Receptor TNF Receptor PGE synthase Interleukin Related	Cardiovascular Disease Infection Inflammation/Immunology
Yangambin is a *PAF* receptor antagonist and UGT1A1/UGT1A3 inhibitor, with an IC₅₀ of 29.7 μM and a K_i of 17.1 μM against human UGT1A1, and an IC₅₀ of 56.5 μM and a K_i of 66.8 μM against human UGT1A3. Yangambin blocks *PAF*-mediated responses, inhibits LTB₄-mediated neutrophil infiltration, and suppresses inflammatory events and anaphylactic contraction. Yangambin acts as a central nervous system inhibitor to reduce spontaneous activity, and also exhibits analgesic, anticonvulsant, antileishmanial, vasodilatory and hypotensive effects. Yangambin blocks voltage-gated Ca ²⁺ channels, reduces the production of NO, TNF-α, IL-6 and PGE2 in cells, increases the production of IL-10, and exerts a protective effect against cardiovascular injury. Yangambin can be used in research related to allergies, cutaneous leishmaniasis, central nervous system diseases and cardiovascular diseases .

HY-105198

Lexipafant BB-882	Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
Lexipafant is a platelet-activating factor (PAF) antagonist that inhibits the inflammatory response and is used in the research of acute pancreatitis.

HY-101833

YM-264	Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
YM-264 is a selective, potent and orally active platelet-activating factor (PAF) antagonist with a pKi value of 8.85 for rabbit platelet membranes.

HY-108908A

Modipafant UK-80067	Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
Modipafant (UK-80067), the (+)-enantiomer of UK-74505, is a potent, orally active, and selective platelet-activating factor *(PAF)* antagonist. Modipafant exhibits approximately double the intrinsic potency of UK-74505 .

HY-121007

Bepafant Web2170	Platelet-activating Factor Receptor (PAFR)	Others
Bepafant (Web2170) is a platelet-activating factor (PAF) antagonist that protects against anaphylactic lethality in active and passive anaphylaxis models in mice and guinea pigs in a dose-dependent manner and attenuates bronchoconstriction and blood pressure changes in anaphylaxis.

HY-U00040

PAF-AN-1	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease Inflammation/Immunology
PAF-AN-1 is a platelet activating factor receptor (PAF) antagonist.

HY-19125

BN-50726	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease Inflammation/Immunology
BN-50726 is a potent platelet-activating factor (PAF) receptor antagonist. BN-50726 inhibits PAF-induced effects (e.g., [3H]-serotonin release and hypotension) (IC₅₀=5.40 nM). BN-50726 is promising for research of PAF-mediated pathological processes (e.g., inflammation, anaphylaxis, hypotension) .

HY-N8218

Homoeriodictyol 7-O-β-D-glucoside	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
Homoeriodictyol 7-O-β-D-glucoside is a natural platelet-activating factor (PAF) antagonist. Homoeriodictyol 7-O-β-D-glucoside inhibits human and rabbit platelet aggregation induced by PAF, with an IC₅₀ of 0.8 μM .

HY-116120

N-Acetyldesloratadine SCH-37370	Platelet-activating Factor Receptor (PAFR) Histamine Receptor	Inflammation/Immunology
N-Acetyldesloratadine (SCH-37370) is a potent, orally active dual antagonist of platelet-activating factor (PAF) and histamine. N-Acetyldesloratadine inhibits PAF-induced aggregation of human platelets, with an IC₅₀ of 0.6 µM. N-Acetyldesloratadine can be used for the study of allergic diseases, such as asthma .

HY-106833

SDZ-62-434 free base	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease Cancer
SDZ-62-434 free base is a platelet-activating factor (PAF) antagonist. SDZ-62-434 free base has antiproliferative activity in human solid and haematological malignancies .

HY-101731

CP-96021 hydrochloride	Leukotriene Receptor	Inflammation/Immunology
CP-96021 hydrochloride is a balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with K_i values of 34 nM and 37 nM, respectively .

HY-106899

MK 287	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
MK 287 is a potent, selective and orally active antagonist of platelet-activating factor receptor (PAFR). MK 287 can inhibit [3H]C18-PAF binding to human platelet, polymorphonuclear leukocyte (PMN) and lung membranes with K1 values of 6.1, 3.2, and 5.49 nM, respectively. MK 287 can inhibit PAF-induced aggregation of platelets in plasma or gel-filtered platelets and elastase release from PMNs with ED₅₀ values of 56, 1.5 and 4.4 nM. MK 287 can be used for the research of cardiovascular disease, such as thrombosis .

HY-N11920

Kadsurenin B	Platelet-activating Factor Receptor (PAFR)	Infection Neurological Disease Inflammation/Immunology
Kadsurenin B is a *PAF* (platelet-activating factor) antagonist with neuroprotective activity. Kadsurenin B has a wide range of pharmacological research potential, such as antibacterial, anti-inflammatory, neuroprotective, antioxidant, antiplatelet aggregation, cytotoxic, antiparasitic, etc .

HY-N12995

α-Bulnesene	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
α-Bulnesene is a novel PAF receptor antagonist with the IC₅₀ of 17.62 μM. α-Bulnesene can be isolated from Pogostemon cablin. α-Bulnesene shows inhibitory effect on platelet-activating factor and arachidonic acid induced rabbit platelet aggregation .

HY-A0300

Cyclopeptide-5 EMD 270179	Integrin	Cardiovascular Disease
Cyclopeptide-5 (EMD 270179) is an αvβ3 antagonist that can improve PAF-induced increased adhesion of sickle red blood cells, capillary post-obstruction, and enhance blood flow dynamics. Cyclopeptide-5 also has cytotoxic effects .

HY-19097

Ro-24-4736	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
Ro 24-4736 is a potent, selective, p.o.-active platelet-activating factor (PAF) antagonist with a long duration of action. Ro-24-4736 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-123397

SCH-44643	Platelet-activating Factor Receptor (PAFR) Histamine Receptor	Cardiovascular Disease
SCH-44643 is an orally active platelet activating factor (PAF) and histamine antagonist .

HY-101235

ICI 185282	Prostaglandin Receptor	Cardiovascular Disease Inflammation/Immunology
ICI 185282 is a potent, selective, orally active thromboxane A2 (TXA₂) receptor antagonist. ICI 185282 causes dose-dependent inhibition of U-46619 (HY-108566)-induced platelet aggregation ex-vivo in guinea-pig. ICI 185,282 inhibits bronchospasm induced by U-46619, PGD₂ (HY-101988), PGF_2α (HY-12956), arachidonic acid (HY-109590), LTD₄ and PAF (HY-108635) in vivo. ICI 185282 can be used for bronchial asthma research .

HY-105790

Piperilate Pipethanate	Cholinesterase (ChE)	Cardiovascular Disease
Piperilate (Pipethanate) is one of the mixtures of hetrazepine derivative PAF antagonists with anticholinergics, can be used for bronchial asthma research. Piperilate also causes hypotension and rescues mice poisoned by the organophosphates .

HY-171253

Clotizolam	Platelet-activating Factor Receptor (PAFR)	Neurological Disease
Clotizolam is a thienobenzodiazepine derivative that has antagonistic activity against platelet-activating factor (PAF). Clotizolam possesses sedative, anxiolytic, anticonvulsant,and muscle relaxant effects .

HY-182583

PAF antagonist-1	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
PAF antagonist-1 is a platelet activating factor (PAF) receptor antagonist with a target K_i of 69 nM. PAF antagonist-1 inhibits PAF binding and displays enhanced affinity at A₁, A₂ ^a, and A₃ adenosine receptor subtypes compared to related dihydropyridine analogs with smaller ester groups. PAF antagonist-1 can be used for cardiovascular disorders, especially hypertension and coronary heart disease .

HY-134101

2-O-Ethyl PAF C-16	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
2-O-Ethyl PAF C-16 is a homolog of PAF and a competitive ligand for PAF receptor (Platelet-activating Factor Receptor (PAFR)). 2-O-Ethyl PAF C-16 inhibits the binding of the PAF antagonist WEB 2086 (HY-108634) to the PAF receptor with an IC₅₀ of 21 nM .

HY-101594

Tulopafant RP 59227	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
Tulopafant is a platelet activating factor (PAF) antagonist.

HY-101675

Setipafant BN-50727	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
Setipafant is a platelet-activating factor (PAF) antagonist.

HY-19084

Ro-24-0238	Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
Ro-24-0238 is an antagonist of platelet activating factor (PAF) and inhibitor of thromboxane synthesis, used for lessening the inflammation and damage resulting from a local release of PAF.

HY-N3436

Kadsurin A	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
Kadsurin A is a new lignan can be isolated from Piper futokadsura. Kadsurin A is a platelet activating factor (PAF) receptor antagonist that weakly inhibits the binding of PAF to its receptor .

HY-10164

E-6123	Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
E-6123 is a platelet-activating factor (PAF) receptor antagonist.

HY-108634S

Apafant-d8 WEB 2086-d₈	Isotope-Labeled Compounds Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
Apafant-d₈ is the deuterium labeled Apafant. Apafant (WEB 2086) is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a K_iof 9.9 nM. Apafant increases the gene expression of PAF-r, α-globin, β-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit .

HY-122126

BN 52111	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
BN 52111 is a potent platelet-activating factor (PAF) receptor antagonist .

HY-100153

48740 RP (Rac)-RP-55778	Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
48740 RP ((Rac)-RP-55778) is a platelet-activating factor (PAF) antagonist.

HY-121377

Epiyangambin	Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology Cancer
Epiyangambin is a competitive platelet activating factor receptor (PAF) antagonist that dose-dependently inhibits PAF-induced platelet aggregation. Epiyangambin also inhibits the growth of human colon cancer cells (SW480 cells) .

HY-125309

ABT-299	Platelet-activating Factor Receptor (PAFR)	Others
ABT-299 is a prodrug of a platelet-activating factor (PAF) antagonist that exhibits significant inhibitory activity on PAF-induced β-platelet globulin release in vitro after in vivo administration in humans, an effect that may be partially attributed to the pyridine-N-oxide metabolite.

HY-124887

L 651142	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
L 651142 is a weak *platelet activating factor (PAF) receptor* antagonist. L 651142 inhibits the binding of [ ³H]PAF to rabbit platelet, human platelet or human lung membranes with K_is of 0.839 μM, 1.82 μM, 3.64 μM, respectively .

HY-153717

LAU-0901	Platelet-activating Factor Receptor (PAFR)	Neurological Disease
LAU-0901, a PAF receptor antagonist, possesses highly neuroprotective activity. LAU-0901 inhibits apoptosis .

HY-121394

L-659,989	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
L-659,989 is an orally active, extremely potent, selective and competitive platelet activating factor (PAF) receptor antagonist .

HY-101654

Rocepafant BN 50730; LAU-8080	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease Inflammation/Immunology
Rocepafant (BN 50730) is a specific platelet activating factor (PAF) antagonist. Rocepafant can be used in rheumatoid arthritis and nervous system research .

HY-19205A

CMI-392 LDP-392	Lipoxygenase	Inflammation/Immunology
CMI-392 is a dual 5-lipoxygenese inhibitor and platelet-activating factor (PAF) receptor antagonist with IC₅₀s of 100 and 10 nM, respectively.

HY-19126

CL-184005	Platelet-activating Factor Receptor (PAFR)	Infection Cardiovascular Disease
CL-184005 is an antagonist for platelet-activating factor (PAF), that inhibits the PAF-induced platelet aggregation with IC₅₀ of 600 nM and 510 nM, in human and rabbit platelet-rich plasma. CL-184005 protects the rats from endotoxin-induced gastrointestinal damage and hypotension. CL-184005 exhibits potential attenuating Gram-negative bacterial sepsis .

HY-106833A

SDZ-62-434	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease Cancer
SDZ-62-434 is a platelet-activating factor (PAF) antagonist. SDZ-62-434 has antiproliferative activity in human solid and haematological malignancies .

HY-123505

Dersalazine sodium UR-12746 sodium	Platelet-activating Factor Receptor (PAFR) Interleukin Related	Inflammation/Immunology
Dersalazine (sodium) is a platelet-activating factor (PAF) antagonist. Dersalazine (sodium) can exert intestinal anti-inflammatory activity in rodent colitis models by downregulating IL-17 expression .

HY-100316

CP-96486	Leukotriene Receptor	Inflammation/Immunology
CP-96486 is a potent and orally active leukotriene D₄ (LTD₄)/platelet activating factor (PAF) receptor antagonist with K_is of 20 and 24 nM, respectively.

HY-133003

L662,025	Platelet-activating Factor Receptor (PAFR)	Metabolic Disease Inflammation/Immunology
L662,025 is a specific, photolabile and irreversible Platelet-activating factor (PAF-receptor) antagonist, with IC₅₀ values of 5.6 μM (platelet aggregation) and 1 μM (receptor binding), respectively .

Cat. No.	Product Name	Target	Research Area

HY-A0300

Cyclopeptide-5 EMD 270179	Integrin	Cardiovascular Disease
Cyclopeptide-5 (EMD 270179) is an αvβ3 antagonist that can improve PAF-induced increased adhesion of sickle red blood cells, capillary post-obstruction, and enhance blood flow dynamics. Cyclopeptide-5 also has cytotoxic effects .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7343

Pregomisin	Phenols Polyphenols Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Source Classification	Platelet-activating Factor Receptor (PAFR)
Pregomisin is a natural compound isolated from the fruits of Schizandra chinensis Baill. Pregomisin showed *PAF* antagonistic activity and the IC₅₀ values were 48 μM .

HY-N4267

Yangambin	Cardiovascular Disease Structural Classification other families Classification of Application Fields Lignans Phenylpropanoids Plants Disease Research Fields Source Classification	Calcium Channel Platelet-activating Factor Receptor (PAFR) UGT Leukotriene Receptor TNF Receptor PGE synthase Interleukin Related
Yangambin is a *PAF* receptor antagonist and UGT1A1/UGT1A3 inhibitor, with an IC₅₀ of 29.7 μM and a K_i of 17.1 μM against human UGT1A1, and an IC₅₀ of 56.5 μM and a K_i of 66.8 μM against human UGT1A3. Yangambin blocks *PAF*-mediated responses, inhibits LTB₄-mediated neutrophil infiltration, and suppresses inflammatory events and anaphylactic contraction. Yangambin acts as a central nervous system inhibitor to reduce spontaneous activity, and also exhibits analgesic, anticonvulsant, antileishmanial, vasodilatory and hypotensive effects. Yangambin blocks voltage-gated Ca ²⁺ channels, reduces the production of NO, TNF-α, IL-6 and PGE2 in cells, increases the production of IL-10, and exerts a protective effect against cardiovascular injury. Yangambin can be used in research related to allergies, cutaneous leishmaniasis, central nervous system diseases and cardiovascular diseases .

HY-N8218

Homoeriodictyol 7-O-β-D-glucoside	Cardiovascular Disease Flavonoids Viscum coloratum (Kom.) Nakai Classification of Application Fields Flavonones Phenols Polyphenols Plants Loranthaceae Disease Research Fields Source Classification	Platelet-activating Factor Receptor (PAFR)
Homoeriodictyol 7-O-β-D-glucoside is a natural platelet-activating factor (PAF) antagonist. Homoeriodictyol 7-O-β-D-glucoside inhibits human and rabbit platelet aggregation induced by PAF, with an IC₅₀ of 0.8 μM .

HY-N11920

Kadsurenin B	Lignans Piperaceae Phenylpropanoids Plants Piper kadsura (Choisy) Ohwi Source Classification	Platelet-activating Factor Receptor (PAFR)
Kadsurenin B is a *PAF* (platelet-activating factor) antagonist with neuroprotective activity. Kadsurenin B has a wide range of pharmacological research potential, such as antibacterial, anti-inflammatory, neuroprotective, antioxidant, antiplatelet aggregation, cytotoxic, antiparasitic, etc .

HY-N12995

α-Bulnesene	Entada phaseoloides (L.) Merr. Terpenoids Labiatae Sesquiterpenes Plants Source Classification	Platelet-activating Factor Receptor (PAFR)
α-Bulnesene is a novel PAF receptor antagonist with the IC₅₀ of 17.62 μM. α-Bulnesene can be isolated from Pogostemon cablin. α-Bulnesene shows inhibitory effect on platelet-activating factor and arachidonic acid induced rabbit platelet aggregation .

HY-N3436

Kadsurin A	Lignans Piperaceae Phenylpropanoids Plants Piper kadsura (Choisy) Ohwi Source Classification	Platelet-activating Factor Receptor (PAFR)
Kadsurin A is a new lignan can be isolated from Piper futokadsura. Kadsurin A is a platelet activating factor (PAF) receptor antagonist that weakly inhibits the binding of PAF to its receptor .

HY-121377

Epiyangambin	Tephrosia deflexa Baker Labiatae Lignans Phenylpropanoids Plants Source Classification	Platelet-activating Factor Receptor (PAFR)
Epiyangambin is a competitive platelet activating factor receptor (PAF) antagonist that dose-dependently inhibits PAF-induced platelet aggregation. Epiyangambin also inhibits the growth of human colon cancer cells (SW480 cells) .

HY-N12707

Kadsurenin C	Lignans Piperaceae Phenylpropanoids Plants Piper kadsura (Choisy) Ohwi Source Classification	Platelet-activating Factor Receptor (PAFR)
Kadsurenin C (compound 1) is a neolignan that can be isolated from the aerial part of Piper kadsura with anti-inflammation activity. Kadsurenin C exhibits significant PAF (Platelet Activating Factor) antagonistic activity with IC₅₀ value of 5.1 μM .

HY-N3055

Pinusolide	Cupressaceae Classification of Application Fields Terpenoids Diterpenoids Plants Disease Research Fields Calocedrus decurrens (Torr.) Florin Source Classification Cancer	Apoptosis AMPK Platelet-activating Factor Receptor (PAFR) Caspase
Pinusolide is an AMPK activator and PAF receptor antagonist. Pinusolide activates AMPK, phosphorylates ACC, enhances IRS-1 tyrosine phosphorylation, boosts glucose uptake, and modulates insulin signaling. Pinusolide inhibits caspase-3/7 activation, intracellular calcium elevation, reactive oxygen species overproduction, lipid peroxidation, and tumor cell proliferation. Pinusolide stabilizes superoxide dismutase activity, reduces apoptotic hallmarks, induces mitochondrial pathway apoptosis, and triggers DNA fragmentation. Pinusolide can be used for the research of type 2 diabetes, neurodegenerative diseases, acute lymphoblastic leukemia, acute myeloid leukemia, and Burkitt lymphoma .

Cat. No.	Product Name	Chemical Structure

HY-108634S

Apafant-d8
Apafant-d₈ is the deuterium labeled Apafant. Apafant (WEB 2086) is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a K_iof 9.9 nM. Apafant increases the gene expression of PAF-r, α-globin, β-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit .

HY-13511AS

Rupatadine-d4 fumarate
Rupatadine-d₄ fumarate is a deuterium labeled Rupatadine fumarate. Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with K_i values of 0.55/0.1 μM (rabbit platelet membranes/guinea pig cerebellum membranes) .

HY-13511S

Rupatadine-d6 D-tartrate
Rupatadine-d₆ (D-tartrate) is deuterated labeled Rupatadine (HY-13511). Rupatadine (UR-12592) is a potent, orally active and long-lasting dual *PAF/H1* antagonist, with K_is of 0.55 μM and 0.1 μM, respectively. Rupatadine can be used for the research of allergic rhinitis and urticaria .

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