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Cat. No.: HY-116120

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N-Acetyldesloratadine

(Synonyms: SCH-37370)

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N-Acetyldesloratadine (SCH-37370) is a potent, orally active dual antagonist of platelet-activating factor (PAF) and histamine. N-Acetyldesloratadine inhibits PAF-induced aggregation of human platelets, with an IC₅₀ of 0.6 µM. N-Acetyldesloratadine can be used for the study of allergic diseases, such as asthma.

For research use only. We do not sell to patients.

Purity: 99.93%
CAS No.: 117796-52-8
Formula: C₂₁H₂₁ClN₂O
Molecular Weight:352.86

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

N-Acetyldesloratadine Chemical Structure

CAS No.: 117796-52-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

All Histamine Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	54.8 μM Compound: 15, SCh-37370	Inhibition of eGFP-tagged human B0AT2 expressed in HEK293 cells measured within 10 mins by [3H]proline uptake assay Inhibition of eGFP-tagged human B0AT2 expressed in HEK293 cells measured within 10 mins by [3H]proline uptake assay	[PMID: 25318072]

In Vivo

N-Acetyldesloratadine (SCH-37370; p.o.) inhibits PAF- and histamine-induced bronchospasm in guinea pigs with ED₅₀ values of 6.0 mg/kg and 2.4 mg/kg, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 117796-52-8
Appearance Solid
Molecular Weight 352.86
Formula C₂₁H₂₁ClN₂O
Color White to off-white
SMILES

ClC1=CC=C2C(CCC3=CC=CN=C3/C2=C4CCN(CC\4)C(C)=O)=C1
Synonyms

SCH-37370
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Billah MM, et, al. Discovery and preliminary pharmacology of Sch 37370, a dual antagonist of PAF and histamine. Lipids. 1991 Dec;26(12):1172-4. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- In Vivo
Chemical Information
Purity & Documentation
References

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N-Acetyldesloratadine

MCE Bioactive Compound Library

Clinical Compound Library Plus

High-Throughput Bioactive Compound Library

All Histamine Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

N-Acetyldesloratadine

MCE Bioactive Compound Library

Clinical Compound Library Plus

High-Throughput Bioactive Compound Library

All Histamine Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

N-Acetyldesloratadine Related Classifications

HY-116120 Related Classifications