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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
PIN1 degrader-2
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "PIN1 degrader-2" in MCE Product Catalog:
Cat. No.: HY-164896
CAS No.: 3080918-74-4
PIN1 degrader-2 is a covalent PIN1 degrader with an IC50 of 4.1 nM. PIN1 degrader-2 induces a decrease in the thermal stability of PIN1 and triggers concentration-dependent PIN1 degradation in various cancer cells. PIN1 degrader-2 covalently modifies PIN1 Cys113. PIN1 degrader-2 also reduces the cell viability of pancreatic cancer, breast cancer, prostate cancer and lung cancer cells. PIN1 degrader-2 can be used in research related to pancreatic cancer, breast cancer, prostate cancer and non-small cell lung cancer [1].
Cat. No.: HY-186218
CAS No.: 3083422-10-7
PROTAC PIN1 degrader-2 is a PROTAC PIN1 degrader. PROTAC PIN1 degrader-2 reduces PIN1-mediated oncogene expression, upregulates PIN1-inhibited tumor suppressor genes, and exerts killing effects on cancer cells. PROTAC PIN1 degrader-2 inhibits tumor growth in breast cancer mouse xenograft models. PROTAC PIN1 degrader-2 can be used for the research of breast cancer [1].
Cat. No.: HY-186219
Research Areas:
PIN1 ligand-3 (Compound I-1) is a PIN1 ligand. PIN1 ligand-3 serves as a Ligand for Target Protein for PROTAC for the synthesis of PIN1 PROTAC degraders, such as PROTAC PIN1 degrader-2 (HY-186218). PIN1 ligand-3 is applicable in cancer research [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
