3080918-74-4
Chemical Structure
PIN1 degrader-2
- CAS No.: 3080918-74-4
- Formula:C31H32ClFN6O4
- Molecular Weight:607.07
InChIKey: CISAHAPWIHDTFR-URORMMCBSA-N
SMILES: NC([C@H](CC1=CNC2=C1C=C(F)C=C2)NC([C@@H]3CCCCN3C([C@@H]4CC5=C(CN4C(CCl)=O)NC6=C5C=CC=C6)=O)=O)=O
Biological Activity: PIN1 degrader-2 is a covalent PIN1 degrader with an IC50 of 4.1 nM. PIN1 degrader-2 induces a decrease in the thermal stability of PIN1 and triggers concentration-dependent PIN1 degradation in various cancer cells. PIN1 degrader-2 covalently modifies PIN1 Cys113. PIN1 degrader-2 also reduces the cell viability of pancreatic cancer, breast cancer, prostate cancer and lung cancer cells. PIN1 degrader-2 can be used in research related to pancreatic cancer, breast cancer, prostate cancer and non-small cell lung cancer[1].
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PIN1 degrader-2 | PIN1 degrader-2 is a covalent PIN1 degrader with an IC50 of 4.1 nM. PIN1 degrader-2 induces a decrease in the thermal stability of PIN1 and triggers concentration-dependent PIN1 degradation in various cancer cells. PIN1 degrader-2 covalently modifies PIN1 Cys113. PIN1 degrader-2 also reduces the cell viability of pancreatic cancer, breast cancer, prostate cancer and lung cancer cells. PIN1 degrader-2 can be used in research related to pancreatic cancer, breast cancer, prostate cancer and non-small cell lung cancer. | |||||||||||||||||||||
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