6366 Results for "

RNA

" in MedChemExpress (MCE) Product Catalog:
Products (6366)

6366 Results for "RNA" in MCE Product Catalog:

223
Remdesivir
Remdesivir
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223 Publications Verification
Cat. No.: HY-104077
CAS No.: 1809249-37-3
Purity:  99.95%
Synonyms: GS-5734
Target:  

DNA/RNA Synthesis SARS-CoV

Research Areas:  

Infection

Remdesivir (GS-5734) is a nucleoside analogue with effective antiviral activity. Remdesivir can inhibit the synthesis of viral DNA or RNA. Remdesivir can be used for the research of infection, such as SARS-CoV and MHV infection .
171
Dihydroethidium
Dihydroethidium
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171 Cited Publications
Cat. No.: HY-D0079
CAS No.: 104821-25-2
Synonyms: Hydroethidine; PD-MY 003
Dihydroethidium, also known as DHE, is a peroxide indicator. Dihydroethidium penetrates cell membranes to form a fluorescent protein complex with blue fluoresces. After entering the cells, Dihydroethidium is mainly localized in the cell membrane, cytoplasm and nucleus, and the staining effect is the strongest in the nucleus. Dihydroethidium produces inherent blue fluorescence with a maximum excitation wavelength of 370 nm and a maximum emission wavelength of 420 nm; after dehydrogenation, Dihydroethidium combines with RNA or DNA to produce red fluorescence with a maximum excitation wavelength of 300 nm and a maximum emission wavelength of 610 nm. 535 nm can also be used as the excitation wavelength for actual observation .
118
Sofosbuvir
Sofosbuvir
0 Images
118 Cited Publications
Cat. No.: HY-15005
CAS No.: 1190307-88-0
Purity:  99.97%
Synonyms: GS-7977; PSI-7977
Target:  

HCV

Research Areas:  

Infection Cancer

Sofosbuvir (GS-7977) is an HCV RNA replication inhibitor with an EC50 of 92 nM .
76
SN-38
SN-38
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76 Cited Publications
Cat. No.: HY-13704
CAS No.: 86639-52-3
Purity:  99.94%
Synonyms: 7-Ethyl-10-hydroxycamptothecin
Category:  

Alkaloids Labiatae Samanea saman (Jacq.) Merr. Quinoline Alkaloids Plants Disease Research Fields Cancer

Target:  

Drug Metabolite Topoisomerase ADC Payloads Autophagy

SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 can bind to RPL15. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) .
70
CX-5461
CX-5461
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70 Cited Publications
Cat. No.: HY-13323
CAS No.: 1138549-36-6
Purity:  99.49%
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

CX-5461 is a potent and oral rRNA synthesis inhibitor. It inhibits RNA polymerase I-driven transcription of rRNA with IC50s of 142, 113, and 54 nM in HCT-116, A375, and MIA PaCa-2 cells, respectively .
63
Polyinosinic-polycytidylic acid sodium
Polyinosinic-polycytidylic acid sodium
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63 Cited Publications
Cat. No.: HY-135748
CAS No.: 42424-50-0
Purity:  99.4%
Synonyms: Poly(I:C) sodium
Target:  

RIG-I-like receptor (RLR) Toll-like Receptor (TLR) Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Polyinosinic-polycytidylic acid (Poly(I:C)) sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis .
62
Polyinosinic-polycytidylic acid
Polyinosinic-polycytidylic acid
0 Images
62 Cited Publications
Cat. No.: HY-107202
CAS No.: 24939-03-5
Purity:  99.40%
Synonyms: Poly(I:C)
Target:  

RIG-I-like receptor (RLR) Toll-like Receptor (TLR) PKD HSP Bcl-2 Family Interleukin Related Apoptosis

Research Areas:  

Infection Inflammation/Immunology Cancer

Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis .
57
Poly (I:C):Kanamycin (1:1) sodium
Poly (I:C):Kanamycin (1:1) sodium
0 Images
57 Cited Publications
Cat. No.: HY-135748A
Target:  

RIG-I-like receptor (RLR) Toll-like Receptor (TLR) Apoptosis

Research Areas:  

Infection Cancer

Poly (I:C):Kanamycin (1:1) sodium is an isometric complex of Poly (I:C) (HY-135748) and Kanamycin (HY-16566). Poly(I:C) sodium, a synthetic analog of double-stranded RNA, is a TLR3 and retinoic acid-inducible gene I receptor (RIG-I and b>MDA5) agonist. Poly(I:C) sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses and induce apoptosis in cancer cells . Kanamycin is an orally active antibacterial agent (Gram-negative/positive bacteria) that inhibits translocation and causes miscoding by binding to the 70S ribosomal subunit. Kanamycin shows good inhibitory activity against Mycobacterium tuberculosis (susceptible and drug-resistant) and Klebsiella pneumoniae, and can be used in the research of tuberculosis and pneumonia .
51
Favipiravir
Favipiravir
0 Images
51 Cited Publications
Cat. No.: HY-14768
CAS No.: 259793-96-9
Purity:  99.97%
Synonyms: T-705
Target:  

DNA/RNA Synthesis Influenza Virus SARS-CoV Bacterial

Research Areas:  

Infection

Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC50 of 341 nM.
49
Baloxavir
Baloxavir
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49 Cited Publications
Cat. No.: HY-109025A
CAS No.: 1985605-59-1
Purity:  99.68%
Synonyms: Baloxavir acid; S-033447
Target:  

Influenza Virus

Research Areas:  

Infection Cancer

Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .
48
α-Amanitin
α-Amanitin
0 Images
48 Cited Publications
Cat. No.: HY-19610
CAS No.: 23109-05-9
Synonyms: α-Amatoxin
Target:  

DNA/RNA Synthesis ADC Payloads

Research Areas:  

Cancer

α-Amanitin is the principal toxin of several deadly poisonous mushrooms, exerting its toxic function by inhibiting RNA-polymerase II.
46
Streptomycin
Streptomycin
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46 Cited Publications
Cat. No.: HY-B1906
CAS No.: 57-92-1
Synonyms: Agrept; Agrimycin; Streptomycin A
Category:  

Microorganisms

Target:  

Environmental Pollutants Antibiotic Bacterial

Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes .
45
Simeprevir
Simeprevir
0 Images
45 Cited Publications
Cat. No.: HY-10241
CAS No.: 923604-59-5
Purity:  98.79%
Synonyms: TMC435; TMC435350
Target:  

HCV HCV Protease SARS-CoV DNA/RNA Synthesis

Research Areas:  

Infection

Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (M pro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .
40
PolyFast Transfection Reagent
PolyFast Transfection Reagent
0 Images
40 Cited Publications
Cat. No.: HY-K1014

MCE PolyFast Transfection Reagent consists of cationic polymers and can introduce nucleic acids (DNA or RNA) into eukaryotic cells efficiently, including some hard-to-transfect cells.

39
Daunorubicin hydrochloride
Daunorubicin hydrochloride
0 Images
39 Cited Publications
Cat. No.: HY-13062
CAS No.: 23541-50-6
Purity:  99.67%
Synonyms: Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride
Category:  

Infection Quinones Microorganisms Anthraquinones Phenols Polyphenols Disease Research Fields

Target:  

Topoisomerase DNA/RNA Synthesis ADC Payloads Bacterial Autophagy Apoptosis Antibiotic

Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .
39
Daunorubicin
Daunorubicin
0 Images
39 Cited Publications
Cat. No.: HY-13062A
CAS No.: 20830-81-3
Synonyms: Daunomycin; RP 13057; Rubidomycin
Category:  

Infection Quinones Microorganisms Anthraquinones Phenols Polyphenols Disease Research Fields

Target:  

Topoisomerase DNA/RNA Synthesis ADC Payloads Autophagy Bacterial Antibiotic Apoptosis

Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .
38
Acridine Orange hydrochloride
Acridine Orange hydrochloride
0 Images
38 Cited Publications
Cat. No.: HY-101879
CAS No.: 65-61-2
Purity:  99.65%
Acridine Orange hydrochloride is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange hydrochloride produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm) .
38
Acridine Orange zinc chloride salt
Acridine Orange zinc chloride salt
0 Images
38 Cited Publications
Cat. No.: HY-D0942
CAS No.: 10127-02-3
Synonyms: Euchrysine 3RX
Acridine Orange (Euchrysine 3RX) zinc chloride salt is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange zinc chloride salt produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm) .
38
Acridine Orange base
Acridine Orange base
0 Images
38 Cited Publications
Cat. No.: HY-D0952
CAS No.: 494-38-2
Acridine Orange base is a cell-permeable fluorescent dye that stains organisms (bacteria, parasites, viruses, etc.) bright orange and, when used under appropriate conditions (pH=3.5, Ex=460 nm), distinguishes human cells in green for detection by fluorescence microscopy. Acridine Orange base fluoresces green when bound to dsDNA (Ex=488, Em=520-524) and red when bound to ssDNA (Ex=457, Em=630-644) or ssRNA (Ex=457, Em=630-644), also can be used in cell cycle assays .
38
Epirubicin
Epirubicin
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38 Cited Publications
Cat. No.: HY-13624
CAS No.: 56420-45-2
Synonyms: 4'-Epidoxorubicin
Target:  

DNA/RNA Synthesis Topoisomerase Apoptosis Antibiotic FOXP

Research Areas:  

Cancer

Epirubicin (4'-Epidoxorubicin), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase . Epirubicin inhibits DNA and RNA synthesis. Epirubicin is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity .
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