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Results for "

RXR agonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	RAR/RXR (45) Aldose Reductase (1) Apoptosis (6) Autophagy (12) Bacterial (2) Caspase (1) CDK (1) Drug Metabolite (1) Endogenous Metabolite (5) Estrogen Receptor/ERR (1) Isotope-Labeled Compounds (4) Ligands for Target Protein for PROTAC (1) LXR (1) NO Synthase (1) Nuclear Hormone Receptor 4A/NR4A (2) PPAR (3) Reference Standards (8) Smo (1) VD/VDR (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (33) Cardiovascular Disease (3) Inflammation/Immunology (8) Metabolic Disease (14) Neurological Disease (14)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: RAR/RXR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14171

Bexarotene Maximum Cited Publications 22 Publications Verification LGD1069	RAR/RXR Autophagy	Cancer
Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-15128

9-cis-Retinoic acid 5 Publications Verification Alitretinoin	RAR/RXR Apoptosis Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent *RAR/RXR* agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities .

HY-N0163

Magnolol Maximum Cited Publications 7 Publications Verification	RAR/RXR PPAR Autophagy Bacterial	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC₅₀ values of 10.4 µM and 17.7 µM, respectively.

HY-13717

AGN194204 IRX4204; NRX194204; VTP 194204	RAR/RXR Apoptosis	Inflammation/Immunology Cancer
AGN194204 (IRX4204) is an orally active and selective *RXR* agonist with K_d values 0.4 nM, 3.6 nM and 3.8 nM and EC₅₀s of 0.2 nM, 0.8 nM and 0.08 nM for RXRα, RXRβ and RXRγ, respectively. AGN194204 is inactive against RAR. AGN194204 has anti-inflammatory and anticarcinogenic actions .

HY-15340

LG100268 5 Publications Verification LG268	RAR/RXR Autophagy	Metabolic Disease
LG100268 (LG268) is a potent, selective and orally active retinoid X receptor (RXR) agonist with EC₅₀ values of 4 nM, 3 nM, and 4 nM for RXR-α, RXR-β, and RXR-γ, respectively . LG100268 displays >1000-fold selectivity for RXR over RAR, the K_i values are 3.4 nM, 6.2 nM and 9.2 nM for RXR-α, RXR-β, and RXR-γ, respectively . LG100268 activates RXR homodimers to induce transcriptional activation. LG100268 can be used for the study of lung carcinogenesisy .

HY-107399

CD3254 3 Publications Verification	RAR/RXR	Metabolic Disease Cancer
CD3254 a potent and selective retinoid-X-receptor (RXR) agonist .

HY-32350

Ercalcitriol 3 Publications Verification 1α,25-Dihydroxy Vitamin D2	VD/VDR Drug Metabolite Endogenous Metabolite	Metabolic Disease
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .

HY-N10361

Drupanin	RAR/RXR PPAR Aldose Reductase	Cancer
Drupanin is an orally active and selective AKR1C3 enzyme inhibitor and an RXRα agonist with an EC₅₀ value of 4.8 μM, which is found in green propolis. Drupanin also activates PPARγ moderately. Drupanin induces adipogenesis and elevates aP2 mRNA levels in 3T3-L1 fibroblasts Drupanin has the potential for the research of breast and prostate cancers .

HY-U00425

PROTAC ERRα ligand 1	Ligands for Target Protein for PROTAC Estrogen Receptor/ERR	Metabolic Disease Cancer
PROTAC ERRα ligand 1 is a PROTAC target protein ligand. PROTAC ERRα ligand 1 is an orally active ERRα inverse agonist with IC₅₀ values of 0.6 μM for ERRα. PROTAC ERRα ligand 1 shows no significant activity against a panel of other nuclear receptors, including ERα ^c, ERRγ, ERβ, PPARα, PPARγ, PPARδ, and RXRα. PROTAC ERRα ligand 1 can provide enhanced insulin sensitivity in vivo. PROTAC ERRα ligand 1 can be used for metabolic diseases research, such as type 2 diabetes and obesity .

HY-B0877

Halcinonide 1 Publications Verification SQ-18566	Smo Caspase RAR/RXR CDK	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Halcinonide (SQ-18566) is an orally active Smoothened (Smo) agonist. Halcinonide activates the Hedgehog signaling pathway by binding to Smo and promoting its internalization and expression, thereby activating Gli transcription factors. Halcinonide not only stimulates cell proliferation, increases the expression of cyclin D2/CDK6 and inhibits the degradation of caspase-3, but also suppresses Bcl-2/Bax-mediated apoptosis, oxidative stress and inflammatory responses. Halcinonide activates RxRγ to upregulate the expression of myelin genes, thereby reducing cerebral infarction and improving behavioral deficits. Halcinonide has been used in studies related to multiple sclerosis and ischemic stroke .

HY-108530

MM11253	RAR/RXR	Cancer
MM11253 is a potent and selective RARγ antagonist with an IC₅₀ of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists .

HY-108523

LG100754 UVI 2112	RAR/RXR	Metabolic Disease
LG100754 (UVI 2112) is a RXR dimers modulater. LG100754 acts as a *RXR:RXR* homodimer antagonist, but functions as a agonist towards RXR:PPARα and RXR:PPARγ heterodimers. LG100754 is an insulin sensitizer that functions through RXR .

HY-153832

MSU-42011	RAR/RXR NO Synthase	Cancer
MSU-42011 is an orally active retinoid X receptor (RXR) agonist. MSU-42011 inhibits the iNOS activity and reduces the expression of p-ERK protein. MSU-42011 has immunomodulatory and antitumor activity .

HY-132334S

9-cis-Retinoic acid-d5	Isotope-Labeled Compounds RAR/RXR Apoptosis Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
9-cis-Retinoic acid-d₅ is the deuterium labeled 9-cis-Retinoic acid. 9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities .

HY-120875

HX600	RAR/RXR	Neurological Disease
HX600 is a synthetic agonist for RXR (Retinoid X Receptor) heterodimer complex. HX600 prevents ischemia-induced neuronal damage. HX600 has orally bioactivity .

HY-162162

RXR agonist 1	RAR/RXR	Neurological Disease Metabolic Disease Cancer
RXR agonist 1 (Compound 33) is a highly selective *RXR* agonist, with EC₅₀s of 9 nM, 18 nM, and 11 nM for RXRα, RXRβ, and RXRγ, respectively. RXR agonist 1 binds to RXR with high affinity (K_d = 0.03 μM) .

HY-108520

HX630	RAR/RXR Apoptosis	Cancer
HX630 is a potent retinoic acid X receptor (RXR) agonist, can induce apoptosis, has anti-tumor effect, and can be used in Cushing's disease research .

HY-14171S

Bexarotene-d4 LGD1069 d₄	RAR/RXR Autophagy	Cancer
Bexarotene-d₄ is a deuterium labeled Bexarotene (LGD1069). Bexarotene (LGD1069) is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma .

HY-104070

LG-100064	RAR/RXR Autophagy	Cancer
LG-100064 is a retinoid-X-receptor (RXR) agonist, with EC₅₀s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ; LG-100064 can be used in the research of cancer.

HY-108525

Fluorobexarotene	RAR/RXR	Cancer
Fluorobexarotene (compound 20) is a potent retinoid-X-receptor (RXR) agonist, with a K_i value of 12 nM and an EC₅₀ value of 43 nM for RXRα receptor. Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene .

HY-155437

NEt-iFQ	RAR/RXR	Others
NEt-iFQ is a fluorescent retinoid X receptor (RXR) agonist with potent solvatochromic properties. NEt-iFQ selectively binds to RXR-LBP and fluoresces .

HY-175480

RXR agonist 2	RAR/RXR	Neurological Disease Metabolic Disease
RXR agonist 2 (Compound 22) is a highly selective retinoid X receptor (RXR) agonist (EC₅₀=0.039 μM). RXR agonist 2 is promising for research of metabolic syndrome and Alzheimer's disease .

HY-162827

*RAR/RXR* agonist-1**	RAR/RXR Apoptosis	Cancer
RAR/RXR agonist-1 (compound 7) is a chlorinated retinoic acid isomer, a selective RARα agonist and a partial RXRα agonist. RAR/RXR agonist-1 can activate RXRα and induce G2/M arrest and apoptosis in cancer cells .

HY-16685

AGN 205327	RAR/RXR Autophagy	Cancer
AGN 205327 is a potent synthetic RARs agonist with EC50 of 3766/734/32 nM for RARα/β/γ respectively; no inhibition on RXR.

HY-163801

*Nurr1 agonist* 9**	Nuclear Hormone Receptor 4A/NR4A	Neurological Disease
Nurr1 agonist 9 (Compound 36) is an agonist for Nurr1 with an EC₅₀ of 0.090 µM and a K_d of 0.17 µM. Nurr1 agonist 9 activates the Nurr1 homodimer (NurRE, EC₅₀=0.094 µM) and the Nurr1-RXR heterodimer (DR5, EC₅₀=0.165 µM). Nurr1 agonist 9 induces the expression of Nurr1-regulated tyrosine hydroxylase (TH) in organoid Parkinson's Disease model. Nurr1 agonist 9 is human brain endothelial cell barrier prmeable .

HY-N0163R

Magnolol (Standard)	Reference Standards RAR/RXR PPAR Autophagy Bacterial	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Magnolol (Standard) is the analytical standard of Magnolol. This product is intended for research and analytical applications. Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 μM and 17.7 μM, respectively.

HY-117376

(all-E)-UAB30 UAB30	RAR/RXR	Cancer
(all-E)-UAB30 (UAB30) is an retinoid X receptor (RXR) selective agonist.(all-E)-UAB30 shows anti-proliferation activity for MyLa, HuT 78, and HH cells with the IC₅₀ of 34.7, 5.1, and 22.4 μM respectively .

HY-180182

RXR agonist 3	RAR/RXR	Neurological Disease Inflammation/Immunology Cancer
RXR agonist 3 (Compound 35) is a potent, partial *RXR* agonist (EC₅₀s: 3, 3, 8 nM for RXRα, RXRβ, RXRγ, respectively). RXR agonist 3 can be used in the research of Alzheimer's disease, multiple sclerosis, and lymphoma .

HY-180576

*Nurr1/RXR* agonist 1**	Nuclear Hormone Receptor 4A/NR4A RAR/RXR	Neurological Disease
Nurr1/RXR dual agonist 1 is a dual activator of Nurr1 (EC₅₀ = 2.6 µM) and *RXR* with K s of 0.6 and 1.1 µM, respectively. Nurr1/RXR dual agonist 1 exclusively activates the heterodimer response element DR5 by selectively destabilizing the Nurr1 homodimer and stabilizing the Nurr1:RXR heterodimer. Nurr1/RXR dual agonist 1 enhances expression of a specific subset of neuroprotective Nurr1 target genes while avoiding induction of genes associated with potential off-target effects in neuronal cells. Nurr1/RXR dual agonist 1 can be used for neurodegenerative diseases research .

HY-15340R

LG100268 (Standard) LG268 (Standard)	RAR/RXR Autophagy Reference Standards	Metabolic Disease
LG100268 (Standard) is the analytical standard of LG100268. This product is intended for research and analytical applications. LG100268 (LG268) is a potent, selective and orally active retinoid X receptor (RXR) agonist with EC50 values of 4 nM, 3 nM, and 4 nM for RXR-α, RXR-β, and RXR-γ, respectively . LG100268 displays >1000-fold selectivity for RXR over RAR, the Ki values are 3.4 nM, 6.2 nM and 9.2 nM for RXR-α, RXR-β, and RXR-γ, respectively . LG100268 activates RXR homodimers to induce transcriptional activation. LG100268 can be used for the study of lung carcinogenesisy .

HY-14171S2

Bexarotene-13C6 LGD1069-¹³C₆	Isotope-Labeled Compounds RAR/RXR Autophagy	Cancer
Bexarotene- ¹³C₆ (LGD1069- ¹³C₆) is ¹³C labeled Bexarotene. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-14171R

Bexarotene (Standard) LGD1069 (Standard)	Reference Standards RAR/RXR Autophagy	Cancer
Bexarotene (Standard) is the analytical standard of Bexarotene. This product is intended for research and analytical applications. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-N2992

16α-Hydroxytrametenolic acid	RAR/RXR	Cancer
16α-Hydroxytrametenolic acid, a natural triterpene, is a potential retinoid X receptor (RXR) selective agonist .

HY-W777169

Bexarotene-13C4 LGD1069-¹³C₄	Isotope-Labeled Compounds RAR/RXR Autophagy	Cancer
Bexarotene- ¹³C₄ (LGD1069- ¹³C₄) is the ¹³C-labeled Bexarotene (HY-14171). Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-N13361

Elodeoidileon A	RAR/RXR	Neurological Disease
Elodeoidileon A is an agonist for RXRα, that interacts with RXRα-LBD protein with a dissociation constant K_d of 5.85 μM. Elodeoidileon A promotes the expression of ATP-binding cassette transporter A1 (ABCA1). Elodeoidileon A reveals the potential in Alzheimer's disease research .

HY-117926

AGN 191701	RAR/RXR	Cancer
AGN 191701 is a selective retinoic acid X receptor (RXR) agonist that causes liver enlargement in rats without hepatocellular necrosis .

HY-118364

AGN 190727	RAR/RXR	Metabolic Disease
AGN 190727 is a structural isomer of AGN 190121 and has no activating effect on RAR/RXR. AGN 190121 is a RAR-specific agonist that causes a dose-dependent increase in serum triglycerides, leading to hypertriglyceridemia.

HY-121671

TBTC	RAR/RXR	Neurological Disease
TBTC is a selective agonist with the activity of improving behavioral deficits in Alzheimer's disease model mice. TBTC can effectively activate the heterodimerization of RXRα with LXRα or PPARγ. TBTC stimulates the expression of apoE, ABCA1, and ABCG1 genes and reduces Aβ content in cells and animal models .

HY-177890

UAB116	LXR RAR/RXR Wnt β-catenin	Cancer
UAB116 is a Liver X Receptor (LXR)/Retinoid X Receptor (RXR) agonist. UAB116 can decreases metastatic phenotype in hepatoblastoma by inhibiting the Wnt/β-Catenin pathway via upregulation of TRIM29. UAB116 can reduce proliferation, stemness and invasiveness of metastatic hepatoblastoma cells .

HY-15128R

9-cis-Retinoic acid (Standard) Alitretinoin (Standard)	Reference Standards RAR/RXR Apoptosis Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
9-cis-Retinoic acid (Standard) is the analytical standard of 9-cis-Retinoic acid. This product is intended for research and analytical applications. 9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities[1][2][3][4][5].

HY-32350S1

Ercalcitriol-d3 1α,25-Dihydroxy Vitamin D2-d₃	Isotope-Labeled Compounds Endogenous Metabolite VD/VDR	Metabolic Disease
Ercalcitriol-d₃ (1α,25-Dihydroxy Vitamin D2-d₃) is the deuterium labeled Ercalcitriol (HY-32350). Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .

HY-108523R

LG100754 (Standard) UVI 2112 (Standard)	Reference Standards RAR/RXR	Metabolic Disease
LG100754 (Standard) is the analytical standard of LG100754 (HY-108523). This product is intended for research and analytical applications. LG100754 (UVI 2112) is a RXR dimers modulater. LG100754 acts as a RXR:RXR homodimer antagonist, but functions as a agonist towards RXR:PPARα and RXR:PPARγ heterodimers. LG100754 is an insulin sensitizer that functions through RXR .

HY-104070R

LG-100064 (Standard)	Reference Standards RAR/RXR Autophagy	Cancer
LG-100064 (Standard) is the analytical standard of LG-100064 (HY-104070). This product is intended for research and analytical applications. LG-100064 is a retinoid-X-receptor (RXR) agonist, with EC₅₀s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ; LG-100064 can be used in the research of cancer.

HY-180181

RXR antagonist 6	RAR/RXR	Metabolic Disease Cancer
RXR antagonist 6 (Compound 34) is a selective partial retinoid X receptor (RXR) antagonist. RXR antagonist 6 shows no agonistic activity for any of the human RXRα/β/γ subtypes but it can strongly inhibit the receptor activation induced by full agonists of RXR (such as Bezafibrate (HY-B0637)) with an IC₅₀ of 2.7 μM. RXR antagonist 6 can enhance PMA (HY-18739)-induced THP-1 cell differentiation. RXR antagonist 6 can be used for the research of cancer, metabolic and neurological disease, such as lymphoma .

HY-119574

GW0791	RAR/RXR	Cancer
GW0791 (Compound 3) is an RXRα agonist with an EC₅₀ of 5 nM. GW0791 can be used for cancer research .

HY-180351

CU-6PMN	RAR/RXR	Others
CU-6PMN is a fluorescent *RXR* agonist. CU-6PMN has a maximum absorption wavelength of 396 nm and an emission wavelength of 453 nm in 0.1 N NaOH aqueous solution. CU-6PMN has an EC₅₀ value of 22 nM and a K_i value of 230 nM for human RXRα. CU-6PMN can be used in research related to the screening of RXR ligands .

HY-107399R

CD3254 (Standard)	Reference Standards RAR/RXR	Metabolic Disease Cancer
CD3254 (Standard) is the analytical standard of CD3254 (HY-107399). This product is intended for research and analytical applications. CD3254 a potent and selective retinoid-X-receptor (RXR) agonist .

HY-167262

AGN-191659	RAR/RXR	Metabolic Disease Cancer
AGN-191659 is an orally active *RAR/RXR* agonist with EC₅₀ values of 11 nM, 23 nM, and 37 nM for RXRα, RARβ, and RARγ, respectively. AGN-191659 activates RXRα, RARβ and RARγ to induce gene transcription. AGN-191659 induces tissue transglutaminase activity, inhibits ornithine decarboxylase activity induced by tumor promoters, and suppresses chondrogenesis. AGN-191659 reverses basic fibroblast growth factor-induced endothelial cell proliferation. AGN-191659 induces hypertriglyceridemia in rat models. AGN-191659 inhibits total heparin-releasable lipase activity. AGN-191659 can be used in research related to promyelocytic leukemia and hypertriglyceridemia .

HY-108530R

MM11253 (Standard)	Reference Standards RAR/RXR	Cancer
MM11253 (Standard) is the analytical standard of MM11253 (HY-108530). This product is intended for research and analytical applications. MM11253 is a potent and selective RARγ antagonist with an IC₅₀ of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15128

9-cis-Retinoic acid 5 Publications Verification Alitretinoin	Classification of Application Fields Terpenoids Diterpenoids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification Cancer	RAR/RXR Apoptosis Endogenous Metabolite
9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent *RAR/RXR* agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities .

HY-N0163

Magnolol Maximum Cited Publications 7 Publications Verification	Cardiovascular Disease Neurological Disease Classification of Application Fields Lignans Plants Magnolia officinalis. Rehd. et Wils. Magnoliaceae Phenols Polyphenols Phenylpropanoids Inflammation/Immunology Disease Research Fields Source Classification	RAR/RXR PPAR Autophagy Bacterial
Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC₅₀ values of 10.4 µM and 17.7 µM, respectively.

HY-32350

Ercalcitriol 3 Publications Verification 1α,25-Dihydroxy Vitamin D2	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	VD/VDR Drug Metabolite Endogenous Metabolite
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .

HY-N10361

Drupanin	Monophenols Animals Classification of Application Fields Phenols Disease Research Fields Source Classification Cancer	RAR/RXR PPAR Aldose Reductase
Drupanin is an orally active and selective AKR1C3 enzyme inhibitor and an RXRα agonist with an EC₅₀ value of 4.8 μM, which is found in green propolis. Drupanin also activates PPARγ moderately. Drupanin induces adipogenesis and elevates aP2 mRNA levels in 3T3-L1 fibroblasts Drupanin has the potential for the research of breast and prostate cancers .

HY-N0163R

Magnolol (Standard)	Structural Classification Magnolia officinalis. Rehd. et Wils. Magnoliaceae Lignans Phenols Polyphenols Phenylpropanoids Plants Source Classification	Reference Standards RAR/RXR PPAR Autophagy Bacterial
Magnolol (Standard) is the analytical standard of Magnolol. This product is intended for research and analytical applications. Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 μM and 17.7 μM, respectively.

HY-N2992

16α-Hydroxytrametenolic acid	Other Terpenoids Classification of Application Fields Terpenoids Polyporaceae Poria cocos Plants Disease Research Fields Cancer Source Classification	RAR/RXR
16α-Hydroxytrametenolic acid, a natural triterpene, is a potential retinoid X receptor (RXR) selective agonist .

HY-N13361

Elodeoidileon A	Other Terpenoids Natural Products Terpenoids Hypericum elodeoides Choisy Hypericaceae Plants Source Classification	RAR/RXR
Elodeoidileon A is an agonist for RXRα, that interacts with RXRα-LBD protein with a dissociation constant K_d of 5.85 μM. Elodeoidileon A promotes the expression of ATP-binding cassette transporter A1 (ABCA1). Elodeoidileon A reveals the potential in Alzheimer's disease research .

HY-15128R

9-cis-Retinoic acid (Standard) Alitretinoin (Standard)	Structural Classification Terpenoids Diterpenoids Endogenous metabolite Source Classification	Reference Standards RAR/RXR Apoptosis Endogenous Metabolite
9-cis-Retinoic acid (Standard) is the analytical standard of 9-cis-Retinoic acid. This product is intended for research and analytical applications. 9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities[1][2][3][4][5].

Cat. No.	Product Name	Chemical Structure

HY-132334S

9-cis-Retinoic acid-d5
9-cis-Retinoic acid-d₅ is the deuterium labeled 9-cis-Retinoic acid. 9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities .

HY-14171S

Bexarotene-d4
Bexarotene-d₄ is a deuterium labeled Bexarotene (LGD1069). Bexarotene (LGD1069) is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma .

HY-14171S2

Bexarotene-13C6
Bexarotene- ¹³C₆ (LGD1069- ¹³C₆) is ¹³C labeled Bexarotene. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-W777169

Bexarotene-13C4

Bexarotene- ¹³C₄ (LGD1069- ¹³C₄) is the ¹³C-labeled Bexarotene (HY-14171). Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-32350S1

Ercalcitriol-d3

Ercalcitriol-d₃ (1α,25-Dihydroxy Vitamin D2-d₃) is the deuterium labeled Ercalcitriol (HY-32350). Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .

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RXR agonist

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NaturalProducts

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