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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
Ref-1/APE1
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "Ref-1/APE1" in MCE Product Catalog:
4
Research Areas:
Erenapursta (E3330) is a direct, orally active and selective inhibitor of Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox factor-1) redox. Erenapursta is able to impair tumor growth and blocks the activity of NF-κB, AP-1, and HIF-1α in pancreatic cancer. Erenapursta shows anticancer activities [1] .
1
1 Cited Publications
Cat. No.: HY-P7523
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: APEX1; APE1; Prev. APEX; DNA-(Apurinic Or Apyrimidinic Site) Endonuclease; APEN; APEX Nuclease; Ref-1; APEX Nuclease (Multifunctional DNA Repair Enzyme); Ref1; Deoxyribonuclease (Apurinic Or Apyrimidinic); HAP1; Apurinic/Apyrimidinic (Abasic) Endonuclease
Species:
Human
Source:
E. coli
Cat. No.: HY-120069
CAS No.: 1415030-15-7
APX2009 is a specific APE1/REF-1 redox inhibitor with anticancer activities which decreases the proliferative, migratory, and invasive properties of breast cancer cell and induces apoptosis in breast cancer cell [1].
Cat. No.: HY-176996
CAS No.: 1136839-60-5
Target:
Research Areas:
Ape1/Ref-1 redox-IN-1 (Compound 52) is an Ape1/Ref-1 redox inhibitor. Ape1/Ref-1 redox-IN-1 can be used in the research of cancer [1].
Cat. No.: HY-120153
CAS No.: 1415030-17-9
Target:
Research Areas:
APX2014 is a Ref-1/APE1 inhibitor that inhibits Ref-1-induced transcription factor-DNA binding, thereby reducing the activation level of NF-κB and the expression of downstream pro-angiogenic targets. APX2014 blocks endothelial cell proliferation, lumen formation, migration and choroidal sprouting to exert anti-angiogenic activity. APX2014 activates the ISR pathway, promotes the death of pancreatic cancer cells and cancer-associated fibroblasts, and induces apoptosis in the absence of PRDX1. APX2014 inhibits the growth of pancreatic cancer spheroids, reduces the volume/weight of xenograft tumors, and decreases Ki-67 levels by targeting PRDX1. APX2014 can be used in research related to macular degeneration, retinopathy and pancreatic ductal adenocarcinoma [1] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
