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Results for "

Retinal degenerative diseases

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Peptides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-134928A
    Pyridinium bisretinoid A2E TFA

    A2E TFA; N-retinylidene-N-retinylethanolamine TFA

    		 Apoptosis Autophagy Reactive Oxygen Species (ROS) Cancer
    Pyridinium bisretinoid A2E (A2E) TFA is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E TFA is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E TFA mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E TFA can be used in the study of retinal degenerative diseases .
    Pyridinium bisretinoid A2E TFA
  • HY-134928
    Pyridinium bisretinoid A2E

    A2E

    		 Apoptosis Autophagy Reactive Oxygen Species (ROS) Cancer
    Pyridinium bisretinoid A2E (A2E) is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E can be used in the study of retinal degenerative diseases .
    Pyridinium bisretinoid A2E
  • HY-135808
    BIZ 114

    		NF-κB Inflammation/Immunology
    BIZ 114 (Example 11) is a fatty acid derivative and potent inhibits the TNF-α activated NF-κΒ pathway. BIZ 114 has the potential to prevent and / or treat ophthalmic disorders such as retinal degenerative disorders and ocular inflammatory diseases .
    BIZ 114
  • HY-178919
    N-19004

    		Formyl Peptide Receptor (FPR) Apoptosis Bacterial Inflammation/Immunology
    N-19004 is a FPR1 antagonist. N-19004 shows broad-spectrum antibacterial effects against a variety of pathogens. N-19004 exhibits significant retinal protective effects in the rd10 mouse model of retinitis pigmentosa (RP). N-19004 can attenuate retinal dysfunction, mitigate rod and cone degeneration, and reduce immune cell activation, gliosis, inflammation, oxidative stress, and apoptosis. N-19004 can reduce the size of laser-induced choroidal lesions and promote edema absorption through dual anti-inflammatory and anti-angiogenic effects. N-19004 can be used for the research of retinal degenerative diseases such as retinitis pigmentosa .
    N-19004
  • HY-161578
    Dithio-CN03

    		PKG Neurological Disease
    Dithio-CN03 is a compound with the highest neuroprotective efficacy. Dithio-CN03 fights the progression of retinitis pigmentosa (RP) by inhibiting the cGMP mediated signaling pathway and reducing photoreceptor cell death. Dithio-CN03 can be used in research into RP and other retinal degenerative diseases .
    Dithio-CN03
  • HY-P1384
    L803

    		Somatostatin Receptor Neurological Disease
    L803 is a selective Somatostatin Receptor Subtype 4 (SST4) agonist. L803 inhibits L-type calcium channel currents (ICa). L803 is promising for research of retinal ganglion cell (RGC) degenerative diseases (e.g., glaucoma) .
    L803
  • HY-W573558
    (tert-Butoxycarbonyl)-DL-glutamine

    		Drug Intermediate Neurological Disease
    (tert-Butoxycarbonyl)-DL-glutamine (Compound 2I) is a tert-butoxycarbonyl-protected glutamine derivative. (tert-Butoxycarbonyl)-DL-glutamine can be used for the synthesis of N-BOC-L-glutamine esters and Apocynin (HY-N0088). (tert-Butoxycarbonyl)-DL-glutamine is applicable to the research of retinal degenerative diseases .
    (tert-Butoxycarbonyl)-DL-glutamine
  • HY-176994
    3-Et-3TC

    		NOD-like Receptor (NLR) Drug Derivative Inflammation/Immunology
    3-Et-3TC (Page 87, Compound 3b) is a structurally modified derivative of Lamivudine (HY-B0250). 3-Et-3TC can inhibit the activation of the NLRP3 inflammasome and can be used for the study of retinal degenerative diseases .
    3-Et-3TC

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