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Rubiadin-1-methyl ether

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Rubiadin-1-methyl ether" in MCE Product Catalog:

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Rubiadin-1-methyl ether
Rubiadin-1-methyl ether
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Cat. No.: HY-N1956
CAS No.: 7460-43-7
Category:  

Quinones Monophenols Anthraquinones Rubiaceae Metabolic Disease Phenols Plants Disease Research Fields Rubia cordifolia L.

Target:  

NF-κB RANKL/RANK Autophagy TGF-β Receptor

Rubiadin-1-methyl ether is an orally potent NF-κB p65 inhibitor and autophagy inhibitor. Rubiadin-1-methyl ether inhibits RANKL-induced phosphorylation and nuclear translocation of p65, suppresses BECN1 transcription, blocks LC3 conversion and autophagosome formation, thereby reducing the levels of BECN1 mRNA and Beclin1 protein. Rubiadin-1-methyl ether inhibits osteoclastogenesis, cell proliferation, macrophage M2 polarization and the TGF-β1 signaling pathway, and effectively alleviates pulmonary inflammation. Rubiadin-1-methyl ether is widely used in research on osteoporosis, pulmonary fibrosis, idiopathic pulmonary fibrosis, acute lung injury and other related diseases .
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