7460-43-7
Chemical Structure
Rubiadin-1-methyl ether
- CAS No.: 7460-43-7
- Formula:C16H12O4
- Molecular Weight:268.26
IUPAC Name: 3-hydroxy-1-methoxy-2-methylanthracene-9,10-dione
InChIKey: NTBUBTCXACOEEC-UHFFFAOYSA-N
SMILES: O=C1C2=C(C=CC=C2)C(C3=CC(O)=C(C)C(OC)=C13)=O
Biological Activity: Rubiadin-1-methyl ether is an orally potent NF-κB p65 inhibitor and autophagy inhibitor. Rubiadin-1-methyl ether inhibits RANKL-induced phosphorylation and nuclear translocation of p65, suppresses BECN1 transcription, blocks LC3 conversion and autophagosome formation, thereby reducing the levels of BECN1 mRNA and Beclin1 protein. Rubiadin-1-methyl ether inhibits osteoclastogenesis, cell proliferation, macrophage M2 polarization and the TGF-β1 signaling pathway, and effectively alleviates pulmonary inflammation. Rubiadin-1-methyl ether is widely used in research on osteoporosis, pulmonary fibrosis, idiopathic pulmonary fibrosis, acute lung injury and other related diseases[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Rubiadin-1-methyl ether | 98.57% | Rubiadin-1-methyl ether is an orally potent NF-κB p65 inhibitor and autophagy inhibitor. Rubiadin-1-methyl ether inhibits RANKL-induced phosphorylation and nuclear translocation of p65, suppresses BECN1 transcription, blocks LC3 conversion and autophagosome formation, thereby reducing the levels of BECN1 mRNA and Beclin1 protein. Rubiadin-1-methyl ether inhibits osteoclastogenesis, cell proliferation, macrophage M2 polarization and the TGF-β1 signaling pathway, and effectively alleviates pulmonary inflammation. Rubiadin-1-methyl ether is widely used in research on osteoporosis, pulmonary fibrosis, idiopathic pulmonary fibrosis, acute lung injury and other related diseases. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Cai S, et al. Rubiadin-1-methyl ether inhibits BECN1 transcription and Beclin1-dependent autophagy during osteoclastogenesis by inhibiting NF-κB p65 activation. Exp Biol Med (Maywood). 2023;248(17):1518-1526. [Content Brief]
- [2]. Zhen X, et al. Rubiadin-1-methyl ether alleviates bleomycin induced pulmonary fibrosis. Sci Rep. 2026;16(1):4864. Published 2026 Jan 8. [Content Brief]
- [3]. Mohr ETB, et al. Evidence That the Anti-Inflammatory Effect of Rubiadin-1-methyl Ether Has an Immunomodulatory Context. Mediators Inflamm. 2019;2019:6474168. Published 2019 Nov 3. [Content Brief]
