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SA

" in MedChemExpress (MCE) Product Catalog:

113

Inhibitors & Agonists

3

Fluorescent Dye

17

Biochemical Assay Reagents

3

Peptides

2

Inhibitory Antibodies

12

Natural
Products

17

Recombinant Proteins

4

Isotope-Labeled Compounds

20

Antibodies

9

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-152182
    ML-SA5
    4 Publications Verification

    TRP Channel Cancer
    ML-SA5 is a potent TRPML1 cation channel agonist that activates the entire endosomal TRPML1 (ML1) current in DMD myocytes with an EC50 of 285 nM and is more potent than ML-SA1. ML-SA5 has anticancer activity and can inhibit tumour growth .
    ML-SA5
  • HY-108462
    ML-SA1
    Maximum Cited Publications
    9 Publications Verification

    Dengue Virus TRP Channel Flavivirus Infection
    ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral .
    ML-SA1
  • HY-B0432A
    Propafenone hydrochloride
    2 Publications Verification

    SA-79 hydrochloride

    Sodium Channel Cardiovascular Disease
    Propafenone (hydrochloride) (SA-79 (hydrochloride)) is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.
    Propafenone hydrochloride
  • HY-12456

    Antibiotic ADC Payload DNA Alkylator/Crosslinker Necroptosis Apoptosis Cancer
    Duocarmycin SA is an orally active antitumor antibiotic with an IC50 of 10 pM . Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro .
    Duocarmycin SA
  • HY-B0432
    Propafenone
    2 Publications Verification

    SA-79

    Sodium Channel Adrenergic Receptor Potassium Channel Cardiovascular Disease Cancer
    Propafenone (SA-79), a sodium-channel blocker, acts an antiarrhythmic agent. Propafenone also has high affinity for the β receptor (IC50=32 nM) . Propafenone blocks the transient outward current (Ito) and the sustained delayed rectifier K current (Isus) with IC50 values of 4.9 μm and 8.6 μm, respectively . Propafenone suppresses esophageal cancer proliferation through inducing mitochondrial dysfunction and induce apoptosis .
    Propafenone
  • HY-P99112

    RG-6168; SA-237

    Interleukin Related Inflammation/Immunology Cancer
    Satralizumab is a humanized monoclonal antibody that targets IL-6R. Satralizumab prevents dTAA formation and progression in rattus norvegicus. Satralizumab can be used for neuromyelitis optica spectrum disorder (NMOSD) and descending thoracic aorta aneurysm (dTAA) research .
    Satralizumab
  • HY-N2594

    Bacterial Infection
    Isoforsythiaside is an antioxidant and antibacterial phenylethanoid glycoside with MICs of 40.83, 40.83, and 81.66 μg/mL for Escherichia coli(E. coli), Pseudomonas aeruginosa(PAO), and Staphylococcus aureus (SA), respectively .
    Isoforsythiaside
  • HY-D0893

    Fluorescent Dye Others
    NSP-SA-NHS is an acridinium ester that can be used for chemiluminescent immunoassay. A rapid and sensitive chemiluminescent immunoassay of Bisphenol A (BPA) with NSP-SA-NHS-labeled has been developed .
    NSP-SA-NHS
  • HY-178159

    RNA MTase Inflammation/Immunology
    SA91-0178 is a METTL1 inhibitor. SA91-0178 inhibits m 7G methylation of RNA, reduces SARM1 stability, mitigates NAD + depletion and metabolic reprogramming in macrophages. SA91-0178 demonstrates excellent protective efficacy against multiple organ injury in cecal ligation and puncture (CLP)-induced and ischemia/reperfusion (I/R)-induced mice. SA91-0178 can be used for the study of systemic inflammatory diseases .
    SA91-0178
  • HY-N8211
    Gypenoside L
    4 Publications Verification

    p38 MAPK ERK NF-κB Inflammation/Immunology Cancer
    Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate p38 and ERK MAPK pathways and NF-κB pathway to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities .
    Gypenoside L
  • HY-D2363

    Radionuclide-Drug Conjugates (RDCs) FAP Prolyl Endopeptidase (PREP) Cancer
    DOTA.SA.FAPi TFA is a selective FAP inhibitor with an IC50 value of 0.9 nM against FAP. DOTA.SA.FAPi TFA forms stable complexes with 68Ga and serves as a PET radiotracer for preclinical imaging of FAP-expressing tumors. DOTA.SA.FAPi TFA can be used in the research of colorectal adenocarcinoma and various other cancers .
    DOTA.SA.FAPi TFA
  • HY-13510
    Cutamesine dihydrochloride
    5+ Cited Publications

    SA4503 dihydrochloride; AGY94806 dihydrochloride

    Sigma Receptor Neurological Disease
    Cutamesine (SA4503) dihydrochloride is a potent and selective sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes. Cutamesine dihydrochloride shows >100-fold less affinity for the sigma 2 receptor (IC50 of 1784 nM). Cutamesine dihydrochloride has antidepressant effects .
    Cutamesine dihydrochloride
  • HY-118530
    Bucillamine
    2 Publications Verification

    SA96; Thiobutarit

    VEGFR Cardiovascular Disease Inflammation/Immunology
    Bucillamine (SA96) is an orally active and potent sulfhydryl donor and antioxidant. Bucillamine is also an antirheumatic agent with antiangiogenic properties. Bucillamine can protect against Ischemia/reperfusion (I/R) injury in high-risk organ transplants. Bucillamine inhibits the production of VEGF. Bucillamine can be used for the research of choroidal neovascularization (CNV) and rheumatoid arthritis (RA) .
    Bucillamine
  • HY-NP0149

    SNA (Biotinylated)

    Biochemical Assay Reagents Others
    Sambucus Nigra Lectin (SNA) (Biotinylated) is a terminal sialic acid (SA) residue-binding lectin with biotinylation modification. Sambucus Nigra Lectin (Biotinylated) binds specifically to terminal sialic acid residues on captured IgG and its subclasses .
    Sambucus Nigra Lectin (Biotinylated)
  • HY-W585952

    SA-2-O-β-D-glucoside

    Drug Metabolite Infection
    Salicylic acid 2-O-β-D-glucoside (SA-2-O-β-D-glucoside) is the glucose-conjugated product of Salicylic Acid (HY-B0167) in plants. Salicylic acid 2-O-β-D-glucoside belongs to an inactive storage form. Salicylic acid 2-O-β-D-glucoside can be used in studies of plant pathogen infection .
    Salicylic acid 2-O-β-D-glucoside
  • HY-14813
    Cutamesine
    5+ Cited Publications

    SA4503; AGY 94806

    Sigma Receptor Neurological Disease
    Cutamesine (SA4503) is a potent and selective sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes. Cutamesine shows >100-fold less affinity for the sigma 2 receptor (IC50 of 1784 nM). Cutamesine has antidepressant effects .
    Cutamesine
  • HY-129356

    Antibiotic ADC Payload DNA Alkylator/Crosslinker Apoptosis Cancer
    Seco-Duocarmycin SA is a DNA alkylator. Seco-Duocarmycin SA is an antitumor antibiotic (IC50 = 10 pM). Seco-Duocarmycin SA can induce a concentration-dependent increase in apoptotic cell death. Seco-Duocarmycin SA can lead to significant cell cycle arrest in S and G2/M phases. Seco-Duocarmycin SA acts as an ADC cytotoxin for antibody-drug conjugates .
    Seco-Duocarmycin SA
  • HY-139742
    ADTL-SA1215
    2 Publications Verification

    Sirtuin Cancer
    ADTL-SA1215 is a first-in-class specific small-molecule activator of SIRT3 that modulates autophagy in triple negative breast cancer.
    ADTL-SA1215
  • HY-135892
    GNE-1858
    3 Publications Verification

    MAP4K Inflammation/Immunology
    GNE-1858 is a potent and ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor, with IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA, respectively .
    GNE-1858
  • HY-111532B

    ClpP Infection
    (3S,4S)-A2-32-01 (compound 24(S,S)), a less active (S,S)-enantiomer of A2-32-01. A2-32-01 is a potent caseinolytic protein proteases (ClpP) inhibitor .
    (3S,4S)-A2-32-01
  • HY-NP163D

    WGA-AF594

    Fluorescent Dye Cancer
    Wheat germ agglutinin-AF594 (WGA-AF594) is a plant lectin that contains the fluorescent dye AF594, which can be used to identify carbohydrate chains. Wheat germ agglutinin-AF594 can be used to assess abnormal glycosylation levels in the body. The specific glycosylation detection sites of Wheat germ agglutinin is bis-GlcNAc, SA .
    Wheat germ agglutinin-AF594
  • HY-171177

    Phosphatase Neurological Disease Cancer
    P5SA-2 is a selective allosteric activator of PPP5C. P5SA-2 exerts its effects by modulating the phosphatase domain of PPP5C and can increase PPP5C activity by 3.2-fold at 100 μM with an apparent affinity constant of 7.8 μM. P5SA-2 can be used in cancer and Alzheimer's disease research .
    P5SA-2
  • HY-126684

    Antibiotic Drug-Linker Conjugates for ADC Cancer
    Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA is a agent-linker conjugate for ADC by using the antitumor antibiotic, Duocarmycin SA, linked via Mal-PEG4-VC-PAB-DMEA-Seco.
    Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA
  • HY-W087988

    Bacterial Sex Pheromone Phytohormone Infection Inflammation/Immunology
    3-Pentanol is an active organic compound produced by plants and is a component of insect-released pheromones. 3-Pentanol can trigger plant immunity against microbial pathogens and pests in crops by activating the SA and JA signaling pathways.
    3-Pentanol
  • HY-NP163E

    WGA-AF647

    Fluorescent Dye Cancer
    Wheat germ agglutinin-AF647 (WGA-AF647) is a plant lectin that contains the fluorescent dye AF647, which can be used to identify carbohydrate chains. Wheat germ agglutinin-AF647 can be used to assess abnormal glycosylation levels in the body. The specific glycosylation detection sites of Wheat germ agglutinin is bis-GlcNAc, SA .
    Wheat germ agglutinin-AF647
  • HY-129356A

    Drug Isomer Cancer
    (S)-Seco-Duocarmycin SA is the S-enantiomer of Seco-Duocarmycin SA (HY-129356). Seco-Duocarmycin SA can be used for cancer research .
    (S)-Seco-Duocarmycin SA
  • HY-18080

    FAAH Autophagy Metabolic Disease
    SA 47 is a selective and potent inhibitor of fatty acid amide hydrolase (FAAH) and carbamate .
    SA 47
  • HY-B0432B
    (S)-Propafenone
    1 Publications Verification

    (S)-SA-79

    Sodium Channel Cardiovascular Disease
    (S)-Propafenone ((S)-SA-79) is the S-enantiomer of Propafenone. (S)-Propafenone ((S)-SA-79) exerts beta-blocking action and the sodium channel-dependent antiarrhythmic class 1 activity .
    (S)-Propafenone
  • HY-171562

    Biochemical Assay Reagents Metabolic Disease
    Cholesterol-SA-PEG2000-Azide is a lipid that can be used for drug delivery. Cholesterol-SA-PEG2000-Azide contains Cholesterol (HY-N0322), Succinic acid (HY-N0420), PEG units and an azide group. Cholesterol-SA-PEG2000-Azide contains an azide group that can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an alkyne group .
    Cholesterol-SA-PEG2000-Azide
  • HY-106446
    Rentiapril
    3 Publications Verification

    SA-446

    Angiotensin-converting Enzyme (ACE) Cardiovascular Disease
    Rentiapril is an orally active angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity .
    Rentiapril
  • HY-164575

    Radionuclide-Drug Conjugates (RDCs) PSMA Cancer
    NH2-NODAGA is a NODAGA-type metal chelator that can bind to radionuclides to prepare radionuclide conjugates (RDCs). NH2-NODAGA can react with diethyl squarate in 0.5M phosphate buffer to obtain NODAGA.SA. NODAGA.SA can target L-lysine urea-L-glutamate (KuE), which is a key structure of prostate-specific membrane antigen (PSMA). NODAGA.SA.KuE can bind [68]Ga and can be used for PET examination of NMRInu/nu nude mice bearing LNCaP tumors.
    NH2-NODAGA
  • HY-NP163

    WGA-AF350

    Fluorescent Dye Cancer
    Wheat germ agglutinin-AF350 (WGA-AF350) is a plant lectin that contains the fluorescent dye AF350, which can be used to identify carbohydrate chains. Wheat germ agglutinin-AF350 can be used to assess abnormal glycosylation levels in the body. The specific glycosylation detection sites of Wheat germ agglutinin is bis-GlcNAc, SA .
    Wheat germ agglutinin-AF350
  • HY-U00074

    SA-446 racemate

    Angiotensin-converting Enzyme (ACE) Cardiovascular Disease
    Rentiapril racemate (SA-446 racemate) is the racemate of Rentiapril. Rentiapril is an angiotensin converting enzyme (ACE) inhibitor.
    Rentiapril racemate
  • HY-155684

    PROTACs VEGFR PDGFR Ephrin Receptor Cancer
    SA-PA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-PA is able to selectively degrade VEGFR-2, PDGFR-β and EphB4 proteins in U87 cells. SA-PA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues .
    SA-PA
  • HY-164364B

    FAP Cancer
    DOTAGA.(SA.FAPi)2 analogue TFA is a DOTAGA.(SA.FAPi)2 TFA (HY-164364A) analogue, in which the ligand and the chelator are identical to those of DOTAGA.(SA.FAPi)2 TFA. DOTAGA.(SA.FAPi)2 TFA is a potent dimeric fibroblast-activation protein inhibitor (FAPi) .
    DOTAGA.(SA.FAPi)2 analogue TFA
  • HY-164364A

    FAP Cancer
    DOTAGA.(SA.FAPi)2 TFA is a potent dimeric fibroblast-activation protein inhibitor (FAPi). DOTAGA.(SA.FAPi)2 TFA has the potential for cancer diagnosis research .
    DOTAGA.(SA.FAPi)2 TFA
  • HY-U00184

    Sesden; SA504

    mAChR Cardiovascular Disease
    Timepidium bromide (Sesden; SA504) is an anticholinergic agent.
    Timepidium bromide
  • HY-103463

    FAAH MAGL Neurological Disease
    SA57 is a potent, selective FAAH inhibitor with IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH. SA57 also inhibits the 2-arachidonoylglycerol hydrolases MAGL (IC50s of 410 nM and 1.4 μM for mouse and human MAGL) and mouse α/β-hydrolase domain-containing protein 6 (mABHD6; IC50 of 850 nM), but not other brain serine hydrolases .
    SA57
  • HY-B0432AS2

    Isotope-Labeled Compounds Sodium Channel Cardiovascular Disease
    Propafenone-d5 (hydrochloride) is the deuterium labeled Propafenone hydrochloride. Propafenone (SA-79) hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias[1].
    Propafenone-d5 hydrochloride
  • HY-165424

    Fluorescent Dye Glycosidase Cardiovascular Disease Cancer
    NIR-BG2 is a near-infrared fluorescent probe targeting senescence-associated β-galactosidase (SA-β-Gal). NIR-BG2 is activated by SA-β-Gal and undergoes hydrolysis to release electrophilic quinone methide that covalently binds to surrounding proteins for in situ labeling, with a 16-fold enhancement of fluorescence signal at 709 nm . NIR-BG2 is promising for research of vivo imaging of cellular senescence .
    NIR-BG2
  • HY-156014

    DNA/RNA Synthesis Infection
    qsl-304 is a DNA gyrase B inhibitor. qsl-304 is an antibacterial agent, with an IC50 of 31.23 mg/mL against the Staphylococcus aureus sa-P2003 .
    qsl-304
  • HY-178285

    Phosphatase Cancer
    VHR-IN-2 (Compound SA9) is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 3.1 μM. VHR-IN-2 can be used for the research of cervical cancer .
    VHR-IN-2
  • HY-178294

    Phosphatase Cancer
    VHR-IN-4 (Compound SA7) is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 1.8 μM. VHR-IN-4 can be used for the research of cervical cancer .
    VHR-IN-4
  • HY-15790H

    (S)-A 3309; (S)-AZD 7806

    Apical Sodium-Dependent Bile Acid Transporter TNF Receptor Interleukin Related Metabolic Disease Inflammation/Immunology
    (S)-Elobixibat is the S enantiomer of Elobixibat (HY-15790). (S)-Elobixibat is an orally effective Apical Sodium-Dependent Bile (IBAT) inhibitor. (S)-Elobixibat decreases LDL cholesterol, increases serum GLP-1, promotes colon motility, and has the potential to study metabolic syndrome. (S)-Elobixibat can be used to study constipation, dyslipidemia, non-alcoholic hepatitis, and liver tumors .
    (S)-Elobixibat
  • HY-NP163I

    WGA-AF 680

    Fluorescent Dye Cancer
    Wheat germ agglutinin-AF680 (WGA-AF 680) is a plant lectin that contains the fluorescent dye AF680, which can be used to identify carbohydrate chains. Wheat germ agglutinin-AF680 can be used to assess abnormal glycosylation levels in the body. The specific glycosylation detection sites of Wheat germ agglutinin is bis-GlcNAc, SA .
    Wheat germ agglutinin-AF680
  • HY-NP163J

    WGA-AF 405

    Fluorescent Dye Cancer
    Wheat germ agglutinin-AF405 (WGA-AF 405) is a plant lectin that contains the fluorescent dye AF405, which can be used to identify carbohydrate chains. Wheat germ agglutinin-AF405 can be used to assess abnormal glycosylation levels in the body. The specific glycosylation detection sites of Wheat germ agglutinin is bis-GlcNAc, SA .
    Wheat germ agglutinin-AF405
  • HY-106427

    TRP Channel Cardiovascular Disease
    SA-13353 is a TRPV1 agonist with cardioprotective effect. SA-13353 can be used for the research of cardiovascular disease .
    SA-13353
  • HY-123120

    Thrombin Others
    SA-152 is an organophosphorus inhibitor. SA-152 modulates the fibrinogen coagulation and TAME esterase activity of bovine α-thrombin .
    SA-152
  • HY-155685

    PROTACs VEGFR Ephrin Receptor Apoptosis Cancer
    SA-VA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-VA is able to selectively degrade VEGFR-2 and EphB4 proteins in U87 cells. SA-VA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues. SA-VA promotes apoptosis and blocks cells in S phase .
    SA-VA
  • HY-150260

    Bacterial Infection
    SA09-Cu is a noncompetitive and potent NDM-1 inhibitor with an IC50 of 9.6 nM. SA09-Cu can convert NDM-1 into an inactive state by oxidizing the Zn(II)-thiolate site of the enzyme and avoids to be reduced by intracellular thiols of bacteria. SA09-Cu exhibits excellent inhibition against a series of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) in restoring the Meropenem (HY-13678) effect, and slows down the development of carbapenem resistance .
    SA09-Cu

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