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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
156 Results for "
SA
" in MedChemExpress (MCE) Product Catalog:
Products (156)
156 Results for "SA" in MCE Product Catalog:
10
10 Publications Verification
Target:
Forschungsgebiete:
ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral .
7
7 Cited Publications
Synonyms: SA4503 dihydrochloride; AGY94806 dihydrochloride
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Forschungsgebiete:
Cutamesine (SA4503) dihydrochloride is a potent and selective sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes. Cutamesine dihydrochloride shows >100-fold less affinity for the sigma 2 receptor (IC50 of 1784 nM). Cutamesine dihydrochloride has antidepressant effects .
7
7 Cited Publications
Synonyms: SA4503; AGY 94806
Target:
Forschungsgebiete:
Cutamesine (SA4503) is a potent and selective sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes. Cutamesine shows >100-fold less affinity for the sigma 2 receptor (IC50 of 1784 nM). Cutamesine has antidepressant effects .
4
4 Cited Publications
Target:
Forschungsgebiete:
ML-SA5 is a potent TRPML1 cation channel agonist that activates the entire endosomal TRPML1 (ML1) current in DMD myocytes with an EC50 of 285 nM and is more potent than ML-SA1. ML-SA5 has anticancer activity and can inhibit tumour growth .
4
4 Cited Publications
Art. -Nr.: HY-N8211
CAS. Nr.: 94987-09-4
3
3 Cited Publications
Target:
Forschungsgebiete:
GNE-1858 is a potent and ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor, with IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA, respectively .
3
Forschungsgebiete:
Rentiapril is an orally active angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity .
2
Target:
Forschungsgebiete:
Propafenone (hydrochloride) (SA-79 (hydrochloride)) is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.
2
Forschungsgebiete:
Propafenone (SA-79), a sodium-channel blocker, acts an antiarrhythmic agent. Propafenone also has high affinity for the β receptor (IC50=32 nM) . Propafenone blocks the transient outward current (Ito) and the sustained delayed rectifier K current (Isus) with IC50 values of 4.9 μm and 8.6 μm, respectively . Propafenone suppresses esophageal cancer proliferation through inducing mitochondrial dysfunction and induce apoptosis .
2
2 Cited Publications
Synonyms: SA96; Thiobutarit
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Forschungsgebiete:
Bucillamine (SA96) is an orally active and potent sulfhydryl donor and antioxidant. Bucillamine is also an antirheumatic agent with antiangiogenic properties. Bucillamine can protect against Ischemia/reperfusion (I/R) injury in high-risk organ transplants. Bucillamine inhibits the production of VEGF. Bucillamine can be used for the research of choroidal neovascularization (CNV) and rheumatoid arthritis (RA) .
2
2 Cited Publications
ADTL-SA1215 is a first-in-class specific small-molecule activator of SIRT3 that modulates autophagy in triple negative breast cancer.
1
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Forschungsgebiete:
(S)-Propafenone ((S)-SA-79) is the S-enantiomer of Propafenone. (S)-Propafenone ((S)-SA-79) exerts beta-blocking action and the sodium channel-dependent antiarrhythmic class 1 activity .
1
1 Cited Publications
Synonyms: GL13; SBB-A-B
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Forschungsgebiete:
SBB-Analogue (GL13) Biotin (GL13; SBB-A-B) consists of a Sudan Black B (SBB) (HY-D0213) derivative conjugated with biotin. SBB-Analogue (GL13) Biotin potently detects senescent cells and eliminates the drawback of false-positive staining caused by serum starvation and cell fusion in SA-β-gal assays. SBB-Analogue (GL13) Biotin can be used in flow cytometry, immunofluorescence analysis, and other applications .
1
1 Cited Publications
Art. -Nr.: HY-P80116
Synonyms: Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody;
Cell growth inhibiting protein 40 antibody;
Cell proliferation inducing protein 61 antibody;
EGF R antibody;
EGFR antibody;
EGFR_HUMAN antibody;
Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) antibody;
Epidermal growth factor receptor antibody;
erb-b2 receptor tyrosine kinase 1 antibody;
ERBB antibody;
ERBB1 antibody;
Errp antibody;
HER1 antibody;
mENA antibody;
NISBD2 antibody;
Oncogen ERBB antibody;
PIG61 antibody;
Proto-oncogene c-ErbB-1 antibody;
Receptor tyrosine protein kinase ErbB 1 antibody;
Receptor tyrosine-protein kinase ErbB-1 antibody;
SA7 antibody;
Species antigen 7 antibody;
Urogastrone antibody;
v-erb-b Avian erythroblastic leukemia viral oncogen homolog antibody;
wa2 antibody;
Wa5 antibody
Forschungsgebiete:
Duocarmycin SA is an orally active antitumor antibiotic with an IC50 of 10 pM . Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro .
Art. -Nr.: HY-P99112
CAS. Nr.: 1535963-91-7
Synonyms: RG-6168; SA-237
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Forschungsgebiete:
Art. -Nr.: HY-N2594
CAS. Nr.: 1357910-26-9
Category:
Infection Oleaceae Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Forsythia suspensa (Thunb.) Vahl Disease Research Fields
Target:
Art. -Nr.: HY-D0893
CAS. Nr.: 199293-83-9
Art. -Nr.: HY-178159
CAS. Nr.: 2244341-81-7
Target:
Forschungsgebiete:
SA91-0178 is a METTL1 inhibitor. SA91-0178 inhibits m 7G methylation of RNA, reduces SARM1 stability, mitigates NAD + depletion and metabolic reprogramming in macrophages. SA91-0178 demonstrates excellent protective efficacy against multiple organ injury in cecal ligation and puncture (CLP)-induced and ischemia/reperfusion (I/R)-induced mice. SA91-0178 can be used for the study of systemic inflammatory diseases .
Art. -Nr.: HY-D2363
Forschungsgebiete:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
