332382-54-4
Chemical Structure
ML-SA1
- No. CAS: 332382-54-4
- Formula:C22H22N2O3
- Molecular Weight:362.42
IUPAC Name: 2-(2-oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione
InChIKey: KDDHBJICVBONAX-UHFFFAOYSA-N
SMILES: O=C1N(CC(N2C(C)(C)CC(C)C3=C2C=CC=C3)=O)C(C4=C1C=CC=C4)=O
Biological Activity: ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral[1].
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ML-SA1 | 99.44% | ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral. | ||||||||||||||||||||
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ML-SA1 (Standard) | ≥98% | ML-SA1 (Standard) is the analytical standard of ML-SA1 (HY-108462). This product is intended for research and analytical applications. ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral. | ||||||||||||||||||||
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Similarity Score 0.53
HY-19818NAN-190 -
Similarity Score 0.53
HY-19818ARNAN-190 hydrobromide (Standard) -
Similarity Score 0.52
HY-126025α-Phthalimidopropiophenone -
Similarity Score 0.52
HY-180296AChE-IN-103 -
Similarity Score 0.51
HY-110258ML334 -
Similarity Score 0.51
HY-110258B(R,S,R)-ML334 -
Similarity Score 0.51
HY-12709RARC 239 (Standard) -
Similarity Score 0.50
HY-75975R(R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione (Standard) -
Similarity Score 0.50
HY-Z3681Rivaroxaban impurity 25 -
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