ARC 239 (Standard)
ARC 239 Standard is the analytical standard of ARC 239 (HY-12709). This product is intended for research and analytical applications. ARC 239 is a selective α2B/C-adrenoceptor antagonist, with pKi values of 5.45, 7.06, and 6.95 for α2A, α2B, and α2C receptors, respectively. ARC 239 selectively antagonizes α2B-AR, blocking norepinephrine signaling and downstream RhoA/ROCK activation and Claudin-5 disruption, without altering plasma norepinephrine levels in the distal tail artery of mice, and does not inhibit α2-adrenoceptor-mediated vasoconstriction. ARC 239 also binds with high affinity to 5-HT1A receptors, with a Ki of 63.1 nM, thereby interfering with subtype-selective α2-adrenoceptor assays. ARC 239 can be used for research on cardiovascular diseases and inflammatory skin diseases.
For research use only. We do not sell to patients.
- CAS No.: 67339-62-2
- Formula: C24H29N3O3
- Molecular Weight:407.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 67339-62-2
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Molecular Weight 407.51
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Formula C24H29N3O3
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SMILES
O=C1N(CCN2CCN(C3=CC=CC=C3OC)CC2)C(C(C)(C)C4=C1C=CC=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Gavin KT, et al. Alpha 2C-adrenoceptors mediate contractile responses to noradrenaline in the human saphenous vein. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):406-11. [Content Brief]
[2]. Meana JJ, et al. The subtype-selective alpha 2-adrenoceptor antagonists BRL 44408 and ARC 239 also recognize 5-HT1A receptors in the rat brain. Eur J Pharmacol. 1996 Oct 3;312(3):385-8. [Content Brief]
[3]. Yu Y, et al. A stress-responsive neurovascular axis shapes skin immune accessibility. iScience. 2026 Mar 20;29(3):115122. [Content Brief]
[4]. Di Cicco E, et al. A TERRA-NONO axis drives fibroblast reprogramming in cancer. Sci Adv. 2026 Oct 2;12(40):eaed3358. [Content Brief]
[5]. Chotani MA, et al. Silent alpha(2C)-adrenergic receptors enable cold-induced vasoconstriction in cutaneous arteries. Am J Physiol Heart Circ Physiol. 2000 Apr;278(4):H1075-83. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ARC 239 (Standard) Related Classifications
HY-12709R Related Classifications
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Keywords
- ARC 239 (Standard)
- 67339-62-2
- Reference Standards
- Adrenergic Receptor
- 5-HT Receptor
- ROCK
- Claudin
- Beta Receptor
- Serotonin Receptor
- 5-hydroxytryptamine Receptor
- Rho-associated protein kinase
- Rho-associated kinase
- Rho-kinase
- ROK
- 5-HT1A receptor
- Claudin-5
- RhoA
- human saphenous vein
- noradrenaline
- vascular leakage
- α1-adrenoceptor
- α2-adrenoceptor
- α2B-adrenoceptor
- Inhibitor
- inhibitor
- inhibit