165377-43-5
165377-43-5
Chemical Structure
Cutamesine
Synonym(s): SA4503; AGY 94806
- CAS No.: 165377-43-5
- Formula:C23H32N2O2
- Molecular Weight:368.51
IUPAC Name: 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine
InChIKey: UVSWWUWQVAQPJR-UHFFFAOYSA-N
SMILES: COC1=CC=C(CCN2CCN(CCCC3=CC=CC=C3)CC2)C=C1OC
Biological Activity: Cutamesine (SA4503) is a potent and selective sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes. Cutamesine shows >100-fold less affinity for the sigma 2 receptor (IC50 of 1784 nM). Cutamesine has antidepressant effects[1][2].
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Cutamesine | 99.18% | Cutamesine (SA4503) is a potent and selective sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes. Cutamesine shows >100-fold less affinity for the sigma 2 receptor (IC50 of 1784 nM). Cutamesine has antidepressant effects. | ||||||||||||||||||||
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References
- [1]. Lever JR, et al. Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse. 2006 May;59(6):350-8. [Content Brief]
- [2]. Ono Y, et al. SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models. Neurosci Lett. 2014 Jan 24;559:174-8. [Content Brief]
Keywords
