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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
Werner protein
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "Werner protein" in MCE Product Catalog:
2
2 Cited Publications
Target:
Research Areas:
H3B-968 is the ATP-competitive inhibitor of Werner syndrome protein (WRN) with an IC50 of about 10 nM .
Cat. No.: HY-168934
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KWR137 is an orally active Werner protein (WRN) inhibitor with a human IC50 of 8 nM. KWR137 inhibits the ATPase activity required for WRN helicase function, induces WRN protein degradation, suppresses cancer cell proliferation, and slows tumor growth without causing weight loss or off-target effects. KWR137 can be used for the research of colorectal cancer .
Cat. No.: HY-178991
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Research Areas:
WRN-IN-21 (Compound 11b) is a WRN helicase inhibitor with pIC50 values for WRN and BLM helicases of 3.6 and 5.4 respectively. WRN-IN-21 can be used for the study of MSI-related cancers .
Cat. No.: HY-182634
CAS No.: 714932-54-4
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Research Areas:
NCGC00063279 is a reversible Werner Syndrome Helicase-Nuclease (WRN) helicase inhibitor with modest selectivity over BLM and FANCJ helicases, and does not inhibit WRN exonuclease activity at active concentrations. NCGC00063279 inhibits Hematopoietic Protein Tyrosine Phosphatase (HePTP) and reduces proliferation of cancer cells. NCGC00063279 can be used for the research of osteosarcoma .
Cat. No.: HY-183610
CAS No.: 3059172-54-9
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Research Areas:
WRN-IN-26 is an orally active Werner syndrome helicase (WRN) inhibitor with a human Ki value of 58.7 μM and an IC50 value of 0.026 μM. WRN-IN-26 selectively targets the cysteine residues of WRN. WRN-IN-26 induces the expression of p21 protein in MSI-H tumor cells. WRN-IN-26 inhibits the growth of MSI-H tumor cells and exhibits potent in vivo efficacy in MSI-H xenograft tumor models. WRN-IN-26 can be used for the research of microsatellite instability-high (MSI-H) cancers .
Cat. No.: HY-P704738
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: WRN; WRN RecQ Like Helicase; RECQL2; RECQ3; Bifunctional 3'-5' Exonuclease/ATP-Dependent Helicase WRN; Werner Syndrome RecQ Like Helicase; DNA Helicase, RecQ-Like Type 3; Werner Syndrome protein; RecQ protein-Like 2; Werner Syndrome ATP-Dependent Helicase
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
