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Yes-associated protein

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標的別:	YAP (6) Apoptosis (1) Autophagy (1) DNA/RNA Synthesis (1) Endogenous Metabolite (1) ERK (1) Ferroptosis (1) Glutathione Peroxidase (1) HSP (1) LPL Receptor (2) Reactive Oxygen Species (ROS) (1) Reference Standards (1) Tyrosinase (1)
研究分野別:	Cancer (5) Cardiovascular Disease (1) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (4)

阻害剤およびアゴニスト

生化学アッセイ試薬

天然物

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Targets Recommended: YAP

製品番号	製品名	Target	研究分野	構造式

HY-13285

Ki16425 Maximum Cited Publications 11 Publications Verification Debio 0719	LPL Receptor YAP	Neurological Disease Cancer
Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with K_is of 0.34 μM and 0.93 μM, respectively. Ki16425 (Debio 0719) reduces the LPA-induced activation of p42/p44 MAPK . Ki16425 can also inhibit LPA-induced dephosphorylation of Yes-associated protein (YAP)/TAZ in HEK293A cells .

HY-Y0669

Pipecolic acid 2 Publications Verification	Endogenous Metabolite YAP Glutathione Peroxidase Ferroptosis	Neurological Disease Metabolic Disease Inflammation/Immunology
Pipecolic acid is an orally bioavailable, blood-brain barrier-permeable metabolite of lysine with antioxidant, inhibitor, and inducer activity. Pipecolic acid modulates the YAP-GPX4 signaling pathway, reduces retinal vascular tube formation, and mitigates ferroptosis. Pipecolic acid potentiates voltage-sensitive Ca ²⁺ channel currents and induces neuronal apoptosis. Pipecolic acid can be used for the research of diabetic retinopathy .

HY-125016

TT-10 2 Publications Verification TAZ-K	YAP	Cardiovascular Disease Cancer
TT-10 (TAZ-K) is an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity. TT-10 can be used for the research of heart diseases accompanied by cardiomyocyte loss .

HY-N0754

Eupalinolide A	YAP HSP Reactive Oxygen Species (ROS) ERK Autophagy Apoptosis Tyrosinase DNA/RNA Synthesis	Neurological Disease Inflammation/Immunology Cancer
Eupalinolide A is a Yes-associated protein (YAP) degrader and HSP70 inducer. Eupalinolide A inhibits osteogenic differentiation of tendon-derived stem cells (TDSCs). Eupalinolide A induces autophagy in hepatocellular carcinoma cells via activating the ROS/ERK signaling pathway. Eupalinolide A protects PAM212 cells from UVB-, Menadione (HY-B0332)-, or heat shock-induced apoptosis. Eupalinolide A alleviates trauma-induced heterotopic ossification (HO) of Achilles tendon and inhibits growth of MHCC97-L and HCCLM3 hepatocellular carcinoma xenograft tumors in mice. Eupalinolide A can be used for the study of traumatic heterotopic ossification of tendons and hepatocellular carcinoma .

HY-157083

mCMY020	YAP	Cancer
mCMY020 is a covalent inhibitor of TEAD. mCMY020 effectively reduces YAP (Yes-associated protein)-driven transcription and selectively slows the proliferation of Hippo-deficient cancer cells. mCMY020 can be used in cancer research .

HY-13285R

Ki16425 (Standard) Debio 0719 (Standard)	LPL Receptor YAP Reference Standards	Neurological Disease Cancer
Ki16425 (Standard) is the analytical standard of Ki16425. This product is intended for research and analytical applications. Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with Kis of 0.34 μM and 0.93 μM, respectively. Ki16425 (Debio 0719) reduces the LPA-induced activation of p42/p44 MAPK . Ki16425 can also inhibit LPA-induced dephosphorylation of Yes-associated protein (YAP)/TAZ in HEK293A cells .

製品番号	製品名	Type

HY-Y0669

Pipecolic acid 2 Publications Verification	生化学アッセイ試薬
Pipecolic acid is an orally bioavailable, blood-brain barrier-permeable metabolite of lysine with antioxidant, inhibitor, and inducer activity. Pipecolic acid modulates the YAP-GPX4 signaling pathway, reduces retinal vascular tube formation, and mitigates ferroptosis. Pipecolic acid potentiates voltage-sensitive Ca ²⁺ channel currents and induces neuronal apoptosis. Pipecolic acid can be used for the research of diabetic retinopathy .

Pipecolic acid

2 Publications Verification

生化学アッセイ試薬

Pipecolic acid is an orally bioavailable, blood-brain barrier-permeable metabolite of lysine with antioxidant, inhibitor, and inducer activity. Pipecolic acid modulates the YAP-GPX4 signaling pathway, reduces retinal vascular tube formation, and mitigates ferroptosis. Pipecolic acid potentiates voltage-sensitive Ca ²⁺ channel currents and induces neuronal apoptosis. Pipecolic acid can be used for the research of diabetic retinopathy .

Eupalinolide A	Structural Classification Classification of Application Fields Melilotus albus Desr. Terpenoids Sesquiterpenes Plants Compositae Inflammation/Immunology Disease Research Fields Source Classification	YAP HSP Reactive Oxygen Species (ROS) ERK Autophagy Apoptosis Tyrosinase DNA/RNA Synthesis
Eupalinolide A is a Yes-associated protein (YAP) degrader and HSP70 inducer. Eupalinolide A inhibits osteogenic differentiation of tendon-derived stem cells (TDSCs). Eupalinolide A induces autophagy in hepatocellular carcinoma cells via activating the ROS/ERK signaling pathway. Eupalinolide A protects PAM212 cells from UVB-, Menadione (HY-B0332)-, or heat shock-induced apoptosis. Eupalinolide A alleviates trauma-induced heterotopic ossification (HO) of Achilles tendon and inhibits growth of MHCC97-L and HCCLM3 hepatocellular carcinoma xenograft tumors in mice. Eupalinolide A can be used for the study of traumatic heterotopic ossification of tendons and hepatocellular carcinoma .

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HY-P704253

	YAP1 Protein, Human (His) Yes-associated protein 1; protein yorkie homolog; Yes-associated protein YAP65 homolog; YAP65; YAP1	Human	E. coli
	YAP1 is a multifunctional transcriptional regulator and an important downstream target in the Hippo signaling pathway, affecting organ size control and tumor suppression through proliferation and apoptosis regulation. STK3/MST2 and STK4/MST1 phosphorylate together with SAV1, inactivating YAP1 and WWTR1/TAZ oncoproteins. YAP1 Protein, Human (His) is the recombinant human-derived YAP1 protein, expressed by E. coli, with C-10*His labeled tag.

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Host:	Rabbit (4)
Reactivity:	Human (4) Rat (4) Mouse (4)
Application:	IHC-P (3) ICC/IF (2) IP (1) WB (4) ELISA (2)
Isotype:	IgG (3) IgG/Kappa (1)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (3) Recombinant (1)
Modification:	Phosphorylated (2) Unmodified (1)

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HY-P86386

	YAP1 Antibody (YA6078) 1 Publications Verification YAP1; YAP65; Yorkie homolog; 65 kDa Yes-associated protein; YAP65	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	YAP1 Antibody (YA6078) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to YAP1.

HY-P80864

	Phospho-YAP1 (Ser127) Antibody (YA136) 1 Publications Verification YAP1; YAP65; Yorkie homolog; 65 kDa Yes-associated protein; YAP65	WB, IHC-P	Human, Mouse, Rat
	Phospho-YAP1 (Ser127) Antibody (YA136) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-YAP1 (Ser127).

HY-P86167

	Phospho-YAP1(Ser127) Antibody (YA5859) YAP1; YAP65; Yorkie homolog; 65 kDa Yes-associated protein; YAP65	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-YAP1(Ser127) Antibody (YA5859) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-YAP1(Ser127).

HY-P80864A

	Phospho-YAP1 (Ser127) Antibody (YA136)(PBS only) YAP1; YAP65; Yorkie homolog; 65 kDa Yes-associated protein; YAP65	WB, IHC-P	Human, Mouse, Rat
	Phospho-YAP1 (Ser127) Antibody (YA136) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-YAP1 (Ser127).

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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