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Zn2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Amino Acid Derivatives (1) Aminopeptidase (3) Amyloid-β (1) Angiotensin-converting Enzyme (ACE) (1) Annexin A (2) Antibiotic (2) Apoptosis (5) Autophagy (6) Bacterial (5) Biochemical Assay Reagents (13) Carboxypeptidase (1) Cholinesterase (ChE) (3) Drug Derivative (1) Drug Intermediate (1) Drug Metabolite (1) Endogenous Metabolite (2) Endonuclease (1) Environmental Pollutants (1) Ferroptosis (1) Fluorescent Dye (17) Fungal (2) GABA Receptor (1) Glycine Receptor (GlyR) (1) GPR39 (5) GSK-3 (1) HDAC (3) Histamine Receptor (1) HIV (1) HSP (1) IAP (1) iGluR (1) Isotope-Labeled Compounds (1) Ligands for Target Protein for PROTAC (1) Lipase (1) Mitophagy (1) MOFs (3) nAChR (1) NF-κB (2) Parasite (1) Prostaglandin Receptor (2) Reactive Oxygen Species (ROS) (4) Reference Standards (6) ROR (1) SOD (1) Tau Protein (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (6) Endocrinology (2) Infection (8) Inflammation/Immunology (8) Metabolic Disease (4) Neurological Disease (13)

By Targets:

5-HT Receptor (1)

Amino Acid Derivatives (1)

Aminopeptidase (3)

Amyloid-β (1)

Angiotensin-converting Enzyme (ACE) (1)

Annexin A (2)

Antibiotic (2)

Apoptosis (5)

Autophagy (6)

Bacterial (5)

Biochemical Assay Reagents (13)

Carboxypeptidase (1)

Cholinesterase (ChE) (3)

Drug Derivative (1)

Drug Intermediate (1)

Drug Metabolite (1)

Endogenous Metabolite (2)

Endonuclease (1)

Environmental Pollutants (1)

Ferroptosis (1)

Fluorescent Dye (17)

Fungal (2)

GABA Receptor (1)

Glycine Receptor (GlyR) (1)

GPR39 (5)

GSK-3 (1)

HDAC (3)

Histamine Receptor (1)

HIV (1)

HSP (1)

IAP (1)

iGluR (1)

Isotope-Labeled Compounds (1)

Ligands for Target Protein for PROTAC (1)

Lipase (1)

Mitophagy (1)

MOFs (3)

nAChR (1)

NF-κB (2)

Parasite (1)

Prostaglandin Receptor (2)

Reactive Oxygen Species (ROS) (4)

Reference Standards (6)

ROR (1)

SOD (1)

Tau Protein (1)

By Research Areas:

Cancer (12)

Cardiovascular Disease (6)

Endocrinology (2)

Infection (8)

Inflammation/Immunology (8)

Metabolic Disease (4)

Neurological Disease (13)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10528

Tasquinimod 15+ Cited Publications ABR-215050	HDAC	Cancer
Tasquinimod is an oral antiangiogenic agent, which has the potential for castration-resistant prostate cancer treatment. Tasquinimod binds to the regulatory Zn ²⁺ binding domain of HDAC4 with K_d of 10-30 nM. Tasquinimod also is a S100A9 inhibitor ^[2] .

HY-101200

Linsidomine hydrochloride SIN-1 chloride	Apoptosis Autophagy Reactive Oxygen Species (ROS) Annexin A NF-κB	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Linsidomine hydrochloride (SIN-1 chloride) is a spontaneous ROS/RNS generator and peroxynitrite donor. Linsidomine hydrochloride is a vasodilator and platelet aggregation inhibitor. Linsidomine hydrochloride induces oxidative stress-induced chondrocyte apoptosis and necrosis. Linsidomine hydrochloride inhibits the migration, proliferation and neointima formation of vascular smooth muscle cells by inhibiting the expression of annexin A2. In addition, low doses of Linsidomine hydrochloride shows protective effects on Zn ²⁺ treated nerve cells ^[2] .

HY-100202

TPEN Maximum Cited Publications 22 Publications Verification TPEDA	MOFs Reactive Oxygen Species (ROS) Apoptosis Autophagy	Cancer
TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. TPEN has a higher affinity for Zn ²⁺, but a lower affinity for Mg ²⁺ and Ca ²⁺. TPEN induces DNA damage and increases intracellular ROS production. TPEN also inhibits cell proliferation and induces apoptosis ^[2] .

HY-14603

Clioquinol 5+ Cited Publications Iodochlorohydroxyquinoline	Environmental Pollutants Antibiotic Autophagy Parasite Fungal Mitophagy	Infection Neurological Disease Inflammation/Immunology Cancer
Clioquinol (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. Clioquinol acts as an oral antimicrobial agent for the research of diarrhea and skin infections. Antibiotic . Clioquinol is a chelator that binds to Zn ²⁺ and Cu ²⁺ with a greater affinity than it binds to Ca ²⁺ and Mg ²⁺. Clioquinol freely crosses the blood-brain barrier. Clioquinol can be used for the study of Alzheimer's disease ^[2].

HY-137255

Taurolithocholic acid 3-sulfate disodium 3-Sulfotaurolithocholic acid disodium	GPR39	Inflammation/Immunology
Taurolithocholic acid 3-sulfate disodium is a GPR39 agonist with EC₅₀s of 71.6  and 69.4 (absence of Zn ²⁺) and 9 and 9.6 μM (presence of Zn ²⁺) in M39-20 and hGPR39-2 cells, respectively. Taurolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn ²⁺ binding sites H17 and H19. Taurolithocholic acid 3-sulfate disodium can be used for the research of gallbladder disease .

HY-16074

ATN-224 4 Publications Verification Bischolinetetrathiomolybdate	SOD	Cancer
ATN-224 is an orally active Cu ²⁺/Zn ²⁺-superoxide dismutase 1 (SOD1) inhibitor. ATN-224 inhibits SOD1 activity in endothelial cells, an effect that is dose dependent with an IC₅₀ of 17.5 nM.

HY-119287

TSQ 5 Publications Verification	Fluorescent Dye	Others
TSQ is a cytosolic zinc ion fluorescence probe that is membrane permeable and can be used for intracellular imaging of zinc proteins (λ_max ~470 nm). TSQ can combine with Zn ²⁺ in the presence of Ca ²⁺ and Mg ²⁺ to produce blue fluorescence (Ex/Em = 334/495 nm) .

HY-W127776

Zn(Ⅱ)-EDTA disodium tetrahydrate Ethylenediaminetetraacetic acid zinc disodium tetrahydrate	Biochemical Assay Reagents	Others
Zn(II)-EDTA (Ethylenediaminetetraacetic acid zinc) disodium tetrahydrate is a coordinating agent. Zn(II)-EDTA disodium tetrahydrate coordinates with Zn ²⁺ to modify its solvated structure, provides pre-synthesized EDTA-Zn complexes that release Zn ²⁺ to repair zinc anode defects under interfacial electric field, adsorbs onto zinc anode surface to block oxygen and water molecules, inhibits corrosion and hydrogen evolution reactions, promotes uniform Zn ²⁺ deposition, suppresses zinc dendrite formation, and modulates the hydrogen bonding network within the electrolyte. Zn(II)-EDTA disodium tetrahydrate acts as an electrolyte additive to enhance reversibility and stability of zinc anodes in aqueous zinc-ion batteries .

HY-113238A

Lithocholic acid 3-sulfate disodium Sulfolithocholic acid disodium; LCAS disodium	GPR39 ROR	Metabolic Disease Inflammation/Immunology
Lithocholic acid 3-sulfate disodium is a GPR39 agonist, with EC₅₀ values of 41 μM and 42.4 μM in M39-20 and hGPR39-2 cells, respectively, in the absence of Zn ²⁺, and 0.88 μM and 0.97 μM in the presence of Zn ²⁺. Lithocholic acid 3-sulfate disodium acts as a RORγt ligand. Lithocholic acid 3-sulfate disodium stimulates the GPR39 receptor to initiate intracellular calcium signaling, independent of the Zn ²⁺-binding sites H17 and H19. LCA-3-S selectively inhibits Th17 cell differentiation by targeting RORγt. Lithocholic acid 3-sulfate disodium can be used in the research of cholestatic liver diseases ^[2].

HY-NP009

α-Lactalbumin	Bacterial	Infection Neurological Disease
α-Lactalbumin is a globular whey protein that exists in milk. α-Lactalbumin binds Ca ²⁺, Mg ²⁺, Mn ²⁺, Na ⁺, K ⁺ and Zn ²⁺ ions; among these, Ca ²⁺ binding enhances protein stability, while Zn ²⁺ binding reduces stability and induces aggregation. α-Lactalbumin forms amyloid fibrils, amorphous aggregates, nanoparticles and nanotubes depending on external conditions. α-Lactalbumin exhibits bactericidal and antiviral activities. α-Lactalbumin has anxiolytic and antidepressant activities, and its effects are enhanced under stress conditions ^[2] .

HY-124171

Zinquin ethyl ester 1 Publications Verification	Fluorescent Dye Drug Derivative	Others
Zinquin ethyl ester is a cell-permeable and lipophilic fluorescent derivative of Zinquin (HY-D0982). Zinquin ethyl ester reacts with protein-bound Zn ²⁺ in cells and forms fluorescent ternary adducts. Zinquin ethyl ester undergoes hydrolysis by intracellular esterases impeding its efflux across the plasma membrane (Ex/Em = 370/470 nm) .

HY-126823

Phen Green SK diacetate (5/6-mixture) PGSK diacetate (5/6-mixture)	Fluorescent Dye	Others
Phen green SK (PGSK) diacetate (PGSK diacetate (5/6-mixture)) is a metal ion-sensitive fluorescent probe that can penetrate cell membranes. Phen green SK (PGSK) diacetate can react with a variety of metal ions, including Fe ²⁺, Cd ²⁺, Co ²⁺, Ni ²⁺, Zn ²⁺, etc. Phen green SK (PGSK) diacetate chelates Fe ²⁺, resulting in fluorescence quenching, which can be restored when a membrane-permeable chelator is added, thereby reflecting the changes in the intracellular chelatable iron pool. The excitation/emission maxima of Phen green SK diacetate are 507/532 nm, respectively ^[2] .

HY-108699

TM-N1324	GPR39	Neurological Disease Endocrinology
TM-N1324 is an agonist of G-Protein-Coupled Receptor 39 (GPR39) with EC₅₀s of 9 nM/5 nM in the presence of Zn ²⁺, and 280 nM/180 nM in the absence of Zn ²⁺ for human/murine GPR39.

HY-B0600

Tafluprost AFP-168; MK2452	Prostaglandin Receptor	Cardiovascular Disease Others
Tafluprost (AFP-168) is an anti-glaucoma prostaglandin (PG) analog. Tafluprost can inhibit the apoptosis of retinal ganglion cells (RGCs) and rat RGCs cells. Tafluprost promotes axon regeneration by regulating Zn ²⁺-mTORpathway, inhibits intracellular lipid accumulation in human preorbital adipocytes. Tafluprost can be used in the study of optic nerve injury in glaucoma ^[2] .

HY-W011060

Cryptand 2.2.2 4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane	Biochemical Assay Reagents	Others
Cryptand 2.2.2 (4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane) is a metal ion chelator. Cryptand 2.2.2 forms stable mononuclear, protonated and dinuclear complexes with copper (II) ions; forms protonated complexes with hydrogen ions; and also forms stable complexes with Zn ²⁺, Co ²⁺, Ni ²⁺, Cd ²⁺, Hg ²⁺ and Pb ²⁺ ions. Cryptand 2.2.2 can be used for the preparation of nanoparticles, transition metal compounds, etc.

HY-D0156

ZnAF-1	Fluorescent Dye	Others
ZnAF-1, a fluorescein-based zinc sensor containing the N,N-bis(2-pyridylmethyl)ethylenediamine chelating unit, can be used for Zn2+ detection . ZnAF-1 can bind Zn(II) with a 1 : 1 stoichiometry .

HY-E70199

Aminopeptidase N (rat) APN/CD13	Aminopeptidase	Cardiovascular Disease
Aminopeptidase N (rat) (APN/CD13) is a Zn ²⁺-dependent membrane-bound exopeptidase that preferentially degrades proteins and peptides with N-terminal neutral amino acids. Aminopeptidase N (rat) is inhibited by angiotensin IV and participates in the regulation of angiotensin IV half-life in the rat striatum ^[2] .

HY-D0982

Zinquin	Fluorescent Dye	Others
Zinquin is a cell-impermeant fluorescent sensor and used to observe reactive Zn ²⁺. λex/λem=368/490 nm.

HY-W587430

Glycolithocholic acid 3-sulfate disodium Glycolithocholate sulfate disodium; Sulfolithocholylglycine disodium; SLCG disodium	HIV GPR39	Infection Inflammation/Immunology
Glycolithocholic acid 3-sulfate disodium is a GPR39 agonist with EC₅₀s of 47.9  and 66.8 μM (absence of Zn ²⁺) and 8 and 8.7 μM (presence of Zn ²⁺) in M39-20 and hGPR39-2 cells, respectively. Glycolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn ²⁺ binding sites H17 and H19. Glycolithocholic acid 3-sulfate disodium also inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate disodium can be used for the research of HIV infection and gallbladder disease ^[2] .

HY-158779

Sulfane sulfur probe 4 SSP4	Fluorescent Dye	Others
Sulfane sulfur probe 4 (SSP4) is a fluorescent probe used to detect sulfane sulfur species (E_x/E_m=494/515 nm). Sulfane sulfur probe 4 exhibits high sensitivity in detecting sulfane sulfur, even in the presence of other substances such as homocysteine, methionine, cysteine, glutathione, N-acetyl-L-cysteine, glycine, tyrosine, tryptophan, arginine, and metal ions (Fe ²⁺, Fe ³⁺, Mg ²⁺, Ca ²⁺, and Zn ²⁺) .

HY-Y1422E

Lipase,Aspergillusniger (Immobilized)	Biochemical Assay Reagents Lipase	Others
Lipase, Aspergillus niger (Immobilized) is an immobilized triacylglycerol acyl hydrolase and biocatalyst. Lipase, Aspergillus niger (Immobilized) broadly catalyzes the hydrolysis of glycerol-long-chain fatty acid esters, exhibits positional selectivity for the 1,3-positions of glycerol, but shows low hydrolysis efficiency for castor oil. Lipase, Aspergillus niger (Immobilized) displays optimal activity at 45°C and pH 7.0, and remains stable at temperatures up to 60°C and over a broad pH range of 2.0-9.0. Lipase, Aspergillus niger (Immobilized) is activated by Ca ²⁺ and Mg ²⁺, but inhibited by Mn ²⁺, Fe ²⁺ and Zn ²⁺ ^[2] .

HY-Y1890B

Cremophor EL-10	Biochemical Assay Reagents	Others
Cremophor EL-10 is a nonionic polyoxyethylene castor oil surfactant with multiple functions including organic solubilizer, mixed zinc anode corrosion inhibitor and dendrite growth inhibitor. By forming a physical barrier to block electrolyte contact and constructing oriented hydration channels to reduce the desolvation energy barrier of Zn ²+ , Cremophor EL-10 achieves a corrosion inhibition efficiency of over 99%. Cremophor EL-10 exerts no significant effects on the mitochondrial activity and cell viability of epithelial cells, making it suitable for in vitro drug delivery and biopharmaceutical research at concentrations ≤10% v/v. However, Cremophor EL-10 may induce sustained non-endothelium-dependent contraction in rat aortic rings and exert concentration-dependent inhibitory effects on acetylcholine-induced endothelium-dependent relaxation responses ^[2] .

HY-Y0850U5

PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) Polyvinyl alcohol (Mw 27000, 98-99% hydrolyzed, ~600 polymerization); Poly(Ethenol) (Mw 27000, 98-99% hydrolyzed, ~600 polymerization)	Biochemical Assay Reagents Fungal	Infection
PVA (Polyvinyl alcohol) (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) is a nonionic ethanol homopolymer with hydrophilicity, water solubility and biodegradability. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) exhibits biocompatibility, non-toxicity and non-carcinogenicity, as well as antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) can serve as a solubilizer, stabilizer, mucoadhesive agent and sustained-release agent, and has a synergistic solubilizing effect on voriconazole/sulfobutyl ether β-cyclodextrin complexes. By stabilizing such complexes, PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) forms freeze-thaw hydrogels with high mucoadhesion, sustained drug release and ex vivo corneal permeability. When compounded with hyaluronic acid hydrogels, PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) supports chondrocyte growth in vitro, and also forms complexes with Cu ²⁺, Co ²⁺, Ni ²⁺ and Zn ²⁺ ions. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) can be used in studies related to fungal keratitis, bacterial infections and fungal infections ^[2] .

HY-137159

Bestatin methyl ester	Aminopeptidase Ligands for Target Protein for PROTAC IAP	Cancer
Bestatin methyl ester is a cell permeable Zn2+-binding aminopeptidases inhibitor. Bestatin methyl ester inhibits spore cell differentiation .

HY-21170E

Zinc trifluoromethanesulfonate Zinc(II) Triflate	Biochemical Assay Reagents	Others
Zinc trifluoromethanesulfonate (Zinc (II) Triflate) is a Zn ²⁺ salt commonly used in potentiometric titration to determine the stability constants of Zn ²⁺-quinoline sulfonamide complexes. Aqueous solutions of Zinc trifluoromethanesulfonate form micellar structures, which result in poor desolvation kinetics of Zn ²⁺ and induce dendrite growth on zinc anodes, failing to support long-term cycling of zinc anodes ^[2] .

HY-E70565

O-Glycoprotease	Endonuclease	Inflammation/Immunology
O-Glycoprotease is an O-glycoprotein-specific endoprotease that catalyzes the hydrolysis of peptide bonds directly adjacent to the O-polymer in native mucin-type O-glycosylated proteins. O-Glycoprotease sequence is from Akkermansia muciniphila, recombinantly expressed in E.coli, with a 6×His tag at the C-terminus. The enzyme maintains high activity between pH 5.5-7.5 and is resistant to 1M NaCl, but is highly sensitive to EDTA (0.5 mM EDTA) and can be inhibited by Zn ²⁺.

HY-D0157

ZnAF-2	Biochemical Assay Reagents	Others
ZnAF-2, 6-iso- is a cell-impermeable compound that acts as a high-affinity Zn2 -specific fluorescent probe (Kd = 2.7 nM). It exhibits low basal fluorescence with an approximately 51-fold increase in fluorescence intensity upon stoichiometric (1:1) binding to Zn2 . Little affinity for Ca2 , Mg2 , Na or K .

HY-D0158

ZnAF-2 DA	Biochemical Assay Reagents	Others
ZnAF-2DAavailable for testing Zn(2+)fluorescence, as Zn(2+)Probe (after esterase hydrolysis).

HY-D1894

5-Br-PAPS	Fluorescent Dye	Others
5-Br-PAPS is a highly specific Zn ²⁺ metallochromic indicator. 5-Br-PAPS is used in assays for measuring free Zn ²⁺ by forming a deeply colored red Zn ²⁺ complex .

HY-D0159

ZnAF-1F	Fluorescent Dye	Others
ZnAF-1F is a potent fluorophore for with an K_d value of 2.2 nM. ZnAF-1F can be used as fluorescent probes for Zn ²⁺ in cells. ZnAF-1F shows λ excitation of 489 nm and λ emission of 514 nm ^[2] .

HY-DY1055

TSQ (solution)	Fluorescent Dye	Others
TSQ (solution) is a cytosolic zinc ion fluorescence probe that is membrane permeable and can be used for intracellular imaging of zinc proteins (λ_max ~470 nm). TSQ can combine with Zn ²⁺ in the presence of Ca ²⁺ and Mg ²⁺ to produce blue fluorescence (Ex/Em = 334/495 nm) . Solvent and concentration: DMSO: 10 mM

HY-D0159A

ZnAF-1F tetraTFA	Fluorescent Dye	Others
ZnAF-1F tetraTFA is a potent fluorophore for with an K_d value of 2.2 nM. ZnAF-1F tetraTFA can be used as fluorescent probes for Zn ²⁺ in cells. ZnAF-1F tetraTFA shows λ excitation of 489 nm and λ emission of 514 nm ^[2] .

HY-W1113135

Carboxymethyl-β-cyclodextrin sodium salt	Biochemical Assay Reagents	Others
Carboxymethyl-β-cyclodextrin sodium salt is a negatively charged β-cyclodextrin derivative, as well as a metal ion chelator and solubilizing reagent. Carboxymethyl-β-cyclodextrin sodium salt forms stable aqueous complexes with Ba ²⁺, Ca ²⁺, Cd ²⁺, Ni ²⁺, Pb ²⁺, Sr ²⁺, and Zn ²⁺ ions. Carboxymethyl-β-cyclodextrin sodium salt derived hydrogel carriers support oral insulin delivery via paracellular permeation across Caco-2 monolayers and produce sustained hypoglycemic effects in diabetic mice. Carboxymethyl-β-cyclodextrin sodium salt can be conjugated onto folate-modified BSA nanoparticles to boost folate receptor-mediated endocytosis, elevate intracellular anticancer drug uptake and trigger cell apoptosis. Carboxymethyl-β-cyclodextrin sodium salt can be utilized for chiral separation in capillary electrophoresis, development of nanoscale drug carriers and nucleic acid transfection research ^[2] .

HY-129200

Aspergillomarasmine A	Endogenous Metabolite	Others
Aspergillomarasmine A is a natural aminopolycarboxylic acid with potent inhibitory activity against class B metallo-β-lactamases (MBLs). Aspergillomarasmine A inactivates MBLs by removing a catalytic Zn2+ cofactor. Aspergillomarasmine A acts as a selective Zn2+ scavenger, promoting the dissociation of the metal cofactor, thereby indirectly inactivating NDM-1. Aspergillomarasmine A causes the loss of Zn2+ ions from the low-affinity binding site of NDM-1. The action of Aspergillomarasmine A results in the rapid degradation of Zn2+-deficient NDM-1, thereby enhancing its potency as a β-lactam enhancer. The mechanism of Aspergillomarasmine A has broad applicability among different Zn2+ chelators .

HY-W856393

Zn2(oxo)(mtz)2	MOFs	Others
Zn2(oxo)(mtz)2 is a metal-organic framework (MOF).

HY-10528R

Tasquinimod (Standard) ABR-215050 (Standard)	Reference Standards HDAC	Cancer
Tasquinimod (Standard) is the analytical standard of Tasquinimod. This product is intended for research and analytical applications. Tasquinimod is an oral antiangiogenic agent, which has the potential for castration-resistant prostate cancer treatment. Tasquinimod binds to the regulatory Zn2+ binding domain of HDAC4 with Kd of 10-30 nM. Tasquinimod also is a S100A9 inhibitor ^[2] .

HY-D1264

PMQA Zn-green	Fluorescent Dye	Others
PMQA (Zn-green), an 8-aminoquinoline-based ratiometric fluorescent sensor, demonstrates the Zn ²⁺-induced redshift of emission (85 nm). PMQA (Zn-green) is a cell membrane-permeable probe and suitable for imaging Zn ²⁺ in living cells .

HY-B0600R

Tafluprost (Standard) AFP-168 (Standard); MK2452 (Standard)	Prostaglandin Receptor Reference Standards	Cardiovascular Disease Others
Tafluprost (Standard) is the analytical standard of Tafluprost. This product is intended for research and analytical applications. Tafluprost (AFP-168) is an anti-glaucoma prostaglandin (PG) analog. Tafluprost can inhibit the apoptosis of retinal ganglion cells (RGCs) and rat RGCs cells. Tafluprost promotes axon regeneration by regulating Zn2+-mTORpathway, inhibits intracellular lipid accumulation in human preorbital adipocytes. Tafluprost can be used in the study of optic nerve injury in glaucoma ^[2] [4] .

HY-D1441

Zinquin AM ester	Fluorescent Dye	Others
Zinquin AM ester is an AM ester form of Zinquin. Zinquin, a fluorescent dye, is a commonly used sensor for cellular Zn ²⁺ status .

HY-B1159S

Nitroxoline-d4 8-Hydroxy-5-nitroquinoline-d₄; 5-Nitro-8-quinolinol-d₄	Bacterial Autophagy Antibiotic	Infection Cancer
Nitroxoline-d₄ is the deuterium labeled Nitroxoline. Nitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline functions by chelating Fe ²⁺ and Zn ²⁺ ions from the biofilm matrix ^[2].

HY-W585934

Fructose-phenylalanine Fru-Phe	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Fructose-phenylalanine (Fru-Phe) is a non-competitive angiotensin-converting enzyme (ACE) inhibitor (IC₅₀ =0.19 mM) with antioxidant activities. Fructose-phenylalanine forms a stable complex with Zn ²⁺ ions at the ACE active site, blocking the conversion of angiotensin I to II and thereby lowering blood pressure. Fructose-phenylalanine is promising for research of cardiovascular diseases ^[2].

HY-10528S

Tasquinimod-d3 ABR-215050-d₃	HDAC Isotope-Labeled Compounds	Cancer
Tasquinimod-d3 (ABR-215050-d3) is the deuterium labeled Tasquinimod (HY-10528). Tasquinimod is an oral antiangiogenic agent, which plays an important role in castration-resistant prostate cancer. Tasquinimod binds to the regulatory Zn ²⁺ binding domain of HDAC4 with K_d of 10-30 nM. Tasquinimod also is a S100A9 inhibitor ^[2] .

HY-136894

Rhod-5N	Fluorescent Dye	Others
Rhod-5N is a cell-impermeant calcium-binding fluorescent dye composed of a BAPTA chelating group and a rhodamine fluorophore. Rhod-5N is often added to MOPS buffer to complex and indicate cation content. The selectivity of Rhod-5N for Cd ²⁺ is higher than other interfering cations ((Na+, K+, Mg ²⁺, Ca ²⁺, Zn ²⁺) except Pb ²⁺), and the detection limit is 3.1 μg/L ^[2].

HY-108699R

TM-N1324 (Standard)	Reference Standards GPR39	Neurological Disease Endocrinology
TM-N1324 (Standard) is the analytical standard of TM-N1324 (HY-108699). This product is intended for research and analytical applications. TM-N1324 is an agonist of G-Protein-Coupled Receptor 39 (GPR39) with EC₅₀s of 9 nM/5 nM in the presence of Zn2+, and 280 nM/180 nM in the absence of Zn2+ for human/murine GPR39.

HY-E70991

D-Ribulose-5-phosphate 3-Epimerase, Baker's yeast (S. cerevisiae)	Biochemical Assay Reagents	Metabolic Disease
D-Ribulose-5-phosphate 3-Epimerase, Baker's yeast (S. cerevisiae) (EC 5.1.3.1) is a metalloenzyme that primarily utilizes divalent zinc ions (Zn2+) for catalysis.

HY-E71172

1,8-Cineole synthase	Biochemical Assay Reagents	Others
1,8-Cineole synthase (EC 4.2.3.108) requires either Mn2+ or Zn2+. 1,8-Cineole is the major product of 1,8-Cineole synthase (EC 4.2.3.108).

HY-W002356

2-Pyridinecarbothioamide	Drug Intermediate	Others
2-Pyridinecarbothioamide is a building block, that can be used for synthesis of Zn ²⁺ responsive fluorescent probe .

HY-171029

C902	Amino Acid Derivatives	Others
C902 is a cysteine residue in the RAG1 protein, that binds to Zn ²⁺ ion and contributes to the DNA cleavage .

HY-162158

DA ZP1	Fluorescent Dye	Others
DA ZP1 is a fluorogenic Zn(II) sensor (K_d Zn ²⁺ = 0.6 nM) . Ex / Em = 490 / 522 nm

HY-100202R

TPEN (Standard) TPEDA (Standard)	Reactive Oxygen Species (ROS) Reference Standards Apoptosis Autophagy	Cancer
TPEN (Standard) is the analytical standard of TPEN (HY-100202). This product is intended for research and analytical applications. TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. TPEN has a higher affinity for Zn2+, but a lower affinity for Mg2+ and Ca2+. TPEN induces DNA damage and increases intracellular ROS production. TPEN also inhibits cell proliferation and induces apoptosis ^[2] .

Cat. No.	Product Name	Type

HY-119287

TSQ 5 Publications Verification	Fluorescent Dye
TSQ is a cytosolic zinc ion fluorescence probe that is membrane permeable and can be used for intracellular imaging of zinc proteins (λ_max ~470 nm). TSQ can combine with Zn ²⁺ in the presence of Ca ²⁺ and Mg ²⁺ to produce blue fluorescence (Ex/Em = 334/495 nm) .

HY-124171

Zinquin ethyl ester 1 Publications Verification	Fluorescent Dye
Zinquin ethyl ester is a cell-permeable and lipophilic fluorescent derivative of Zinquin (HY-D0982). Zinquin ethyl ester reacts with protein-bound Zn ²⁺ in cells and forms fluorescent ternary adducts. Zinquin ethyl ester undergoes hydrolysis by intracellular esterases impeding its efflux across the plasma membrane (Ex/Em = 370/470 nm) .

HY-D0156

ZnAF-1	Fluorescent Dye
ZnAF-1, a fluorescein-based zinc sensor containing the N,N-bis(2-pyridylmethyl)ethylenediamine chelating unit, can be used for Zn2+ detection . ZnAF-1 can bind Zn(II) with a 1 : 1 stoichiometry .

HY-D0982

Zinquin	Fluorescent Dye
Zinquin is a cell-impermeant fluorescent sensor and used to observe reactive Zn ²⁺. λex/λem=368/490 nm.

HY-158779

Sulfane sulfur probe 4

SSP4

Fluorescent Dye

Sulfane sulfur probe 4 (SSP4) is a fluorescent probe used to detect sulfane sulfur species (E_x/E_m=494/515 nm). Sulfane sulfur probe 4 exhibits high sensitivity in detecting sulfane sulfur, even in the presence of other substances such as homocysteine, methionine, cysteine, glutathione, N-acetyl-L-cysteine, glycine, tyrosine, tryptophan, arginine, and metal ions (Fe ²⁺, Fe ³⁺, Mg ²⁺, Ca ²⁺, and Zn ²⁺) .

HY-D1894

5-Br-PAPS	Fluorescent Dye
5-Br-PAPS is a highly specific Zn ²⁺ metallochromic indicator. 5-Br-PAPS is used in assays for measuring free Zn ²⁺ by forming a deeply colored red Zn ²⁺ complex .

HY-D0159

ZnAF-1F	Fluorescent Dye
ZnAF-1F is a potent fluorophore for with an K_d value of 2.2 nM. ZnAF-1F can be used as fluorescent probes for Zn ²⁺ in cells. ZnAF-1F shows λ excitation of 489 nm and λ emission of 514 nm ^[2] .

HY-DY1055

TSQ (solution)	Fluorescent Dye
TSQ (solution) is a cytosolic zinc ion fluorescence probe that is membrane permeable and can be used for intracellular imaging of zinc proteins (λ_max ~470 nm). TSQ can combine with Zn ²⁺ in the presence of Ca ²⁺ and Mg ²⁺ to produce blue fluorescence (Ex/Em = 334/495 nm) . Solvent and concentration: DMSO: 10 mM

HY-D0159A

ZnAF-1F tetraTFA	Fluorescent Dye
ZnAF-1F tetraTFA is a potent fluorophore for with an K_d value of 2.2 nM. ZnAF-1F tetraTFA can be used as fluorescent probes for Zn ²⁺ in cells. ZnAF-1F tetraTFA shows λ excitation of 489 nm and λ emission of 514 nm ^[2] .

HY-D1264

PMQA Zn-green	Fluorescent Dye
PMQA (Zn-green), an 8-aminoquinoline-based ratiometric fluorescent sensor, demonstrates the Zn ²⁺-induced redshift of emission (85 nm). PMQA (Zn-green) is a cell membrane-permeable probe and suitable for imaging Zn ²⁺ in living cells .

HY-136894

Rhod-5N	Fluorescent Dye
Rhod-5N is a cell-impermeant calcium-binding fluorescent dye composed of a BAPTA chelating group and a rhodamine fluorophore. Rhod-5N is often added to MOPS buffer to complex and indicate cation content. The selectivity of Rhod-5N for Cd ²⁺ is higher than other interfering cations ((Na+, K+, Mg ²⁺, Ca ²⁺, Zn ²⁺) except Pb ²⁺), and the detection limit is 3.1 μg/L ^[2].

HY-D2958

ZP1BG	Fluorescent Dye
ZP1BG is a SNAP tag fluorescent probe for detecting Zn ²⁺, which is formed by the covalent connection of the zinc sensor ZP1 from the Zinpyr family with the benzyl guanine group. ZP1BG can be used to detect the concentration of Zn ²⁺ in neuronal organelles such as the Golgi apparatus and mitochondria .

HY-DY1083

Zinquin (solution)	Fluorescent Dye
Zinquin (solution) is a cell-impermeant fluorescent sensor and used to observe reactive Zn ²⁺. λex/λem=368/490 nm. Solvent and concentration: DMSO: 5 mM

HY-D3226

Zinc(II) probe-1

Fluorescent Dye

Zinc (II) probe-1 (Compound DNP) is a dual-color Fluorescent probe that can simultaneously monitor Zn ²⁺ and H ⁺. Upon interaction with Zn ²⁺, Zinc (II) probe-1 produces bright blue fluorescence (excitation wavelength: 405 nm; blue channel wavelength: 420-500 nm). Upon interaction with H ⁺, Zinc (II) probe-1 exhibits red fluorescence (excitation wavelength: 561 nm; red channel emission wavelength: 630-730 nm). Zinc (II) probe-1 can be used in studies related to depression .

Cat. No.	Product Name	Type

HY-137255

Taurolithocholic acid 3-sulfate disodium

3-Sulfotaurolithocholic acid disodium

Biochemical Assay Reagents

Taurolithocholic acid 3-sulfate disodium is a GPR39 agonist with EC₅₀s of 71.6  and 69.4 (absence of Zn ²⁺) and 9 and 9.6 μM (presence of Zn ²⁺) in M39-20 and hGPR39-2 cells, respectively. Taurolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn ²⁺ binding sites H17 and H19. Taurolithocholic acid 3-sulfate disodium can be used for the research of gallbladder disease .

HY-W127776

Zn(Ⅱ)-EDTA disodium tetrahydrate

Ethylenediaminetetraacetic acid zinc disodium tetrahydrate

Biochemical Assay Reagents

Zn(II)-EDTA (Ethylenediaminetetraacetic acid zinc) disodium tetrahydrate is a coordinating agent. Zn(II)-EDTA disodium tetrahydrate coordinates with Zn ²⁺ to modify its solvated structure, provides pre-synthesized EDTA-Zn complexes that release Zn ²⁺ to repair zinc anode defects under interfacial electric field, adsorbs onto zinc anode surface to block oxygen and water molecules, inhibits corrosion and hydrogen evolution reactions, promotes uniform Zn ²⁺ deposition, suppresses zinc dendrite formation, and modulates the hydrogen bonding network within the electrolyte. Zn(II)-EDTA disodium tetrahydrate acts as an electrolyte additive to enhance reversibility and stability of zinc anodes in aqueous zinc-ion batteries .

HY-113238A

Lithocholic acid 3-sulfate disodium

Sulfolithocholic acid disodium; LCAS disodium

Biochemical Assay Reagents

Lithocholic acid 3-sulfate disodium is a GPR39 agonist, with EC₅₀ values of 41 μM and 42.4 μM in M39-20 and hGPR39-2 cells, respectively, in the absence of Zn ²⁺, and 0.88 μM and 0.97 μM in the presence of Zn ²⁺. Lithocholic acid 3-sulfate disodium acts as a RORγt ligand. Lithocholic acid 3-sulfate disodium stimulates the GPR39 receptor to initiate intracellular calcium signaling, independent of the Zn ²⁺-binding sites H17 and H19. LCA-3-S selectively inhibits Th17 cell differentiation by targeting RORγt. Lithocholic acid 3-sulfate disodium can be used in the research of cholestatic liver diseases ^[2].

HY-NP009

α-Lactalbumin

Biochemical Assay Reagents

α-Lactalbumin is a globular whey protein that exists in milk. α-Lactalbumin binds Ca ²⁺, Mg ²⁺, Mn ²⁺, Na ⁺, K ⁺ and Zn ²⁺ ions; among these, Ca ²⁺ binding enhances protein stability, while Zn ²⁺ binding reduces stability and induces aggregation. α-Lactalbumin forms amyloid fibrils, amorphous aggregates, nanoparticles and nanotubes depending on external conditions. α-Lactalbumin exhibits bactericidal and antiviral activities. α-Lactalbumin has anxiolytic and antidepressant activities, and its effects are enhanced under stress conditions ^[2] .

HY-W011060

Cryptand 2.2.2

4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane

Biochemical Assay Reagents

Cryptand 2.2.2 (4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane) is a metal ion chelator. Cryptand 2.2.2 forms stable mononuclear, protonated and dinuclear complexes with copper (II) ions; forms protonated complexes with hydrogen ions; and also forms stable complexes with Zn ²⁺, Co ²⁺, Ni ²⁺, Cd ²⁺, Hg ²⁺ and Pb ²⁺ ions. Cryptand 2.2.2 can be used for the preparation of nanoparticles, transition metal compounds, etc.

HY-Y1890B

Cremophor EL-10

Biochemical Assay Reagents

Cremophor EL-10 is a nonionic polyoxyethylene castor oil surfactant with multiple functions including organic solubilizer, mixed zinc anode corrosion inhibitor and dendrite growth inhibitor. By forming a physical barrier to block electrolyte contact and constructing oriented hydration channels to reduce the desolvation energy barrier of Zn ²+ , Cremophor EL-10 achieves a corrosion inhibition efficiency of over 99%. Cremophor EL-10 exerts no significant effects on the mitochondrial activity and cell viability of epithelial cells, making it suitable for in vitro drug delivery and biopharmaceutical research at concentrations ≤10% v/v. However, Cremophor EL-10 may induce sustained non-endothelium-dependent contraction in rat aortic rings and exert concentration-dependent inhibitory effects on acetylcholine-induced endothelium-dependent relaxation responses ^[2] .

HY-Y0850U5

PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization)

Polyvinyl alcohol (Mw 27000, 98-99% hydrolyzed, ~600 polymerization); Poly(Ethenol) (Mw 27000, 98-99% hydrolyzed, ~600 polymerization)

Biochemical Assay Reagents

PVA (Polyvinyl alcohol) (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) is a nonionic ethanol homopolymer with hydrophilicity, water solubility and biodegradability. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) exhibits biocompatibility, non-toxicity and non-carcinogenicity, as well as antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) can serve as a solubilizer, stabilizer, mucoadhesive agent and sustained-release agent, and has a synergistic solubilizing effect on voriconazole/sulfobutyl ether β-cyclodextrin complexes. By stabilizing such complexes, PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) forms freeze-thaw hydrogels with high mucoadhesion, sustained drug release and ex vivo corneal permeability. When compounded with hyaluronic acid hydrogels, PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) supports chondrocyte growth in vitro, and also forms complexes with Cu ²⁺, Co ²⁺, Ni ²⁺ and Zn ²⁺ ions. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) can be used in studies related to fungal keratitis, bacterial infections and fungal infections ^[2] .

HY-D0157

ZnAF-2	Biochemical Assay Reagents
ZnAF-2, 6-iso- is a cell-impermeable compound that acts as a high-affinity Zn2 -specific fluorescent probe (Kd = 2.7 nM). It exhibits low basal fluorescence with an approximately 51-fold increase in fluorescence intensity upon stoichiometric (1:1) binding to Zn2 . Little affinity for Ca2 , Mg2 , Na or K .

HY-D0158

ZnAF-2 DA	Biochemical Assay Reagents
ZnAF-2DAavailable for testing Zn(2+)fluorescence, as Zn(2+)Probe (after esterase hydrolysis).

HY-W011060R

Cryptand 2.2.2 (Standard)

4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane (Standard)

Biochemical Assay Reagents

Cryptand 2.2.2 (Standard) is the analytical standard of Cryptand 2.2.2 (HY-W011060). This product is intended for research and analytical applications. Cryptand 2.2.2 is a metal ion chelating agent that can selectively form complexes with metal ions. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn ²⁺, Co ²⁺, Ni ²⁺, Cu ²⁺). Cryptand 2.2.2 can be used in the preparation of nanoparticles, transition metal compounds, and so on .

Cat. No.	Product Name	Target	Research Area

HY-P1285

Conantokin R Con-R	iGluR	Neurological Disease
Conantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC₅₀ of 93 nM. Conantokin R binds Zn ²⁺ and Mg ²⁺ with K_ds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity ^[2].

Cat. No.	Product Name

HY-K0256

Chelating Agarose (IDA) 6FF
MCE Chelating Agarose (IDA) 6FF allows flexible chelation with metal ions such as Zn²⁺, Ni²⁺, or Cu²⁺, and is suitable for the purification of His-tagged recombinant proteins expressed in bacterial, mammalian, insect, and baculovirus systems.

HY-K0255

IMAC Agarose (NTA) 6FF

MCE IMAC Agarose (NTA) 6FF is prepared by covalently coupling tetradentate nitrilotriacetic acid (NTA) to an agarose matrix. It features high binding capacity, excellent specificity, and superior ligand stability. The resin allows flexible chelation with metal ions such as Zn²⁺, Ni²⁺, or Cu²⁺, and is suitable for the purification of His-tagged recombinant proteins expressed in bacterial, mammalian, insect, and baculovirus systems.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-129200

Aspergillomarasmine A	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite
Aspergillomarasmine A is a natural aminopolycarboxylic acid with potent inhibitory activity against class B metallo-β-lactamases (MBLs). Aspergillomarasmine A inactivates MBLs by removing a catalytic Zn2+ cofactor. Aspergillomarasmine A acts as a selective Zn2+ scavenger, promoting the dissociation of the metal cofactor, thereby indirectly inactivating NDM-1. Aspergillomarasmine A causes the loss of Zn2+ ions from the low-affinity binding site of NDM-1. The action of Aspergillomarasmine A results in the rapid degradation of Zn2+-deficient NDM-1, thereby enhancing its potency as a β-lactam enhancer. The mechanism of Aspergillomarasmine A has broad applicability among different Zn2+ chelators .

HY-N15079

Arphamenine B	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Arphamenine B is a Zn ²⁺-dependent exopeptidase that selectively removes arginine and/or lysine residues from the NH2-terminus of several peptide substrates. Arphamenine B is an inhibitor of aminopeptidase B that can be isolated from bacteria. Arphamenine B enhances the immune response and is used to characterize novel proteases ^[2] .

HY-W722245

Pyochelin	Structural Classification Monophenols Microorganisms Ketones, Aldehydes, Acids Phenols Source Classification	Endogenous Metabolite Bacterial
Pyochelin is a salicylate-based nonribosomal peptide siderophore produced by Pseudomonas aeruginosa. Pyochelin chelates Fe ³⁺ and transports it back into bacterial cells, providing the iron essential for bacterial survival. Pyochelin can also chelate other metals such as Zn ²⁺, Co ²⁺, and Ni ²⁺, which helps bacteria maintain intracellular metal ion homeostasis by chelating and excreting excess metals in response to toxic metal stress. Pyochelin can be used in studies related to Pseudomonas aeruginosa infection ^[2] .

Cat. No.	Product Name	Chemical Structure

HY-B1159S

Nitroxoline-d4
Nitroxoline-d₄ is the deuterium labeled Nitroxoline. Nitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline functions by chelating Fe ²⁺ and Zn ²⁺ ions from the biofilm matrix ^[2].

HY-10528S

Tasquinimod-d3
Tasquinimod-d3 (ABR-215050-d3) is the deuterium labeled Tasquinimod (HY-10528). Tasquinimod is an oral antiangiogenic agent, which plays an important role in castration-resistant prostate cancer. Tasquinimod binds to the regulatory Zn ²⁺ binding domain of HDAC4 with K_d of 10-30 nM. Tasquinimod also is a S100A9 inhibitor ^[2] .

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