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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
acetyl-H3K27
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "acetyl-H3K27" in MCE Product Catalog:
4
4 Cited Publications
Cat. No.: HY-P2161B
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Cat. No.: HY-P5544
CAS No.: 60230-21-9
Synonyms: N-acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid
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Cat. No.: HY-P2161
CAS No.: 872719-49-8
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Cat. No.: HY-P2115
CAS No.: 127932-90-5
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Cat. No.: HY-181758
CAS No.: 3109024-12-3
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PROTAC CBP/p300/BRD4 Degrader-1 is a dual-target PROTAC degrader with DC50 values of 8.8 pM (BRD4), 6.55 nM (CBP), and 1.05 nM (p300). PROTAC CBP/p300/BRD4 Degrader-1 induces CRBN- and proteasome-dependent degradation of BRD4 and CBP/p300, downregulates c-Myc and acetyl-H3K27, induces apoptosis. PROTAC CBP/p300/BRD4 Degrader-1 acts as an antiproliferative and antitumor agent, induces tumor growth inhibition in xenograft models. PROTAC CBP/p300/BRD4 Degrader-1 can be used for the research of prostate cancer and colorectal cancer .
Cat. No.: HY-P5544A
Synonyms: N-acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid TFA
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Cat. No.: HY-P2161A
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Cat. No.: HY-181759
CAS No.: 3086024-48-5
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CBP/p300/BRD4 ligand-1 is a small-molecule inhibitor targeting CBP, p300, and BRD4. CBP/p300/BRD4 ligand-1 competitively binds to the functional domains of target proteins without disrupting key interactions. CBP/p300/BRD4 ligand-1 can be used for the construction of dual-target PROTAC degraders (HY-181758) in studies related to prostate cancer and other cancers .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
