2. PROTAC Epigenetics
  3. Ligands for Target Protein for PROTAC Epigenetic Reader Domain Histone Acetyltransferase
  4. CBP/p300/BRD4 ligand-1

CBP/p300/BRD4 ligand-1 is a small-molecule inhibitor targeting CBP, p300, and BRD4. CBP/p300/BRD4 ligand-1 competitively binds to the functional domains of target proteins without disrupting key interactions. CBP/p300/BRD4 ligand-1 can be used for the construction of dual-target PROTAC degraders (HY-181758) in studies related to prostate cancer and other cancers.

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CBP/p300/BRD4 ligand-1

CBP/p300/BRD4 ligand-1 Chemical Structure

CAS No. : 3086024-48-5

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CBP/p300/BRD4 ligand-1 Related Antibodies

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Description

CBP/p300/BRD4 ligand-1 is a small-molecule inhibitor targeting CBP, p300, and BRD4. CBP/p300/BRD4 ligand-1 competitively binds to the functional domains of target proteins without disrupting key interactions. CBP/p300/BRD4 ligand-1 can be used for the construction of dual-target PROTAC degraders (HY-181758) in studies related to prostate cancer and other cancers[1].

IC50 & Target[1]

BRD4 (BD1)

 

BRD4 (BD2)

 

CBP

 

p300

 

In Vitro

CBP/p300/BRD4 ligand-1 (compound 6) (1 μM starting concentration, 3-fold serial dilution; 30 minutes-2 hours) exhibits inhibitory activity against CBP, p300, BRD4 (BD1) and BRD4 (BD2) in in vitro biochemical assays, with potency comparable to that of NEO2734 (HY-136938)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CBP/p300/BRD4 ligand-1 Related Antibodies
Molecular Weight

434.45

Formula

C22H25F3N4O2
CAS No.
SMILES

CC1=CC(C(C=C2N3CCOC(F)(F)F)=CC=C2N=C3C4CCNCC4)=CN(C1=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CBP/p300/BRD4 ligand-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CBP/p300/BRD4 ligand-13086024-48-5Ligands for Target Protein for PROTACEpigenetic Reader DomainHistone AcetyltransferaseTarget Protein-binding MoietyHATsHATc-Mycacetyl-H3K27CRBNxenograft modelsCBP/p300colorectal cancerPC-3 prostate cancer cellsBRD4proteasomeprostate cancerInhibitorinhibitorinhibit

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CBP/p300/BRD4 ligand-1
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