CBP/p300/BRD4 ligand-1
CBP/p300/BRD4 ligand-1 is a small-molecule inhibitor targeting CBP, p300, and BRD4. CBP/p300/BRD4 ligand-1 competitively binds to the functional domains of target proteins without disrupting key interactions. CBP/p300/BRD4 ligand-1 can be used for the construction of dual-target PROTAC degraders (HY-181758) in studies related to prostate cancer and other cancers.
For research use only. We do not sell to patients.
- CAS No.: 3086024-48-5
- Formula: C22H25F3N4O2
- Molecular Weight:434.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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BRD4 (BD1) |
BRD4 (BD2) |
CBP |
p300 |
CBP/p300/BRD4 ligand-1 (compound 6) (1 μM starting concentration, 3-fold serial dilution; 30 minutes-2 hours) exhibits inhibitory activity against CBP, p300, BRD4 (BD1) and BRD4 (BD2) in in vitro biochemical assays, with potency comparable to that of NEO2734 (HY-136938)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3086024-48-5
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Molecular Weight 434.45
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Formula C22H25F3N4O2
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SMILES
CC1=CC(C(C=C2N3CCOC(F)(F)F)=CC=C2N=C3C4CCNCC4)=CN(C1=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CBP/p300/BRD4 ligand-1 Related Classifications
HY-181759 Related Classifications
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