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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
adriamycin
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "adriamycin" in MCE Product Catalog:
698
698 Publications Verification
Synonyms: Hydroxydaunorubicin hydrochloride; ADR
2
2 Cited Publications
Cat. No.: HY-121309
CAS No.: 24385-10-2
Synonyms: adriamycin aglycone; adriamycinone
Cat. No.: HY-15142A
CAS No.: 23214-92-8
Synonyms: Hydroxydaunorubicin
Category:
Infection Quinones Anthraquinones Phenols Polyphenols Plants Solanaceae Disease Research Fields Rhizophora mucronata Lam
Target:
Cat. No.: HY-106556
CAS No.: 54083-22-6
Synonyms: Rubidazon; Rubidazone
Target:
Research Areas:
Zorubicin (Rubidazon) is a derivative of Daunorubicin (HY-13062A). Zorubicin interacts with topoisomerase II and inhibits DNA polymerases. Zorubicin can be used for the research of acute leukemias and sarcomas .
Cat. No.: HY-121309R
CAS No.: 24385-10-2
Synonyms: adriamycin aglycone (Standard); adriamycinone (Standard)
Category:
Cat. No.: HY-144774
CAS No.: 2513461-95-3
Target:
Research Areas:
Topoisomerase I inhibitor 5 is an effective topoisomerase inhibitor with IC50 value of. Topoisomerase I inhibitor 5 can interfere with DNA and significantly inhibit the activity of Topoisomerase I. Topoisomerase I inhibitor 5 can arrest cell cycle at the G1 phase and induce MCF-7 cells apoptosis. Topoisomerase I inhibitor 5 has potency in reversing P-gp-mediated resistance to Adriamycin .
Cat. No.: HY-176421
CAS No.: 3070438-85-3
Target:
PROTACs PI3K Apoptosis Akt Bcl-2 Family Caspase P-glycoprotein
Research Areas:
PROTAC PI3K/110β degrader-1 is a VHL-recruiting PROTAC degrader targeting PI3K/110β, with DC50 values of 0.416 μM (MCF-7) and 19.66 μM (A549), respectively. PROTAC PI3K/110β degrader-1 recruits VHL to induce proteasomal degradation of PI3K/110β. It activates endoplasmic reticulum stress (ERS)-mediated mitochondrial apoptosis via the PERK/ATF4/CHOP unfolded protein response (UPR) pathway, downregulates p-AKT and Bcl-2, upregulates Bax, cleaved-caspase-9 and cleaved-caspase-3, inhibits the expression and activity of P-gp, and exerts synergistic anti-tumor effects with Doxorubicin (Adriamycin, ADM) (HY-15142A) and Cisplatin (DDP) (HY-17394). PROTAC PI3K/110β degrader-1 can be used in research related to multidrug-resistant cancers .
Cat. No.: HY-113771
CAS No.: 99260-70-5
Category:
Target:
Cat. No.: HY-N13868
CAS No.: 99260-69-2
Category:
Target:
Cat. No.: HY-N13870
CAS No.: 99260-66-9
Category:
Target:
Cat. No.: HY-151165R
CAS No.: 2810894-92-7
Target:
Research Areas:
Quinizarin (Standard) is the analytical standard of Quinizarin. This product is intended for research and analytical applications. Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (Kd=86.1 μM). Quinizarin is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth .
Cat. No.: HY-117285
CAS No.: 60227-09-0
Synonyms: Lactoquinomycin A; LQM-A
Category:
Target:
Cat. No.: HY-N14774
CAS No.: 101342-94-3
Category:
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Cat. No.: HY-126802
CAS No.: 99260-68-1
Category:
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Cat. No.: HY-N17419
CAS No.: 790234-59-2
Target:
Cat. No.: HY-106326
CAS No.: 116521-53-0
Synonyms: FAD 104
ME 2303 (FAD 104) is a fluoro-pyranosyl adriamycin analogue with anti-tumor potential. ME 2303 can inhibit the proliferation of acute undifferentiated myeloblastic leukemia (AML) blast cells in a dose-dependent manner. ME 2303 can be used for the study of acute undifferentiated myeloblastic leukemia (AML) .
Cat. No.: HY-19211
CAS No.: 207862-44-0
Target:
Research Areas:
KW-2170 hydrochloride is an alkylating agent and topoisomerase II inhibitor. KW-2170 hydrochloride stabilizes the topoisomerase II-DNA complex, causing DNA double-strand breaks, thereby preventing DNA replication and transcription, and ultimately leading to the death of tumor cells. KW-2170 hydrochloride exhibits potent and broad-spectrum anti-tumor activity in various mouse and human tumor models. KW-2170 hydrochloride can be used in the research of solid tumors .
Cat. No.: HY-181556
CAS No.: 3085181-00-3
Target:
Research Areas:
JNK3-IN-10 is a blood-brain barrier-impermeable JNK3 inhibitor (IC50=0.257 nM) with over 400-fold selectivity over JNK1. JNK3-IN-10 blocks the JNK3-mediated signaling pathway downstream of TGF-β1, inhibits TGF-β1-induced phosphorylation of c-Jun, reduces the expression of pro-fibrotic markers, and restores the expression of the epithelial protein E-cadherin. JNK3-IN-10 exhibits low cytotoxicity, anti-fibrotic, cytoprotective and renoprotective effects, and alleviates albuminuria, glomerulosclerosis and podocyte foot process fusion. JNK3-IN-10 can be used for the research of chronic kidney disease, glomerulosclerosis and adriamycin-induced nephropathy .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
