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aids

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (3) Antibiotic (3) Apoptosis (17) Autophagy (1) Bacterial (5) Biochemical Assay Reagents (5) Calcium Channel (10) CDK (1) CMV (6) Cytochrome P450 (1) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (7) Drug Intermediate (2) Drug Metabolite (2) EBV (1) Endogenous Metabolite (10) Environmental Pollutants (1) Epigenetic Reader Domain (2) Fungal (1) Glucocorticoid Receptor (3) HBV (1) HIV (99) HIV Integrase (6) HIV Protease (24) HSV (1) Interleukin Related (6) Isotope-Labeled Compounds (11) JNK (6) Ligands for Target Protein for PROTAC (1) Liposome (2) Microtubule/Tubulin (1) mRNA (2) NF-κB (1) NO Synthase (6) Nucleoside Antimetabolite/Analog (2) OAT (3) Orthopoxvirus (4) p38 MAPK (6) Parasite (3) PKA (2) Potassium Channel (1) Progesterone Receptor (4) PROTACs (2) RAR/RXR (1) Reactive Oxygen Species (ROS) (7) Reference Standards (16) Reverse Transcriptase (24) SARS-CoV (8) Toll-like Receptor (TLR) (6) Virus Protease (1) β-glucuronidase (1)
By Research Areas:	Cancer (32) Cardiovascular Disease (11) Endocrinology (1) Infection (120) Inflammation/Immunology (34) Metabolic Disease (7) Neurological Disease (15)
Oligonucleotides:	Chemokine & Receptors (1) Cationic Lipids (1) mRNA (2) Antisense Oligonucleotides (1)

150

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-90001

Ritonavir 30+ Cited Publications ABT 538; RTV	HIV Protease HIV SARS-CoV Apoptosis	Infection Neurological Disease Inflammation/Immunology Cancer
Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 1.61 μM. Ritonavir (ABT 538) can penetrate the blood brain barrier (BBB) .

HY-17007

Saquinavir 15+ Cited Publications Ro 31-8959	HIV HIV Protease Apoptosis Reactive Oxygen Species (ROS) Calcium Channel NO Synthase Interleukin Related Toll-like Receptor (TLR) p38 MAPK JNK	Infection Cardiovascular Disease Inflammation/Immunology
Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells .

HY-10570

Nevirapine 5+ Cited Publications BI-RG 587; NSC 641530; NVP	HIV Reverse Transcriptase Parasite	Infection Cancer
Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

HY-15592

Cabotegravir 10+ Cited Publications GSK-1265744; S/GSK1265744	OAT HIV HIV Integrase	Infection
Cabotegravir (GSK-1265744) is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC₅₀ values of 2.5 nM, 0.41 μM and 0.81 μM for HIV_ADA, OAT3 and OAT1, respectively. Cabotegravir is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir can be used to research AIDS .

HY-17003

Saquinavir mesylate 15+ Cited Publications Ro 31-8959/003	HIV HIV Protease Apoptosis Reactive Oxygen Species (ROS) Calcium Channel NO Synthase Interleukin Related Toll-like Receptor (TLR) p38 MAPK JNK	Infection Cardiovascular Disease Inflammation/Immunology
Saquinavir (Ro 31-8959) mesylate is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir mesylate also has anti-inflammatory activity and can induce apoptosis of human red blood cells .

HY-109528

Fomivirsen sodium 2 Publications Verification ISIS-2922 sodium	CMV	Infection
Fomivirsen (ISIS-2922) sodium is an antisense 21 mer phosphorothioate oligonucleotide. Fomivirsen sodium is an antiviral agent that is used cytomegalovirus retinitis (CMV) research, incluiding in AIDs. Fomivirsen sodium binds to and degrades the mRNAs encoding CMV immediate-early 2 protein, thus inhibiting virus proliferation .

HY-136548B

Tenofovir diphosphate disodium TFV-DP disodium	HIV Reverse Transcriptase	Infection Inflammation/Immunology
Tenofovir diphosphate disodium is an antiretroviral agent. Tenofovir diphosphate disodium is an inhibitor of HIV reverse transcriptase DNA (K_i = 1.55 μM) and RNA (K_i = 0.022 μM). Tenofovir diphosphate disodium can be used for the research of AIDS .

HY-10571A

Delavirdine mesylate 3 Publications Verification U 90152 mesylate; BHAP-U 90152 mesylate	HIV Reverse Transcriptase	Infection
Delavirdine (U 90152) mesylate is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine mesylate selectively inhibits HIV-1 reverse transcriptase (RT) (IC₅₀=0.26 μM) over DNA polymerase α (IC₅₀=440 μM) and polymerase δ (IC₅₀>550 μM). Delavirdine mesylate is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-10571

Delavirdine 3 Publications Verification U 90152; BHAP-U 90152	HIV Reverse Transcriptase	Infection
Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC₅₀=0.26 μM) over DNA polymerase α (IC₅₀=440 μM) and polymerase δ (IC₅₀>550 μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-15815

Bromosporine 5 Publications Verification	Epigenetic Reader Domain Apoptosis CDK HIV	Cancer
Bromosporine, a chemical probe, is a potent BET inhibitor with an IC₅₀ value of 2.1 μM for PCAF. Bromosporine can arrest cell cycle and induce apoptosis in cancer cells. Bromosporine exhibits excellent antitumor activity in xenograft mice model when combined with 5-Fluorouracil (HY-90006). Bromosporine can increase CDK9 T-loop phosphorylation in HIV-1 latency models, resulting the protection of reactivate HIV-1 replication from latency. Bromosporine can be used to research colorectal cancer, acute myeloid leukemia (AML) and AIDS .

HY-17041

Darunavir Ethanolate 15+ Cited Publications TMC114 Ethanolate	HIV HIV Protease	Infection
Darunavir ethanolate (TMC114 Ethanolate) is a potent HIV protease inhibitor used to treat and prevent HIV/AIDS. Darunavir has a K_i of 1 nM for wild type HIV-1 protease.

HY-136548

Tenofovir diphosphate TFV-DP	Reverse Transcriptase HIV	Infection Inflammation/Immunology
Tenofovir diphosphate is an antiretroviral agent. Tenofovir diphosphate is an inhibitor of HIV reverse transcriptase DNA (K_i = 1.55 μM) and RNA (K_i = 0.022 μM). Tenofovir diphosphate can be used for the research of AIDS .

HY-B2224

Thiamine disulfide	HIV Endogenous Metabolite	Infection Metabolic Disease
Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity .

HY-B1834

Megestrol	Progesterone Receptor Glucocorticoid Receptor	Infection Neurological Disease Inflammation/Immunology Cancer
Megestrol is an orally active glucocorticoid and progesterone receptor agonist. Megestrol can alleviate anorexia, cachexia or unexplained significant weight loss associated with acquired immunodeficiency syndrome (AIDS). Megestrol may cause manifestations similar to those of glucocorticoids and increase the risk of mental disorders .

HY-B1435

Moxisylyte hydrochloride Thymoxamine hydrochloride	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease
Moxisylyte (Thymoxamine) hydrochloride is a selective α₁A-adrenergic receptor antagonist. Moxisylyte hydrochloride competitively antagonizes the activation mediated by norepinephrine. Moxisylyte hydrochloride relaxes penile cavernous smooth muscle and aids erectile function. Moxisylyte hydrochloride is applicable to research related to erectile dysfunction and multiple system atrophy .

HY-15592A

Cabotegravir sodium 10+ Cited Publications GSK-1265744 sodium; S/GSK1265744 sodium	OAT HIV HIV Integrase	Infection
Cabotegravir (GSK-1265744) sodium is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC₅₀ values of 2.5 nM, 0.41 μM and 0.81 μM for HIV_ADA, OAT3 and OAT1, respectively. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir sodium can be used to research AIDS .

HY-106434

Piritrexim BW 301U; NSC 351521	Dihydrofolate reductase (DHFR)	Infection Cancer
Piritrexim (BW 301U) is a potent dihydrofolate reductase (DHFR) inhibitor against Pneumocystis carinii and Toxoplasma gondii, with IC₅₀ values of 0.038 and 0.011 μM, respectively. Piritrexim can be used for acquired immune deficiency syndrome (AIDS) research. Piritrexim also is an anticancer agent .

HY-P1075

CALP3 2 Publications Verification	Calcium Channel	Neurological Disease Cancer
CALP3, a Ca ²⁺-like peptide, is a potent Ca ²⁺ channel blocker that activates EF hand motifs of Ca ²⁺-binding proteins. CALP3 can functionally mimic increased [Ca ²⁺]_i by modulating the activity of Calmodulin (CaM), Ca ²⁺ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia .

HY-N0685

Pseudohypericin	HIV	Infection
Pseudohypericin and its congener Hypericin are the major hydroxylated phenanthroperylenediones present in Hypericum species. Pseudohypericin shows anti-HIV activity .

HY-10570R

Nevirapine (Standard) BI-RG 587 (Standard); NSC 641530 (Standard); NVP (Standard)	Reference Standards HIV Reverse Transcriptase Parasite	Infection Cancer
Nevirapine (Standard) is the analytical standard of Nevirapine. This product is intended for research and analytical applications. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

HY-90001S

Ritonavir-d6 ABT 538-d₆; RTV-d₆	HIV Protease HIV SARS-CoV Apoptosis	Infection
Ritonavir-d₆ is the deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 1.61 μM .

HY-B1538A

Bamethan hemisulfate DL-Bamethane hemisulfate	Endogenous Metabolite	Cardiovascular Disease
Bamethan (DL-Bamethane) hemisulfate is a vasodilator that exhibits significant activity in enhancing blood flow and reducing vascular resistance. Bamethan hemisulfate plays a crucial role in the treatment of cardiovascular conditions by improving oxygen delivery to tissues. Bamethan hemisulfate also aids in the management of hypertension through its relaxing effects on blood vessels.

HY-162836

Rifamycin B 4-O-(Carboxymethyl)-Rifamycin	Antibiotic Bacterial	Infection
Rifamycin B (4-O-(Carboxymethyl)-Rifamycin) is a member of ansamycin antibiotics family with an anti-mycobacterial activity against tuberculosis, leprosy and AIDS-related mycobacterial infections. Rifamycin B is a metabolic product of Nocardia inediterranei, which can yield Rifamycin O and Rifamycin S (HY-125365) by microbial transformation .

HY-145569A

Fipravirimat dihydrochloride GSK3640254 dihydrochloride	HIV	Infection
Fipravirimat dihydrochloride is a potent HIV-1 inhibitor. Fipravirimat dihydrochloride has the potential for HIV and AIDS research .

HY-B1046S

Clofazimine-d7	Bacterial Antibiotic	Inflammation/Immunology
Clofazimine-d₇ is deuterium labeled Clofazimine. Clofazimine is an iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial agents to treat AIDS and Crohn's disease.

HY-90001R

Ritonavir (Standard) ABT 538 (Standard); RTV (Standard)	Reference Standards HIV Protease HIV SARS-CoV Apoptosis	Infection Cancer
Ritonavir (Standard) is the analytical standard of Ritonavir. This product is intended for research and analytical applications. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 1.61 μM.

HY-P10358

TAT-CBD3A6K	Calcium Channel	Neurological Disease
TAT-CBD3A6K, is a modified TAT-CBD3 peptide. TAT-CBD3A6K reduces T- and R-type voltage-dependent calcium currents in dorsal root ganglion (DRG) neurons. TAT-CBD3A6K shows anti-nociceptive effects in a model of AIDS-induced peripheral neuropathy by preventing CRMP-2-mediated enhancement of T- and R-type calcium channel function .

HY-137565

Hydroxy ritonavir	Drug Metabolite	Others
Hydroxy ritonavir is a metabolite of Ritonavir. Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS .

HY-W115757

Magnesium trisilicate	Environmental Pollutants Biochemical Assay Reagents	Others
Magnesium trisilicate, is an antacid and filter aid. Magnesium trisilicate is a biomaterial or organic compound that can be used in life science research .

HY-W016664

4-(Trifluoromethoxy)aniline	Biochemical Assay Reagents Drug Intermediate	Infection
4-(Trifluoromethoxy)aniline is an intermediate. 4-(Trifluoromethoxy)aniline can be used in the synthesis of Compound 80. 4-(Trifluoromethoxy)aniline can be used in AIDS research .

HY-106920

Kynostatin 272 KNI 272; Kynostatin; NSC 651714	HIV Protease	Infection
Kynostatin 272 (KNI 272) is a potent HIV protease inhibitor. Kynostatin 272 inhibits the activity of the HIV protease by simulating the substrate transition state of the HIV protease, thus preventing a key step in the replication of the HIV virus. Kynostatin 272 provides an important research foundation for the development of drugs for HIV and AIDS .

HY-123330

GW695634	HIV Reverse Transcriptase	Infection
GW695634 is an orally active prodrug of GW678248. GW695634 undergoes amidolysis in vivo to release the active ingredient GW678248, thereby inhibiting viral replication. GW678248 is a non-nucleoside reverse transcriptase inhibitor (NNRTi) with potent antiviral activity against Efavirenz (HY-10572)-resistant and Nevirapine (HY-10570)-resistant HIV and *AIDS* viruses .

HY-146353

HIV-1 inhibitor-29	HIV	Infection Inflammation/Immunology
HIV-1 inhibitor-29 (compound 14d2) is a potent HIV-1 inhibitor with an EC₅₀ of 2.18 μM for HIV-1 IIIB. HIV-1 inhibitor-29 has high anti-resistance profile toward F227L/V106A strain (EC₅₀ = 0.974 μM), and exhibits low cytotoxicity in MT-4 cells (CC₅₀ = 211 μM). HIV-1 inhibitor-29 can be used for researching AIDS .

HY-15592R

Cabotegravir (Standard) GSK-1265744 (Standard); S/GSK1265744 (Standard)	OAT Reference Standards HIV HIV Integrase	Infection
Cabotegravir (Standard) is the analytical standard of Cabotegravir. This product is intended for research and analytical applications. Cabotegravir (GSK-1265744) is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC₅₀ values of 2.5 nM, 0.41 μM and 0.81 μM for HIV_ADA, OAT3 and OAT1, respectively. Cabotegravir is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir can be used to research AIDS .

HY-171859

FC-14367	PROTACs HIV	Cancer
FC-14367 is a PROTAC degrader targeting HIV-1 Nef protein. FC-14367 forms a ternary complex by binding Nef and Cereblon E3 ubiquitin ligase, inducing Nef ubiquitination and proteasomal degradation, restoring cell-surface CD4 and MHC-I expression and inhibiting HIV-1 replication. FC-14367 can be used in research on HIV infection and AIDS . (Black: Glycolic acid (HY-W015967); Blue: 2-(2,6-Dioxopiperidin-3-yl)phthalimidine (HY-138793))

HY-174303

NNRT-IN-9	HIV Reverse Transcriptase	Infection
NNRT-IN-9 (Compound EG28) is a non-nucleoside reverse transcriptase (NNRT) inhibitor. NNRT-IN-9 has potent antiviral and anti-resistance activity against wild-type (WT) HIV-1 and various clinically relevant mutations (E138K and K103N + Y181C) with EC₅₀s of 55, 67 and 3910 nM, respectively. NNRT-IN-9 can be used for acquired immune deficiency syndrome (AIDS) research .

HY-145569

Fipravirimat GSK3640254	HIV	Infection
Fipravirimat is a potent HIV-1 inhibitor. Fipravirimat has the potential for HIV and AIDS research .

HY-177071

Asuptegravir	HIV	Infection
Asuptegravir (Compound 1) is an inhibitor of HIV integrase activity. Asuptegravir inhibits HIV in HEK293T cells (EC₅₀ = 1.08 nM). Asuptegravir can be studied in anti-AIDs/HIV research .

HY-106155

Amdoxovir DAPD	HIV Reverse Transcriptase	Infection
Amdoxovir (DAPD) is an orally active nucleoside reverse transcriptase inhibitor. Amdoxovir is active against wild-type and NRTl-resistant viruses. Amdoxovir is the prodrug of dioxolane guanosine. Amdoxovir can be used for research of HIV/AIDS .

HY-117879

PF-4776548	HIV HIV Integrase	Infection
PF-4776548 is a highly potent HIV integrase inhibitor. PF-477654 blocks the process of integrating HIV viral DNA into the host cell genome. PF-4776548 is promising for research of AIDS .

HY-136548A

Tenofovir diphosphate triethylamine TFV-DP triethylamine	Reverse Transcriptase HIV	Infection Inflammation/Immunology
Tenofovir diphosphate triethylamine is an antiretroviral agent. Tenofovir diphosphate triethylamine is an inhibitor of HIV reverse transcriptase DNA (K_i = 1.55 μM) and RNA (K_i = 0.022 μM). Tenofovir diphosphate triethylamine can be used for the research of AIDS .

HY-B2224R

Thiamine disulfide (Standard)	Reference Standards HIV Endogenous Metabolite	Infection Metabolic Disease
Thiamine disulfide (Standard) is the analytical standard of Thiamine disulfide. This product is intended for research and analytical applications. Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity .

HY-163852

HIV-1 inhibitor-72	Ligands for Target Protein for PROTAC HIV	Infection Cancer
HIV-1 inhibitor-72 (compound 5m) is a target protein ligand of PROTAC Vif degrader-1 (HY-163851). HIV-1 inhibitor-72 is a potent HIV-1 inhibitor .

HY-105098

Lobucavir BMS-180194; SQ 34514	HBV HIV CMV EBV Nucleoside Antimetabolite/Analog	Infection
Lobucavir (BMS-180194; SQ 34514)，a nucleoside analogue，is an antiviral agent. Lobucavir shows a broad spectrum of activity against *HBV，HIV/AIDS*，and α，β，and γ herpes viruses including CMV，herpes-simplex，varicella-zoster，and Epstein-Barr virus .

HY-106276

(D-Ala)-Peptide T	HIV	Infection Neurological Disease
(D-Ala)-Peptide T is an octapeptide derived from gp120. (D-Ala)-Peptide T releases chemokines and prevents HIV-1 GP120-induced neuronal death. (D-Ala)-Peptide T can be used in research on infectious and neurological diseases such as AIDS-related dementia .

HY-120880

SKF107457	HIV Protease	Infection
SKF107457 is an HIV-1 protease inhibitor that can be used in AIDS research .

HY-120712

Ro 31-8588	HIV Protease	Infection
Ro 31-8588 is a HIV protease inhibitor with the K_i of 0.3 nM. Ro 31-8588 can be used for study of AIDS .

HY-146088

HIV-1 inhibitor-31	HIV	Infection
HIV-1 inhibitor-31 (compound 4) is a potent HIV-1 inhibitor. HIV-1 inhibitor-31 can be used for researching AIDS .

HY-151197

HIV protease-IN-1	HIV Protease	Infection
HIV protease-IN-1 (compound 1·succinate) is a potent HIV protease non-peptidic inhibitor, can be used to research AIDS .

HY-125712

CGP 53820	HIV HIV Protease	Infection
CGP 53820 is an inhibitor for HIV protease, inhibits the complex of HIV-1 and HIV-2 protease with K_i of 9 and 53 nM for HIV-1 protease and HIV-2 protease. CGP 53820 can be used in AIDS research .

Cat. No.	Product Name

HY-L057

Phenols Library

1,290 compounds

Phenolic compounds are usually referred to as a diverse group of naturally occurring compounds with multiple medical properties, such as antioxidants, antimicrobial properties. Those compounds are commonly found in food and plants. They have high synthetic, medicinal and industrial values. Polyphenols are compounds with multiple phenolic functionalities. Naturally occurring polyphenols are known to have biological activities for use as drugs, for example, in diseases like AIDS, heart ailments, ulcer formation, bacterial infection, mutagenesis and neural disorders.

MCE offers a unique collection of 1,290 natural phenol compounds which is a useful tool for drug discovery as an important source of lead compounds.

HY-L197

Vitamin Compound Library

133 compounds

Vitamins are a category of trace organic compounds essential for maintaining normal physiological functions in living organisms. They are classified into fat-soluble and water-soluble vitamins. Fat-soluble vitamins play a role in maintaining vision, bone health, reproductive functions, and blood coagulation. Water-soluble vitamins are involved in energy metabolism, nervous system function, and cellular repair processes. Most vitamins cannot be synthesized by the organism and must be obtained through diet. In recent years, vitamins and their derivatives have become increasingly important in the field of drug development due to their extensive physiological activities. Additionally, vitamins and their derivatives can be used to construct research platforms for vitamin metabolism, which helps to delve into the metabolic pathways and dynamic changes of vitamins within the body and aids in identifying new biomarkers for certain diseases.

MCE included 133 vitamins and their derivatives, including Vitamin A, Vitamin B, Vitamin D, etc., which is a good tool for studying vitamin metabolism.

HY-L208

Bile Acids Library

61 compounds

Bile acids are a class of amphiphilic molecules derived from the metabolic breakdown of cholesterol, primarily synthesized in the liver, and play a crucial role in the intestines. Based on their structural characteristics, bile acids are mainly divided into two categories: free bile acids (including Cholic acid, Deoxycholic acid, Chenodeoxycholic acid) and conjugated bile acids (including Glycocholic acid, Glycochenodeoxycholic acid, Taurocholic acid, etc.). Bile acids play a significant role in the pathophysiological research of liver and gastrointestinal diseases and are closely associated with the occurrence of metabolic diseases such as obesity, type II diabetes, non-alcoholic fatty liver disease, and atherosclerosis. Bile acids maintain metabolic balance within the body by regulating sugar metabolism, lipid metabolism, and amino acid metabolism, and they influence the activity of metabolism-related enzymes and transporters. In addition, Bile acids can also be used to construct a bile acid metabolism research platform, which helps to delve into the metabolic pathways and dynamic changes of bile acids in living organisms and aids in identifying new biomarkers for certain diseases.

MCE included 61 bile acids, including Cholic acid, Deoxycholic acid, Glycocholic acid, etc., which are effective tools for the study of liver and gallbladder diseases.

HY-L132

Chemokine Compound Library

237 compounds

Chemokines, or chemotactic cytokines, are small cytokines or signaling proteins secreted by cells. They are a component of intercellular communication, controlling the directional movement of immune cells especially leukocytes, as well as other cell types, for instance, endothelial and epithelial cells, which are essential to maintain human health and the function of the immune system.

The biological effects of chemokines are achieved by binding to chemokine receptors, which are G protein-coupled receptors found on the surface of leukocytes. Some chemokine receptors are involved in directing tumor metastasis and over-expression by certain tumors. So inhibiting the interaction between chemokine and chemokine receptors on the surface of tumor cells may be a new possible therapeutic approach. Some chemokine receptors are coreceptors for HIV entry, and related inhibitors have been approved by the FDA to treat patients with HIV. Obviously, chemokines and chemokine receptors have become new targets for studying cancer, HIV, inflammation, and other diseases.

MCE supplies a unique collection of 237 chemokine or chemokine receptor inhibitors and activators, all of which have the identified inhibitory or activated effect on chemokine or chemokine receptors. MCE Chemokine Library is a useful tool for drug research related to cancer, AIDS, and wound therapy.

Cat. No.	Product Name	Type

HY-138170GL

ALC-0315 (GMP Like)

Fluorescent Dye

ALC-0315 (GMP Like) is ALC-0315 (HY-138170) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .

Cat. No.	Product Name	Type

HY-138170

ALC-0315 35+ Cited Publications	Biochemical Assay Reagents
ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .

HY-138170GL

ALC-0315 (GMP Like)

Biochemical Assay Reagents

HY-W115757

Magnesium trisilicate	Biochemical Assay Reagents
Magnesium trisilicate, is an antacid and filter aid. Magnesium trisilicate is a biomaterial or organic compound that can be used in life science research .

HY-W016664

4-(Trifluoromethoxy)aniline	Biochemical Assay Reagents
4-(Trifluoromethoxy)aniline is an intermediate. 4-(Trifluoromethoxy)aniline can be used in the synthesis of Compound 80. 4-(Trifluoromethoxy)aniline can be used in AIDS research .

HY-W016664R

4-(Trifluoromethoxy)aniline (Standard)	Biochemical Assay Reagents
4-(Trifluoromethoxy)aniline (Standard) is the analytical standard of 4-(Trifluoromethoxy)aniline (HY-W016664). This product is intended for research and analytical applications. 4-(Trifluoromethoxy)aniline is an intermediate. 4-(Trifluoromethoxy)aniline can be used in the synthesis of Compound 80. 4-(Trifluoromethoxy)aniline can be used in AIDS research .

Cat. No.	Product Name	Target	Research Area

HY-P1075

CALP3 2 Publications Verification	Calcium Channel	Neurological Disease Cancer
CALP3, a Ca ²⁺-like peptide, is a potent Ca ²⁺ channel blocker that activates EF hand motifs of Ca ²⁺-binding proteins. CALP3 can functionally mimic increased [Ca ²⁺]_i by modulating the activity of Calmodulin (CaM), Ca ²⁺ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia .

HY-P10358

TAT-CBD3A6K	Calcium Channel	Neurological Disease
TAT-CBD3A6K, is a modified TAT-CBD3 peptide. TAT-CBD3A6K reduces T- and R-type voltage-dependent calcium currents in dorsal root ganglion (DRG) neurons. TAT-CBD3A6K shows anti-nociceptive effects in a model of AIDS-induced peripheral neuropathy by preventing CRMP-2-mediated enhancement of T- and R-type calcium channel function .

HY-106276

(D-Ala)-Peptide T	HIV	Infection Neurological Disease
(D-Ala)-Peptide T is an octapeptide derived from gp120. (D-Ala)-Peptide T releases chemokines and prevents HIV-1 GP120-induced neuronal death. (D-Ala)-Peptide T can be used in research on infectious and neurological diseases such as AIDS-related dementia .

HY-120880

SKF107457	HIV Protease	Infection
SKF107457 is an HIV-1 protease inhibitor that can be used in AIDS research .

HY-P10358A

TAT-CBD3A6K acetate	Calcium Channel	Neurological Disease
TAT-CBD3A6K acetate, is a modified TAT-CBD3 peptide. TAT-CBD3A6K acetate reduces T- and R-type voltage-dependent calcium currents in dorsal root ganglion (DRG) neurons. TAT-CBD3A6K acetate shows anti-nociceptive effects in a model of AIDS-induced peripheral neuropathy by preventing CRMP-2-mediated enhancement of T- and R-type calcium channel function .

HY-P1075A

CALP3 TFA	Calcium Channel	Neurological Disease Cancer
CALP3 TFA, a Ca ²⁺-like peptide, is a potent Ca ²⁺ channel blocker that activates EF hand motifs of Ca ²⁺-binding proteins. CALP3 TFA can functionally mimic increased [Ca ²⁺]_i by modulating the activity of Calmodulin (CaM), Ca ²⁺ channels and pumps. CALP3 TFA has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia .

HY-P11152

HIV-1 tat Protein (1-9)	HIV	Infection Inflammation/Immunology
HIV-1 tat Protein (1-9) occurs extracellularly and has a role in the immunosuppression of non-HIV-1-infected T cells in acquired AIDS. HIV-1 tat Protein (1-9) is an inhibitor of DP IV. HIV-1 tat Protein (1-9) can be synthesized by phase peptide synthesis with Fmoc (N-(9-fluorenyl)methoxycarbonyl) technique using the peptide synthesizer 431A. HIV-1 tat Protein (1-9) can be studied in research on HIV-1 .

HY-P5415

DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS	HIV	Others
DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is a biological active peptide. (DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is also called HIV protease substrate I in some literature. It is widely used for the continuous assay for HIV protease activity. The 11-K_d protease (PR) encoded by the human immunodeficiency virus 1 (HIV-1) is essential for the correct processing of viral polyproteins and the maturation of infectious virus, and is therefore a target for the design of selective acquired immunodeficiency syndrome (AIDS) therapeutics. The FRET-based fluorogenic substrate is derived from a natural processing site for HIV-1 PR. Incubation of recombinant HIV-1 PR with the fluorogenic substrate resulted in specific cleavage at the Tyr-Pro bond and a time-dependent increase in fluorescence intensity that is linearly related to the extent of substrate hydrolysis. The fluorescence quantum yields of the HIV-1 PR substrate in the FRET assay increased by 40.0- and 34.4-fold, respectively, per mole of substrate cleaved. Because of its simplicity and precision in the determination of reaction rates required for kinetic analysis, this substrate offers many advantages over the commonly used HPLC or electrophoresis-based assays for peptide substrate hydrolysis by retroviral PRs. Abs/Em = 340nm/490nm.)

Cat. No.	Product Name	Target	Research Area	Image

HY-P992073

OpSCF INS1148	Inhibitory Antibodies	Inflammation/Immunology
OpSCF (INS1148) is an antibody that specifically binds and inactivates inflammatory stem cell factor (SCF), blocks the positive feedback cycle of chronic inflammation, and aids tissue repair.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-17438

Cidofovir 10+ Cited Publications GS 0504; HPMPC; (S)-HPMPC	Infection Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	CMV Apoptosis DNA/RNA Synthesis Orthopoxvirus Endogenous Metabolite
Cidofovir (GS 0504) is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir also has anti-orthopoxvirus and anti-variola activities .

HY-10571

Delavirdine 3 Publications Verification U 90152; BHAP-U 90152	Infection Classification of Application Fields Disease Research Fields	HIV Reverse Transcriptase
Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC₅₀=0.26 μM) over DNA polymerase α (IC₅₀=440 μM) and polymerase δ (IC₅₀>550 μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-B2224

Thiamine disulfide	Infection Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	HIV Endogenous Metabolite
Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity .

HY-N0685

Pseudohypericin	Infection Quinones Classification of Application Fields Anthraquinones Guttiferae Phenols Polyphenols Hyperlcurn perforatum L. Plants Disease Research Fields Source Classification	HIV
Pseudohypericin and its congener Hypericin are the major hydroxylated phenanthroperylenediones present in Hypericum species. Pseudohypericin shows anti-HIV activity .

HY-17438A

Cidofovir dihydrate GS 0504 dihydrate; HPMPC dihydrate; (S)-HPMPC dihydrate	Infection Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	CMV DNA/RNA Synthesis Orthopoxvirus Apoptosis Endogenous Metabolite
Cidofovir (GS 0504; HPMPC; (S)-HPMPC) dihydrate is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir dihydrate inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir dihydrate induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir dihydrate also has anti-orthopoxvirus and anti-variola activities .

HY-B2224R

Thiamine disulfide (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards HIV Endogenous Metabolite
Thiamine disulfide (Standard) is the analytical standard of Thiamine disulfide. This product is intended for research and analytical applications. Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity .

HY-17438R

Cidofovir (Standard) GS 0504 (Standard); HPMPC (Standard); (S)-HPMPC (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards CMV Apoptosis DNA/RNA Synthesis Orthopoxvirus Endogenous Metabolite
Cidofovir (Standard) is the analytical standard of Cidofovir. This product is intended for research and analytical applications. Cidofovir (GS 0504) is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir also has anti-orthopoxvirus and anti-variola activities .

HY-N12082

HIV-IN-8	Phenols Polyphenols Plants Boraginaceae Arnebia euchroma (Royle) Johnst. Source Classification	HIV
HIV-IN-8 (Compound 9) is a HIV inhibitor. HIV-IN-8 inhibits HIV replication with an EC₅₀ of 13 μg/mL .

HY-N0685R

Pseudohypericin (Standard)	Quinones Structural Classification Anthraquinones Guttiferae Phenols Polyphenols Hyperlcurn perforatum L. Plants Source Classification	Reference Standards HIV
Pseudohypericin (Standard) is the analytical standard of Pseudohypericin. This product is intended for research and analytical applications. Pseudohypericin and its congener Hypericin are the major hydroxylated phenanthroperylenediones present in Hypericum species. Pseudohypericin shows anti-HIV activity .

HY-N15294

3β-Hydroxy-27-p-Z-coumaroyloxyurs-12-en-28-oic acid	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Triterpenes Structural Classification Terpenoids Rubiaceae Plants Source Classification	HIV HIV Protease
3β-Hydroxy-27-p-Z-coumaroyloxyurs-12-en-28-oic acid (compound 8) is a triterpenoid ester HIV-1 protease inhibitor with the potential for use in the antiretroviral combination therapy of AIDS .

HY-N19042

Sapindus mokorossi extract	Structural Classification Extract	Bacterial
Sapindus mokorossi extract, derived from the fruit of the soapberry tree, possesses cleansing, antioxidant, and anti-inflammatory properties. Its main active ingredient is saponin, a natural surfactant that aids in foam formation and provides gentle cleansing.

HY-136972A

GB-1a Biflavanone GB-1a	Structural Classification Flavonoids Plants Biflavones Toxicodendron vernicifluum (Stokes) F. A. Barkl. Anacardiaceae Source Classification	HIV Reverse Transcriptase
GB-1a (Biflavanone GB-1a) is a biflavanone HIV-1 reverse transcriptase inhibitor (IC₅₀=236 μM), with an EC₅₀ of 38.0 μM for HIV-1 replication. GB-1a can block the conversion of HIV-1 genomic RNA to DNA and can be used in research related to AIDS (HIV-1 infection). GB-1a can be naturally extracted from the heartwood of Garcinia multiflora Champ .

HY-N16760

Wikstrol B	Structural Classification Flavonoids Flavones Thymelaeaceae Phenols Plants Source Classification Wikstroemia indica	Microtubule/Tubulin HIV
Wikstrol B (compound 5) is a biflavonoid microtubule/tubulin inhibitor and HIV-1 inhibitor. Wikstrol B has an IC₅₀ value of 184 μM for microtubule polymerization and an EC₅₀ of 3.02 μM against HIV-1, acting on early events of HIV-1 replication. Wikstrol B exerts antifungal activity by inducing morphological deformation of Pyricularia oryzae hyphae and exerts anti-mitotic activity by inhibiting microtubule polymerization. Wikstrol B can be used in research related to antifungal, antitumor, and anti-AIDS applications. Wikstrol B can be naturally extracted from the roots of Wikstroemia indica .

Cat. No.	Product Name	Chemical Structure

HY-90001S

Ritonavir-d6
Ritonavir-d₆ is the deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 1.61 μM .

HY-B1046S

Clofazimine-d7
Clofazimine-d₇ is deuterium labeled Clofazimine. Clofazimine is an iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial agents to treat AIDS and Crohn's disease.

HY-17007S

Saquinavir-d9
Saquinavir-d₉ (Ro 31-8959-d₉) is the deuterium labeled Saquinavir (HY-17007). Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells .

HY-10570S

Nevirapine-d4
Nevirapine-d₄ is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

HY-15592S2

Cabotegravir-d3-1
Cabotegravir d3-1 (GSK-1265744-d3-1) is a deuterium substitute of Cabotegravir. Cabotegravir is a potent HIV integrase inhibitor used in AIDS research

HY-10570S1

Nevirapine-d3
Nevirapine-d₃ (BI-RG 587-d₃) is the deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

HY-10570S2

Nevirapine-d8
Nevirapine-d₈ (BI-RG 587-d₈) is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

HY-W653853

Ritonavir-13C3
Ritonavir- ¹³C₃ is ¹³C labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 1.61 μM .

HY-90001S2

Ritonavir-d8
Ritonavir-d₈ is deuterated labeled Ritonavir (HY-90001). Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 1.61 μM.

HY-90001S1

Ritonavir-13C,d3
Ritonavir- ¹³C,d₃ is the ¹³C- and deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM.

HY-B1834S1

Megestrol-d5
Megestrol-d₅ is the deuterium labeled Megestrol. Megestrol is an orally active glucocorticoid and progesterone receptor agonist. Megestrol can alleviate anorexia, cachexia or unexplained significant weight loss associated with acquired immunodeficiency syndrome (AIDS). Megestrol may cause glucocorticoid-like effects and an increased risk of mental disorders.

HY-17007S2

Saquinavir-13C6
Saquinavir- ¹³C₆ (Ro 31-8959- ¹³C₆) is ¹³C labeled Saquinavir (HY-17007). Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells .

HY-90001S3

rel-Ritonavir-d6
rel-Ritonavir-d₆ (rel-ABT 538-d₆) is the deuterium labeled rel-Ritonavir. rel-Ritonavir is a relative configuration of Ritonavir (HY-90001). Ritonavir (ABT 538) is an inhibitor of HIV protease used to study of HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 1.61 μM .

HY-10570S3

Nevirapine-d5
Nevirapine-d₅ (BI-RG 587-d₅) is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

Cat. No.	Product Name		Classification

HY-138170

ALC-0315 35+ Cited Publications		Cationic Lipids
ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .

HY-109528

Fomivirsen sodium 2 Publications Verification ISIS-2922 sodium		Antisense Oligonucleotides
Fomivirsen (ISIS-2922) sodium is an antisense 21 mer phosphorothioate oligonucleotide. Fomivirsen sodium is an antiviral agent that is used cytomegalovirus retinitis (CMV) research, incluiding in AIDs. Fomivirsen sodium binds to and degrades the mRNAs encoding CMV immediate-early 2 protein, thus inhibiting virus proliferation .

HY-174548

Human PDGFRB mRNA		mRNA
Human PDGFRB mRNA encodes the human platelet derived growth factor receptor beta (PDGFRB) protein, a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. PDGFRB is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton.

HY-174731

Human CX3CR1 mRNA		mRNA Chemokine & Receptors
Human CX3CR1 mRNA encodes the human C-X3-C motif chemokine receptor 1 (CX3CR1) protein, a receptor for fractalkine. CX3CR1 is also a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS.

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138170GL

ALC-0315 (GMP Like)	Liposome SARS-CoV	Infection
ALC-0315 (GMP Like) is ALC-0315 (HY-138170) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .

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