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Pathways Recommended: Cell Cycle/DNA Damage
Results for "

bacterial DNA gyrase subunit B

" in MedChemExpress (MCE) Product Catalog:
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Art. -Nr. Produktname Target Forschungsgebiete Chemical Structure
  • HY-16742B
    Gepotidacin mesylate hydrate
    10+ Cited Publications

    		 Antibiotic Bacterial Topoisomerase Infection
    Gepotidacin mesylate hydrate is an orally active triazaacenaphthylene antibiotic and bacterial type II topoisomerase inhibitor. Gepotidacin mesylate hydrate inhibits bacterial DNA replication by blocking topoisomerase enzymes. Gepotidacin mesylate hydrate selectively inhibits topoisomerase IV and the B subunit of DNA gyrase .
    Gepotidacin mesylate hydrate
  • HY-123515
    Clorobiocin

    		Infection
    Clorobiocin is an antibacterial agent with an IC50 of 0.21 μM against the B subunit of E. coli DNA gyrase. Clorobiocin targets the mLaC protein of Gram-negative bacteria. Clorobiocin potently inhibits bacterial DNA replication. Clorobiocin can be used in studies on Gram-negative bacterial infections, such as Acinetobacter baumannii and E. coli infections .
    Clorobiocin
  • HY-182417
    PD 0305970

    		Bacterial Topoisomerase Infection
    PD 0305970 is an orally active bacterial gyrase and topoisomerase inhibitor. PD 0305970 shows exceptional activity against gram-positive and fastidious organisms and more modest activity against gram-negative species. PD 0305970 shows low spontaneous resistance frequencies. PD 0305970 shows antibacterial efficacy in murine streptococcal sepsis and pneumococcal pneumonia models. PD 0305970 can be used for the research of bacterial infection .
    PD 0305970

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