39868-96-7
Chemical Structure
Clorobiocin
- CAS No.: 39868-96-7
- Formula:C35H37ClN2O11
- Molecular Weight:697.13
IUPAC Name: (3R,4S,5R,6S)-6-((8-chloro-4-hydroxy-3-(4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamido)-2-oxo-2H-chromen-7-yl)oxy)-5-hydroxy-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl 5-methyl-1H-pyrrole-2-carboxylate
InChIKey: FJAQNRBDVKIIKK-LFLQOBSNSA-N
SMILES: OC(C(C(OC1=O)=C2Cl)=CC=C2O[C@H](OC3(C)C)[C@@H]([C@@H]([C@H]3OC)OC(C(N4)=CC=C4C)=O)O)=C1NC(C(C=C5)=CC(C/C=C(C)\C)=C5O)=O
Biological Activity: Clorobiocin is an antibacterial agent with an IC50 of 0.21 μM against the B subunit of E. coli DNA gyrase. Clorobiocin targets the mLaC protein of Gram-negative bacteria. Clorobiocin potently inhibits bacterial DNA replication. Clorobiocin can be used in studies on Gram-negative bacterial infections, such as Acinetobacter baumannii and E. coli infections[1][2].
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Clorobiocin | Clorobiocin is an antibacterial agent with an IC50 of 0.21 μM against the B subunit of E. coli DNA gyrase. Clorobiocin targets the mLaC protein of Gram-negative bacteria. Clorobiocin potently inhibits bacterial DNA replication. Clorobiocin can be used in studies on Gram-negative bacterial infections, such as Acinetobacter baumannii and E. coli infections. | |||||||||||||||||||||
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- [1]. Huang YM, et al. Docking simulation and antibiotic discovery targeting the MlaC protein in Gram-negative bacteria. Chem Biol Drug Des. 2019;93(4):647-652. [Content Brief]
- [2]. Hooper DC, et al. Effects of novobiocin, coumermycin A1, clorobiocin, and their analogs on Escherichia coli DNA gyrase and bacterial growth. Antimicrob Agents Chemother. 1982;22(4):662-671. [Content Brief]
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