2. Search Result
Search Result
Results for "

blocking peptide

" in MedChemExpress (MCE) Product Catalog:

304

Inhibitors & Agonists

4

Screening Libraries

1

Fluorescent Dye

6

Biochemical Assay Reagents

202

Peptides

1

MCE Kits

3

Inhibitory Antibodies

5

Natural
Products

9

Isotope-Labeled Compounds

10

Click Chemistry

5

Oligonucleotides

1

GMP Molecules

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-Y1636
    Fmoc-Arg(Pbf)-OH

    		Amino Acid Derivatives Drug Intermediate Metabolic Disease
    Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis) .
    Fmoc-Arg(Pbf)-OH
  • HY-P0256
    Apamin
    5+ Cited Publications

    Apamine

    		 Potassium Channel Neurological Disease Inflammation/Immunology
    Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca 2+-activated K + (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity .
    Apamin
  • HY-P0173A
    Chlorotoxin
    2 Publications Verification

    		 Chloride Channel Cancer
    Chlorotoxin is a 36 amino-acid peptide from the venom of the Israeli scorpion Leiurus quinquestriatus with anticancer activity. Chlorotoxin is a chloride channel blocker.
    Chlorotoxin
  • HY-P0062B
    Ziconotide acetate
    2 Publications Verification

    SNX-111 acetate

    		 Calcium Channel Cardiovascular Disease Inflammation/Immunology Cancer
    Ziconotide acetate (SNX-111 acetate), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide acetate reduces synaptic transmission, and can be used for chronic pain research .
    Ziconotide acetate
  • HY-P4157
    FOXO4-DRI

    		MDM-2/p53 Apoptosis Metabolic Disease
    FOXO4-DRI is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53. FOXO4-DRI is a senolytic peptide that induces apoptosis of senescent cells .
    FOXO4-DRI
  • HY-P2565
    Pepinh-TRIF TFA
    5+ Cited Publications

    		 Toll-like Receptor (TLR) Inflammation/Immunology
    Pepinh-TRIF (TFA) is a 30 aa peptide that blocks TIR-domain-containing adapter-inducing interferon-β (TRIF) signaling by interfering with TLR-TRIF interaction .
    Pepinh-TRIF TFA
  • HY-P3212
    Allo-aca
    5+ Cited Publications

    		 Neuropeptide Y Receptor Others Cancer
    Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models .
    Allo-aca
  • HY-A0162
    Quinupristin
    1 Publications Verification

    		 Bacterial Infection
    Quinupristin is a streptogramin antibiotic. Quinupristin blocks peptide bond synthesis to prevent the extension of polypeptide chains and promote the detachment of incomplete protein chains in the bacterial ribosomal subunits .
    Quinupristin
  • HY-W008558
    Fmoc-N-Me-Leu-OH

    		Amino Acid Derivatives Others
    Fmoc-N-Me-Leu-OH is an N-Fmoc-N-methyl amino acid that can be used in peptide coupling reactions. Fmoc-N-Me-Leu-OH is primarily used as a standard building block in solid-phase peptide synthesis (SPPS) to introduce N-methylleucine residues into peptide chains, thereby enhancing the enzymatic stability, altering conformational flexibility, and modifying the biological activity of the target peptide .
    Fmoc-N-Me-Leu-OH
  • HY-P1082
    Gap 26
    5+ Cited Publications

    		 Connexin Gap Junction Protein Cardiovascular Disease
    Gap 26 is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif .
    Gap 26
  • HY-P10533
    Cysteine peptide

    		Tyrosinase Others
    Cysteine peptide is a tyrosinase inhibitor with skin-whitening, antioxidant and multi-regulatory activities. Cysteine peptide inhibits enzyme activity and blocks melanin transport, effectively reducing UV-B-induced skin erythema and pigmentation. Cysteine peptide synergistically maintains skin health by quenching ROS, resisting oxidative stress and promoting pheomelanin production. Cysteine peptide safely prevents daily ultraviolet damage and supports moderate sun exposure for vitamin D synthesis. Cysteine peptide also acts as a plant signaling factor to regulate vegetative growth, development and stress resistance responses .
    Cysteine peptide
  • HY-P10091
    CD24/Siglec-10 blocking peptide, CSBP

    		PD-1/PD-L1 Cancer
    CD24/Siglec-10 blocking peptide, CSBP can not only block the interaction of CD24/Siglec-10 but also PD-1/PD-L1. CD24/Siglec-10 blocking peptide, CSBP can induce the phagocytosis of tumor cell .
    CD24/Siglec-10 blocking peptide, CSBP
  • HY-P0191
    Charybdotoxin

    		Potassium Channel Inflammation/Immunology
    Charybdotoxin, a 37-amino acid peptide, is a K + channel blocker .
    Charybdotoxin
  • HY-W008235
    Fmoc-N-Me-Ala-OH

    		Amino Acid Derivatives Drug Intermediate Cancer
    Fmoc-N-Me-Ala-OH is an Fmoc-protected N-methyl-L-alanine and also a building block for solid-phase peptide synthesis. As a building block, Fmoc-N-Me-Ala-OH is used to synthesize peptidomimetic antagonists of XIAP BIR3 derived from Smac/DIABLO .
    Fmoc-N-Me-Ala-OH
  • HY-P0062
    Ziconotide

    SNX-111

    		 Calcium Channel Neurological Disease Inflammation/Immunology Cancer
    Ziconotide (SNX-111), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide reduces synaptic transmission, and can be used for chronic pain research .
    Ziconotide
  • HY-P2280
    TAT-P110

    P110

    		 Dynamin Neurological Disease Inflammation/Immunology
    TAT-P110, a peptide inhibitor of Drp1-Fis1 interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1 .
    TAT-P110
  • HY-P1111
    Lyn peptide inhibitor

    		Src Interleukin Related Inflammation/Immunology
    Lyn peptide inhibitor (YGYRLRRKWEEKIPNP-NH2) is a potent, cell-permeable Lyn kinase inhibitor that inhibits Lyn-coupled signaling pathways associated with the IL-5 receptor while preserving the integrity of other signals. Lyn peptide inhibitor blocks the activation of Lyn and inhibits the binding of Lyn tyrosine kinase to the βc subunit of the IL-3/GM-CSF/IL-5 receptor. Lyn peptide inhibitor can be used in the research of eosinophilic diseases such as asthma and allergy .
    Lyn peptide inhibitor
  • HY-P0191A
    Charybdotoxin TFA

    		Potassium Channel Inflammation/Immunology
    Charybdotoxin TFA, a 37-amino acid peptide, is a K + channel blocker .
    Charybdotoxin TFA
  • HY-P10440
    Cdk5i peptide

    		CDK Neurological Disease
    Cdk5i peptide is a CDK5 inhibitory peptide with high binding affinity for Cdk5/p25 (Kd of 0.17 μM), which can block the interaction between CDK5 and p25 and reduce the kinase activity of CDK5/p25. Cdk5i peptide can be used in the stud y of neurodegenerative diseases .
    Cdk5i peptide
  • HY-P10816
    PACE4 Inhibitory peptide C23

    Ac-(DLeu)LLLRVK-Amba

    		 Bacterial Infection Cancer
    PACE4 Inhibitory peptide C23 (Compound C23; Ac-(DLeu)LLLRVK-Amba)), a potent peptidomimetic inhibitor, is a PACE4 inhibitor. PACE4 Inhibitory peptide C23e shows antiproliferative effects against PCa cell lines (Ki = 5 nM; IC50 = 25 and 40 μM for DU145 and LNCaP, respectively). PACE4 Inhibitory peptide C23 also blocks tumor growth in vivo in LNCaP xenograft-bearing mice .
    PACE4 Inhibitory peptide C23
  • HY-W024615
    Me-diazirine-cooh

    3-(3-Methyl-3H-diazirin-3-yl)propanoic acid

    		 Drug Intermediate Biochemical Assay Reagents Others
    Me-diazirine-cooh (3-(3-Methyl-3H-diazirin-3-yl) propanoic acid) is a molecular building block containing an aliphatic diazirine ring. Me-diazirine-cooh undergoes orthogonal coupling in solid-phase peptide synthesis to introduce the Diazirine group into collagen-mimetic peptides. Me-diazirine-cooh is used to construct the photoaffinity probe P1 .
    Me-diazirine-cooh
  • HY-P0173B
    Chlorotoxin TFA
    2 Publications Verification

    		 Chloride Channel Cancer
    Chlorotoxin TFA is a peptide isolated from the venom of the scorpion Leiurus quinquestriatus, acts as a chloride channel blocker . Anti-cancer activity .
    Chlorotoxin TFA
  • HY-P1284
    ZIP
    2 Publications Verification

    		 PKC Neurological Disease Cancer
    ZIP is a selective peptide inhibitor of PKMζ. ZIP injections can block the impairment in morphine conditioned place preference induced .
    ZIP
  • HY-P3695
    VSPPLTLGQLLS

    		FGFR Cancer
    VSPPLTLGQLLS is a small peptide FGFR3 inhibitor, peptide P3, inhibits FGFR3 phosphorylation. VSPPLTLGQLLS inhibits 9-cisRA-induced tracheal lymphangiogenesis and blocks lymphatic endothelial cell (LEC) proliferation, migration, and tubule formation .
    VSPPLTLGQLLS
  • HY-P1074
    SNX-482
    1 Publications Verification

    		 Calcium Channel Neurological Disease
    SNX-482, a peptide, is a potent, high affinity, selective and voltage-dependent R-type CaV2.3 channel blocker with an IC50 of 30 nM. SNX-482 has antinociceptive effect .
    SNX-482
  • HY-P1083
    Dynamin inhibitory peptide
    1 Publications Verification

    		 Dynamin Neurological Disease
    Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide blocks the dopamine D3 effect on GABAA receptors .
    Dynamin inhibitory peptide
  • HY-P5351A
    Hyaluronan-binding peptide, biotin labeled TFA

    		Transmembrane Glycoprotein Inflammation/Immunology Cancer
    Hyaluronan-binding peptide, biotin labeled TFA is a biological active peptide. (This peptide is a hyaluronan-binding peptide biotinylated through a C-terminal GGGSK linker. Hyaluronan (HA) is a nonsulfated glycosaminoglycan expressed in the extracellular matrix and on cell surfaces. HA plays a role in fertilization, embryonic development, wound healing, angiogenesis, leukocyte trafficking to inflamed tissues, and cancer metastasis. This peptide has been shown to block HA binding to CD44 receptors and inhibit T cell proliferation.) .
    Hyaluronan-binding peptide, biotin labeled TFA
  • HY-P1082A
    Gap 26 TFA
    5+ Cited Publications

    		 Connexin Gap Junction Protein Cardiovascular Disease
    Gap 26 TFA is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif .
    Gap 26 TFA
  • HY-P2402
    Fmoc-Gly-Thr(psi(Me,Me)pro)-OH

    		Amino Acid Derivatives Biochemical Assay Reagents Others
    Fmoc-Gly-Thr(psi(Me,Me)pro)-OH is a protected amino acid derivative and building block. Fmoc-Gly-Thr(psi(Me,Me)pro)-OH can be used in peptide synthesis .
    Fmoc-Gly-Thr(psi(Me,Me)pro)-OH
  • HY-P10934
    LXY3

    LXY2

    		 Integrin Cancer
    LXY3 (LXY2) is a VLA-3-blocking peptide that inhibits the interaction between integrin α3β1 (VLA-3) on neutrophil surfaces and laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is used to block neutrophil-mediated nanoparticle release from perivascular pools into the tumor interstitium. LXY3 is commonly employed for targeted imaging of breast cancer .
    LXY3
  • HY-P11097
    Pep-20

    		CD47 Cancer
    Pep-20 is a CD47/SIRPα blocking peptide with KD values of 2.91 and 3.63 μM for human and mouse CD47, respectively. IC50 values for blocking the human and mouse CD47/SIRPα interaction are 24.56 and 12.03 μM, respectively. Pep-20 has antitumor activity .
    Pep-20
  • HY-P10634
    P17 Peptide

    		TGF-beta/Smad Others
    P17 Peptide is a human TGF-β1 inhibitory peptide. P17 Peptide can block woodchuck TGF-β1 activity .
    P17 Peptide
  • HY-P10839
    NBD peptide

    		NF-κB Inflammation/Immunology
    NBD peptide inhibits NF-κB signaling pathway through inhibition of the NEMO-IKK complex combination. NBD peptide exhibits anti-inflammatory efficacy through block of pro-inflammatory cytokines production. NBD peptide exhibits immunosuppressive activity through regulation of immune cells. NBD peptide enhances its transmembrane ability by combining with cell-penetrating peptide HIV-TAT .
    NBD peptide
  • HY-P5785A
    Heteropodatoxin-2 TFA

    		Potassium Channel Neurological Disease
    Heteropodatoxin-2 (TFA), a peptides of 30-amino acid, is a heteropodatoxin. Heteropodatoxin-2 blocks Kv4.2 current expressed in Xenopus laevis oocytes in a voltage-dependent manner, with less block at more positive potentials .
    Heteropodatoxin-2 TFA
  • HY-151783
    DAPOA

    		ADC Linker Others
    DAPOA is a click chemistry reagent containing an azide group. DAPOA can be used in peptide synthesis as a linker that can be further modified at the azido-groups using Staudinger ligation or click-chemistry . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    DAPOA
  • HY-P2405
    Fmoc-Gly-Ser(psi(Me,Me)pro)-OH

    		Biochemical Assay Reagents Amino Acid Derivatives Others
    Fmoc-Gly-Ser(psi(Me,Me)pro)-OH is a side-chain protected amino acid building block. Fmoc-Gly-Ser(psi(Me,Me)pro)-OH can be used for peptide synthesis .
    Fmoc-Gly-Ser(psi(Me,Me)pro)-OH
  • HY-125053A
    Batifiban TFA

    		Glycoprotein VI Cardiovascular Disease
    Batifiban TFA, a cyclic peptide, is an antagonist of platelet glycoprotein GPⅡb/Ⅲa and inhibits platelet aggregation. Batifiban blocks the binding of circulating vitronectin to integrin ανβ3 .
    Batifiban TFA
  • HY-P5917A
    Vm24-toxin TFA

    Vaejovis mexicanus peptide 24 TFA

    		 Potassium Channel Inflammation/Immunology Cancer
    Vm24-toxin (Vaejovis mexicanus peptide 24) TFA, a 36-residue peptide, is a potent and selective Kv1.3 blocker with a Kd of ~3 pM in lymphocytes. Vm24-toxin TFA shows >1500-fold affinity for Kv1.3 over other assayed potassium channels. Vm24-toxin TFA folds into a distorted cystine-stabilized α/β motif consisting of a single-turn α-helix and a three-stranded antiparallel β-sheet, stabilized by four disulfide bridges. Vm24-toxin TFA attenuates the CD4 + effector memory T cell response to T cell receptor (TCR) stimulation .
    Vm24-toxin TFA
  • HY-135133
    S-Phenylsulfonylcysteine

    		Biochemical Assay Reagents Others
    S-Phenylsulfonylcysteine is a reagent for blocking thiol (-SH) groups on proteins and peptides .
    S-Phenylsulfonylcysteine
  • HY-P11045
    JNJ63955918

    		Sodium Channel Neurological Disease
    JNJ63955918 is a potent, highly selective, blocked-state Nav1.7 blocking peptide with an IC50 of 8.0 nM. JNJ63955918 can be used in pain research .
    JNJ63955918
  • HY-P4157A
    FOXO4-DRI acetate

    		MDM-2/p53 Apoptosis Metabolic Disease
    FOXO4-DRI acetate is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53. FOXO4-DRI acetate is a senolytic peptide that induces apoptosis of senescent cells .
    FOXO4-DRI acetate
  • HY-P5881
    PKCα (C2-4) inhibitor peptide

    		PKC Cardiovascular Disease
    PKCα (C2-4) inhibitor peptide is a PKCα specific inhibitor peptide that blocks the inhibition of IKr by the α1A adrenoreceptor agonist A-61603 (HY-101366) .
    PKCα (C2-4) inhibitor peptide
  • HY-P4886A
    Amyloid β-Protein (3-42) TFA

    		Amyloid-β Neurological Disease
    Amyloid β-Protein (3-42) TFA is a precursor of Pyr peptide. Pyroglutamic acid-modified Aβ (pEAβ) (3-42) is the core of the amyloid plaque in Alzheimer's disease. pEAβ (3-42) accelerates the aggregation of Aβ(1-42), while Aβ(1-42) significantly slows down the primary and secondary nucleation of pEAβ(3-42).
    Amyloid β-Protein (3-42) TFA
  • HY-P3892
    Protein Kinase C (19-35) Peptide

    		PKC Inflammation/Immunology
    Protein Kinase C (19-35) Peptide is the PKC pseudosubstrate inhibitor/region. Protein Kinase C (19-35) Peptide possibly blocks the substrate-binding site in its kinase domain, makes the cytoplasmic form of PKC inactive .
    Protein Kinase C (19-35) Peptide
  • HY-108479
    Nolpitantium

    SR140333

    		 Neurokinin Receptor Neurological Disease
    Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin NK1 receptor antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation .
    Nolpitantium
  • HY-P3967
    Thymopoietin i/ii (29-41) (bovine)

    		Transmembrane Glycoprotein Neurological Disease
    Thymopoietin i/ii (29-41) (bovine) is a peptide corresponding to positions 29-41 of bovine thymopoietin II. Thymopoietin i/ii (29-41) (bovine) is a neuromuscular blocker .
    Thymopoietin i/ii (29-41) (bovine)
  • HY-N8152
    Randialic acid B

    		Reactive Oxygen Species (ROS) Inflammation/Immunology
    Randialic acid B, a triterpenoid compound, is a formyl peptide receptor 1 (FPR1) antagonist. Randialic acid B blocks FPR1 in human neutrophils and attenuates psoriasis-like inflammation in vivo .
    Randialic acid B
  • HY-P10457
    15-Hydroxy prostaglandin dehydrogenase blocking peptide

    15-PGDH (92-105)

    		 15-PGDH Others
    5-Hydroxy prostaglandin dehydrogenase blocking peptide (15-PGDH (92-105)) is a blocking peptide that corresponds to the amino acids (AGVNNEKNWEKTLQ) located at positions 92-105 of the 15-hydroxy prostaglandin dehydrogenase (15-PGDH) sequence. 5-Hydroxy prostaglandin dehydrogenase blocking peptide can block the formation of protein-antibody complexes during immunohistochemical analysis of 15-PGDH .
    15-Hydroxy prostaglandin dehydrogenase blocking peptide
  • HY-P4886
    Amyloid β-Protein (3-42)

    		Amyloid-β Neurological Disease
    Amyloid β-Protein (3-42) is the precursor of Pyr peptide. Pyroglutamate-modified Aβ (pEAβ) (3-42) is the core of the amyloid template block in Alzheimer's disease. pEAβ(3-42) accelerated the aggregation of Aβ(1-42), while Aβ(1-42) significantly slowed the primary and secondary nucleation of pEAβ(3-42) .
    Amyloid β-Protein (3-42)
  • HY-W716776
    H-Pro-His-OH

    		Drug Intermediate Others
    H-Pro-His-OH is a commonly used amino acid building block in biochemistry and peptide synthesis.
    H-Pro-His-OH

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: